La qualità erogata da un'azienda di trasporto collettivo in ambito urbano: calcolo del livello di servizio delle principali linee di ATC (BO)

Oggetto di questa tesi è lo studio della qualità del servizio di trasporto erogato che condiziona la qualità percepita dall’utente, poiché spesso proprio a causa di un errato processo di pianificazione e gestione della rete, molte aziende non sono in grado di consolidare un alto livello di efficienza che permetta loro di attrarre e servire la crescente domanda. Per questo motivo, si è deciso di indagare sugli aspetti che determinano la qualità erogata e sui fattori che la influenzano, anche attraverso la definizione di alcuni indicatori rappresentativi del servizio erogato. L’area di studio considerata è stata quella urbana di Bologna, e sono state prese in esame due linee di ATC, la 19 e la 27, caratterizzate entrambe da una domanda di trasporto molto elevata. L’interesse è ricaduto in modo particolare sugli aspetti legati alla regolarità del servizio, ovvero al rispetto della cadenza programmata delle corse e alla puntualità, ossia il rispetto dell’orario programmato delle stesse. Proprio da questi due aspetti, infatti, dipende in larga misura la percezione della qualità che gli utenti hanno del servizio di trasporto collettivo. Lo studio è stato condotto sulla base di dati raccolti attraverso due campagne di rilevamento, una effettuata nel mese di maggio dell’anno 2008 e l’altra nel mese di settembre dello stesso anno. La scelta del periodo, della zona e delle modalità di rilevamento è strettamente connessa all’obiettivo prefissato. Il servizio è influenzato dalle caratteristiche del sistema di trasporto: sia da quelle legate alla domanda che da quelle legate all’offerta. Nel caso della domanda di trasporto si considera l’influenza sul servizio del numero di passeggeri saliti e del tempo di sosta alle fermate. Nel caso dell’offerta di trasporto si osservano soprattutto gli aspetti legati alla rete di trasporto su cui si muovono gli autobus, analizzando quindi i tempi di movimento e le velocità dei mezzi, per vedere come le caratteristiche dell’infrastruttura possano condizionare il servizio. A tale proposito è opportuno dire che, mentre i dati della prima analisi ci sono utili per lo studio dell’influenza del tempo di sosta sull’intertempo, nella seconda analisi si vuole cercare di effettuare ulteriori osservazioni sull’influenza del tempo di movimento sulla cadenza, prendendo in esame altri elementi, come ad esempio tratti di linea differenti rispetto al caso precedente. Un’attenzione particolare, inoltre, verrà riservata alla verifica del rispetto della cadenza, dalla quale scaturisce la definizione del livello di servizio per ciò che riguarda la regolarità. Per quest’ultima verrà, inoltre, determinato anche il LOS relativo alla puntualità. Collegato al problema del rispetto della cadenza è il fenomeno dell’accodamento: questo si verifica quando i mezzi di una stessa linea arrivano contemporaneamente ad una fermata uno dietro l’altro. L’accodamento ha, infatti, origine dal mancato rispetto della cadenza programmata tra i mezzi ed è un’evidente manifestazione del mal funzionamento di un servizio di trasporto. Verrà infine condotta un’analisi dei fattori che possono influenzare le prestazioni del servizio di trasporto pubblico, così da collocare i dati ottenuti dalle operazioni di rilevamento in un quadro più preciso, capace di sottolineare alcuni elementi di criticità e possibili rapporti di causalità.

Exploring physical processes related to past climate proxies: lake sediments and stable water isotopes

