Performance characteristics of automotive engines in the United States. First series--report no. 15. 1975 Dodge Colt 98 CID (1.6 liters), 2V. Interim report.

Transportation Systems Center, Cambridge, Mass.

Wings at war series; an interim report. no. 1-6.

1. The AAF in the invasion of southern France.--2. Sunday punch in Normandy, the tactical use of heavy bombardment in the Normandy invasion.--3. Pacific counterblow, the 11th Bombardment Group and the 67th Fighter Squadron in the battle for Guadalcanal.--4. Airborne assault on Holland.--5. Air-ground teamwork on the western front, the role of the XIX Tactical Air Command during Aug. 1944.--6. The AAF in northwest Africa.

Performance characteristics of automotive engines in the United States. Third series - report no. 7, 1978 Ford, 98 CID (1.6 liters), 2V. Interim report.

National Highway Traffic Safety Administration, Office of Research and Development, Washington, D.C.

Performance characteristics of automotive engines in the United States. Third series - report no. 10, 1978 Honda, 98 CID (1.6 liters). Interim report.

National Highway Traffic Safety Administration, Office of Research and Development, Washington, D.C.

Round-robin pretest analyses of a 1:6-scale reinforced concrete containment model subject to static internal pressurization /

"SAND87-0891, R1 and RD."

Technical manual, operator and organizational manual : grader, road, motorized, DED, type 1, 6 wheel, 4 wheel drive, front wheel steering, 12-foot blade, Caterpillar model 120, FSN 3805-466-0084.

Includes index.

Either interleukin-12 or interferon-gamma can correct the dendritic cell defect induced by transforming growth factor beta(1) in patients with myeloma

The poor response to immunotherapy in patients with multiple myeloma (MM) indicates that a better understanding of any defects in the immune response in these patients is required before effective therapeutic strategies can be developed. Recently we reported that high potency (CMRF44(+)) dendritic cells (DC) in the peripheral blood of patients with MM failed to significantly up-regulate the expression of the B7 co-stimulatory molecules, CD80 and CD86, in response to an appropriate signal from soluble trimeric human CD40 ligand. This defect was caused by transforming growth factor beta(1) (TGFbeta(1)) and interleukin (IL)-10, produced by malignant plasma cells, and the defect was neutralized in vitro with anti-TGFbeta(1). As this defect could impact on immunotherapeutic strategies and may be a major cause of the failure of recent trials, it was important to identify a more clinically useful agent that could correct the defect in vivo. In this study of 59 MM patients, the relative and absolute numbers of blood DC were only significantly decreased in patients with stage III disease and CD80 up-regulation was reduced in both stage I and stage III. It was demonstrated that both IL-12 and interferon-gamma neutralized the failure to stimulate CD80 up-regulation by huCD40LT in vitro. IL-12 did not cause a change in the distribution of DC subsets that were predominantly myeloid (CD11c+ and CDw123-) suggesting that there would be a predominantly T-helper cell type response. The addition of IL-12 or interferon-gamma to future immunotherapy trials involving these patients should be considered.

Carvedilol blocks beta(2)- more than beta(1)-adrenoceptors in human heart

Objective: To understand the basis of the effectiveness of carvedilol in heart failure by determining its specific properties at human heart and beta(2)-adrenoceptors. Methods: The positive inotropic effects of noradrenaline (in the presence of the beta(2)-selective antagonist ICI118551) and adrenaline (in the presence of the beta(1)-selective antagonist CGP20712), mediated through beta(1)- and beta(2)-adrenoceptors, respectively, were investigated in atrial and ventricular trabeculae. The patch-clamp technique was used to investigate effects of noradrenaline and adrenaline on L-type Ca2+ current in human atrial myocytes. Results: Carvedilol was a 13-fold more potent competitive antagonist of the effects of adrenaline at 1 2-adrenoceptors (-logK(B) = 10.13 +/- 0.08) than of noradrenaline at beta(1)-adrenoceptors (-logK(B) = 9.02 +/- 0.07) in human right atrium. Chronic carvedilol treatment of patients with non-terminal heart failure reduced the inotropic sensitivity of atrial trabeculae to noradrenaline and adrenaline 5.6-fold and 91.2-fold, respectively, compared to beta(1)-blocker-treated patients, consistent with persistent preferential blockade of beta(2)-adrenoceptors. In terminal heart failure carvedilol treatment reduced 1.8-fold and 25.1-fold the sensitivity of right ventricular trabeculae to noradrenaline and adrenaline, respectively, but metoprolol treatment did not reduce the sensitivity to the catecholamines. Increases of current (I-Ca,I-L) produced by noradrenaline and adrenaline were not different in atrial myocytes obtained from non-terminal heart failure patients treated with metoprolol or carvedilol, consistent with dissociation of both beta-blockers from the receptors. Conclusions: Carvedilol blocks human cardiac beta(2)-adrenoceptors more than beta(1)-adrenoceptors, thereby conceivably contributing to the beneficial effects in heart failure. The persistent blockade of beta-adrenoceptors is attributed to accumulation of carvedilol in cardiac tissue. (c) 2005 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.

