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Ramón Muntaner [Texto impreso] : cronista dels reys de Aragó ciutadà de Valencia

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Determination of selected pharmaceutical compounds in biosolids bysupported liquid extraction and gas chromatography?tandem massspectrometry

In this work, an analytical method was developed for the determination of pharmaceutical drugs inbiosolids. Samples were extracted with an acidic mixture of water and acetone (1:2, v/v) and supportedliquid extraction was used for the clean-up of extracts, eluting with ethyl acetate:methanol (90:10, v/v).The compounds were determined by gas chromatography?tandem mass spectrometry using matrix-match calibration after silylation to form their t-butyldimethylsilyl derivatives. This method presentsvarious advantages, such as a fairly simple operation for the analysis of complex matrices, the use ofinexpensive glassware and low solvent volumes. Satisfactory mean recoveries were obtained with thedeveloped method ranging from 70 to 120% with relative standard deviations (RSDs) ? 13%, and limitsof detection between 0.5 and 3.6 ng g?1. The method was then successfully applied to biosolids samplescollected in Madrid and Catalonia (Spain). Eleven of the sixteen target compounds were detected in thestudied samples, at levels up to 1.1 ?g g?1(salicylic acid). Ibuprofen, caffeine, paracetamol and fenofibratewere detected in all of the samples analyzed.

Peptide analogue studies of the hypothalamic neuropeptide Y receptor mediating pituitary adrenocorticotrophic hormone release

Hypothalamic neuropeptide Y (NPY) is thought to be important in the regulation of feeding and also in the release of Adrenocorticotrophic hormone (ACTH). Intracerebroventricular administration of NPY to male rats significantly increased plasma ACTH 10 min after injection and stimulated 2-h food intake. A series of analogues of NPY that have a greatly reduced affinity for the Y1 [human pancreatic polypeptide (human PP), NPY(3–36)], the Y2 ([Pro34]NPY, human PP), the Y3 (peptide YY), and the Y6 (human PP) receptor, all markedly stimulated ACTH release. Rat PP, which binds with high affinity to the Y4 receptor, was unable to stimulate ACTH release. A novel analogue fragment [Pro34]NPY(13–36) was synthesized as a ligand with low Y1 and Y2 receptor affinity. Interestingly, neither [Pro34]NPY(13–36) nor the selective Y5 receptor agonist [d-Trp32]NPY stimulated food intake, whereas both significantly increased plasma ACTH. Thus the hypothalamic NPY receptor mediating increases in plasma ACTH has a fragment activation profile unlike the Y1–Y4 or Y6 receptors and appears distinct from the NPY receptor controlling food intake.

Marked decrease of neuropeptide Y Y2 receptor binding sites in the hippocampus in murine prion disease

Using autoradiographic binding methodology with monoiodinated peptide YY together with the agonists neuropeptide Y (NPY) and NPY (13–36), as well as in situ hybridization with oligonucleotide probes complementary to the NPY Y2 receptor (Y2-R) mRNA, we have studied whether or not intracerebral prion inoculation affects Y2-Rs in male CD-1 mice. Monoiodinated peptide YY binding, mainly representing Y2-Rs, was down-regulated by 85% in the CA1 strata oriens and radiatum and by 50–65% in the CA3 stratum oriens 110–140 days postinoculation. In the CA3 stratum radiatum, where the mossy fibers from the dentate granule cells project, there was a significant decrease in PYY binding at 110–120 days. Y2-R mRNA, moderately expressed both in the CA1 and CA3 pyramidal cell layers and the granule cell layer in the dentate gyrus, showed a slight, but not significant, decrease in CA3 neurons 130 days postinoculation. The results indicate that the accumulation of the scrapie prion protein in the CA1–3 region strongly inhibits NPY binding at the Y2-Rs, which, however, is only marginally due to reduced Y2-R mRNA expression. The loss of the ability of NPY to bind to inhibitory Y2-Rs may cause dysfunction of hippocampal circuits and may contribute to the clinical symptoms in mouse scrapie.