Proxy data are essential for the investigation of climate variability on time scales larger than the historical meteorological observation period. The potential value of a proxy depends on our ability to understand and quantify the physical processes that relate the corresponding climate parameter and the signal in the proxy archive. These processes can be explored under present-day conditions. In this thesis, both statistical and physical models are applied for their analysis, focusing on two specific types of proxies, lake sediment data and stable water isotopes.rnIn the first part of this work, the basis is established for statistically calibrating new proxies from lake sediments in western Germany. A comprehensive meteorological and hydrological data set is compiled and statistically analyzed. In this way, meteorological times series are identified that can be applied for the calibration of various climate proxies. A particular focus is laid on the investigation of extreme weather events, which have rarely been the objective of paleoclimate reconstructions so far. Subsequently, a concrete example of a proxy calibration is presented. Maxima in the quartz grain concentration from a lake sediment core are compared to recent windstorms. The latter are identified from the meteorological data with the help of a newly developed windstorm index, combining local measurements and reanalysis data. The statistical significance of the correlation between extreme windstorms and signals in the sediment is verified with the help of a Monte Carlo method. This correlation is fundamental for employing lake sediment data as a new proxy to reconstruct windstorm records of the geological past.rnThe second part of this thesis deals with the analysis and simulation of stable water isotopes in atmospheric vapor on daily time scales. In this way, a better understanding of the physical processes determining these isotope ratios can be obtained, which is an important prerequisite for the interpretation of isotope data from ice cores and the reconstruction of past temperature. In particular, the focus here is on the deuterium excess and its relation to the environmental conditions during evaporation of water from the ocean. As a basis for the diagnostic analysis and for evaluating the simulations, isotope measurements from Rehovot (Israel) are used, provided by the Weizmann Institute of Science. First, a Lagrangian moisture source diagnostic is employed in order to establish quantitative linkages between the measurements and the evaporation conditions of the vapor (and thus to calibrate the isotope signal). A strong negative correlation between relative humidity in the source regions and measured deuterium excess is found. On the contrary, sea surface temperature in the evaporation regions does not correlate well with deuterium excess. Although requiring confirmation by isotope data from different regions and longer time scales, this weak correlation might be of major importance for the reconstruction of moisture source temperatures from ice core data. Second, the Lagrangian source diagnostic is combined with a Craig-Gordon fractionation parameterization for the identified evaporation events in order to simulate the isotope ratios at Rehovot. In this way, the Craig-Gordon model can be directly evaluated with atmospheric isotope data, and better constraints for uncertain model parameters can be obtained. A comparison of the simulated deuterium excess with the measurements reveals that a much better agreement can be achieved using a wind speed independent formulation of the non-equilibrium fractionation factor instead of the classical parameterization introduced by Merlivat and Jouzel, which is widely applied in isotope GCMs. Finally, the first steps of the implementation of water isotope physics in the limited-area COSMO model are described, and an approach is outlined that allows to compare simulated isotope ratios to measurements in an event-based manner by using a water tagging technique. The good agreement between model results from several case studies and measurements at Rehovot demonstrates the applicability of the approach. Because the model can be run with high, potentially cloud-resolving spatial resolution, and because it contains sophisticated parameterizations of many atmospheric processes, a complete implementation of isotope physics will allow detailed, process-oriented studies of the complex variability of stable isotopes in atmospheric waters in future research.rn

Mobi - kids - rischio di tumori cerebrali ed esposizione a campi a radiofrequenza nei bambini e negli adolescenti

Introduzione. Il rapido e globale incremento dell’utilizzo dei telefoni cellulari da parte degli adolescenti e dei bambini ha generato un considerevole interesse circa i possibili effetti sulla salute dell’esposizione a campi elettromagnetici a radiofrequenza. Perciò è stato avviato lo studio internazionale caso-controllo Mobi-kids, all’interno del quale si colloca quello italiano condotto in 4 Regioni (Piemonte, Lombardia, Toscana, Emilia-Romagna). Obiettivi. Lo studio ha come obiettivo quello di valutare la stima del rischio degli effetti potenzialmente avversi di queste esposizioni sul sistema nervoso centrale nei bambini e negli adolescenti. Materiali e Metodi. La popolazione include tutte le persone di età compresa tra 10 e 24 anni residenti nelle 4 Regioni, con una diagnosi confermata di neoplasia cerebrale primitiva, diagnosticata durante il periodo di studio (3 anni). Sono stati selezionati due controlli - ospedalizzati per appendicite acuta - per ciascun caso. I controlli sono stati appaiati individualmente a ciascun caso per età, sesso e residenza del caso. Risultati. In Italia sono stati intervistati a Giugno 2014, 106 casi e 191 controlli. In Emilia-Romagna i casi reclutati sono stati fino ad ora 21 e i controlli 20, con una rispondenza del’81% e dell’65% rispettivamente. Dei 41 soggetti totali, il 61% era di sesso maschile con un’età media generale pari a 16,5 (±4,5) anni. Inoltre il 44% degli intervistati proveniva dalla classe di età più giovane (10-14). In merito allo stato di appaiamento, nella nostra Regione sono state effettuate 7 triplette (33%) - 1 caso e 2 controlli - e 6 doppiette (29%) - 1 caso ed 1 controllo. Conclusioni. Nonostante le varie difficoltà affrontate data la natura del progetto, l’esperienza maturata fin ad ora ha comunque portato alla fattibilità dello studio e porterà probabilmente a risultati che contribuiranno alla comprensione dei potenziali rischi di neoplasie cerebrali associati all'uso di telefoni cellulari tra i giovani.

