Biodegradacao da hepatotoxina(D-Leu1)-microcistina-LR por bactérias presentes em filtros biológicos de carvão

The persistence of MCs in aquatic environments and their difficult removal in the conventional water treatment is a challenge to companies of sanitation. However, the MCs are susceptible to degradation by bacteria present in water, sediment and sewage effluents. In this study, we investigated the biodegradation of MCs by microorganism present in carbon filters with biological activity (BAC) and their phylogenetic identification by sequencing gene 16S RNA. A study of water containing MCs was used, with different compositions, plus a filters BAC effluent. The results showed that of MCs were biodegraded by microorganism present in the biofilm. This study provides the ability to complete biodegradation of MCs by bacteria present in BAC filters and the possible use of these microorganisms as alternative of the removal of MCs in the treatment of drinking water

Estudo de aspectos químicos, biológicos e biossintéticos em Piper fuligineum Kunth(Piperaceae)

Pós-graduação em Química - IQ

Efeitos de cultivares de algodoeiro que expressam as proteínas Cry1Ac e Cry1F nos parâmetros biológicos de Chrysodeixis includens (Walker, 1857) (Lepidoptera: Noctuidae)

Pós-graduação em Agronomia (Entomologia Agrícola) - FCAV

Aspectos biológicos e técnica de criação do gorgulho-da-goiaba, Conotrachelus psidii marshall (Coleoptera: Curculionidae)

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Parâmetros biológicos da lagarta falsa-medideira em cultivares de algodoeiro com as proteínas Cry1Ac e Cry1F

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Compatibilidade entre produtos químicos e biológicos à base de Bacillus thuringiensis Berliner no controle de Tuta absoluta (Meyrick) (Lepidoptera: Gelechiidae)

Pós-graduação em Agronomia (Entomologia Agrícola) - FCAV

Oxidação de lisozima por haloaminas: caracterização química e efeitos biológicos

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Desenvolvimento e caracterização de sistemas líquido-cristalinos para aplicação tópica de metotrexato: estudo da bioadesão e ensaios biológicos in vitro

A psoríase é uma doença inflamatória relativamente comum da pele e das articulações, podendo se tornar crônica. Nos últimos anos, a expansão do arsenal terapêutico para o paciente com psoríase tem permitido aos médicos combaterem, de forma mais agressiva, a patogênese da doença. Um fármaco utilizado para o tratamento é o metotrexato, que, apesar de ser bastante eficaz, possui potencial para a toxicidade sistêmica, como toxicidade hematológica, hepática e pulmonar. Sendo assim, muita atenção tem sido dada ao desenvolvimento de novos veículos com o objetivo não só de aumentar a eficácia terapêutica de substâncias ativas, como também de permitir a redução da sua dose total necessária, minimizando os efeitos colaterais tóxicos. Os cristais-líquidos são sistemas promissores para aplicação tópica, pois promovem liberação controlada de fármacos, contribuindo para amenizar efeitos adversos, por exemplo, do metotrexato. Uma vez que há possibilidade de as substâncias incorporadas em formulações tópicas serem absorvidas pela pele e mucosas, existe a necessidade de garantir que as formulações sejam seguras. Este trabalho teve o objetivo de avaliar a bioadesão e a citotoxicidade in vitro de três sistemas líquido-cristalinos contendo metotrexato para o tratamento da psoríase. Resultados de bioadesão revelaram que as três formulações analisadas apresentaram forças bioadesivas próximas, sendo o sistema A mais bioadesivo. Com relação a estudos de reologia, houve comportamento de fluido não-newtoniano, pseudoplástico e tixotrópico. Além disso, a adição de metotrexato à formulação A, aumentou a viscosidade do sistema. Ensaios de citotoxicidade sugerem a possibilidade de liberação prolongada de metotrexato, contribuindo para o aumento da viabilidade celular

