New foundations.

Escrito principalmente para su uso en el aula, los textos están pensados para estudiantes de diferentes capacidades y para trabajar a diferentes niveles, abarca los temas: tiempo y el clima, las inundaciones fluviales, asentamientos, transporte, el Reino Unido, mapa de competencias. Las actividades incluyen completar esquemas, respondiendo a preguntas breves y comparación de datos, escribiendo un argumento y expresando la propia opinión sobre un tema en particular. Incluye secciones sobre investigación, que enseña a los niños a hacer sus propias preguntas para promover el aprendizaje permanente. Hay cuestiones de revisión en cada página, así como un glosario de palabras clave al final de la publicación.

Science 3-6 : laying the foundations in the early years.

Se sugieren formas y actitudes para ayudar a los niños en las primeras fases de escolarización a lograr capacidades de aprendizaje para el futuro. Los capítulos hacen hincapié en: la justificación de la ciencia, el aprendizaje a través de la exploración y la investigación, la importancia de la lengua en la ciencia por medio de actividades cotidianas, la promoción de la igualdad y la ciudadanía. Se incluyen propuestas para los puntos de partida y objetivos de aprendizaje, esquemas de trabajo para la ciencia en guarderías y escuelas, con ideas para prácticas adecuadas y recursos de software.

Edexcel GCSE Geography A geograhical foundations. Teacher guide.

Esta guía consta de una planificación de curso y de notas para el profesor relacionadas estrechamente con el contenido del libro del alumno en que se apoya para ofrecer una enseñanza activa y práctica de la geografía. Este recurso se completa con un CD-ROM que ofrece versiones con materiales personalizados para cada una de las cuatro unidades en que se divide el libro y para cada uno de los temas.

Edexcel GCSE Geography A geographical foundations. Student book.

Proporciona los contenidos y prácticas necesarios para el examen de General Certificate Secondary Education (GCSE) realizado por el organismo Edexcel para el año 2009. Permite a los alumnos conocer y comprender el mundo en el que viven, realizar trabajos prácticos fuera del aula y desarrollar habilidades geográficas, aprender a trabajar en equipo y aprender mediante la investigación. Tiene como material de apoyo el recurso para el profesor.

Symptoms of imbalance associated with cervical spine pathology

The goals of the present study are: to determine the prevalence of dizziness or imbalance in a population of patients with cervical-spine pathology as compared to that in the general population; to determine correlations between cervical spinal pathology and symptoms of dizziness or imbalance.

The pathology of Plasmodium chabaudi infection is not ameliorated by the secreted filarial nematode immunomodulatory molecule, ES-62

ES-62 is a phosphorylcholine-containing glycoprotein secreted by filarial nematodes. This molecule has been shown to reduce the severity of inflammation in collagen-induced arthritis (CIA) in mice, a model of rheumatoid arthritis, via down-regulation of anti-collagen type 1 immune responses. Malaria parasites induce a pro-inflammatory host immune response and many of the symptoms of malaria are immune system-mediated. Therefore we have asked whether the immunomodulatory properties of ES-62 can down-regulate the severity of malaria infection in BALB/c mice infected with Plasmodium chabaudi. We have found that ES-62 has no significant effect on the course of P. chabaudi parasitaemia, and does not significantly affect any of the measures of malaria-induced pathology taken throughout infection.

Coxsackievirus B3-associated myocardial pathology and viral load reduced by recombinant soluble human decay-accelerating factor in mice

Coxsackievirus B3 (CVB3) infection can result in myocarditis, which in turn may lead to a protracted immune response and subsequent dilated cardiomyopathy. Human decay-accelerating factor (DAF), a binding receptor for CVB3, was synthesized as a soluble IgG1-Fc fusion protein (DAF-Fc). In vitro, DAF-Fc was able to inhibit complement activity and block infection by CVB3, although blockade of infection varied widely among strains of CVB3. To determine the effects of DAF-Fc in vivo, 40 adolescent A/J mice were infected with a myopathic strain of CVB3 and given DAF-Fc treatment 3 days before infection, during infection, or 3 days after infection; the mice were compared with virus alone and sham-infected animals. Sections of heart, spleen, kidney, pancreas, and liver were stained with hematoxylin and eosin and submitted to in situ hybridization for both positive-strand and negative-strand viral RNA to determine the extent of myocarditis and viral infection, respectively. Salient histopathologic features, including myocardial lesion area, cell death, calcification and inflammatory cell infiltration, pancreatitis, and hepatitis were scored without knowledge of the experimental groups. DAF-Fc treatment of mice either preceding or concurrent with CVB3 infection resulted in a significant decrease in myocardial lesion area and cell death and a reduction in the presence of viral RNA. All DAF-Fc treatment groups had reduced infectious CVB3 recoverable from the heart after infection. DAF-Fc may be a novel therapeutic agent for active myocarditis and acute dilated cardiomyopathy if given early in the infectious period, although more studies are needed to determine its mechanism and efficacy.

Evolution in software systems: foundations of the SPE classification scheme

The SPE taxonomy of evolving software systems, first proposed by Lehman in 1980, is re-examined in this work. The primary concepts of software evolution are related to generic theories of evolution, particularly Dawkins' concept of a replicator, to the hermeneutic tradition in philosophy and to Kuhn's concept of paradigm. These concepts provide the foundations that are needed for understanding the phenomenon of software evolution and for refining the definitions of the SPE categories. In particular, this work argues that a software system should be defined as of type P if its controlling stakeholders have made a strategic decision that the system must comply with a single paradigm in its representation of domain knowledge. The proposed refinement of SPE is expected to provide a more productive basis for developing testable hypotheses and models about possible differences in the evolution of E- and P-type systems than is provided by the original scheme. Copyright (C) 2005 John Wiley & Sons, Ltd.