General passcharta öfwer Österjöön och Skager-Rack, uthwysandes alla courserne på det aldranogaste och accurateste, som det uhti platt och effter een medierat compassens afwykningh görligit warit

Julkaisussa: General hydrographisk chart-book öfwer Östersjön och Katte-Gatt till sin raetta figur och stoorleek

Selective destruction of nigrostriatal dopaminergic neurons does not alter [3H]-ryanodine binding in rat striatum

Dopamine nigrostriatal neurons are important for motor control and may contain a particularly dense population of ryanodine receptors involved in the control of dopamine release. To test this hypothesis, we used a classical model of unilateral selective lesion of these neurons in rats based on 6-hydroxydopamine (6-OHDA) injection into the substantia nigra. Binding of [3H]-GBR 12935, used as a presynaptic marker since it labels specifically the dopamine uptake complex, was dramatically decreased by 83-100% in striatum homogenates after 6-OHDA lesion. On the contrary, no reduction of [3H]-ryanodine binding was observed. The present data indicate that [3H]-ryanodine binding sites present in rat striatum are not preferentially localized in dopaminergic terminals.

Heparan sulfate and control of cell division: adhesion and proliferation of mutant CHO-745 cells lacking xylosyl transferase

We have examined the role of cell surface glycosaminoglycans in cell division: adhesion and proliferation of Chinese hamster ovary (CHO) cells. We used both wild-type (CHO-K1) cells and a mutant (CHO-745) which is deficient in the synthesis of proteoglycans due to lack of activity of xylosyl transferase. Using different amounts of wild-type and mutant cells, little adhesion was observed in the presence of laminin and type I collagen. However, when fibronectin or vitronectin was used as substrate, there was an enhancement in the adhesion of wild-type and mutant cells. Only CHO-K1 cells showed a time-dependent adhesion on type IV collagen. These results suggest that the two cell lines present different adhesive profiles. Several lines of experimental evidence suggest that heparan sulfate proteoglycans play a role in cell adhesion as positive modulators of cell proliferation and as key participants in the process of cell division. Proliferation and cell cycle assays clearly demonstrate that a decrease in the amount of glycosaminoglycans does not inhibit the proliferation of mutant CHO-745 cells when compared to the wild type CHO-K1, in agreement with the findings that both CHO-K1 and CHO-745 cells take 8 h to enter the S phase.

Ligand-induced endocytosis and nuclear localization of angiotensin II receptors expressed in CHO cells

A construct (AT1R-NF) containing a "Flag" sequence added to the N-terminus of the rat AT1 receptor was stably expressed in Chinese hamster ovary cells and quantified in the cell membrane by confocal microscopy after reaction with a fluorescein-labeled anti-Flag monoclonal antibody. Angiotensin II bound to AT1R-NF and induced endocytosis with a half-time of 2 min. After 60-90 min, fluorescence accumulated around the cell nucleus, suggesting migration of the ligand-receptor complex to the nuclear membrane. Angiotensin antagonists also induced endocytosis, suggesting that a common step in the transduction signal mechanism occurring after ligand binding may be responsible for the ligand-receptor complex internalization.

Tuotannon make or buy– päätöksentekoprosessi kansainvälisessä teknologiayrityksessä Case: Yritys X

Tutkimuksen tarkoituksena tutkia millaisia make or buy- työkaluja on olemassa ja millaiset teoriat vaikuttavat make or buy- päätösten taustalla. Tutkimuksessa tutkittiin myös miten nämä ilmiöt ja mallit vaikuttavat ja toteutuvat käytännössä teknologia-alalla

Upland : Upsala och Stockholms län : Upsala erkestifts södra del på grund af topografiska och ekonomiska karteverken och offentliga handlingar

Kartta kuuluu A. E. Nordenskiöldin kokoelmaan

Skåne och Bleking : Malmöhus, Christianstads och Blekinge län : Lunds stift på grund af topografiska och ekonomiska karteverken och offentliga handlingar

Kartta kuuluu A. E. Nordenskiöldin kokoelmaan

Geologisk kart over öerne ved Kristiania (etagen 4) : på grundlag af kart over Kristiania havnedistrikt optaget 1884 og 1885

Kartta kuuluu A. E. Nordenskiöldin kokoelmaan

General karta öfver Göta canalen föreslagen till sammanbindande af Wenern och Wettern med Östersjön på konungens allernådigste befallning utstakad under öfversten och riddaren frih.re von Platens inseende af Th. Telford 1808

Kartta kuuluu A. E. Nordenskiöldin kokoelmaan

Karta öfver Sverge : på föranstaltande af Emil Ericsson

Kartta kuuluu A. E. Nordenskiöldin kokoelmaan

Karta öfver Sverige upptagande jernvägar och diligens-leder samt språk-djur-och trädgränser m.m. : på föranstaltande af brukegaren Emil Ericsson : norra delen

Kartta kuuluu A. E. Nordenskiöldin kokoelmaan

Karta öfver Sverige upptagande jernvägar och diligens-leder samt språk-djur-och trädgränser m.m. : på föranstaltande af brukegaren Emil Ericsson : södra delen

Kartta kuuluu A. E. Nordenskiöldin kokoelmaan

A geological and topographical sketch map of the New York and Westmoreland Gas Coal Company's lands, at Manor Sta., Westm'd Co., Pa.

Kartta kuuluu A. E. Nordenskiöldin kokoelmaan

The secondary alcohol and aglycone metabolites of doxorubicin alter metabolism of human erythrocytes

Anthracyclines, a class of antitumor drugs widely used for the treatment of solid and hematological malignancies, cause a cumulative dose-dependent cardiac toxicity whose biochemical basis is unclear. Recent studies of the role of the metabolites of anthracyclines, i.e., the alcohol metabolite doxorubicinol and aglycone metabolites, have suggested new hypotheses about the mechanisms of anthracycline cardiotoxicity. In the present study, human red blood cells were used as a cell model. Exposure (1 h at 37ºC) of intact human red blood cells to doxorubicinol (40 µM) and to aglycone derivatives of doxorubicin (40 µM) induced, compared with untreated red cells: i) a ~2-fold stimulation of the pentose phosphate pathway (PPP) and ii) a marked inhibition of the red cell antioxidant enzymes, glutathione peroxidase (~20%) and superoxide dismutase (~60%). In contrast to doxorubicin-derived metabolites, doxorubicin itself induced a slighter PPP stimulation (~35%) and this metabolic event was not associated with any alteration in glutathione reductase, glutathione peroxidase, catalase or superoxide dismutase activity. Furthermore, the interaction of hemoglobin with doxorubicin and its metabolites induced a significant increase (~22%) in oxygen affinity compared with hemoglobin incubated without drugs. On the basis of the results obtained in the present study, a new hypothesis, involving doxorubicinol and aglycone metabolites, has been proposed to clarify the mechanisms responsible for the doxorubicin-induced red blood cell toxicity.

[Topografičeskaâ karta 1:42000]. XI-49, XI-50, X-49, X-50, Vyb. gub., u. Stranda i Èurâpâ / snimali: Ivanov", snimal" i čertil" Filimonov".

1:42000.