Heat shock proteins (HSP): dermatological implications and perspectives

In recent years, several studies have demonstrated the protective effect of Heat Shock Proteins (HSP) on different organs and tissues under stressful conditions. However, most research explores the performance of those molecular chaperones during immune responses or pathological conditions like cancer, whereas the number of studies related to the performance of HSPs in the skin during diverse natural or physiopathological conditions is very low. Therefore, the aim of this article was to summarize the main concepts concerning the expression and performance of HSPs, from analysis of current medicine and cosmetics publications, as well as exploring the importance of these proteins in the dermatological area in physiological events such as cutaneous aging, skin cancer and wound healing and to present final considerations related to biotechnology performance in this area.

Dimensioning the fear of dermatologic diseases

The symbolic representation of a disease is related to personal perceptions and cultural background. In the present study, the authors evaluate the population knowledge and fears related to skin and other prevalent or severe diseases. This survey was based on a semi-structured form to investigate demographic aspects, dermatologic consultations, fears and knowledge of 19 dermatoses and 11 prevalent or severe diseases. We interviewed 302 people, of which 54% were women and the mean age was 39 years. Some fears of dermatoses surpass those of severe diseases. Skin cancer and total alopecia disclosed fears similar to that of myocardial infarction. - fundament, fundamentals - objective, objectives - method, methods - result, results - conclusion, conclusions

Você conhece esta síndrome?

A síndrome de Rothmund-Thomson é distúrbio autossômico recessivo de expressividade variável associado a mutações do gene RecQL4. Caracteriza-se por poiquilodermia, alopecia, defeitos de crescimento e desenvolvimento, catarata juvenil, alterações dentárias e esqueléticas e predisposição ao câncer cutâneo e ao osteossarcoma. Relata-se caso de paciente de 29 anos de idade com lesões cutâneas desde a infância, catarata bilateral antes dos 20 anos e carcinoma espinocelular aos 26 anos de idade.

Liquid crystalline formulations containing modified surface TiO2 nanoparticles obtained by sol-gel process

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Câncer de pele: uso de medidas preventivas e perfil demográfico de um grupo de risco na cidade de Botucatu

Buscou-se junto a um grupo de risco para o câncer de pele seu o perfil demográfico e analisou-se o uso de medidas preventivas utilizadas pelos mesmos e pela empresa. Estudo quantitativo com 33 carteiros da Empresa Brasileira de Correios e Telégrafos em Botucatu, Brasil. Dados obtidos por meio de um formulário que investigava perfil demográfico, tempo de trabalho na empresa, horário de exposição ao sol, história de queimaduras solares, história de câncer na família e formas de prevenção do câncer de pele utilizadas. Na análise dos dados, utilizou-se estatística descritiva segundo Teste Exato de Fisher ao nível de 5% de probabilidade. Os resultados mostraram que a faixa etária predominante foi de 26 a 30 e de 31 a 35 anos, correspondendo a 42,42% da amostra, a cor da pele foi à branca com 93,94% e 81,82% trabalham há mais de cinco anos na empresa. O hábito de usar filtro solar foi encontrado em 63,63% dos entrevistados, sendo a não aderência a este justificada em 75% por falta de costume. em relação aos equipamentos protetores do sol a empresa fornece para 100% deles. Os achados permitem a caracterização da população estudada, identificada como de risco para o câncer de pele, propiciando a profilaxia através de ações em saúde, visando à sensibilização dos mesmos para com as medidas preventivas que podem ser adotadas.

Multiple cytogenetic clones in a basal cell carcinoma

Chromosome analysis of short-term culture of a basal cell carcinoma showed five clonal chromosome abnormalities, t(9;14)(q12 or q13;p11), del(1)(q23 or q25), trisomy 5, trisomy 7, and monosomy X. In addition, several nonclonal structural and numerical changes were seen in the tumor cells.

Teledermatologia - Passado, presente e futuro

Teledermatology is the area of Telemedicine that studies the application of telecommunication and information technology to dermatology practice without the presence of a specialist. It is a potential manner to deliver health planning, research, education, clinical meetings, second medical opinions and dermatological care to populations who cannot easily travel. The evolution, cost reduction and dissemination of telecommunication and information technology have enabled the implementation of low cost and comprehensive teledermatology systems to support clinical practice all over the world. © 2005 by Anais Brasileiros de Dermatologia.

Association between solitary keratoacanthoma and cigarette smoking: A case-control study

Solitary keratoacanthoma (KA) is a common benign epithelial tumor of the skin characterized by rapid growth and a tendency toward spontaneous regression. The exact etiology and classification of KA are a matter of debate. Smokers also seem to be more affected than persons who never smoke. The objective of this study was to evaluate the association between solitary KA and smoking habit. A case-control study involving 78 patients diagnosed with KA and 199 controls from the related community was performed to evaluate the association between cigarette smoking and KA. A higher smoking prevalence was noted in cases (69.2 %) than controls (21.6 %) and the odds ratio adjusted for sex and age was 9.1 (95 % CI 4.9 to 17.1, p< 0.01). The mean tumoral diameter at surgery and the site of involvement was not statistically related to smoking. These findings suggest that cigarette smoking is associated with the development of KA. © 2006 Dermatology Online Journal.

Inorganic UV filters

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Influence of natural polymer derived from starch as a sensory modifier in sunscreen formulations

Background: Nowadays, there has been increased incidence of skin cancer, which is mainly related to increased sun exposure. Although sunscreen products may prevent the appearing of this disease, consumers may not use them due to some factors, including the sensory properties. The Aluminum Starch Octenylsuccinate (Dry-Flo® Pure, Akzo Nobel), an aluminum salt produced by the reaction of anhydride octenylsuccinic with starch, is able to improve the spreadability on the skin and reduce the oiliness of the formulation. Objective: To verify volunteers' acceptance for sunscreen formulation with natural polymer, compared with a control formulation (without polymer). Methods: To carry out the sensory analysis a formulation with or without 2. 0% Aluminum Starch Octenylsuccinate was prepared. Formulations had FPS 15, with critical wavelength of 353 nm, determined by testing in silico using the BASF® Sunscreen Simulator. Sensory analysis was performed on 60 students of both sexes, aged between 18 and 25 years, regular users of sunscreen products. Results: The results suggested that the polymer was able to promote a very soft and velvety feel on the skin when used in a sunscreen formulation, and it was able to mitigate and noticeably reduce the oiliness of the skin. Of the 60 volunteers who participated in the study, 45 volunteers (75%) considered that the polymer formulation provides little brightness or did not notice the difference in brightness of the skin after application. Conclusions: It was able to improve the sensory of the product, contributing to greater volunteers' acceptance.

Técnicas de imagem para triagem de melanoma

Pós-graduação em Pesquisa e Desenvolvimento (Biotecnologia Médica) - FMB

Tratamento de queratose actínica disseminada através da terapia fotodinâmica

Pós-graduação em Pesquisa e Desenvolvimento (Biotecnologia Médica) - FMB

Expressão de fator de crescimento semelhante à insulina (IGF-1), alvo da rapamicina em mamíferos (M-TOR), fator de célula tronco (SCF) e receptor C-KIT (CD117) em mastocitomas cutânios caninos em lâminas de arranjo de matriz tecidual (TMA)

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Avaliação da prliferação e apoptose com a utilização de arranjos em matriz de amostra tecidual (Tissue Microarray - TMA) em mastocitomas cutâneos caninos

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Antineoplásico potencial: síntese de derivado de salicilato de octila e5-fluoruracila para tratamento do câncer de pele

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)