Prof. Dr. Th. Rosenheim [Illustration] : (Porträt)

Scan von Monochrom-Mikroform

Franz M. Th. Böhl [Rezension]

F.

N. Th. Bunakow über die Juden und den Zionismus

N. Th. Bunakow

TH and XFKBP12 interact and regulate proliferation and differentiation in neural ectoderm through the TOR signaling pathway

During development, embryos must carefully integrate the processes of cell proliferation and differentiation. TH has been identified in Xenopus laevis as a gene product that functions in regulating differentiation of the neural ectoderm through its effect on cell proliferation. However, the mechanism and molecular pathway through which TH functions are not known. We identified the Xenopus FK506 binding protein homolog (XFKBP12) as a protein that interacted with TH in a yeast two-hybrid screen with TH as the bait. The direct and specific interaction between TH and XFKBP12 was supported by several tests including CO-IP, drug competence assay and mutagenesis analysis. To investigate the function of XFKBP12 during embryogenesis, we created an XFKBP12 loss of function embryo using antisense morpholino oligonucleotides (MO). XFKBP12 MO injected embryos displayed similar phenotypes as TH depleted embryos. We also demonstrated that both TH and XFKBP12 functioned through the TOR signaling pathway which is a target for cancer therapies. The interaction between TH and XFKBP 12 was required to regulate the proliferation of neural cells. Therefore, our study indicates that TH represents the endogenous ligand of XFKBP12 and together they coordinate neural cell proliferation and differentiation through the conserved rapamycin sensitive TOR pathway. Thus, understanding how this pathway functions in development will not only provide us important insights into the relationship between proliferation and differentiation, but help design rational cancer therapies targeting this pathway. ^

Schreiben an Master Th... in Triest über Kohelet

Heinrich Graetz

Schreiben an Master Th... in Triest über Kohelet

Heinrich Graetz

Ein Brief Th. Herzls an Martin Buber

Theodor Herzl

Ms.Ff.F.Stoltze 3. 76 - Brief von Georg Heinrich Otto Volger, Eduard Heyden und Th. Schider von Freies Deutsches Hochstift an Friedrich Stoltze

Frankfurter Latern: Freiexemplare, Übersendung einer Mitgliedsmarke

Angraecum sesquipedale Pet. Th. : nebst Angabe seiner Kultur

vom Obergärtner Kraus

Na 1 Nachlass Max Horkheimer, 500 - Korrespondenzen mit Theodor W. Adorno (p. VI 1, 1 - 121)

Briefwechsel zwischen Max Horkheimer und Theodor W. Adorno und Gretel Adorno, 1927 - 1938; 1 Brief (Kopie) von Henri Bergson an Theodor W. Adorno, 1935;

Na 1 Nachlass Max Horkheimer, 501 - Korrespondenzen von Theodor W. Adorno (p. VI 1, 122 - 268)

Briefwechsel zwischen Max Horkheimer und Theodor W. Adorno und Gretel Adorno, 1927 - 1938; 1 Brief vom United States of America General Consulat in London an Theodor W. Adorno, 1937; 1 Brief von Theodor W. Adorno an Frau Sing, 1937; 1 Brief von Theodor W. Adorno an ... Kluthe, 1937; 1 Brief von Theodor W. Adorno an ... Wolfenstein, 1937; 2 Briefe von Theodor W. Adorno und Max Horkheimer an Ernst Krenek, 1937; 1 Brief von Ernst Krenek an Max Horkheimer, 1937; 1 Brief von Paul Oppenheim an Max Horkheimer, 1937; 2 Briefe von Oscar und Maria Wiesengrund an Max Horkheimer, 1937; 1 Brief von Theodor W. Adorno an Siegfried Kracauer, 1937;

Na 1 Nachlass Max Horkheimer, 502 - Korrespondenzen mit Theodor W. Adorno (p. VI 1, 269 - 366; VI 1 A, 1 - 55)

Briefwechsel zwischen Max Horkheimer und Theodor W. Adorno, 1927 - 1938; 1 Brief von Theodor W. Adorno an Hans F. Redlich, 1938; 1 Brief von Max Horkheimer an United States of America General Consul in Stuttgart, 1938; 1 Brief von Rudolph Kolisch an Theodor W. Adorno, 1938; 1 Brief von Paul F. Lazarsfeld an Theodor W. Adorno, 1938; 2 Briefe von Theodor W. Adorno an Paul F. Lazarsfeld, 1938; 1 Brief von Hanna Maaß an Gretel Adorno, 1937; Briefwechsel und Beilagen zwischen Max Horkheimer, Theodor W. Adorno und Gretel Adorno, 1939 - 1940; 1 Brief (Entwurf) von Theodor W. Adorno an Robert M. Hutchins, 1940; 4 Briefe von Friedrich Pollock an Theodor W. Adorno, 1940; 2 Briefe von Margot von Mendelssohn an Theodor W. Adorno, 1940; 2 Briefe von Theodor W. Adorno an Margot von Mendelssohn, 1940; 1 Brief von Franz L. Neumann an Theodor W. Adorno, 1940; 1 Brief (Entwurf von T.W. Adorno) von Max Horkheimer an Mrs. Charles E. Mitchell, 1940; 1 Brief und Beilage von Gretel Adorno an Frederick Wild, 1939; 1 Brief von French und Co. Eifert an Gretel Adorno, 1939; 2 Briefe von Theodor W. Adorno an Herbert W. Schneider, 1939; 1 Brief von Theodor W. Adorno an Jean Wahl, 1939; 1 Brief von Max Horkheimer an Roger M. Howson von der Columbia University Library in New York, 1939;

Na 1 Nachlass Max Horkheimer, 503 - Korrespondenzen mit Theodor W. Adorno (p. VI 1B, 1-132)

Briefwechsel und Beilagen zwischen Theodor W. Adorno und Gretel Adorno, 1941; 2 Briefe von Frederick Wild an Gretel Adorno, 1941; 1 Brief von Gretel Adorno an Frederick Wild, 1941; 1 Brief von Theodor W. Adorno an Paul Hagen von American Friends of German Freedom in New York, 1941; Briefwechsel zwischen Theodor W. Adorno und Margot von Mendelssohn, 1941; 1 Brief (Entwurf?) von Theodor W. Adorno an Franz L. Neumann, 1941; 1 Brief von Eva Hempel an Margo von Mendelssohn, 1941; 1 Brief von Theodor W. Adorno an ... David, 1941;

Na 1 Nachlass Max Horkheimer, 504 - Korrespondenzen mit Theodor W. Adorno (p. VI 1B, 133 - 295)

Briefwechsel und Beilagen zwischen Max Horkheimer, Theodor W. Adorno und Gretel Adorno, 1942 - 1944; 1 Brief von Friedrich Pollock an Theodor W. Adorno, 1942; 1 Brief von Theodor W. Adorno an Friedrich Pollock, 1944; 1 Brief von Else Frenkel-Brunswick an Theodor W. Adorno, 1944; 1 Brief von Max Horkheimer an das American Jewish Commitee, 1944; Briefwechsel und Beilagen zwischen Gretel Adorno, Theodor W. Adorno und Frederick Wild, 1942 - 1944; 1 Brief von Gretel Adorno an Leo Löwenthal, 1944; 1 Brief von Monroe E. Deutsch an Theodor W. Adorno, 1944; Briefwechsel zwischen Theodor W. Adorno und Margot von Mendelssohn, 1942 - 1943; 1 Brief von der Bank of America in Los Angeles an Frederick Wild, 1942;