The Labdane Ent-3-Acetoxy-Labda-8(17), 13-Dien-15-Oic Decreases Blood Pressure In Hypertensive Rats

Abstract Background: Labdane-type diterpenes induce lower blood pressure via relaxation of vascular smooth muscle; however, there are no studies describing the effects of labdanes in hypertensive rats. Objective: The present study was designed to investigate the cardiovascular actions of the labdane-type diterpene ent-3-acetoxy-labda-8(17), 13-dien-15-oic acid (labda-15-oic acid) in two-kidney 1 clip (2K-1C) renal hypertension. Methods: Vascular reactivity experiments were performed in aortic rings isolated from 2K-1C and normotensive (2K) male Wistar rats. Nitrate/nitrite (NOx) measurement was performed in aortas by colorimetric assay. Blood pressure measurements were performed in conscious rats. Results: Labda-15-oic acid (0.1-300 µmol/l) and forskolin (0.1 nmol/l - 1 µmol/l) relaxed endothelium-intact and endothelium-denuded aortas from both 2K-1C and 2K rats. Labda-15-oic acid was more effective at inducing relaxation in endothelium-intact aortas from 2K pre-contracted with phenylephrine when compared to the endothelium-denuded ones. Forskolin was more potent than labda-15-oic acid at inducing vascular relaxation in arteries from both 2K and 2K-1C rats. Labda-15-oic acid-induced increase in NOx levels was lower in arteries from 2K-1C rats when compared to 2K rats. Intravenous administration of labda-15-oic acid (0.3-3 mg/kg) or forskolin (0.1-1 mg/kg) induced hypotension in conscious 2K-1C and 2K rats. Conclusion: The present findings show that labda-15-oic acid induces vascular relaxation and hypotension in hypertensive rats.

Total synthesis of 8,9-Dehydro-Epothilone C

Magdeburg, Univ., Fak. für Verfahrens- und Systemtechnik, Diss., 2010

Motor- und Aggregate-Akustik : 8. Magdeburger Akustik-Symposium ; Tagungsband [02. und 03. Juli 2014]

Hermann Rottengruber; Wilfried Henze; Tommy Luft (Hrsg.) und 54 Mitautoren

Efeito do sódio na produção de matéria seca em mudas de duas cultivares de algodoeiro mocó (Gossypium hirsutum L., var. Maria Galante Hucth.): cv. '9193' e 'c-71'

Durante um período de noventa dias, foi conduzido em casa de vegetação, um experimento inteiramente casualizado, com quatro repetições. Foram testados cinco níveis de sódio (0; 4; 40; 400; 4.000 ppm de sódio) utilizando-se duas fontes, cloreto e sulfato de sódio e duas cultivares de algodoeiro mocó (G. hirsutum, var. Maria Galante, Hucth.) !9193' e 'c-71', cultivadas em solução nutritiva. Os resultados mostraram que a dose 4 ppm de sódio provocou aumento na produção de matéria seca do algodoeiro, enquanto as doses 400 e 4.000 ppm de sódio, provocaram diminuição. Ocorreu efeito negativo na produção de materia seca da cultivar '9193' provocado pelo cloreto.

Qualifizierung einer Destillationsapparatur für die Herstellung von gereinigtem Wasser nach PhEur 8

In der Arbeit wird die Qualifizierung eines Wasserdestillationsapperates durchgeführt. Die Qualifizierung beinhaltet die Designqualifizierung (DQ), Installationsqualifizierung (IQ), die Funktionsqualifizierung (OQ) und die Leistungsqualifizierung (PQ). Die Qualifizierung wird nach GMP durchgeführt. GMP ist die Richtlinie für die Qualifizierung von Geräten und die Herstellung von Arzneimitteln. Bei der Leistungsqualifizierung wird das hergestellte Wasser nach dem europäischen Arzneibuch überprüft. Es werden drei Prüfungen durchgeführt, um die Menge an Mikroorganismen, die Leitfähigkeit und den TOC-Wert zu bestimmen. Die erhaltenen Ergebnisse und Messwerte werden in Qualifizierungsprotokollen zusammengefasst, aus denen hervorgeht, ob der geprüfte Wasserdestillierapperat den Anforderungen entspricht.

Programação do gladíolo (Gladiolus grandiflorus) andr. cv. Snow Princess, através de cormilhos tipo 7 e 8

Os cormilhos tipo 7 produziram bulbos e cormilhos dos tipos de 1 a 8 em maior quantidade que o tipo 8 e os bulbos tipos 1, 2, 3, 4 e 5 mais pesados. Os cormilhos tipo 8 também produziram bulbos e cormilhos dos tipos 1 a 8, porém seus cormilhos foram mais pesados que os cormilhos produzidos pelo tipo 7.

The Indian tribes of the Chicago region, with special reference to the Illinois and the Potawatomi / by William Duncan Strong -- Former Assistant Curator of North American Ethnology and Archaeology. 8 plates.

no.24(1926)