Fas ligand and tumour counter-attack in colorectal cancer stratified according to microsatellite instability status

Expression of membrane-bound Fas ligand (FasL) by colorectal cancer cells may allow the development of an immune-privileged site by eliminating incoming tumour-infiltrating lymphocytes (TILs) in a Fas-mediated counter-attack. Sporadic colorectal cancer can be subdivided into three groups based on the level of DNA microsatellite instability (NISI). High-level NISI (NISI-High) is characterized by the presence of TILs and a favourable prognosis, while microsatellite-stable (MSS) cancers are TIL-deficient and low-level MSI (MSI-Low) is associated with an intermediate TIL density. The purpose of this study was to establish the relationship between MSI status and FasL expression in primary colorectal adenocarcinoma. Using immunohistochemistry and a selected series of 101 cancers previously classified as 31 MSI-High, 30 NISI-Low, and 40 MISS, the present study sought to confirm the hypothesis that increased TIL density in MSI-High cancers is associated with low or absent membrane-bound FasL expression, while increased FasL in MSS cancers allows the killing of host TILs. TUNEL/CD3 double staining was also used to determine whether MSS cancers contain higher numbers of apoptotic TILs in vivo than MSI-High or MSI-Low cancers. Contrary to the initial hypothesis, it was found that MSI-High cancers were associated with higher FasL expression (p = 0.04) and a stronger intensity of FasL staining (p = 0.007). In addition, mucinous carcinomas were independently characterized by increased FasL expression (p = 0.03) and staining intensity (p = 0.0005). Higher FasL expression and staining intensity did not correlate with reduced TIL density or increased numbers of apoptotic TILs. However, consistent with the hypothesis that curtailment of the host anti-tumour immune response contributes to the poor prognosis in MSS cancers, it was found that apoptotic TILs were most abundant in MSS carcinomas and metastatic Dukes' stage C or D tumours (p = 0.004; p = 0.046 respectively). This study therefore suggests that MSS colorectal cancers are killing incoming TILs in an effective tumour counter-attack, but apparently not via membrane-bound FasL. Copyright (C) 2003 John Wiley Sons, Ltd.

Sitting time and work patterns as indicators of overweight and obesity in Australian adults

BACKGROUND: Increasing levels of physical inactivity and sedentariness are contributing to the current overweight and obesity epidemic. In this paper, the findings of two recent studies are used to explore the relationships between sitting time ( in transport, work and leisure), physical activity and body mass index (BMI) in two contrasting samples of adult Australians. METHODS: Data on sitting time, physical activity, BMI and a number of demographic characteristics were compared for participants in two studies-529 women who were participants in a preschool health promotion project ('mothers'), and 185 men and women who were involved in a workplace pedometer study ('workers'). Relationships between age, number of children, physical activity, sitting time, BMI, gender and work patterns were explored. Logistic regression was used to predict the likelihood of being overweight or obese, among participants with different physical activity, sitting time and work patterns. RESULTS: The total reported time spent sitting per day ( across all domains) was almost 6 h less among the mothers than the workers (P

Neoinstitutionalism and the appropriation of bourdieu's work: a critical assessment

Despite the still present hegemony of the structural-functionalist orthodoxy, the mid 1980's witnesses the insurgence of new philosophical approaches. This body of work had become a vital intellectual and ideological resource for those who wanted to confront the functionalist dominance in organization studies, such as structuration theory, labour process theory and neoinstitutionalist theory. The purpose of this paper is to review the incorporation of Bourdieu's work into neoinstitutionalism. I argue that this appropriation has resulted in a significant loss of theoretical strength. By giving place to the cognitivist metaphors of mental models, "scripts" and "schemas", instead of adopting the notion of habitus, neoinstitutionalism reinforces some of the ever-present dichotomies in social sciences, especially those of agency/structure and individual/society. While neoinstitutionalism was refining the cognitive approach in the 1990's, Bourdieu was moving towards psychoanalysis. Some indications for future research are provided in the concluding notes.

Interaction between information systems and work in the Brazilian banking sector

This article presents the results of a research to understand the conditions of interaction between work and three specific information systems (ISs) used in the Brazilian banking sector. We sought to understand how systems are redesigned in work practices, and how work is modified by the insertion of new systems. Data gathering included 46 semi-structured interviews, together with an analysis of system-related documents. We tried to identify what is behind the practices that modify the ISs and work. The data analysis revealed an operating structure: a combination of different practices ensuring that the interaction between agents and systems will take place. We discovered a structure of reciprocal conversion caused by the increased technical skills of the agent and the humanization of the systems. It is through ongoing adjustment between work and ISs that technology is tailored to the context and people become more prepared to handle with technology.

Continuing and life-long education for Social Work

Pretende defender que a educação contínua e ao longo da vida para o Serviço Social deve levar em conta os caminhos e as perspectivas que ultrapassam a arena da profissão do assistente social, e essa educação deve dialogar com os avanços nas vidas e nos trabalhos profissionais. Os assistentes sociais podem desta maneira moverem-se entre a prática, a gestão, a política profissional e a educação. Desde a experiência pré-qualificadora até à reforma, a avaliação e a supervisão podem ajudar a desenvolver caminhos profissionais e planos de educação relevantes. O exemplo deste processo de educação contínua multiprofissional em St. Christopher’s Hospice London pode ajudar a compreender como as pessoas podem desenvolver-se como pessoas e nos seus projectos profissionais.

Current issues in Social Work Theory

São aqui analisados os discursos sobre as tendências gerais na teoria de Serviço Social. Estes discursos sobre o papel do Serviço Social são tratados no contexto da sociedade, bem como do cliente -assistente sócial -agência. A teoria da prática representa um discurso entre as perspectivas de Serviço Social nos seus aspectos transformacionais, terapêuticos e de ordem social. São também abordadas as suas várias combinações e interacções em todo o tipo de prática e organização de Serviço Social. O discurso sobre a eficácia baseia¬se em estudos comprovados da construção social, potenciação (empowerment), e realismo crítico ainda polémico. A prática reflectiva e crítica constitui os modelos actuais que interligam a teoria e a prática.

The Challenges of Globalisation and Harmonisation for European Social Work

A globalização tem provocado alterações importantes na educação e na prática de Serviço Social. Estas têm a ver com a privatização, dependência do mercado, e a “nova gestão”. Estes factores determinam a resposta dos assistentes sociais aos clientes e a maneira como são tratados como empregados. Os formadores de Serviço Social devem integrar nos seus currículos os elementos associados com a globalização, os conhecimentos e as competências necessárias para a prática em contextos diversificados, e a potenciação (empowerment) dos clientes. É um desafio que está aberto para os planeadores da formação em Serviço Social. A União Europeia tem todo interesse em avançar com uma globalização inclusiva, solidariedade social e justiça social através de Serviço Social relevante. Existem todavia muitos obstáculos que precisam de ser previstos, contornados e ultrapassados.