543 resultados para 1047


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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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trans,trans-2,4-Decadienal (DDE) is an important breakdown product of lipid peroxidation. This aldehyde is cytotoxic to mammalian cells and is known to be implicated in DNA damage. Therefore, attempts were made in this work to assess the reactivity of DDE with 2'-deoxyadenosine (dAdo). It was shown that DDE is able to bind to 2'-deoxyadenosine, yielding highly fluorescent products. Besides 1,N-6-etheno-2'-deoxyadenosine (epsilon dAdo), two other related adducts, 1-[3-(2-deoxy-beta-D-erythro-pentofuranosyl)3H-imidazo[2,1-i]purin-7-yl]-1,2,3-octanetriol and 1-[3-(2-deoxy-beta-D-erythro-pentofuranosyl)-3H-imidazo[2,1-i]purin-7-yl]-1,2-heptanediol, were isolated by reverse phase high-performance liquid chromatography and characterized on the basis of their UV, fluorescence, nuclear magnetic resonance, and mass spectrometry features. The reaction mechanism for the formation of the DDE-2'-deoxyadenosine adducts involves 2,4-decadienal epoxidation and subsequent addition to the N-2 amino group of 2'-deoxyadenosine, followed by cyclization at the N-1 site. Adducts differ by the length of carbon side chain and the number of hydroxyl groups. The present data indicate that DDE can be epoxidized by peroxides, and the resulting products are able to form several adducts with 2'-deoxyadenosine and/or DNA. Endogenous DNA adduct formation can contribute to the already reported high cytotoxicity of DDE to mammalian cells.

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The objetive of this paper is discuss, briefly, how are configured the dimensions of experience and ethics in society called "liquid" - from the discussions conducted by Zygmunt Bauman. It is observed that there is a difficulty of construction and maintenance of human relations which also leads to impoverishment of experience. This condition is related to the conexion of the bonds with the logic of consumption, which favors the ephemerality, disposability and transforming the other into an object of satisfaction. As a result, a new ethic becomes necessary, being guided in the rediscovery of public spaces as places of exchange (for exemple, the school institution), the experience with the other recognized as an autonomous subject and the reconfiguration of social ties from a policy of friendship.

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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A transmission line is characterized by the fact that its parameters are distributed along its length. This fact makes the voltages and currents along the line to behave like waves and these are described by differential equations. In general, the differential equations mentioned are difficult to solve in the time domain, due to the convolution integral, but in the frequency domain these equations become simpler and their solutions are known. The transmission line can be represented by a cascade of π circuits. This model has the advantage of being developed directly in the time domain, but there is a need to apply numerical integration methods. In this work a comparison of the model that considers the fact that the parameters are distributed (Universal Line Model) and the fact that the parameters considered concentrated along the line (π circuit model) using the trapezoidal integration method, and Simpson's rule Runge-Kutta in a single-phase transmission line length of 100 km subjected to an operation power. © 2003-2012 IEEE.

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The aim of this study was to assess the dentistry profile, based on social and demographic data, post-graduation formation, and to verify the insertion of dental graduates in the labour force. The participants were professionals graduated from a Brazilian Public Dental School, between 2000 and 2010. An instrument was sent by mail and/or e-mail to them. It was used Kruskal Wallis Test. Among 1047 questionnaires, 189 returned and 65.6% were answered by female. In relation to post-graduation course, 57.7% of professionals performed it, however 56.9% not attended only in their area; 66.6% of professionals are concentrated in cities larger than 100 thousand habitants. There was association between income and gender, and others. The predominant work modality was self-employed. Among the total, 36.5% want to work part-time in dentistry. The female gender was predominant and there was wage discrepancy between genders. The professionals have been concentrated in largest cities.

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The air part of the cassava is a residue which presents possibilities of being used as a non-wooden raw material in the production of pulp due to the fact that its 81 % of the adult plants air part, besides having high availability and presenting a high concentration of fibers. Studies were developed with the purpose of producing the pulps through the kraft process, which is a mix of the Na2S and NaOH in water heated up to the temperature of 160º C for about 90 minutes to the extraction of lignin. The paper sheets obtained in the practices went through an experimenting process. Studies related to the paper characteristics were accomplished in order to assess its use in the visual communication through printing techniques, silk screen, pictures and others graphical processes. The research results are able to conclude the utilization viability of this material in graphics communication.

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The Walter Caswell Sullivan Papers consist of correspondence; bills of sale; a biographical sketch of Edward Walter Hall (1859-1949), pioneer educator of Rock Hill; a journal (1912-1915) of the Eats Club in Rock Hill; and war ration books. Most of the correspondence concerns a John H. Allen of Chester and subjects include the health and financial affairs, the shooting of a doctor, Hall family genealogy, and business transactions. The Eats Club's members were Julia Cork, Eva Fewell, Josie Hall, Anne Claire Hutchison, and Susan Steele.

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Background: In the British Isles, control of cattle tuberculosis (TB) is hindered by persistent infection of wild badger (Meles meles) populations. A large-scale field trial—the Randomised Badger Culling Trial (RBCT)—previously showed that widespread badger culling produced modest reductions in cattle TB incidence during culling, which were offset by elevated TB risks for cattle on adjoining lands. Once culling was halted, beneficial effects inside culling areas increased, while detrimental effects on adjoining lands disappeared. However, a full assessment of the utility of badger culling requires information on the duration of culling effects. Methodology/Principal Findings: We monitored cattle TB incidence in and around RBCT areas after culling ended. We found that benefits inside culled areas declined over time, and were no longer detectable by three years post-culling. On adjoining lands, a trend suggesting beneficial effects immediately after the end of culling was insignificant, and disappeared after 18 months post-culling. From completion of the first cull to the loss of detectable effects (an average five-year culling period plus 2.5 years post-culling), cattle TB incidence was 28.7% lower (95% confidence interval [CI] 20.7 to 35.8% lower) inside ten 100 km2 culled areas than inside ten matched no-culling areas, and comparable (11.7% higher, 95% CI: 13.0% lower to 43.4% higher, p = 0.39) on lands #2 km outside culled and no-culling areas. The financial costs of culling an idealized 150 km2 area would exceed the savings achieved through reduced cattle TB, by factors of 2 to 3.5. Conclusions/Significance: Our findings show that the reductions in cattle TB incidence achieved by repeated badger culling were not sustained in the long term after culling ended and did not offset the financial costs of culling. These results, combined with evaluation of alternative culling methods, suggest that badger culling is unlikely to contribute effectively to the control of cattle TB in Britain.

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Table of Contents: SCWDS History Continued: The Domestic Animal Connection WNV Still With Us: Other Arboviruses May Follow Avian Influenza Update – Spring 2007 Scholarship in Memory of Ed Couvillion Chronic Lead Poisoning in Raptors Unusual Deer Tumor Kevin Keel Receives Award New Edition of Wild Bird Diseases Book

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Kathy and Susie, members of the faculty, and staff of the School of Natural Resource Sciences, ladies and gentlemen. There are some things in this world that, try as we may, just cannot be adequately accomplished. One of those things, for me at least, is to express adequately what I feel about the passing of Dr. Edward (Ted) Elliot. Ted came to this University of Nebraska a few months before I arrived, and it was my distinct honor to count him among my friends at this great University. Ted was a man of exceptional scientific standing and wisdom, and his loss leaves a void in all of our lives that will not be readily filled.