Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 129 - Grußschreiben anlässlich des Umzugs Schopenhauers nach Hamburg

u.a.: Anthime Gregoire de Blésimaire;

Der künstlerische Nachlass [Teils.] von Lesser Ury : 129 Ölgemälde, 123 Pastelle; Ausstellung: ... 13. Okt. bis ... 15. Okt. 1932 ... ; Versteigerung: Freitag, den 21. Oktober 1932 ... bei Paul Cassirer, Berlin

Auktionsleitung: Paul Cassirer

Ms. Praed. 129 - Breviloquium

Vorbesitzer: Kraft (Cratho); Dominikanerkloster Frankfurt am Main

Ms.Ff.F.Stoltze 3. 129 - Brief von Otto Hörth an Friedrich Stoltze

Ziegenhain, Briefzensur, Albert Dulk, Carl Mayer, Texte für die Frankfurter Latern

Ms. lat. oct. 129 - Stundenbuch nach dem Gebrauch von Paris

Vorbesitzer: C.J. (E.J.?) Brugrade (Vorbesitzer?); Jérôme Colot; Freiherrl. Carl von Rothschild'sche Bibliothek Frankfurt am Main

Mus Hs 129 Nr. 1 - Sieg! : Ouverture für großes Orchester ; August 1870

von Ferdinand Hiller

Ms. lat. qu. 129 - Kapitular der Prokuratoren von S. Marco

Vorbesitzer: Francesco Cornelio

Identification of germ cell tumor modifier genes from the 129.MOLF-Chr19 consomic mouse strain

Naturally occurring genetic variants confer susceptibility to disease in the human population, including in testicular germ cell tumor development. Disease susceptibility loci for testicular germ cell tumors have been identified by genetic mapping in humans and mice. However, the identity of many of the susceptibility genes remains unclear. My study utilized a chromosome substitution strain, the 129.MOLF-Chr 19 (or M19 strain), to identify candidate testicular germ cell tumor susceptibility genes. Males of this strain have a high incidence of germ cell tumors in the testes. By forward genetic approaches, five susceptibility loci were fine-mapped and the genetic interactions were dissected. In addition, I identified three protein-coding genes and one micro-RNA as testicular tumor susceptibility genes by genomic screening. Using reverse genetic approaches, I verified one of the candidates, Splicing factor 1, as a modifier of testicular tumor. Deficiency of SF1 significantly reduces the incidence of testicular tumors in mice. This study highlights the advantage of the 129.MOLF-Chr 19 consomic strain in disease gene identification and validation. It also sets the stage to elucidate the molecular mechanisms of tumorigenesis in the testis. ^