Temperature reconstruction from 10 to 120 kyr b2k from the NGRIP ice core

In order to reconstruct the temperature of the North Greenland Ice Core Project (NGRIP) site, new measurements of δ15N have been performed covering the time period from the beginning of the Holocene to Dansgaard–Oeschger (DO) event 8. Together with previously measured and mostly published δ15N data, we present for the first time a NGRIP temperature reconstruction for the whole last glacial period from 10 to 120 kyr b2k (thousand years before 2000 AD) including every DO event based on δ15N isotope measurements combined with a firn densification and heat diffusion model. The detected temperature rises at the onset of DO events range from 5 °C (DO 25) up to 16.5 °C (DO 11) with an uncertainty of ±3 °C. To bring measured and modelled data into agreement, we had to reduce the accumulation rate given by the NGRIP ss09sea06bm timescale in some periods by 30 to 35%, especially during the last glacial maximum. A comparison between reconstructed temperature and δ18Oice data confirms that the isotopic composition of the stadial was strongly influenced by seasonality. We evidence an anticorrelation between the variations of the δ18Oice sensitivity to temperature (referred to as α) and obliquity in agreement with a simple Rayleigh distillation model. Finally, we suggest that α might be influenced by the Northern Hemisphere ice sheet volume.

Search for light top squark pair production in final states with leptons and b⁻ jets with the ATLAS detector in sqrts=7 TeV proton-proton collisions

The results of a search for pair production of light top squarks are presented, using 4.7 fb(-1) of root s = 7 TeV proton-proton collisions collected with the ATLAS detector at the Large Hadron Collider. This search targets top squarks with masses similar to, or lighter than, the top quark mass. Final states containing exclusively one or two leptons (e, mu), large missing transverse momentum, light-flavour jets and b-jets are used to reconstruct the top squark pair system. Event-based mass scale variables are used to separate the signal from a large t (t) over bar background. No excess over the Standard Model expectations is found. The results are interpreted in the framework of the Minimal Supersymmetric Standard Model, assuming the top squark decays exclusively to a chargino and a b-quark, while requiring different mass relationships between the Supersymmetric particles in the decay chain. Light top squarks with masses between 123-167 GeV are excluded for neutralino masses around 55 GeV.

Studying changes in life circumstances and personality: It's about time

Most theories of personality development posit that changes in life circumstances (e.g. due to major life events) can lead to changes in personality, but few studies have examined the exact time course of these changes. In this article, we argue that time needs to be considered explicitly in theories and empirical studies on personality development. We discuss six notions on the role of time in personality development. First, people can differ before the event. Second, change can be non-linear and discontinuous. Third, change can be reversible. Fourth, change can occur before the event. Fifth, control groups are needed to disentangle age-related and event-related changes. Sixth, we need to move beyond examining single major life events and study the effects of non-normative events, non-events, multiple events, and minor events on personality. We conclude by summarizing the methodological and theoretical implications of these notions.

Recent improvements in antigene technology

DNA triple helix based approaches to control and modulate cellular functions on the level of genomic DNA (antigene technology) suffered in the past from a stepmother like treatment in comparison to the flourishing field of oligonucleotide based control of translation (antisense technology). This was mostly due to lack of affinity of triplex forming oligonucleotides (TFOs) to their DNA target, to sequence restriciton constraints imposed by the triple helical recogniton motifs and by open questions to the accessibility of the target DNA. Recent developments in the area have brought about new bases that specifically recognize pyrimidine-purine inversion sites as well as sugar modifications, e.g. the 2'-aminoethoxy-oligonucleotides or oligonucleotides based on the locked nucleic acid (LNA) sugar unit, that greatly enhance triplex stability and alleviate in part the sequence restriction constraints. With this, sequence specific genomic DNA manipulation starts to become a useful tool in biotechnology

Parent modeling and child food consumption

Obesity, among both children and adults, is a growing public health epidemic. One area of interest relates to how and why obesity is developing at such a rapid pace among children. Despite a broad consensus about how controlling feeding practices relate to child food consumption and obesity prevalence, much less is known about how non-controlling feeding practices, including modeling, relate to child food consumption. This study investigates how different forms of parent modeling (no modeling, simple modeling, and enthusiastic modeling) and parent adiposity relate to child food consumption, food preferences, and behaviors towards foods. Participants in this experimental study were 65 children (25 boys and 40 girls) aged 3-9 and their parents. Each parent was trained on how to perform their assigned modeling behavior towards a food identified as neutral (not liked, nor disliked) by their child during a pre-session food-rating task. Parents performed their assigned modeling behavior when cued during a ten-minute observation period with their child. Child food consumption (pieces eaten, grams eaten, and calories consumed) was measured and food behaviors (positive comments toward food and food requests) were recorded by event-based coding. After the session, parents self-reported on their height and weight, and children completed a post-session food-rating task. Results indicate that parent modeling (both simple and enthusiastic forms) did not significantly relate to child food consumption, food preferences, or food requests. However, enthusiastic modeling significantly increased the number of positive food comments made by children. Children's food consumption in response to parent modeling did not differ based on parent obesity status. The practical implications of this study are discussed, along with its strengths and limitations, and directions for future research.^

