A cyclic peptide mimic of an RNA recognition motif of human La protein is a potent inhibitor of hepatitis C virus

Due to limited available therapeutic options, developing new lead compounds against hepatitis C virus is an urgent need. Human La protein stimulates hepatitis C virus translation through interaction with the hepatitis C viral RNA. A cyclic peptide mimicking the beta-turn of the human La protein that interacts with the viral RNA was synthesized. It inhibits hepatitis C viral RNA translation significantly better than the corresponding linear peptide at longer post-treatment times. The cyclic peptide also inhibited replication as measured by replicon RNA levels using real time RT-PCR. The cyclic peptide emerges as a promising lead compound against hepatitis C.

Lowestoft College - Riding the waves of change: How mobile learning has guided learners through rough seas

Over the past six years Lowestoft College has embraced the revolution in mobile learning by welcoming Web 2.0, social media, cloud computing and Bring Your Own Device (BYOD). This open attitude to new technologies has led to a marked improvement in student achievement rates, has increased staff and student satisfaction and has resulted in a variety of cost savings for senior management during the current economic downturn.

What is the Code of Conduct for Responsible Fisheries?

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