Manobrar a vertigem posicional paroxística benigna do canal semicircular posterior

Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2014

LTPP seasonal monitoring program : instrumentation installation and data collection guidelines /

"April 1994."

Drilled shafts for bridge foundations /

"August 1993."

CCR5-Delta 32 mutation is strongly associated with primary sclerosing cholangitis

CCR5 plays a key role in the distribution of CD45RO+ T cells and contributes to generation of a T helper 1 immune response. CCR5-Delta32 is a 32-bp deletion associated with significant reduction in cell surface expression of the receptor. We investigated the role of CCR5-Delta32 on susceptibility to ulcerative colitis (UC), Crohn's disease ( CD) and primary sclerosing cholangitis (PSC). Genotype and allelic association analyses were performed in 162 patients with UC, 131 with CD, 71 with PSC and 419 matched controls. There was a significant difference in CCR5 genotype (OR 2.27, P = 0.003) between patients with sclerosing cholangitis and controls. Similarly, CCR5-Delta32 allele frequency was significantly higher in sclerosing cholangitis (17.6%) compared to controls (9.9%, OR 2.47, P = 0.007) and inflammatory bowel disease patients without sclerosing cholangitis ( 11.3%, OR 1.9, P = 0.027). There were no significant differences in CCR5 genotype or allele frequency between those with either UC or CD and controls. Genotypes with the CCR5-Delta32 variant were increased in patients with severe liver disease defined by portal hypertension and/or transplantation (45%) compared to those with mild liver disease (21%, OR 3.17, P = 0.03). The CCR5-Delta32 mutation may influence disease susceptibility and severity in patients with PSC.

A SUBSTITUIÇÃO DO TRABALHO VIVO PELO TRABALHO MORTO: UM ESTUDO NOS INTEGRANTES NA REDE DE SERVIÇOS CREDENCIADA DE UMA EMPRESA DO SETOR ELETROELETRÔNICO

O presente estudo confirmou a existência da substituição do trabalho vivo pelo trabalho morto, descrita por Karl Marx e outros importantes estudiosos, pela EC ABC, empresa do setor eletroeletrônico brasileiro (segmento das empresas industriais estabelecidas no Brasil, responsáveis pela produção de equipamentos que atendem a linha marrom que congrega produtos como, Televisores, Monitores de Vídeo, Áudio, reprodutores e/ou gravadores de Disco de Vídeo Versátil - DVD e Disco Compacto - CD), inicialmente no seu Departamento de Serviços Nacional e em seguida, nos Postos de Serviços Credenciados da sua Rede de Serviços Nacional, em função da informatização e mudança do modelo de gestão do conhecimento o que ocasionou a descapitalização intelectual nos Postos de Serviços Credenciados e a perda de qualidade nos serviços oferecidos pelos PSC aos clientes e revendedores. Adotou-se a forma de pesquisa exploratória deste fenômeno, atualmente ainda pouco examinado, em 120 PSC no Brasil.(AU)

Organizations driving positive social change:a review and an integrative framework of change processes

Academic and practitioner interest in how market-based organizations can drive positive social change (PSC) is steadily growing. This paper helps to recast how organizations relate to society. It integrates research on projects stimulating PSC – the transformational processes to advance societal well-being – which is fragmented across different streams of research in management and related disciplines. Focusing on the mechanisms at play in how organizations and their projects affect change in targets outside of organizational boundaries, we 1) clarify the nature of PSC as a process, 2) develop an integrative framework that specifies two distinct PSC strategies, 3) take stock of and offer a categorization scheme for change mechanisms and enabling organizational practices, and 4) outline opportunities for future research. Our conceptual framework differentiates between surface- and deep-level PSC strategies understood as distinct combinations of change mechanisms and enabling organizational practices. These strategies differ in the nature and speed of transformation experienced by the targets of change projects and the resulting quality (pervasiveness and durability), timing, and reach of social impact. Our findings provide a solid base for integrating and advancing knowledge across the largely disparate streams of management research on Corporate Social Responsibility, Social Entrepreneurship, and Base of the Pyramid, and open up important new avenues for future research on organizing for PSC and on unpacking PSC processes.

Specific Increase in MDR1 Mediated Drug-Efflux in Human Brain Endothelial Cells following Co-Exposure to HIV-1 and Saquinavir