Engineering an Ontology for Autonomous Systems - The OASys Ontology

This paper describes the development of an ontology for autonomous systems, as the initial stage of a research programe on autonomous systems’ engineering within a model-based control approach. The ontology aims at providing a unified conceptual framework for the autonomous systems’ stakeholders, from developers to software engineers. The modular ontology contains both generic and domain-specific concepts for autonomous systems description and engineering. The ontology serves as the basis in a methodology to obtain the autonomous system’s conceptual models. The objective is to obtain and to use these models as main input for the autonomous system’s model-based control system.

Catadioptric panoramic stereovision for humanoid robots

This paper proposes a novel design of a reconfigurable humanoid robot head, based on biological likeness of human being so that the humanoid robot could agreeably interact with people in various everyday tasks. The proposed humanoid head has a modular and adaptive structural design and is equipped with three main components: frame, neck motion system and omnidirectional stereovision system modules. The omnidirectional stereovision system module being the last module, a motivating contribution with regard to other computer vision systems implemented in former humanoids, it opens new research possibilities for achieving human-like behaviour. A proposal for a real-time catadioptric stereovision system is presented, including stereo geometry for rectifying the system configuration and depth estimation. The methodology for an initial approach for visual servoing tasks is divided into two phases, first related to the robust detection of moving objects, their depth estimation and position calculation, and second the development of attention-based control strategies. Perception capabilities provided allow the extraction of 3D information from a wide range of visions from uncontrolled dynamic environments, and work results are illustrated through a number of experiments.

A linear chained approach for service invocation in IP multimedia subsystem.

IP Multimedia Subsystem (IMS) is considered to provide multimedia services to users through an IP-based control plane. The current IMS service invocation mechanism, however, requires the Serving-Call Session Control Function (S-CSCF) invokes each Application Server (AS) sequentially to perform service subscription pro?le, which results in the heavy load of the S-CSCF and the long session set-up delay. To solve this issue, this paper proposes a linear chained service invocation mechanism to invoke each AS consecutively. By checking all the initial Filter Criteria (iFC) one-time and adding the addresses of all involved ASs to the ?Route? header, this new approach enables multiple services to be invoked as a linear chain during a session. We model the service invocation mechanisms through Jackson networks, which are validated through simulations. The analytic results verify that the linear chained service invocation mechanism can effectively reduce session set-up delay of the service layer and decrease the load level of the S-CSCF

Seguridad estructural para construcciones en zonas inundables : criterio de diseño : soluciones de minoración del riesgo de fallo

La gestión de riesgos debe ser entendida como una determinación de vínculos entre lo que se asume como vulnerabilidad, y la forma en la que se determinarían o estimarían la probabilidad en la concurrencia de un determinado hecho, partiendo de la idea de la concurrencia de un fenómeno y las acciones necesarias que deberán llevarse a cabo. El tema de vulnerabilidad y riesgo, cada día toma más importancia a nivel mundial, a medida que pasa el tiempo es más notoria la vulnerabilidad de ciertas poblaciones ante la presencia de determinados peligros naturales como son: inundaciones, desbordes de ríos, deslizamientos de tierra y movimientos sísmicos. La vulnerabilidad aumenta, a medida que crece la deforestación. La construcción en lugares de alto riesgo, como por ejemplo, viviendas a orillas de los ríos, está condicionada por la localización y las condiciones de uso del suelo, infraestructura, construcciones, viviendas, distribución y densidad de población, capacidad de organización, etc. Es ahora donde la gestión de riesgos, juega un papel muy importante en la sociedad moderna, siendo esta cada vez más exigente con los resultados y calidad de productos y servicios, además de cumplir también, con la responsabilidad jurídica que trae la concepción, diseño y construcción de proyectos en zonas inundables. El presente trabajo de investigación, se centra en identificar los riesgos, aplicando soluciones estructurales y recomendaciones resilientes para edificaciones que se encuentren emplazadas en zonas inundables. Disminuyendo así el riesgo de fallo estructural y el número de víctimas considerablemente. Concluyendo con un Catálogo de Riesgos y Soluciones para edificaciones en zonas inundables. Risk management should be understood as a determination of links between what is assumed to be vulnerable , and how that would be determined or would estimate the probability in the occurrence of a certain event, based on the idea of the occurrence of a phenomenon and necessary actions to be carried out . The issue of vulnerability and risk, every day takes more importance globally, as time passes is more notorious vulnerability of certain populations in the presence of certain natural hazards such as floods, swollen rivers, landslides and earthquakes. Vulnerability increases as it grows deforestation. The construction in high-risk locations, such as homes on the banks of rivers, is conditioned by the location and conditions of land use, infrastructure, construction, housing, distribution and population density, organizational skills, etc. Now where risk management plays a very important role in modern society, is being increasingly demanding with the results and quality of products and services, and also comply with the legal responsibility that brings the conception, design and construction projects in flood zones. This research focuses on identifying risks, implementing structural solutions and resilients’ recommendations for buildings that are emplaced in flood zones. Thus decreasing the risk of structural failure and the number of victims significantly. Concluding with a Catalogue of Risks and Solutions for buildings in flood zones.

