Organizational and direct support, repair parts, and special tools list for drill, pneumatic, drifter, crawler mounted, self propelled, dry type, 220 lb class, minimum 4-1/2 inch bore, power feed, 1-1/2 inch lugged shank chuck w/ 12 each [sic] shank rock drill (Chicago Pneumatic Tool Company model G-900) (NSN 3820-00-930-1917).

"May 1976."

Hand receipt covering contents of components of end items (COEI), basic issue items (BII), and additional authorization list (AAL) for truck, cargo, 1 1/4 ton, 4 x 4, M880 (2320-00-579-8942)...; truck, cargo, 1 1/4 ton, 4 x 2, M890 (2320-00-579-8991)...; truck, ambulance, 1 1/4 ton, 4 x 2, M886 (2310-00-579-9078); truck, ambulance, 1 1/4 ton, 4 x 4, M893 (2310-00-125-5679); truck, telephone maintenance, tactical, 1 1/4 ton, 4 x 4, M888 (2320-01-044-0333).

"May 1983."

King Horn, with fragments of Floriz and Blauncheflur, and of the Assumption of Our Lady, from a ms. (G G.4.27.2.) in the Cambridge University Library. Also, from mss. in the British Museum, the Assumption of Our Lady (add. mss. 10036), and fragments of the Floyres and Blancheflur (Cotton Vitellius D. III)

This number was re-edited from the manuscript in 1901 by George H. McKnight.

Ueber das 1-phenyl-2,3,4-trimethyl-2,5-thiopyrazol, oder methyl...

Thesis (doctoral)--

Zur kenntnis des 2.4.2'.4'.6'.-penta- und 2.4.6.2'.4'.6'.-hex.

Thesis (doctoral)--

Guidelines for projects with industry to provide training and employment to handicapped individuals under section 4(a)(2)(B) of the Vocational Rehabilitation Act.

Cover title.

Synthesis and evaluation of N1-substituted-3-propyl-1,4-benzodiazepine-2-ones as cholecystokinin (CCK2) receptor ligands

A novel synthetic approach towards N1-alkylated 3-propyl-1,4-benzodiazepines was developed in five synthetic steps from 2-amino-4-chlorobenzophenone, in which the N-oxide 4 served as a key intermediate. The structure-activity relationship optimization of this 3-prophyl-1,4-benzodiazepine template was carried out on the N1-position by selective alkylation reactions and resulted in a ligand with an improved affinity on the cholecystokinin (CCK2) receptor. The N-allyl-3-propyl-benzodiazepine 6d displayed an affinity towards the CCK2 (CCK-B) receptor of 170 nM in a radiolabelled receptor-binding assay. The anxiolytic activity of this allyl-3-propyl-1,4-benzodiazepine 6d was subsequently determined in in-vivo psychotropic assays. This novel ligand had ED50 values of 4.7 and 5.2 mg kg-1 in the black and white box test and the x-maze, respectively, and no significant sedation/muscle relaxation was observed.

Cytotoxicity of 3,4-dihalogenated 2(5H)-furanones

Mucohalogen acids have been used for the preparation of a variety of 3,4-clihalogenated 2(5H)-furanones. In one synthetic step the carbarnates 2a-c and the pseudoanhydrides 4a-e were prepared using isocyanates and acid anhydrides. A series of 5-alkoxylated 3,4-dichloro-2(5H)-furanones 5a-o have been synthesized with a wide range of lipophilicity, using the hydroxy-form of mucohalogen acids 1a and 1b. The 5-allyl-3,4-dichloro-2(5H)-furanone 5f was derived into the dihydro-isoxazol 6 and the oxirane 7. The methyl ester 5a was converted with ammonia into the tetramic acid chloride 11. The pseudo acid chloride 3 was reacted further into the bis aziricline 8. Reduction of the mucochloric acid 1a furnished the trichlorofuranone 3. The cytotoxicity of these simple and bis-cyclic butenolides have been evaluated in tissue culture on MAC13 and MAC16 cancer cell lines using the MTT cytotoxicity assay. The ester 5g, the acetate 4b and the carbamate 2b displayed a cytotoxicity in the low micromolar range. Further, an IC50 (50% inhibitory concentration) of 50 nM and 30 nm was determined forthe epoxide 7 and the aziridine 18. © 2004 The Authors Recieved.

The lipid peroxidation product 4-hydroxy-2-nonenal:advances in chemistry and analysis

4-Hydroxy-2-nonenal (HNE) is one of the most studied products of phospholipid peroxidation, owing to its reactivity and cytotoxicity. It can be formed by several radical-dependent oxidative routes involving the formation of hydroperoxides, alkoxyl radicals, epoxides, and fatty acyl cross-linking reactions. Cleavage of the oxidized fatty acyl chain results in formation of HNE from the methyl end, and 9-oxo-nonanoic acid from the carboxylate or esterified end of the chain, although many other products are also possible. HNE can be metabolized in tissues by a variety of pathways, leading to detoxification and excretion. HNE-adducts to proteins have been detected in inflammatory situations such as atherosclerotic lesions using polyclonal and monoclonal antibodies, which have also been applied in ELISAs and western blotting. However, in order to identify the proteins modified and the exact sites and nature of the modifications, mass spectrometry approaches are required. Combinations of enrichment strategies with targetted mass spectrometry routines such as neutral loss scanning are now facilitating detection of HNE-modified proteins in complex biological samples. This is important for characterizing the interactions of HNE with redox sensitive cell signalling proteins and understanding how it may modulate their activities either physiologically or in disease. © 2013 The Author.