Kundmachung: Der hohe Reichstag hat zu Folge seines gestern gefaßten Beschlusses dem Ministerium die Ausführung der geeigneten Maßregeln überlassen ...

Welsch (Projektbearbeiter): Aufforderung an bedürftige Gewerbetreibende, sich zwecks Einreichung von Hilfsgesuchen an ihre Vertrauensmänner in den jeweiligen Innungen zu wenden

Evidence for chronic low-grade systemic inflammation in individuals with agoraphobia from a population-based prospective study.

BACKGROUND Anxiety disorders have been linked to an increased risk of incident coronary heart disease in which inflammation plays a key pathogenic role. To date, no studies have looked at the association between proinflammatory markers and agoraphobia. METHODS In a random Swiss population sample of 2890 persons (35-67 years, 53% women), we diagnosed a total of 124 individuals (4.3%) with agoraphobia using a validated semi-structured psychiatric interview. We also assessed socioeconomic status, traditional cardiovascular risk factors (i.e., body mass index, hypertension, blood glucose levels, total cholesterol/high-density lipoprotein-cholesterol ratio), and health behaviors (i.e., smoking, alcohol consumption, and physical activity), and other major psychiatric diseases (other anxiety disorders, major depressive disorder, drug dependence) which were treated as covariates in linear regression models. Circulating levels of inflammatory markers, statistically controlled for the baseline demographic and health-related measures, were determined at a mean follow-up of 5.5 ± 0.4 years (range 4.7 - 8.5). RESULTS Individuals with agoraphobia had significantly higher follow-up levels of C-reactive protein (p = 0.007) and tumor-necrosis-factor-α (p = 0.042) as well as lower levels of the cardioprotective marker adiponectin (p = 0.032) than their non-agoraphobic counterparts. Follow-up levels of interleukin (IL)-1β and IL-6 did not significantly differ between the two groups. CONCLUSIONS Our results suggest an increase in chronic low-grade inflammation in agoraphobia over time. Such a mechanism might link agoraphobia with an increased risk of atherosclerosis and coronary heart disease, and needs to be tested in longitudinal studies.

Treatment allocation in hepatocellular carcinoma: Assessment of the BCLC algorithm

BACKGROUND AND AIMS The Barcelona Clinic Liver Cancer (BCLC) staging system is the algorithm most widely used to manage patients with hepatocellular carcinoma (HCC). We aimed to investigate the extent to which the BCLC recommendations effectively guide clinical practice and assess the reasons for any deviation from the recommendations. MATERIAL AND METHODS The first-line treatments assigned to patients included in the prospective Bern HCC cohort were analyzed. RESULTS Among 223 patients included in the cohort, 116 were not treated according to the BCLC algorithm. Eighty percent of the patients in BCLC stage 0 (very early HCC) and 60% of the patients in BCLC stage A (early HCC) received recommended curative treatment. Only 29% of the BCLC stage B patients (intermediate HCC) and 33% of the BCLC stage C patients (advanced HCC) were treated according to the algorithm. Eighty-nine percent of the BCLC stage D patients (terminal HCC) were treated with best supportive care, as recommended. In 98 patients (44%) the performance status was disregarded in the stage assignment. CONCLUSION The management of HCC in clinical practice frequently deviates from the BCLC recommendations. Most of the curative therapy options, which have well-defined selection criteria, were allocated according to the recommendations, while the majority of the palliative therapy options were assigned to patients with tumor stages not aligned with the recommendations. The only parameter which is subjective in the algorithm, the performance status, is also the least respected.

Gutachten der Abtheilung über den Entwurf eines Wahlgesetzes für die zur Vereinbarung der Preußischen Staats-Verfassung zu berufende Versammlung: Die Abtheilung hat zuvörderst die Aufgabe der auf Grund des Wahlgesetzes zu berufenden Versammlung ...

Welsch (Projektbearbeiter): Gutachten von 18 Abgeordneten des Vereinigten Landtages die Urwahlen zur zukünftigen Preußischen Nationalversammlung betreffend: wahlberechtigt ist demnach jeder männliche preußische Staatsbürger nach Vollendung des 24. Lebensjahres, der sich im Besitz der bürgerlichen Rechte befindet, mindestens 6 Monate in einer bestimmten Gemeinde ansässig ist und keine öffentliche Armenunterstützung bezieht

Handbuch der Heilmittellehre

von Fr. Oesterlen

Jubal, der Erfinder der Musik [Illustration]

Friedrich August von Kloeber

Liebe und Tod im Werk R. M. Rilkes

Friedrich Franz von Unruh

Die ersten Mutterpflichten und die erste Kindespflege : [Belehrungsbuch für junge Frauen und Mütter]

von F. A. von Ammon

Wappen der Löblichen Bürgerschaft in Schaffhausen

von J. Fried. Schalch

Felddienst-Instruction für Schützen und Reuter

Entworfen von dem General Grafen von Bismark

Mus Hs 1204 - Arien und Gesänge mit Begleitung des Piano-Forte

Für Singstimme und Klavier

Ms. germ. qu. 51 - Mainzer Chronik 1332 - 1452

Vorbesitzer: Johann Friedrich Faust von Aschaffenburg; Wilhelm Fitzer; Matthaeus Merian; Johann Maximilian zum Jungen;

Bemerkungen über einige Arten der Gattung Carex

von H. F. Link

Handbuch der Heilmittellehre

von Fr. Oesterlen

Über die Verwandtschaftsverhältnisse und die Verbreitung der amerikanischen Arten der Gattung Draba

von Ernst Gilg