Determination of the anomeric configurations of 2,3,4,6-tetra-O-acetyl-D-mannopyranosyl azide

The structures of 2,3,4,6-tetra-O-acetyl-alpha-D-mannopyranosyl azide and 2,3,4,6-tetra-O-acetyl-beta-D-mannopyranosyl azide were determined using X-ray crystallographic and one-dimensional NOESY techniques.

Isaías 24,1-6 na perspectiva da profecia apocalipsista resultante de um complexo processo sócio-teológico em transição

A dissertação objetiva estudar o papel que o apocalipsismo, desempenhou na história e no contexto da redação do oráculo isaiano em Isaías 24,1-6. A proposta é de que sua função foi de grande importância no processo de formação do judaísmo pós-exílico, fomentando uma nova reidentificação e reetnização dos israelitas-judaítas num contexto de frustração nacionalista e religiosa que gerou uma grande heterogeneidade teológica. Identificamos este contexto como sendo o ambiente em que se deu um complexo processo de transição sócio-teológica na história dos judaitas no período de dominação persa. O apocalipsismo, enquanto fenômeno religioso e sócio-histórico, se mostrou como resultado de uma realidade hostil e desumanizadora na qual a identidade teológico-cultural e os relacionamentos sócioeconômicos das pessoas foram extremamente ameaçados e violentados gerando uma contraposição aos desígnios de Yahweh expressos na aliança firmada por ele para com seu povo. Através da pesquisa e análise exegética de Isaías 24,1-6, a presente dissertação propõe que, a partir dessa realidade conflituosa, a profecia apocalipsista isaiana se manifesta contra as estruturas e suas articulações geradoras de segregação e desumanidade, lançando uma esperança no ato transformador por intermédio de Yahweh, o senhor da história, que possibilita um reverso histórico, a partir do qual será possível reconstruir relacionamentos favoráveis no âmbito social e espiritual.(AU)

Presidents Park, Reservation no. 1 : [Washington D.C.].

Shows buildings plantings, drives, telephone and electric light cables, water pipes, hydrants, etc.

Synthesis and characterization of the [Ru(3)O(CH(3)COO)(6)(py)(2)(BPE)Ru(bpy)(2)Cl](PF(6))(2) dimer

The polymetallic [Ru(3)O(CH(3)COO)(6)(py)(2)(BPE)Ru( bpy)(2)Cl](PF(6))(2) complex (bpy = 2,2`-bipyridine, BPE = trans- 1,2-bis(4-pyridil) ethylene and py = pyridine) was assembled by the combination of an electroactive [Ru(3)O] moiety with a [ Ru( bpy) 2( BPE) Cl] photoactive centre, and its structure was determined using positive ion electrospray (ESI-MS) and tandem mass (ESI-MS/MS) spectrometry. The [Ru(3)O(CH(3)COO)(6)(py)(2)(BPE)Ru(bpy)(2)Cl] (2+) doubly charged ion of m/z 732 was mass-selected and subject to 15 eV collision-induced dissociation, leading to a specific dissociation pattern, diagnostic of the complex structure. The electronic spectra display broad bands at 409, 491 and 692 nm ascribed to the [Ru(bpy)(2)(BPE)] charge-transfer bands and to the [Ru(3)O] internal cluster transitions. The cyclic voltammetry shows five reversible waves at - 1.07 V, 0.13 V, 1.17 V, 2.91 V and - 1.29 V (vs SHE) assigned to the [Ru(3)O](-1/0/+ 1/+ 2/+3) and to the bpy (0/-1) redox processes; also a wave is observed at 0.96 V, assigned to the Ru (+2/+ 3) pair. Despite the conjugated BPE bridge, the electrochemical and spectroelectrochemical results indicate only a weak coupling through the pi-system, and preliminary photophysical essays showed the compound decomposes under visible light irradiation.