A model to develop a platform for personalised health applications

Antecedentes Europa vive una situación insostenible. Desde el 2008 se han reducido los recursos de los gobiernos a raíz de la crisis económica. El continente Europeo envejece con ritmo constante al punto que se prevé que en 2050 habrá sólo dos trabajadores por jubilado [54]. A esta situación se le añade el aumento de la incidencia de las enfermedades crónicas, relacionadas con el envejecimiento, cuyo coste puede alcanzar el 7% del PIB de un país [51]. Es necesario un cambio de paradigma. Una nueva manera de cuidar de la salud de las personas: sustentable, eficaz y preventiva más que curativa. Algunos estudios abogan por el cuidado personalizado de la salud (pHealth). En este modelo las prácticas médicas son adaptadas e individualizadas al paciente, desde la detección de los factores de riesgo hasta la personalización de los tratamientos basada en la respuesta del individuo [81]. El cuidado personalizado de la salud está asociado a menudo al uso de las tecnologías de la información y comunicación (TICs) que, con su desarrollo exponencial, ofrecen oportunidades interesantes para la mejora de la salud. El cambio de paradigma hacia el pHealth está lentamente ocurriendo, tanto en el ámbito de la investigación como en la industria, pero todavía no de manera significativa. Existen todavía muchas barreras relacionadas a la economía, a la política y la cultura. También existen barreras puramente tecnológicas, como la falta de sistemas de información interoperables [199]. A pesar de que los aspectos de interoperabilidad están evolucionando, todavía hace falta un diseño de referencia especialmente direccionado a la implementación y el despliegue en gran escala de sistemas basados en pHealth. La presente Tesis representa un intento de organizar la disciplina de la aplicación de las TICs al cuidado personalizado de la salud en un modelo de referencia, que permita la creación de plataformas de desarrollo de software para simplificar tareas comunes de desarrollo en este dominio. Preguntas de investigación RQ1 >Es posible definir un modelo, basado en técnicas de ingeniería del software, que represente el dominio del cuidado personalizado de la salud de una forma abstracta y representativa? RQ2 >Es posible construir una plataforma de desarrollo basada en este modelo? RQ3 >Esta plataforma ayuda a los desarrolladores a crear sistemas pHealth complejos e integrados? Métodos Para la descripción del modelo se adoptó el estándar ISO/IEC/IEEE 42010por ser lo suficientemente general y abstracto para el amplio enfoque de esta tesis [25]. El modelo está definido en varias partes: un modelo conceptual, expresado a través de mapas conceptuales que representan las partes interesadas (stakeholders), los artefactos y la información compartida; y escenarios y casos de uso para la descripción de sus funcionalidades. El modelo fue desarrollado de acuerdo a la información obtenida del análisis de la literatura, incluyendo 7 informes industriales y científicos, 9 estándares, 10 artículos en conferencias, 37 artículos en revistas, 25 páginas web y 5 libros. Basándose en el modelo se definieron los requisitos para la creación de la plataforma de desarrollo, enriquecidos por otros requisitos recolectados a través de una encuesta realizada a 11 ingenieros con experiencia en la rama. Para el desarrollo de la plataforma, se adoptó la metodología de integración continua [74] que permitió ejecutar tests automáticos en un servidor y también desplegar aplicaciones en una página web. En cuanto a la metodología utilizada para la validación se adoptó un marco para la formulación de teorías en la ingeniería del software [181]. Esto requiere el desarrollo de modelos y proposiciones que han de ser validados dentro de un ámbito de investigación definido, y que sirvan para guiar al investigador en la búsqueda de la evidencia necesaria para justificarla. La validación del modelo fue desarrollada mediante una encuesta online en tres rondas con un número creciente de invitados. El cuestionario fue enviado a 134 contactos y distribuido en algunos canales públicos como listas de correo y redes sociales. El objetivo era evaluar la legibilidad del modelo, su nivel de cobertura del dominio y su potencial utilidad en el diseño de sistemas derivados. El cuestionario incluía preguntas cuantitativas de tipo Likert y campos para recolección de comentarios. La plataforma de desarrollo fue validada en dos etapas. En la primera etapa se utilizó la plataforma en un experimento a pequeña escala, que consistió en una sesión de entrenamiento de 12 horas en la que 4 desarrolladores tuvieron que desarrollar algunos casos de uso y reunirse en un grupo focal para discutir su uso. La segunda etapa se realizó durante los tests de un proyecto en gran escala llamado HeartCycle [160]. En este proyecto un equipo de diseñadores y programadores desarrollaron tres aplicaciones en el campo de las enfermedades cardio-vasculares. Una de estas aplicaciones fue testeada en un ensayo clínico con pacientes reales. Al analizar el proyecto, el equipo de desarrollo se reunió en un grupo focal para identificar las ventajas y desventajas de la plataforma y su utilidad. Resultados Por lo que concierne el modelo que describe el dominio del pHealth, la parte conceptual incluye una descripción de los roles principales