Persistence of HIV-1 reservoirs within the Central Nervous System (CNS) remains a significant challenge to the efficacy of potent anti-HIV-1 drugs. The primary human Brain Microvascular Endothelial Cells (HBMVEC) constitutes the Blood Brain Barrier (BBB) which interferes with anti-HIV drug delivery into the CNS. The ATP binding cassette (ABC) transporters expressed on HBMVEC can efflux HIV-1 protease inhibitors (HPI), enabling the persistence of HIV-1 in CNS. Constitutive low level expression of several ABC-transporters, such as MDR1 (a.k.a. P-gp) and MRPs are documented in HBMVEC. Although it is recognized that inflammatory cytokines and exposure to xenobiotic drug substrates (e.g HPI) can augment the expression of these transporters, it is not known whether concomitant exposure to virus and anti-retroviral drugs can increase drug-efflux functions in HBMVEC. Our in vitro studies showed that exposure of HBMVEC to HIV-1 significantly up-regulates both MDR1 gene expression and protein levels; however, no significant increases in either MRP-1 or MRP-2 were observed. Furthermore, calcein-AM dye-efflux assays using HBMVEC showed that, compared to virus exposure alone, the MDR1 mediated drug-efflux function was significantly induced following concomitant exposure to both HIV-1 and saquinavir (SQV). This increase in MDR1 mediated drug-efflux was further substantiated via increased intracellular retention of radiolabeled [3H-] SQV. The crucial role of MDR1 in 3H-SQV efflux from HBMVEC was further confirmed by using both a MDR1 specific blocker (PSC-833) and MDR1 specific siRNAs. Therefore, MDR1 specific drug-efflux function increases in HBMVEC following co-exposure to HIV-1 and SQV which can reduce the penetration of HPIs into the infected brain reservoirs of HIV-1. A targeted suppression of MDR1 in the BBB may thus provide a novel strategy to suppress residual viral replication in the CNS, by augmenting the therapeutic efficacy of HAART drugs.

“Escritores da liberdade”: histórias reais de jovens que cumpriram medidas socioeducativas em meio aberto no município do Natal/RN

Such work aims to analyze aspects of the lives of adolescents, authors of Infraction, after completion of the Socio-Educational Measures in Half Open (Probation - LA and Services to the Community - PSC) in the city of Natal / RN in 2010. Thus, it become necessary to point out and consider the socio-historical determinations that permeate the lives of these young men, estimating the economic, social, political and historical aspects. We understand that these individuals experience numerous expressions of Social Issues, such as lack of opportunities, violence, unemployment, among others. In the reduction context of the State actions for the social, and investments negligible in public policies. Thus, the research aimed to identify such determinations in the lives of adolescents, young people today, and aimed to know these adolescents and analyze the family situation, socio-economic and political these, after completion of educational measures; and to evaluate the inclusion in school life and in the labor market. Therefore, we used as a methodological way the qualiquantitative research, using the procedure of 4 (four) semi-structured interviews, 9 (nine) analysis processes by configuring so documentary research, through the analysis of reports, processes and monitoring documents. The universe of analysis went adolescents who fulfilled socio-educational measures in liberty in the city of Natal / RN. The sample consisted of nine (9) young, that we follow during the mandatory curricular training, in the period of graduation in Social Work at the Federal University of Rio Grande do Norte, in 2010. The time frame of the research took place between 2010 - 2014. The results of this study indicate that the solution to problems of violence is not the reduction of criminal majority. It is necessary to take actions in ensuring rights and allow other living conditions to the children and adolescents, because, in fact, in the society there is a tendency to regression of rights. We learn that, despite all the difficulties, as: low education, access to the labor market, low income, among others, young people interviewed understand the Socio-Educational Measures such as a watershed in their lives, because, they do not practice more illicit acts, they seek a better life, they have dreams and plans for the future, and they continue writing their histories.

“Escritores da liberdade”: histórias reais de jovens que cumpriram medidas socioeducativas em meio aberto no município do Natal/RN

Such work aims to analyze aspects of the lives of adolescents, authors of Infraction, after completion of the Socio-Educational Measures in Half Open (Probation - LA and Services to the Community - PSC) in the city of Natal / RN in 2010. Thus, it become necessary to point out and consider the socio-historical determinations that permeate the lives of these young men, estimating the economic, social, political and historical aspects. We understand that these individuals experience numerous expressions of Social Issues, such as lack of opportunities, violence, unemployment, among others. In the reduction context of the State actions for the social, and investments negligible in public policies. Thus, the research aimed to identify such determinations in the lives of adolescents, young people today, and aimed to know these adolescents and analyze the family situation, socio-economic and political these, after completion of educational measures; and to evaluate the inclusion in school life and in the labor market. Therefore, we used as a methodological way the qualiquantitative research, using the procedure of 4 (four) semi-structured interviews, 9 (nine) analysis processes by configuring so documentary research, through the analysis of reports, processes and monitoring documents. The universe of analysis went adolescents who fulfilled socio-educational measures in liberty in the city of Natal / RN. The sample consisted of nine (9) young, that we follow during the mandatory curricular training, in the period of graduation in Social Work at the Federal University of Rio Grande do Norte, in 2010. The time frame of the research took place between 2010 - 2014. The results of this study indicate that the solution to problems of violence is not the reduction of criminal majority. It is necessary to take actions in ensuring rights and allow other living conditions to the children and adolescents, because, in fact, in the society there is a tendency to regression of rights. We learn that, despite all the difficulties, as: low education, access to the labor market, low income, among others, young people interviewed understand the Socio-Educational Measures such as a watershed in their lives, because, they do not practice more illicit acts, they seek a better life, they have dreams and plans for the future, and they continue writing their histories.

