964 resultados para Friedrich August I, King of Saxony, 1750-1827.


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Selma Stern

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Selma Stern

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A series of studies were undertaken to analyze and compare various aspects of murine class I glycoproteins. An initial area of investigation characterized the Qa-1 alloantigens using two-dimensional gel electrophoresis. Analysis of the products of the Qa-1('b), Qa-1('c) and Qa-1('d) alleles indicated that these were distinct molecules as determined by their lack of comigration upon comparative two-dimensional gel analysis. The importance of asparagine-linked glycosylation in the cell surface expression of class I molecules was also examined. These studies employed tunicamycin, an inhibitor of N-linked glycosylation. Tunicamycin treatment of activated T lymphocytes diminished the surface expression of Qa-1 to undetectable levels; the levels of other class I molecules exhibited little or no decrease. These results indicated that N-linked glycosylation has a differential importance in the cell surface expression of various class I molecules. The molecular weight diversity of class I molecules was also investigated. Molecular weight determination of both the fully glycosylated and unglycosylated forms of H-2 and Qa/Tla region encoded molecules established that there is a significant variation in the sizes of these forms of various class I molecules. The most significant difference ((TURN)9,000 daltons) exists between the unglycosylated forms of H-2K('b) and Qa-2, suggesting that the structural organization of these two molecules may be very different. A comparative two-dimensional gel analysis of various class I glycoproteins isolated from resting and activated T and B lymphocytes indicated that class I molecules expressed on activated T cells exhibited an isoelectrophoretic pattern that was distinct from the isoelectrophoretic pattern of class I molecules expessed on the other cell populations. This difference was attributed to a lower sialic acid content of the molecules expressed on activated T cells. Analysis of cell homogenates determined that activated T cells contained a higher level of endogenous neuraminidase activity than was detected in the other populations, suggesting that this may be the basis of the lower sialic acid content. The relationship of the Qa-4 and Qa-2 alloantigens was also examined. It was established that upon mitogen activation, the expression of Qa-4 was greatly decreased, whereas Qa-2 expression was not decreased. However, an anti-Qa-2 monoclonal antibody blocked the binding of an anti-Qa-4 monoclonal antibody to resting cells. These studies established that Qa-4 is a determinant restricted to resting cells, which is closely associated on the surface with the Qa-2 molecule. ^

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Wilhelm Sauerwein: "Der Gräff, wie er leibt und lebt", Georg Friedrich Gräff, Samuel Friedrich Hassel

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Frankfurter Dialekttheater, Wilhelm Sauerwein: "Der Gräff, wie er leibt und lebt", "Gräff im Grünen", "Der Amerikaner", Carl Malß, Pfeifer: "Die Brunnenfahrt", Sauerwein: Briefe an Wilhelm Rieger (verloren), Collegzeitung, Geplante Sauerwein-Gesamtausgabe

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Signatur des Originals: S 36/F01020

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Signatur des Originals: S 36/F01021

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Signatur des Originals: S 36/F03237

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Signatur des Originals: S 36/G00858

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allunterthänigst überreicht von den Aeltesten und Deputirten im Namen der Israelitischen Gemeinde allhier

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In the present study, proxy data concerning changes in atmospheric CO2 and climatic conditions from the Late Eocene to the Early Miocene were acquired by applying palaeobotanical methods. Fossil floras from 10 well-documented locations in Saxony, Germany, were investigated with respect to (1) stomatal density/index of fossil leaves from three different taxa (Eotrigonobalanus furcinervis, Laurophyllum pseudoprinceps and Laurophyllum acutimontanum), (2) the coexistence approach (CA) based on nearest living relatives (NLR) and (3) leaf margin analysis (LMA). Whereas the results of approach (1) indicate changes in atmospheric CO2 concentration, approaches (2) and (3) provide climate data. The results of the analysis of stomatal parameters indicate that the atmospheric CO2 concentration was higher during the Late Eocene than during the Early Oligocene and increased towards the Late Oligocene. A lower atmospheric pCO2 level after the Late Eocene is also suggested by an increase in marine palaeoproductivity at this time. From the Late Oligocene onwards, no changes in atmospheric CO2 concentration can be detected with the present data. For the considered sites, the results of the coexistence approach and of the leaf margin analysis document a significant cooling event from the Late Eocene to the Early Oligocene. The pCO2 decrease from the Late Eocene to the Early Oligocene indicated by the stomatal data raised in this study was thus coupled to a temperature decrease which is reflected by the present datasets. From the Early Oligocene onwards, however, no further fundamental climate change can be inferred for the considered locations. The pCO2 increase from the Early Oligocene to the Late Oligocene, which is indicated by the present data, is thus not accompanied by a climate change at the considered sites. A warming event during the Late Oligocene is, however, recorded by marine climate archives. According to the present data, no change in pCO2 occurred during the cooling event at the Oligocene/Miocene boundary, which is also indicated by marine data. The quality and validity of stomatal parameters as sensors for atmospheric CO2 concentration are discussed.

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The thesis represents the first part of a reference book to the Tertiary flora of Saxony. All taxa based on leaves of angiosperms and on Ginkgo are included in this compendium. After an overview about the geological state of knowledge on the Tertiary in Saxony, phytostratigraphic concepts are introduced and a historical survey on the Tertiary paleobotanical research in Saxony is given. All plant macrofossils published from Saxonian Tertiary until end of 2013 and their sites of discovery (primary data) were recorded. This data were supplemented by additional attributes and unified through project-based M.Sc. theses. Subsequently, taxa of fossil leaves were selected, their data evaluated and brought to a consistent state of research. Data sheets for 187 out of 235 examined taxa were established for a determination atlas. Macro- and micromorphological attributes are described in this atlas and information are given about the systematic, synonymy, palaeoecology and spatial and temporal distribution. The describing part is illustrated by images and instructive drawings. The documented data were surveyed and discussed related to their quality within the literature in the result part. A bibliography of the extensive palaeobotanical literature for plant fossils of Saxony completes the work. The taxon and locality related data are implemented into an open source geographical information system (GIS) in order to visualize and to manage them effectively. For the first time, the results of this thesis implemented in the GIS allow the generation of distribution maps for the taxa of leaves of Tertiary angiospermes and Ginkgo in Saxony. Furthermore it enables to query topographical, geological and paleobotanical information about the fossil sites. A determination key was developed for the fossil material that allows a rough determination of the findings in the field. The compendium will be available for free use in a printed as well as in a digital version.