Multivalent DNA-binding properties of the HMG-1 proteins.

HMG-I proteins are DNA-binding proteins thought to affect the formation and function of transcription complexes. Each protein contains three DNA-binding motifs, known as AT-hooks, that bind in the minor groove of AT tracts in DNA. Multiple AT-hooks within a polypeptide chain should contact multiple AT tracts, but the rules governing these interactions have not been defined. In this study, we demonstrate that high-affinity binding uses two or three appropriately spaced AT tracts as a single multivalent binding site. These principles have implications for binding to regulatory elements such as the interferon beta enhancer, TATA boxes, and serum response elements.

A selective phenomenology of the seismicity of Southern California.

Predictions of earthquakes that are based on observations of precursory seismicity cannot depend on the average properties of the seismicity, such as the Gutenberg-Richter (G-R) distribution. Instead it must depend on the fluctuations in seismicity. We summarize the observational data of the fluctuations of seismicity in space, in time, and in a coupled space-time regime over the past 60 yr in Southern California, to provide a basis for determining whether these fluctuations are correlated with the times and locations of future strong earthquakes in an appropriate time- and space-scale. The simple extrapolation of the G-R distribution must lead to an overestimate of the risk due to large earthquakes. There may be two classes of earthquakes: the small earthquakes that satisfy the G-R law and the larger and large ones. Most observations of fluctuations of seismicity are of the rate of occurrence of smaller earthquakes. Large earthquakes are observed to be preceded by significant quiescence on the faults on which they occur and by an intensification of activity at distance. It is likely that the fluctuations are due to the nature of fractures on individual faults of the network of faults. There are significant inhomogeneities on these faults, which we assume will have an important influence on the nature of self-organization of seismicity. The principal source of the inhomogeneity on the large scale is the influence of geometry--i.e., of the nonplanarity of faults and the system of faults.

An Architecture by means of Anthropology. Beyond learning the tools of social science

Los arquitectos y urbanistas tienen una larga tradición en el aprendizaje de las herramientas de las ciencias sociales, especialmente las que les permiten analizar y describir mejor los entornos y las personas para las que trabajan. Esto ha llevado a los arquitectos a desarrollar mejores herramientas de observación y descripción del ámbito social y no sólo el material. Sin embargo, la mayoría de las veces este acercamiento interdisciplinar ha identificado las ciencias sociales, especialmente la antropología, con la etnografía. Este artículo parte de la crítica a esta identificación hecha por el antropólogo Tim Ingold y se centra en lo que él propone como el método central de la antropología, la observación participante. Para después revisar varias propuestas actuales de científicos sociales que tratan de desarrollar una disciplina no representacional y orientada al futuro, un objetivo más cercano al de la arquitectura. El artículo intenta imaginar cómo esta práctica transdisciplinar podría desarrollarse.

The Lisbon Treaty and Spain: Background, Context and Impact. Jean Monnet/Robert Schuman Paper Series Special Issue 1, August 2012

The year 2010 will be remembered in the European Union (EU) circles of governmental Spain as a crucial milestone regarding the role of the country in one of the most important alliances of world history. During the first semester, from January to June 2010, Spain had previously been scheduled to hold the rotating presidency as done since the times of the inception of the predecessor of the EU, the European Economic Community (EEC). Furthermore, on June 12, Spain would be ready to celebrate the 25th anniversary of its adhesion (along with Portugal) to the European integration experiment, by signing the treaty, effectively acceding to the European Community (EC) on January 1, 1986. While all of this was set to occur, the new Reform Treaty (“of Lisbon”) was set to be implemented as a substitute for the failed constitutional text floated during the first years of the new century. Moreover, these spectacular events unraveled in the middle of one of the worst economic crises of the world, with considerable impact on the evolution of the EU and, most especially, Spain. This paper will review the background, context and impact of particular novel aspects of the new treaty governing the EU and several milestones regarding the experience of Spain in the European process.

All Roads Lead to Rome: Background, Context and Legacy of the Treaty on the European Community. Jean Monnet/Robert Schuman Paper Series Special Issue 3, August 2012

From the Introduction. The rejection by the French National Assembly of the ill-fated European Defense Community (EDC) Treaty in August 30, 1954, together with the automatic shelving of the equally faulty European Political Community (EPC) proposal, put an end, at least for the time being, to any form of political and military union of the existing Western Europe on a supranational level. The times were difficult in Europe and the international atmosphere was cloudy. The end of the Korean War coincided with the insistence of the Soviets to stick to a policy of détente, leading to the suppression of the Hungarian rebellion. France was facing opposition to her colonial presence in Indochina, as well as in North Africa. But the crisis of Suez prompted the French government to distance itself from the British and the United States. The defeat of the EDC and EPC was not going to be the end of the story and the dream inaugurated by Monnet and Schuman in 1950. It was not long before plans in favor of a European re-launch were taking shape. 1

