Regulation of NAMPT in human gingival fibroblasts and biopsies

Adipokines, such as nicotinamide phosphoribosyltransferase (NAMPT), are molecules, which are produced in adipose tissue. Recent studies suggest that NAMPT might also be produced in the tooth-supporting tissues, that is, periodontium, which also includes the gingiva. The aim of this study was to examine if and under what conditions NAMPT is produced in gingival fibroblasts and biopsies from healthy and inflamed gingiva. Gingival fibroblasts produced constitutively NAMPT, and this synthesis was significantly increased by interleukin-1β and the oral bacteria P. gingivalis and F. nucleatum. Inhibition of the MEK1/2 and NFκB pathways abrogated the stimulatory effects of F. nucleatum on NAMPT. Furthermore, the expression and protein levels of NAMPT were significantly enhanced in gingival biopsies from patients with periodontitis, a chronic inflammatory infectious disease of the periodontium, as compared to gingiva from periodontally healthy individuals. In summary, the present study provides original evidence that gingival fibroblasts produce NAMPT and that this synthesis is increased under inflammatory and infectious conditions. Local synthesis of NAMPT in the inflamed gingiva may contribute to the enhanced gingival and serum levels of NAMPT, as observed in periodontitis patients. Moreover, local production of NAMPT by gingival fibroblasts may represent a possible mechanism whereby periodontitis may impact on systemic diseases.

Letter from William Croswell to James Scott, 1803 November 1

One-page letter from Croswell to Captain James Scott, Master of the Boston Marine Society, that accompanied Croswell's work on lunar observations.

The College Law Book, 1734

Handwritten copy of the 1734 College Laws transcribed by Meshech Weare (Harvard AB 1735) into a small notebook. The volume has a modern hardcover binding.

College Laws, 1734

Handwritten copy of the 1734 College Laws transcribed into a soft-cover notebook. The volume includes the name "Johannes Winthrop" ornately detailed at the end of the transcription.

[Admittatur of Timothy Prout (Harvard AB 1741)], 1737

Notebook with a handwritten copy of the 1734 College laws copied in English by Harvard undergraduate Timothy Prout and signed by President Edward Holyoke, Fellows Henry Flynt and Nathan Prince, and Tutors Stephen Sewall and Daniel Rogers on October 5, 1737. The flyleaf includes the note, "This Body of Colledge Laws was transcribed by Timo. Prout July ye 10th anno Domini 1737.

[Admittatur of Jonathan Townsend (Harvard AB 1741)], 1737

Notebook, in modern hardcover binding, with a handwritten copy of the 1734 College laws in English prepared by Harvard undergraduate Jonathan Townsend and signed by President Edward Holyoke and Fellow Nathan Prince on October 6, 1737.

[Admittatur of Joseph Roby (Harvard AB 1742)], 1738

Notebook with a handwritten copy of the 1734 College laws in English prepared by Harvard undergraduate Joseph Roby and signed by President Edward Holyoke and Fellows Henry Flynt and Nathan Prince on September 12, 1738. The "College Customs" are copied onto the last pages of the notebook.

[Admittatur of Ebenezer Storer (Harvard AB 1747)], 1743

Marbled paper-covered notebook with a handwritten copy of the 1734 College laws in English prepared by Harvard undergraduate Ebenezer Storer and signed by President Edward Holyoke, Fellow Henry Flynt, Tutor Belcher Hancock, Fellow Joseph Mayhew, and Tutor Thomas Marsh on September 11, 1743.

[Admittatur of Cotton Tufts (Harvard AB 1749)], 1745

Notebook with a handwritten copy of the 1734 College laws in English prepared by Harvard undergraduate Cotton Tufts and signed by President Edward Holyoke, Tutor Belcher Hancock, Fellow Joseph Mayhew, and Tutor Thomas Marsh on November 8, 1745.

[Admittatur of William Clark (Harvard AB 1759)], 1756

Notebook with a handwritten copy of the 1734 College laws in English prepared by Harvard undergraduate William Clark and signed by President Edward Holyoke, Tutors Belcher Hancock and Thomas Marsh, and William Symmes and William Kneeland on January 3, 1756.

[Admittatur of Benjamin Dolbeare (Harvard AB 1763)], 1760

Notebook with a handwritten copy of the 1734 College laws and additional laws approved by the Corporation between 1756 and 1760 in English prepared by Harvard undergraduate Benjamin Dolbeare and signed by President Edward Holyoke, Tutors Belcher Hancock and Thomas Marsh, and William Kneeland and Josephus Jackson on January 12, 1760.

[Admittatur of Joseph Willard (Harvard AB 1765)], 1762

Notebook with a handwritten copy of the 1734 College laws and the additional laws approved by the Corporation on March 29, 1757 in English prepared by Harvard undergraduate Joseph Willard and signed by President Edward Holyoke, Tutors Belcher Hancock and Thomas Marsh, and William Kneeland and Ebenezer Thayer on May 6, 1762.

Justice of the peace day book, 1797-1816

Contains records of summons and judgements in various court cases, and fines paid.

Diary of Elias Mann, 1796-1800

Elias Mann kept this diary during his undergraduate years at Harvard College. The diary begins August 17, 1796 and ends in August of 1800 and also includes several undated sheets filled with excerpts of poems. The daily entries describe many aspects of Mann's life, including not only his experiences at Harvard but also his involvement in the larger community. Entries related to life at Harvard describe club meetings (coffee club, Hasty Pudding Club and Phi Beta Kappa); trips to the theater; dinners at taverns; games and recreation, including a card game called "Loo," cribbage, backgammon, bowling, playing ball, fishing, skating and going for sleigh rides; gathering, and sometimes taking from others' gardens, food (most often plums, peaches, nuts and apples); what he ate (including one breakfast of three raw eggs and two glasses of wine); what he read (including Tristram Shandy and one of "Mrs. Ratcliffe's novels"); his friends, often mentioned by name; and academic work and formalities. In one entry he mentions the theft of several possessions from his room, and there are several entries about trips to Fresh Pond.