y las preocupaciones de los participantes, un modelo de los artefactos TIC que se usan comúnmente y un modelo para representar los datos típicos que son necesarios formalizar e intercambiar entre sistemas basados en pHealth. El modelo funcional incluye un conjunto de 18 escenarios, repartidos en: punto de vista de la persona asistida, punto de vista del cuidador, punto de vista del desarrollador, punto de vista de los proveedores de tecnologías y punto de vista de las autoridades; y un conjunto de 52 casos de uso repartidos en 6 categorías: actividades de la persona asistida, reacciones del sistema, actividades del cuidador, \engagement" del usuario, actividades del desarrollador y actividades de despliegue. Como resultado del cuestionario de validación del modelo, un total de 65 personas revisó el modelo proporcionando su nivel de acuerdo con las dimensiones evaluadas y un total de 248 comentarios sobre cómo mejorar el modelo. Los conocimientos de los participantes variaban desde la ingeniería del software (70%) hasta las especialidades médicas (15%), con declarado interés en eHealth (24%), mHealth (16%), Ambient Assisted Living (21%), medicina personalizada (5%), sistemas basados en pHealth (15%), informática médica (10%) e ingeniería biomédica (8%) con una media de 7.25_4.99 años de experiencia en estas áreas. Los resultados de la encuesta muestran que los expertos contactados consideran el modelo fácil de leer (media de 1.89_0.79 siendo 1 el valor más favorable y 5 el peor), suficientemente abstracto (1.99_0.88) y formal (2.13_0.77), con una cobertura suficiente del dominio (2.26_0.95), útil para describir el dominio (2.02_0.7) y para generar sistemas más específicos (2_0.75). Los expertos también reportan un interés parcial en utilizar el modelo en su trabajo (2.48_0.91). Gracias a sus comentarios, el modelo fue mejorado y enriquecido con conceptos que faltaban, aunque no se pudo demonstrar su mejora en las dimensiones evaluadas, dada la composición diferente de personas en las tres rondas de evaluación. Desde el modelo, se generó una plataforma de desarrollo llamada \pHealth Patient Platform (pHPP)". La plataforma desarrollada incluye librerías, herramientas de programación y desarrollo, un tutorial y una aplicación de ejemplo. Se definieron cuatro módulos principales de la arquitectura: el Data Collection Engine, que permite abstraer las fuentes de datos como sensores o servicios externos, mapeando los datos a bases de datos u ontologías, y permitiendo interacción basada en eventos; el GUI Engine, que abstrae la interfaz de usuario en un modelo de interacción basado en mensajes; y el Rule Engine, que proporciona a los desarrolladores un medio simple para programar la lógica de la aplicación en forma de reglas \if-then". Después de que la plataforma pHPP fue utilizada durante 5 años en el proyecto HeartCycle, 5 desarrolladores fueron reunidos en un grupo de discusión para analizar y evaluar la plataforma. De estas evaluaciones se concluye que la plataforma fue diseñada para encajar las necesidades de los ingenieros que trabajan en la rama, permitiendo la separación de problemas entre las distintas especialidades, y simplificando algunas tareas de desarrollo como el manejo de datos y la interacción asíncrona. A pesar de ello, se encontraron algunos defectos a causa de la inmadurez de algunas tecnologías empleadas, y la ausencia de algunas herramientas específicas para el dominio como el procesado de datos o algunos protocolos de comunicación relacionados con la salud. Dentro del proyecto HeartCycle la plataforma fue utilizada para el desarrollo de la aplicación \Guided Exercise", un sistema TIC para la rehabilitación de pacientes que han sufrido un infarto del miocardio. El sistema fue testeado en un ensayo clínico randomizado en el cual a 55 pacientes se les dio el sistema para su uso por 21 semanas. De los resultados técnicos del ensayo se puede concluir que, a pesar de algunos errores menores prontamente corregidos durante el estudio, la plataforma es estable y fiable. Conclusiones La investigación llevada a cabo en esta Tesis y los resultados obtenidos proporcionan las respuestas a las tres preguntas de investigación que motivaron este trabajo: RQ1 Se ha desarrollado un modelo para representar el dominio de los sistemas personalizados de salud. La evaluación hecha por los expertos de la rama concluye que el modelo representa el dominio con precisión y con un balance apropiado entre abstracción y detalle. RQ2 Se ha desarrollado, con éxito, una plataforma de desarrollo basada en el modelo. RQ3 Se ha demostrado que la plataforma es capaz de ayudar a los desarrolladores en la creación de software pHealth complejos. Las ventajas de la plataforma han sido demostradas en el ámbito de un proyecto de gran escala, aunque el enfoque genérico adoptado indica que la plataforma podría ofrecer beneficios también en otros contextos. Los resultados de estas evaluaciones ofrecen indicios de que, ambos, el modelo y la plataforma serán buenos candidatos para poderse convertir en una referencia para futuros desarrollos de sistemas pHealth. ABSTRACT Background Europe is living in an unsustainable situation. The economic crisis has been reducing governments' economic resources since 2008 and threatening social and health systems, while the proportion of older people in the European