13-12-19, stade Jean-Bouin, hockey [sur gazon], équipe des Possibles : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57224

Délire religieux treize ans après traumatisme crânien [Religious delusion 13 years after brain injury].

We report here with a case of religious delusion in a 39 years old woman. She had suffered a head injury with right temporal concussion 13 years before but had no earlier history of psychiatric disorder. In view of the fact that this acute psychiatric state lasted for a short duration of time and that personality and affects were preserved, this incident is compared to the schizophreniform disorder of the type DSM-III-R. The hypothesis of an acquired predisposition due to head injury has been put forward as an explanation.

MicroRNA-122 modulates the rhythmic expression profile of the circadian deadenylase Nocturnin in mouse liver.

Nocturnin is a circadian clock-regulated deadenylase thought to control mRNA expression post-transcriptionally through poly(A) tail removal. The expression of Nocturnin is robustly rhythmic in liver at both the mRNA and protein levels, and mice lacking Nocturnin are resistant to diet-induced obesity and hepatic steatosis. Here we report that Nocturnin expression is regulated by microRNA-122 (miR-122), a liver specific miRNA. We found that the 3'-untranslated region (3'-UTR) of Nocturnin mRNA harbors one putative recognition site for miR-122, and this site is conserved among mammals. Using a luciferase reporter construct with wild-type or mutant Nocturnin 3'-UTR sequence, we demonstrated that overexpression of miR-122 can down-regulate luciferase activity levels and that this effect is dependent on the presence of the putative miR-122 recognition site. Additionally, the use of an antisense oligonucleotide to knock down miR-122 in vivo resulted in significant up-regulation of both Nocturnin mRNA and protein expression in mouse liver during the night, resulting in Nocturnin rhythms with increased amplitude. Together, these data demonstrate that the normal rhythmic profile of Nocturnin expression in liver is shaped in part by miR-122. Previous studies have implicated Nocturnin and miR-122 as important post-transcriptional regulators of both lipid metabolism and circadian clock controlled gene expression in the liver. Therefore, the demonstration that miR-122 plays a role in regulating Nocturnin expression suggests that this may be an important intersection between hepatic metabolic and circadian control.

Iowa Developments, January 2004, Vol.13, no.1

Resource to help educate business or communities about state-sponsored programs.

ABD e-News, February 13, 2004

Weekly newsletter for the State of Iowa Alcoholic Beverages Division

Report of Recommendations to the Iowa Workforce Development on the Review of Selected General Controls, May 30, 2003 - June 13, 2003

State Agency Audit Report

13-12-19, stade Jean-Bouin, hockey [sur gazon], équipe des Possibles : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57223

13-12-19, stade Jean-Bouin, équipe des Probables [hockey sur gazon] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57221

Lottery Action, July 12-25, 2004, Vol. 11, no. 13

Iowa Lottery Authority Retailer Information Newsletter

13-12-19, stade Jean-Bouin, équipe des Probables [hockey sur gazon] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57222

13-12-19, cardinal Mercier [de Malines, arrivé à Paris le 11 décembre 1919] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57211