'The power gained, we will never surrender': Russian ruling elite versus the succession and economic crisis. OSW Point of View (Policy Brief), October 2009

Even though the economic crisis proved harmful to the Russian economy and people's living standards, it has nonetheless failed to make the elite revise its policy. Despite some problems, the government has managed to sustain economic and political stability, thanks to the reserves it amassed in the times of prosperity, and to the propaganda campaign that protected it, above all Vladimir Putin. The crisis failed to force the elite to implement deeper structural and political reforms. Moreover, it has actually reinforced existing tendencies, such as state control over the economy and its oil-oriented character, the elite's economic expansion at the expense of private businesses, and the preservation of political power. Thus, the crisis has so far failed to dismantle Putinism, indeed quite the reverse - it has in fact contributed to its becoming 'set in stone'.

Struggling with an Opportunity: The first 10 years with the EU for Central Europe and the Baltics - A few lessons. CEPS Essay No. 12, 2 May 2014

In 2004, ten new members joined the European Union, radically reshaping its geography and governance characteristics. Earlier expectations predicted a more gradual process of accession – like a more gradual earlier evolution had been expected for the new European currency that had been adopted in 1999 by no less than 11 members. But these were the times of euro-enthusiasm. In their new CEPS Essay, Kálmán Mizsei and Ádám Kullmann offer some interesting and instructive insights from the experience in the newest member states following their accession 10 years ago for improving the effectiveness with which the EU structural and cohesion funds are spent.

Shock tube studies of the effects of sharp-rising, long-duration overpressures on biological systems /

Shock tubes have been used successfully by a number of investigators to study the biological effects of variations in environmental pressures (1,2,3). Recently an unusually versatile laboratory pressurization source became available with the capability of consistently reproducing a wide variety of pressure-time phenomena of durations equal to and well beyond those associated with the detonation of nuclear devices (4). Thus it became possible to supplement costly full-scale field research in blast biology carried out at the Nevada Test Site (5,6) by using an economical yet realistic laboratory tool. In one exploratory study employing pressure pulses of 5 to 10 sec duration wherein the times to max overpressure and the magnitudes of the overpressures were varied, a relatively high tolerance of biological media to pressures well over 150 psi was demonstrated (7). In contrast, the present paper will describe the relatively high biological susceptibility to long duration overpressures in which the pressure rises occurred in single and double fast-rising steps.

[Speeches delivered in the Senate and House of Representatives in 1844.]

[no. 1] Evans, George. The tariff of 1842 vindicated.--[no. 2] Evans, George. Discussion on the tariff.--[no. 3] Stewart, Andrew. Speech ... in defence of the tariff and distribution.--[no. 4] Wethered, John. Speech ... on the tariff.--[no. 5] Dayton, W.L. Speech ... on the tariff.--[no. 6] Stephens, A.H. Speech ... against the tariff bill reported by the committee of ways and means.--[no. 7] Rives, W.C. Speech ... on Mr. McDuffie's proposition to repeal the tariff act of 1842.--[no. 8] The tariff, a tract for the times, by a citizen of Virginia.--[no. 9] Tariff doctrine.--[no. 10] The sub-treasury.--[no. 11] Stuart, A.H.H. Speech ... on the bill to incorporate the subscribers to the fiscal bank of the United States.--[no. 12] Archer, W.S. Speech ... on the treaty for the annexation of Texas.--[no. 13] Jarnagin, Spencer. Speech ... on the treaty for the annexation of Texas.--[no. 14] Benton, T.H. Texas annexation bill.--[no. 15] Whig text book.--[no. 16] Hardin, J.J. Speech ... reviewing the public life & political principles of Mr. Van Buren.--[no. 17] White, John. Speech ... in defence of Mr. Clay upon the charge of "Bargain and sale".--[no. 18] Davis, Garret. Extract from the speech ... exhibiting the expenditures of Mr. Van Buren's administration, the public debt, and the condition of the Treasury at its close.--[no. 19] Barnard, D.D. Letter ... in review of the report of the committee of ways and means on the finances and the public debt.

The finance of the railways in the United Kingdom /

"Reprinted from "The Times.".

The truth about "The Protocols" : a literary forgery.

Comprises 3 articles by the Constantinople correspondent of the Times, Philip P. Graves (half-brother of Robert Graves), Aug. 16-18, and a leading article from the Times of Aug. 18.

Hamilton, the Birmingham of Canada.

Plates printed on both sides.

Year book ... of the Confederate Memorial Literary Society.

Annual reports and membership list included.

Cottoni posthuma: divers choice pieces of that renowned antiquary Sir Robert Cotton, knight and baronet, preserved from the injury of time and exposed to publick light for the benefit of posterity

Reprint of the 1679 ed. of the collection of Cotton's tracts made by James Howell, with reproductions of the general t. p. of the collection and of the special title pages preceding each of the 16 tracts except the first.

The vision splendid,

Half-title: The vision splendid, verse for the times and the times to come.