population continues to increase so that it is foreseen that in 2050 there will be only two workers per retiree [54]. To this situation it should be added the rise, strongly related to age, of chronic diseases the burden of which has been estimated to be up to the 7% of a country's gross domestic product [51]. There is a need for a paradigm shift, the need for a new way of caring for people's health, shifting the focus from curing conditions that have arisen to a sustainable and effective approach with the emphasis on prevention. Some advocate the adoption of personalised health care (pHealth), a model where medical practices are tailored to the patient's unique life, from the detection of risk factors to the customization of treatments based on each individual's response [81]. Personalised health is often associated to the use of Information and Communications Technology (ICT), that, with its exponential development, offers interesting opportunities for improving healthcare. The shift towards pHealth is slowly taking place, both in research and in industry, but the change is not significant yet. Many barriers still exist related to economy, politics and culture, while others are purely technological, like the lack of interoperable information systems [199]. Though interoperability aspects are evolving, there is still the need of a reference design, especially tackling implementation and large scale deployment of pHealth systems. This thesis contributes to organizing the subject of ICT systems for personalised health into a reference model that allows for the creation of software development platforms to ease common development issues in the domain. Research questions RQ1 Is it possible to define a model, based on software engineering techniques, for representing the personalised health domain in an abstract and representative way? RQ2 Is it possible to build a development platform based on this model? RQ3 Does the development platform help developers create complex integrated pHealth systems? Methods As method for describing the model, the ISO/IEC/IEEE 42010 framework [25] is adopted for its generality and high level of abstraction. The model is specified in different parts: a conceptual model, which makes use of concept maps, for representing stakeholders, artefacts and shared information, and in scenarios and use cases for the representation of the functionalities of pHealth systems. The model was derived from literature analysis, including 7 industrial and scientific reports, 9 electronic standards, 10 conference proceedings papers, 37 journal papers, 25 websites and 5 books. Based on the reference model, requirements were drawn for building the development platform enriched with a set of requirements gathered in a survey run among 11 experienced engineers. For developing the platform, the continuous integration methodology [74] was adopted which allowed to perform automatic tests on a server and also to deploy packaged releases on a web site. As a validation methodology, a theory building framework for SW engineering was adopted from [181]. The framework, chosen as a guide to find evidence for justifying the research questions, imposed the creation of theories based on models and propositions to be validated within a scope. The validation of the model was conducted as an on-line survey in three validation rounds, encompassing a growing number of participants. The survey was submitted to 134 experts of the field and on some public channels like relevant mailing lists and social networks. Its objective was to assess the model's readability, its level of coverage of the domain and its potential usefulness in the design of actual, derived systems. The questionnaires included quantitative Likert scale questions and free text inputs for comments. The development platform was validated in two scopes. As a small-scale experiment, the platform was used in a 12 hours training session where 4 developers had to perform an exercise consisting in developing a set of typical pHealth use cases At the end of the session, a focus group was held to identify benefits and drawbacks of the platform. The second validation was held as a test-case study in a large scale research project called HeartCycle the aim of which was to develop a closed-loop disease management system for heart failure and coronary heart disease patients [160]. During this project three applications were developed by a team of programmers and designers. One of these applications was tested in a clinical trial with actual patients. At the end of the project, the team was interviewed in a focus group to assess the role the platform had within the project. Results For what regards the model that describes the pHealth domain, its conceptual part includes a description of the main roles and concerns of pHealth stakeholders, a model of the ICT artefacts that are commonly adopted and a model representing the typical data that need to be formalized among pHealth systems. The functional model includes a set of 18 scenarios, divided into assisted person's view, caregiver's view, developer's view, technology and services providers' view and authority's view, and a set of 52 Use Cases grouped in 6 categories: assisted person's activities, system reactions, caregiver's activities, user engagement, developer's activities and deployer's