Genetics for clinicians: from candidate genes to whole genome scans (technological advances).

Human genetics has progressed at an unprecedented pace during the past 10 years. DNA microarrays currently allow screening of the entire human genome with high level of coverage and we are now entering the era of high-throughput sequencing. These remarkable technical advances are influencing the way medical research is conducted and have boosted our understanding of the structure of the human genome as well as of disease biology. In this context, it is crucial for clinicians to understand the main concepts and limitations of modern genetics. This review will describe key concepts in genetics, including the different types of genetic markers in the human genome, review current methods to detect DNA variation, describe major online public databases in genetics, explain key concepts in statistical genetics and finally present commonly used study designs in clinical and epidemiological research. This review will therefore concentrate on human genetic variation analysis.

Public Art, strategies for the regeneration of public space

This paper discusses some of the key concepts in the consideration of public art as a central element in urban regeneration processes, especially in reference to its role in the processes of citizen participation.

Public Art, strategies for the regeneration of public space

This paper discusses some of the key concepts in the consideration of public art as a central element in urban regeneration processes, especially in reference to its role in the processes of citizen participation.

Programming Principles: Introduction to Java

In this lecture we look at key concepts in Java: how to write, compile and run Java programs, define a simple class, create a main method, and use if/else structures to define behaviour.

A interação entre gerenciamento de projetos e gestão do conhecimento: estudos de casos múltiplos de tecnologia de informação em um banco brasileiro

Esta tese reúne os principais conceitos em gerenciamento de projetos. Em destaque, trata dos mecanismos e processos envolvidos na gestão do conhecimento interprojetos de uma organização, na busca da melhoria do desempenho do conjunto de seus projetos. Assim, é proposta uma estrutura, composta por elementos que, combinados, contemplem tanto o conhecimento explícito quanto o conhecimento tácito, além da consideração de fatores culturais organizacionais envolvidos. Para buscar a comprovação da estrutura, foi usada uma pesquisa qualitativa explanatória, operacionalizada através de quatro estudos de casos, realizados numa organização brasileira. Como resultado, encontramos a comprovação da estrutura proposta, além da inclusão de novos elementos que influenciam no processo. O campo de estudo do conhecimento envolvendo interprojetos demonstra ser uma área fértil e com muitas oportunidades de exploração, principalmente quando focamos na questão nacional.

A REVISIONARY APPROACH TO CROSS-CURRICULAR LITERACY WORK

In this dissertation, I use qualitative research methods to study relationships between compositionists and faculty in other disciplines in the context of cross-curricular literacy (CCL) work. Drawing on a two-year CCL project in the biology department, for which I was a participant observer, I argue that compositionists need to attend more carefully to issues that influence day-to-day interactions with disciplinary faculty in order to develop more meaningful CCL relationships. Toward that end, I offer a revisionary approach to cross-curricular literacy work that cultivates complex relationships by delaying consensus and embracing disconnection and disorientation. More specifically, I employ revisionary stance as a discursive strategy to complicate three key concepts in CCL literature and scholarship—expertise, change, and outcomes. I re-vision three texts produced during my time in the biology department in order to illuminate the complexities of negotiating expertise, recognizing change, and pursuing outcomes in CCL contexts. Given the reciprocal relationship between discursive and material change (Lee), I maintain that revision of CCL discourse can inspire revision on a pedagogical level, shaping how compositionists and disciplinary faculty participate in CCL interactions. Thus, a revisionary approach leads me to conceptualize revisionary pedagogy for cross-curricular literacy work. I theorize revisionary pedagogy as a means of fostering pedagogical relationships in CCL contexts, complicating how relationships are framed in traditional Writing Across the Curriculum/Writing in the Disciplines scholarship. The literature advances three main conceptual models of CCL, each of which embraces expertise, change, and outcomes in ways that sponsor potentially problematic relationships between compositionists and disciplinary faculty. I draw on Composition scholars’ rich conceptualization of revision (Jung; Lee; Welch) and pedagogy (Kameen; Qualley; Stenberg) to challenge the litany of next-best models and imagine alternative possibilities for relationships in CCL contexts. Revisionary pedagogy is a means of approaching material circumstances that reconstitutes how compositionists and disciplinary faculty conceive of and participate in CCL relationships.

Las paradojas de nadie : Una genealogía del no-sujeto

Cada época histórica construye, a través de discursos y prácticas específicas, sus formas legitimadas de subjetividad. Sin embargo, por debajo de estas identidades institucionalizadas, se ha ido gestando a lo largo de la historia una forma paradójica de subjetividad cuyo nombre, desde Homero en adelante, es Nadie. Esta figura excéntrica hace posible, cada vez que reaparece en la trama de los discursos y las prácticas, la subversión de las categorías fundamentales de la ontología y la política que han definido al hombre históricamente. Este trabajo pretende reconstruir la genealogía de esta particular figura con el fin de mostrar la posibilidad de una lectura diferente (y paradójica) de algunos de los conceptos centrales de la metafísica de Occidente

