Preliminary check list of secondary works in railway history. For distribution to members of the Lexington Group in Railway History.

Mode of access: Internet.

Railway injuries: with special reference to those of the back and nervous system, in their medico-legal and clinical aspects. ...

"Reprinted from Wood's medical and surgical monographs."

Increase of pensions to veterans of the regular establishment for service-connected disabilities : Hearings before the Committee on Invalid Pensions House of Representatives, Seventy-seventh Congress, first session on H.R. 2472 and H.R. 3257 bills providing rates equivalent to 90 per cent and 100 per cent of the compensation payable to war veterans for similar service-connected disabilities, July 15, 1941.

Mode of access: Internet.

The life and struggles of William Lovett, in his pursuit of bread, knowledge, and freedom ; with some short account of the different associations he belonged to, and of the opinions he entertained /

Mode of access: Internet.

Increased benefits for World war veterans and their dependents; miscellaneous legislation relating to administration of the Veterans' Administration : Hearing before a subcommittee of the Committee on Finance, United States Senate, Seventy-seventh Congress, first session, on H.R. 4, an act to provide more adequate compensation for certain dependents of world war veterans, and for other purposes, and H.R. 4845, an act to increase the rate of pension to world war veterans from $30 to $40 per month, to grant such rate at age 65 and for other purposes, November 27, 1941.

Bennett Champ Clark, chairman of subcommittee.

A voyage to Africa: including a narrative of an embassy to one of the interior kingdoms, in the year 1820; with remarks on the course and termination of the Niger, and other principal rivers in that country.

Mode of access: Internet.

Various authorizations to units of the national park system and an addition to the wild and scenic river system : hearing before the Subcommittee on Public Lands, Reserved Water, and Resource Conservation of the Committee on Energy and Natural Resources, United States Senate, Ninety-ninth Congress, second session ....

Shipping list no.: 86-432-P (pt. 2).

Changes to peptide structure, not concentration, contribute to expansion of the lowest avidity cytotoxic T lymphocytes

The efficient in vitro expansion of antigen-specific CD8(+) cytotoxic T lymphocytes (CTL) for use in adoptive immunotherapy represents an important clinical goal. Furthermore, the avidity of expanded CTL populations often correlates closely with clinical outcome. In our study, high-avidity CTL lines could be expanded ex vivo from an antigen-primed animal using low peptide concentration, and intermediate peptide concentrations favored the generation of lower avidity CTL. Further increases in peptide concentration during culture inhibited the expansion of all peptide-specific CD8(+) cells. In contrast, a single amino acid variant peptide efficiently generated functional CTL populations at high or low peptide concentration, which responded to wild-type epitope with the lowest average avidity seen in this study. We propose that for some peptides, the efficient generation of low-avidity CTL responses will be favored by stimulation with altered peptide rather than high concentrations of wild-type epitope. In addition, some variant peptides designed to have improved binding to major histocompatibility complex class I may reduce rather than enhance the functional avidity for the wild-type peptide of ex vivo-expanded CTL. These observations are relevant to in vitro expansion of CTL for immunotherapy and strategies to elicit regulatory or therapeutic immunity to neo-self-antigen when central tolerance has eliminated high-avidity, cognate T cells.

Experiments and observations on the behaviour and brain of the aging female mouse with special reference to dementia of the Alzheimer type

The objective of this research was to investigate the effects of normal aging and the additional effects of chronic exposure to two experimental diets, one enriched in aluminium, the other enriched in lecithin, on aspects of the behaviour and brain histology of the female mouse. The aluminium diet was administered in an attempt to develop a rodent model of Dementia of the Alzheimer Type (DAT). With normal aging, almost all assessed aspects of behaviour were found to be impaired. As regards cognition, selective impairments of single-trial passive avoidance and Morris place learning were observed. While all aspects of open-field behaviour were impaired, the degree of impairment was directly related to the degree of motoric complexity. Deficits were also observed on non-visual sensorimotor coordination tasks and in olfactory discrimination. Histologically, neuron loss, gliosis, vacuolation and congophilic angiopathy were observed in several of the brain regions/fibre tracts believed to contribute to the control of some of the assessed behaviours. The aluminium treatment had very selective effects on both behaviour and brain histology, inducing several features observed in DAT. Behaviourally, the treatment induced impaired spatial reference memory; reduced ambulation; disturbed olfactory function and induced the premature development of the senile pattern of swimming. Histologically, significant neuron loss and gliosis were observed in the hippocampus, entorhinal cortex, amygdala, medial septum, pyriform and pr-frontal cortex. In addition, the brain distribution of congophilic angiopathy was significantly increased by the treatment. The lecithin treatment had effects on both non-cognitive and cognitive aspects of behaviour. The effects of aging on open-field ambulation and rearing were partially ameliorated by the treatment. A similar effect was observed for single-trial passive avoidance performance. Age-dependent improvements in acquisition/retention were observed in 17-23 month mice and Morris place task performance was improved in 11 and 17 month mice. Histologically, a partial sparing of neurons in the cerebellum, hippocampus, entorhinal cortex and subiculum was observed.

A contribution to knowledge of the biodiversity of Syrphidae (Diptera) in Spain

Data are provided on two hoverfly species new to the Iberian Peninsula, Brachyopa grunewaldensis Kassebeer and Criorhina floccosa (Meigen), and one new to Spain, Eumerus consimilis Šimić & Vujić. New habitat and breeding data are presented.