activities. For what concerns the validation of the model, a total of 65 people participated in the online survey providing their level of agreement in all the assessed dimensions and a total of 248 comments on how to improve and complete the model. Participants' background spanned from engineering and software development (70%) to medical specialities (15%), with declared interest in the fields of eHealth (24%), mHealth (16%), Ambient Assisted Living (21%), Personalized Medicine (5%), Personal Health Systems (15%), Medical Informatics (10%) and Biomedical Engineering (8%) with an average of 7.25_4.99 years of experience in these fields. From the analysis of the answers it is possible to observe that the contacted experts considered the model easily readable (average of 1.89_0.79 being 1 the most favourable scoring and 5 the worst), sufficiently abstract (1.99_0.88) and formal (2.13_0.77) for its purpose, with a sufficient coverage of the domain (2.26_0.95), useful for describing the domain (2.02_0.7) and for generating more specific systems (2_0.75) and they reported a partial interest in using the model in their job (2.48_0.91). Thanks to their comments, the model was improved and enriched with concepts that were missing at the beginning, nonetheless it was not possible to prove an improvement among the iterations, due to the diversity of the participants in the three rounds. From the model, a development platform for the pHealth domain was generated called pHealth Patient Platform (pHPP). The platform includes a set of libraries, programming and deployment tools, a tutorial and a sample application. The main four modules of the architecture are: the Data Collection Engine, which allows abstracting sources of information like sensors or external services, mapping data to databases and ontologies, and allowing event-based interaction and filtering, the GUI Engine, which abstracts the user interface in a message-like interaction model, the Workow Engine, which allows programming the application's user interaction ows with graphical workows, and the Rule Engine, which gives developers a simple means for programming the application's logic in the form of \if-then" rules. After the 5 years experience of HeartCycle, partially programmed with pHPP, 5 developers were joined in a focus group to discuss the advantages and drawbacks of the platform. The view that emerged from the training course and the focus group was that the platform is well-suited to the needs of the engineers working in the field, it allowed the separation of concerns among the different specialities and it simplified some common development tasks like data management and asynchronous interaction. Nevertheless, some deficiencies were pointed out in terms of a lack of maturity of some technological choices, and for the absence of some domain-specific tools, e.g. for data processing or for health-related communication protocols. Within HeartCycle, the platform was used to develop part of the Guided Exercise system, a composition of ICT tools for the physical rehabilitation of patients who suffered from myocardial infarction. The system developed using the platform was tested in a randomized controlled clinical trial, in which 55 patients used the system for 21 weeks. The technical results of this trial showed that the system was stable and reliable. Some minor bugs were detected, but these were promptly corrected using the platform. This shows that the platform, as well as facilitating the development task, can be successfully used to produce reliable software. Conclusions The research work carried out in developing this thesis provides responses to the three three research questions that were the motivation for the work. RQ1 A model was developed representing the domain of personalised health systems, and the assessment of experts in the field was that it represents the domain accurately, with an appropriate balance between abstraction and detail. RQ2 A development platform based on the model was successfully developed. RQ3 The platform has been shown to assist developers create complex pHealth software. This was demonstrated within the scope of one large-scale project, but the generic approach adopted provides indications that it would offer benefits more widely. The results of these evaluations provide indications that both the model and the platform are good candidates for being a reference for future pHealth developments.

Accurate Analysis of Subharmonic Oscillations of V^2 and V^2Ic Controls Applied to Buck Converter

V2Ic control provides very fast dynamic performance to the Buck converter both under load steps and under voltage reference steps. However, the design of this control is complex since it is prone to subharmonic oscillations and several parameters affect the stability of the system. This paper derives and validates a very accurate modeling and stability analysis of a closed-loop V2Ic control using the Floquet theory. This allows the derivation of sensitivity analysis to design a robust converter. The proposed methodology is validated on a 5-MHz Buck converter. The work is also extended to V2 control using the same methodology, showing high accuracy and robustness. The paper also demonstrates, on the V2 control, that even a low bandwidth-linear controller can affect the stability of a ripple-based control.