Recensão: David Santos, "A Reinvenção do real – Curadoria e Arte contemporânea no Museu do Neo-realismo"

Recensão de: David Santos, "A Reinvenção do real – Curadoria e Arte contemporânea no Museu do Neo-realismo", Lisboa: Sistema Solar CRL (Documenta), 2014

Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus.

Both obesity and being underweight have been associated with increased mortality. Underweight, defined as a body mass index (BMI) ≤ 18.5 kg per m(2) in adults and ≤ -2 standard deviations from the mean in children, is the main sign of a series of heterogeneous clinical conditions including failure to thrive, feeding and eating disorder and/or anorexia nervosa. In contrast to obesity, few genetic variants underlying these clinical conditions have been reported. We previously showed that hemizygosity of a ∼600-kilobase (kb) region on the short arm of chromosome 16 causes a highly penetrant form of obesity that is often associated with hyperphagia and intellectual disabilities. Here we show that the corresponding reciprocal duplication is associated with being underweight. We identified 138 duplication carriers (including 132 novel cases and 108 unrelated carriers) from individuals clinically referred for developmental or intellectual disabilities (DD/ID) or psychiatric disorders, or recruited from population-based cohorts. These carriers show significantly reduced postnatal weight and BMI. Half of the boys younger than five years are underweight with a probable diagnosis of failure to thrive, whereas adult duplication carriers have an 8.3-fold increased risk of being clinically underweight. We observe a trend towards increased severity in males, as well as a depletion of male carriers among non-medically ascertained cases. These features are associated with an unusually high frequency of selective and restrictive eating behaviours and a significant reduction in head circumference. Each of the observed phenotypes is the converse of one reported in carriers of deletions at this locus. The phenotypes correlate with changes in transcript levels for genes mapping within the duplication but not in flanking regions. The reciprocal impact of these 16p11.2 copy-number variants indicates that severe obesity and being underweight could have mirror aetiologies, possibly through contrasting effects on energy balance.

Grève de cheminots anglais, M. [le ministre du Travail George Henry] Roberts et sir David Shackleton [secrétaire permanent du ministère du Travail] quittant Downing Street : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 56199

Paraphrase des C.L. Pseaumes de David tant literale que mystique avec annotations necessaires... Edition seconde... Par Antoine de Laval...

[Bible. A.T.. Psaumes (latin-français). 1614. Laval]

« L'Istoire royale », ou « Livre traittant comment par la vaillance de trois jeunes princes le royaulme de Naples fut jadis delivré du povoir des Sarrasins... grossé par DAVID AUBERT ».

Commençant par : « Les fais des anciens doit l'on voulontiers lire... » et finissant par : «... et trouvay escript au dessoubz : C'est le livre et histoire royal. Le present livre fut grossé... en la ville de Sesdin, par David Aubert, l'an de l'Incarnation N. S. J. C. 1463 » .

Départements de MM. les fermiers généraux, pour le service des Fermes royales unies, pendant la 1re année du bail de Me Laurent David...

[Acte. 1774-12-13. Paris]

Liste des noms et demeures de MM. les fermiers généraux des fermes royales unies. Pour la quatrième année du bail de Laurent David

[Acte. 1776]

Départements de Messieurs les fermiers généraux, pour le service des fermes royales unies, pendant la quatrième année du bail de Me Laurent David

[Acte. 1777-12-08. Paris]