Las paradojas de nadie : Una genealogía del no-sujeto

Cada época histórica construye, a través de discursos y prácticas específicas, sus formas legitimadas de subjetividad. Sin embargo, por debajo de estas identidades institucionalizadas, se ha ido gestando a lo largo de la historia una forma paradójica de subjetividad cuyo nombre, desde Homero en adelante, es Nadie. Esta figura excéntrica hace posible, cada vez que reaparece en la trama de los discursos y las prácticas, la subversión de las categorías fundamentales de la ontología y la política que han definido al hombre históricamente. Este trabajo pretende reconstruir la genealogía de esta particular figura con el fin de mostrar la posibilidad de una lectura diferente (y paradójica) de algunos de los conceptos centrales de la metafísica de Occidente

Las paradojas de nadie : Una genealogía del no-sujeto

Cada época histórica construye, a través de discursos y prácticas específicas, sus formas legitimadas de subjetividad. Sin embargo, por debajo de estas identidades institucionalizadas, se ha ido gestando a lo largo de la historia una forma paradójica de subjetividad cuyo nombre, desde Homero en adelante, es Nadie. Esta figura excéntrica hace posible, cada vez que reaparece en la trama de los discursos y las prácticas, la subversión de las categorías fundamentales de la ontología y la política que han definido al hombre históricamente. Este trabajo pretende reconstruir la genealogía de esta particular figura con el fin de mostrar la posibilidad de una lectura diferente (y paradójica) de algunos de los conceptos centrales de la metafísica de Occidente

Le Corbusier y el proyecto para Saint Marie de la Tourette: De la celda al espacio inefable