Caracterização fitoquímica e ensaios biológicos de Coleus blumei Benth

Coleus blumei Benth (Lamiaceae), popularly known in Brazil as heart-hurt or coleus-of-Java is an ornamental plant widely used due to the color of its leaves. Several species of the genus Coleus present compounds with antioxidant, antimicrobial and allopathic activities due to the presence of chemicals such coleonol, forskolin and rosmarinic acid. Therefore, this study aimed to carry out phytochemical study and biological tests to evaluate the antibacterial, antioxidant and allopathic activities of the 70% ethanol extract and its fractions ethyl acetate, dichloromethane and end aqueous fraction leaf of Coleus blumei Benth. The plant extract was prepared by turbolisis from the powder of dried leaves, as a solvent for extraction using 70% ethanol. The ethanol extract was fractionated with solvents dichloromethane and ethyl acetate. The phytochemical study identified the presence of saponins, free anthraquinones, flavonoids and anthocyanidins. In evaluating the antibacterial dichloromethane fraction showed activity against all microorganisms tested both in agar diffusion test and microdilution test. The 70% ethanol extract showed activity against the micro-organisms S. aureus and S. epidermidis in agar diffusion test and against all microorganisms tested in microdilution test. The ethyl acetate fraction showed activity against the micro-organism S. aureus in the agar diffusion test and against all microorganisms tested in microdilution test. The end aqueous fraction showed no activity against any micro-organism tested. In the test of evaluation activity allopathic dichloromethane fraction showed greater inhibition of seed germination and growth of tomato (Lycopersicon esculentum Mill), followed by 70% ethanolic extract, the ethyl acetate fraction and the end aqueous fraction. In testing the antioxidant activity with DPPH ethyl acetate fraction showed higher antioxidant activity followed... (Complete abstract click electronic access below)

Diagnóstico ambiental do Córrego Bandeirantes, município de Rio Claro, SP: parâmetros biológicos e metais-traço

This study was conducted to verify water quality and environmental impacts related to the occupation of the watershed of the Bandeirantes stream, located in Rio Claro, SP. The intention is to propose measures to enable the mitigation of negative impacts, and boosting the recovery and maintenance of the quality of water resources, preventing its complete degradation. Water analysis were performed at three different points, east, crossing the Ring Road (dirt road) and near the confluence with the Ribeirão Claro. The results indicated significant degradation of water, especially after the crossing, where it witnessed the accumulation of solid waste and easy access to the stream, both for animals as for people, due to limited riparian it. Another impact was observed the current construction of the Forum of Rio Claro in the right side of the stream studied, causing change in the landscape, change the flow properties and removal of existing vegetation at the site of work, defined as an environmentally protected area, as determined by existing law. Measures such as: restoration of riparian zones, effluent treatment, planned urban growth and environmental education of the population, would be essential to mitigate the environmental impacts of watershed Bandeirantes stream

Classificação e quantificação de tecidos Biológicos para construção de fantomas pediátricos

Paediatric diagnostic radiology can be considered as a separate specialty and with distinct characteristics of the radiology applied in adult patients. This in reason of the variability in the anatomical structures size and bigger sensitivity of tissues. The literature present in its majority methodologies for segmentation and tissue classification in adult patients, and works on tissue quantification are rare. This work had for objective the development of a biological tissue classifier and quantifier algorithm, from histograms, and that converts the quantified average thickness of these tissues for its respective simulator materials. The results will be used in the optimization process of paediatrics images, in future works, since these patients are frequently over exposed to the radiation in the repeated attempts of if getting considered good quality radiographic images. The developed algorithm was capable to read and store the name of all the archives, in the operational system, to filter artifacs, to count and quantify each biological tissues from the histogram of the examination, to obtain the biological tissues average thicknesses and to convert this value into its respective simulator material. The results show that it is possible to distinguish bone, soft, fat and pulmonary tissues from histograms of tomographic examinations of thorax. The quantification of the constituent materials of anthropomorphic phantom made by the algorithm, compared with the data of literature shows that the biggest difference was of 21,6% for bone. However, the literature shows that variations of up to 30% in bone thickness do not influence of significant form in the radiographic image quality. The average thicknesses of biological tissues, quantified for paediatrics patients, show that one phantom can simulate patients with distinct DAP ranges, since variations... (Complete abstract click electronic access below)

Dinâmica populacional de Zaprionus indianus Gupta 1970 (Diptera: Drosophilidae) e caracterização de alguns aspectos biológicos

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Efeitos biológicos do laser de baixa potência sobre o cultivo de células-tronco mesenquimais provenientes do tecido adiposo e da medula óssea de cães

Pós-graduação em Medicina Veterinária - FMVZ

Aspectos biológicos, morfometria e técnica de criação de Abaris basistriata Chaudoir, 1873 e Selenophorus seriatoporus Putzeys, 1878 (Coleoptera: carabidae)

Pós-graduação em Agronomia (Entomologia Agrícola) - FCAV

Aplicação de cinza de bagaço de cana-de-açúcar nos atributos químicos e biológicos do solo

Pós-graduação em Agronomia (Produção Vegetal) - FCAV