Reseñas

Contiene: INQUISITIONES. INQUIRIÇÕES GERAIS DE D. DINIS: 1284. José Augusto de Sotto Mayor Pizarro (ed.) Lisboa, Academia das Ciências de Lisboa, 2007. (Portugaliae Monumenta Historica: a saeculo octavo post Christum usque ad quintum decimum, Nova Série, vol. 3). ISBN 978-972-623-101-1. 133 páginas / Inés Calderón Medina ; EL BAILE GENERAL DE ARAGÓN DURANTE EL REINADO DE PEDRO IV EL CEREMONIOSO (1336-1387). Luís Blanco Domingo. La fiscalidad regia. Institución “Fernando el Católico” (C.S.I.C.). Zaragoza. 2009. 253. I.S.B.N.: 978-84-9911-018-9 / Héctor García López ; LA ENCOMIENDA DE MARTOS DE LA ORDEN DE CALATRAVA (SIGLOS XIII-XV). Francisco Luis Ruiz Fúnez (Ed. Ayuntamiento de Martos. Martos, 2010. 164 págs. + fotos y planos) ISBN: 978-84-923864-2-0 / José Carlos Gutiérrez Pérez ; LA FRONTERA SEFARDÍ. LA RECONQUISTA Y LA COMUNIDAD JUDÍA EN LA ESPAÑA MEDIEVAL. Jonathan Ray. Alianza Editorial, Madrid, 2009, 302 p. I.S.B.N.: 978-84-206-8395-9 / Jorge Maíz Chacón ; BATTAGLIE E PROTAGONISTI DELLA SARDEGNA MEDIOEVALE. Alessandra Cioppi. AMD Edizioni, Cagliari, 2008. ISBN: 978-88-95462-15-8. 434 Págs. / Esther Martí ; LIBRO DE LA BAILÍA DE CANTAVIEJA (1428-1470). Germán Navarro Espinach y Concepción Villanueva Morte. Departamento de Historia Medieval, Ciencias y Técnicas Historiográficas y Estudios Árabes e Islámicos de la Universidad de Zaragoza, Instituto de Estudios Turolenses y Grupo de investigación CEMA, Zaragoza, 2009, 374 páginas. / Francisco Vicente Navarro ; LA NOBLEZA SEÑORIAL EN LA CORONA DE CASTILLA. Mª Concepción Quintanilla Raso. Universidad de Granada, Granada, 2008. ISSN: 978-84-338-4854-3. 357 págs. / Santiago Ponsoda López de Atalaya ; TESTAMENTI ECLESIAE PORTUGALIAE (1071-1325), COLECÇÃO HISTÓRIA RELIGIOSA: FONTES E SUBSIDIOS 6. Maria do Rosario Barbosa Morujão (coord.) Centro de estudios de Historia Religiosa da Universidade Católica Portuguesa, Lisboa, 2010. ISBN: 978-972-8361-31-0. 767 Páginas, 39 imágenes / Néstor Vigil Montes.

Tectonic control on the sedimentary record of the central Moldavidian Basin (Eastern Carpathians, Romania)

The sedimentary record of the Tarcău and Vrancea Nappes, belonging to the flysch accretionary zone of the Eastern Carpathians (Eastern Carpathian Outer Flysch), registered Cretaceous-Miocene events during the evolution of the Moldavidian Basin. Our biostratigraphic data indicate that the deposits studied are younger than previously reported. The comparison of sedimentary record studied with the Late Cretaceous-Early Miocene global eustatic curve indicates that eustatic factor played a secondary role, after the tectonic one. Four main stages of different processes influenced by tectonics are recognized in the sedimentary record: (1) Campanian-Maastrichtian-earliest Paleocene; (2) latest Ypresian-Lutetian; (3) late Chattian-earliest Aquitanian, and (4) late Aquitanian-early Burdigalian. The late Chattian- earliest Aquitanian and late Aquitanian-early Burdigalian records indicate a high tectonic influence. The first event was related to the foredeep stage of the sedimentary domain studied, and the second one to the deformation stage of the same domain. The sedimentary records of tectonic influence recognized during these stages are useful tools for geodynamic reconstructions. The stratigraphic correlation of Tarcău and Vrancea sedimentary records are used

Measuring the effective focal length and shape factor of a thick lens using a microscope

The optical power of a thick spherical lens and its Coddington shape factor are essential magnitudes that characterize its image quality. Here, we propose an experimental procedure and apparatus that allow accurate determination of those magnitudes for any spherical lens from geometrical measurements. The performance of the technique and the used instruments are simple since it only requires a microscope and an optical mouse. The propose overcomes the drawbacks of other devices that need of the refractive index or may damage the lens surfaces, like spherometers, and provides similar results to those from commercial lensmeters.

Three-dimensional planar object tracking with sub-pixel accuracy

Subpixel techniques are commonly used to increase the spatial resolution in tracking tasks. Object tracking with targets of known shape permits obtaining information about object position and orientation in the three-dimensional space. A proper selection of the target shape allows us to determine its position inside a plane and its angular and azimuthal orientation under certain limits. Our proposal is demonstrated both numerical and experimentally and provides an increase the accuracy of more than one order of magnitude compared to the nominal resolution of the sensor. The experiment has been performed with a high-speed camera, which simultaneously provides high spatial and temporal resolution, so it may be interesting for some applications where this kind of targets can be attached, such as vibration monitoring and structural analysis.

Tarih-i Timur Gürgan

li-Nazmizade Efendi.

Risālah : manuscript, [ca. 1918]

Title supplied by cataloger.

Hādhihi risālat Tanbīh al-muhtadīn ʻalá dasāʼis al-muʻtadīn / li-muʻallifihi al-ʻAllāmah al-Humām Dhū al-Qadr al-Aʻdal al-Sayyid Muḥammad [ibn] Muḥammad ibn ʻAbd al-Qādir al-Ahdal : manuscript, 1918

Copy completed 15 Jumādá al-Thānī 1336 [March 28, 1918] in the hand of Muḥammad ʻAbd al-Jalīl, from a copy dated 22 Ṣafar 1323 [April 27, 1905].

Fatḥ al-Raḥmān bi-al-jawāb ʻalá ahl Qalībān / jamʻ al-Shaykh al-ʻAllāmah wa-al-Sayyid al-Fahhāmah ʻAbd Allāh ibn ʻUmar ibn Yaḥyá Bāʻalawī : manuscript, 1918

Written in 1248 [1832-3].

Hādhā kitāb sammāhu muʼallifuhu Natāʼij al-fiṭan fī ibrāz faḍāʼil al-Yaman / wa-al-muʼallif al-Shaykh Muḥammad ibn Muḥammad al-Shīrāzī al-Zabīdī : manuscript, 1918

Copy completed on 16 Jumād[á] al-Thānī 1336 [March 29, 1918] from a copy dated 16 Rabīʻ al-Awwal 1323 [May 21, 1905].