El convento de la Tourette se concibe en un marco temporal concreto. Sin embargo sería erróneo limitarse a él a la hora de intentar desentrañar las claves del proyecto y llegar a un entendimiento completo del mismo. Es necesario analizarlo atendiendo al conjunto global de la producción del arquitecto, la cual ha ido forjando una forma propia de hacer que condicionará en gran medida las decisiones tomadas en cada momento. Esta tesis realiza una investigación de doble sentido (recogida en los dos volúmenes que la componen). Por un lado analiza el proceso evolutivo en el que se enhebra la obra intentando desentrañar la influencia de aquel en ésta, pero por otro, invirtiendo el sentido, también desvela ciertas claves de la arquitectura de Le Corbusier a través del preciso análisis de proyecto de la Tourette. Pero aún más, la pertenencia del convento de la Tourette al “tipo monacal” introduce la presencia de un tiempo histórico “ab origine, in hillo tempore” del que la investigación se hace eco. Un tiempo al que Le Corbusier siempre volverá la mirada, y que en este caso se encuentra muy presente, determinando el devenir del proyecto de una forma particular y definitiva. Por tanto este trabajo pretende convocar los dos tiempos que conviven en el proyecto del convento de la Tourette, el corto, concreto y cerrado de su génesis y desarrollo, que se circunscribe al periodo de proyecto comprendido entre los años 1953 y 1956, y el más dilatado, abstracto y abierto, que enlaza el proyecto con la producción de Le Corbusier, y aún más atrás, con el tiempo histórico. En la primera parte del trabajo (A. “PROYECTO”) se realiza un análisis cronológico de la documentación gráfica ‐incluyendo su re‐dibujo‐ y escrita del proyecto, desde los croquis que el arquitecto esboza en su primera visita al valle del Turdine hasta el documento final del project d’exécution, a partir del cual se materializará la obra. El objetivo de la investigación no es describir la realidad construida, sino participar del secreto de su génesis analizando y intentando comprender los dibujos o el pensamiento de sus creadores. Frente a la multitud de escritos sobre la obra del convento de la Tourette el foco de atención de la tesis se centra en el proyecto. Es en esta fase de elaboración y desarrollo de las ideas, previa a la acción de construir, donde pensamos que La deriva de la propia actividad del arquitecto avala esta decisión. A lo largo de su carrera Le Corbusier va reduciendo progresivamente su presencia en la obra centrándose cada vez más en las fases de la concepción y proyecto arquitectónico. Considera que en ellas se produce lo “esencial” mientras que deja las decisiones de obra en manos de sus colaboradores y de los diversos “operadores”, participando tan solo en el visto bueno final de las mismas (esta posición contrasta con la entrega de los constructores para quienes el arquitecto encarna la innovación tecnológica). En la Tourette realiza exclusivamente tres visitas de obra en las que actúa como un mero escenógrafo, ajustando aquí y allá pequeñas decisiones de la construcción. Esta distancia refuerza su posición en el proceso y subraya su búsqueda de un ideal teórico desarrollado sobre todo en la fase de proyecto frente a lo subsidiario de la realidad práctica. En la segunda parte de la tesis, denominada “RE‐VISIONES”, se abre el campo de acción a otras facetas de la ingente actividad de Le Corbusier como la pintura, la escritura o incluso la escultura; una nueva MIRADA bajo el prisma de una serie de conceptos‐llave recurrentes en su Petit vocabulaire (l’homme, la céllule, la bôite, l’organisme). Se amplía, por tanto, el marco temporal, repasando de modo genérico y transversal la evolución de los mismos en la trayectoria del arquitecto, comprobándose como el convento de la Tourette es un eslabón característico y clave en todos ellos. ABSTRACT The Convent of La Tourette is conceived in a specific time frame. However, it would be erroneous to limit oneself simply to this when trying to unravel the keys to the project and to fully understand it. It is necessary to analyse the project attending to the entire production of the architect, who progressively shaped his own way of doing things which would condition to a large extent the decisions taken at each point in time. This thesis carries out its research in a dual sense (brought together in both its volumes). On the one hand, it analyses the development process threading the work attempting to fathom the influence of the former on the latter but, on the other hand, inverting the sense which also reveals certain keys to the architecture of Le Corbusier by means of a detailed analysis of the project for La Tourette. Even more so, the Convent of La Tourette belonging to the “monastic type” introduces the presence of a historical period “ab origine, in hillo tempore" reflected in the research. A period to which Le Corbusier would always look back on and which is extremely present in this case, determining the evolution of the project in a particular and definitive manner. Therefore, this piece of work attempts to bring together both time periods co‐existing in the project for the Convent of La Tourette, the short, specific and closed one regarding its genesis development, encompassing the project period going from 1953 to 1956, and the broader, more abstract and open one linking the project with the production by Le Corbusier, and even further back, with the historical period. The first part of this work (A. “PROJECT") performs a chronological analysis of the graphic – including its re‐drawing –and written documentation of the project, from the outlines the architect sketched in his first visit to the Turdine valley up to the final document of the project d’exécution from which the works would materialise. The main object of the investigation is not intend to describe the reality constructed, but to participate in the secret of its genesis, analysing and trying to understand the drawings or the thoughts of its creators. As opposed to the many writings on the work of the Convent of La Tourette, the attention of this thesis focusses on the project. It is in this preparation and development stage, previous to the construction action, where it is believed the real keys to understand and explain it lie. The enormous work collecting, ordering and analysing the abundant graphic and written information reveals “a multidirectional process, full of regrets and securities, errors and certainties, leaps backwards and tremendous foresight in the process” directed not only by the conditions of the assignment, but also by the way of doing things of Le Corbusier and his collaborator I. Xenakis. A web of hidden relationships is weaved in this open space of the process, often distant in time, allowing us to draw a new route, not only towards the constructed works of the Convent of La Tourette, but towards understanding his entire production. It is in the creation of this new path of knowledge, and not only in its conclusion, where the “thesis” acquires its true meaning. In second place, the drift in the actual activity of the architect backs this decision. Throughout his career, Le Corbusier progressively reduced his presence on site, focussing more and more on the conception and architectural project stages. He considered that which was “essential” took place in these, while leaving the on‐site decisions to his collaborators and the different “operators”, only participating in their final approval (this position is in contrast with the delivery by the constructors for whom the architect embodies the technological innovation). In La Tourette he exclusively made three on‐site visits, in which acted as a pure stage designer, adjusting small construction decisions here and there. This distance reinforces his position in the process and underlines his search for a theoretical ideal developed primarily in the project stage as opposed to that which is secondary of the practical reality. The second part of the thesis, called “RE‐VISIONS”, widens the scope of action to other aspects of the huge activity by Le Corbusier, encompassing painting, writing or even sculpture; a new VIEW under the prism of a series of recurrent key concepts in his Petit vocabulaire (l’homme, la céllule, la bôite, l’organisme). The time frame is therefore extended, revising in a generic and transversal manner the development of these concepts throughout the career of Le Corbusier, confirming how the Convent of La Tourette is a characteristic and key link to each of them.

General introduction

Knowledge is of crucial, and growing importance in social, political and economic relations in modern society. The range and variety of available knowledge dramatically enlarges the available options of social action. Featuring essays from philosophers who have investigated the foundations of knowledge, and addressing different forms of knowledge in society such as common sense and practical knowledge, this collection also discusses the role of knowledge in economic process and gives attention to the role of expert knowledge in political decision making.

Valuing landscape identity of local inhabitants through a tourism discourse

Landscape, people and identity Landscape is about the interaction of a place or an area with people, which is reflected in the material interaction of people creating or shaping the landscape as well as in their mental perception, valuation and symbolic meaning of that landscape (Cosgrove 1998). This mutual and dynamic interaction forms the fundamental principle of the concept of landscape identity. Landscape identity has been described in scientific literature as a concept to bridge the physical, social and cultural aspects of landscapes. Also policy documents related with landscape and heritage (for example the UNESCO World Heritage Convention, the European Landscape Convention, the Faro Convention) are mentioning identity and landscape as key concepts. In those examples, landscape identity can refer to either the landscape itself - its features that makes the landscape unique (thus the landscape character), or to the social and personal construction. However, there is an interdependency between those two perspectives that needs to be conceptualised. Landscape identity is therefore defined as the multiple ways and dynamic relation between landscape and people (Loupa Ramos et al 2016).