Analisi di aspetti di Security da attacchi informatici su Impianti di Processo

Gli impianti industriali moderni sono di tipo automatizzato, i processi sono cioè pilotati da un’unità di calcolo che fornisce i comandi necessari atti al corretto funzionamento dell’impianto. Queste tecnologie espongono le apparecchiature a problemi di Security, dunque attacchi volontari provenienti dall’esterno, al sistema di controllo. Esso può diventare la variabile manipolabile del terrorista informatico il quale può causare lo shut down del segnale o cambiare l’impostazione dei parametri di processo.Lo studio esposto si propone di identificare le possibili modalità di attacco e di individuare uno strumento sistematico che permetta di valutarne la vulnerabilità ad un possibile atto di sabotaggio. La procedura proposta è la PSC-SHaRP (Process System Cyber-Security Hazard Review Procedure) essa consta di due strutture chiamate rispettivamente Alpha e Beta. La metodologia è volta a individuare i potenziali pericoli posti dagli attacchi informatici piuttosto che a stimarne un profilo di rischio e/o probabilità di successo. La ShaRP Alpha, viene utilizzata per analizzare le conseguenze di deviazioni cyber su singole macchine presenti in impianto o sistemi modulari. La ShaRP Beta viene utilizzata per analizzare le conseguenze di attacchi cyber sul sistema costituito dall’impianto di processo. Essa è quindi in grado di analizzare le ripercussioni che manipolazioni su una o più apparecchiature possono avere sull’impianto nel suo complesso. Nell’ultima parte dell’elaborato sono state trattate le possibilità di accesso da parte del ‘’terrorista’’ al sistema di controllo e sicurezza, dunque i sistemi di gestione del DCS e del SIS e le barriere software e hardware che possono essere presenti.

Trabajo de campo en geografía : Experiencia en región con conflictos socioambientales

El artículo rescata la importancia del trabajo de campo geográfico en una región con conflictos socioambientales, como el del el agua en las Sierras Chicas de Córdoba. Se hace eje en una experiencia pedagógica, la Práctica Sociocomunitaria (PSC), llevada a cabo por profesores, alumnos y ayudantes de la materia Geografía Rural, de la carrera de Licenciatura en Geografía de la Facultad de Filosofía y Humanidades (FFyH), en la localidad de La Granja, departamento Colón, de la provincia de Córdoba. La PSC es una experiencia que acerca a los alumnos al campo social de los conflictos territoriales. Se trata de una modalidad que va más allá de un proyecto de extensión, ya que involucra a todos los alumnos del grado que cursan la materia. Y es también una manera de aunar, en nuestro caso desde el quehacer geográfico, las funciones de docencia, investigación y extensión propias de los universitarios. Se pretende, a través de la PSC, acercar a los alumnos de Geografía Rural al trabajo de campo, con organizaciones sociales de base local motorizadas que conocen los problemas de su localidad en profundidad y que trabajan junto con nuestro equipo de investigación. A la vez, el contacto, las reflexiones grupales e individuales, los debates con los estudiantes universitarios, aportarán al colectivo social, una ampliación de la esfera de conocimientos de la realidad sobre la que viven y luchan. El artículo comienza definiendo qué se entiende por PSC. Luego, atendiendo específicamente a nuestra práctica, desarrollamos lo que para nosotros son las dos lógicas que sustentan el trabajo en terreno. Una, referida a la construcción del conocimiento, a los modos diversos de aprender y de saber. Otra, vinculada a la comprensión del conflicto socioterritorial, en relación con el escenario donde se realiza la práctica: la Mesa del Agua y Ambiente de La Granja. Incluimos un apartado sobre la descripción de la experiencia y los resultados, para finalizar con algunas reflexiones pensadas en función de la continuidad de la práctica.

Trabajo de campo en geografía : Experiencia en región con conflictos socioambientales

El artículo rescata la importancia del trabajo de campo geográfico en una región con conflictos socioambientales, como el del el agua en las Sierras Chicas de Córdoba. Se hace eje en una experiencia pedagógica, la Práctica Sociocomunitaria (PSC), llevada a cabo por profesores, alumnos y ayudantes de la materia Geografía Rural, de la carrera de Licenciatura en Geografía de la Facultad de Filosofía y Humanidades (FFyH), en la localidad de La Granja, departamento Colón, de la provincia de Córdoba. La PSC es una experiencia que acerca a los alumnos al campo social de los conflictos territoriales. Se trata de una modalidad que va más allá de un proyecto de extensión, ya que involucra a todos los alumnos del grado que cursan la materia. Y es también una manera de aunar, en nuestro caso desde el quehacer geográfico, las funciones de docencia, investigación y extensión propias de los universitarios. Se pretende, a través de la PSC, acercar a los alumnos de Geografía Rural al trabajo de campo, con organizaciones sociales de base local motorizadas que conocen los problemas de su localidad en profundidad y que trabajan junto con nuestro equipo de investigación. A la vez, el contacto, las reflexiones grupales e individuales, los debates con los estudiantes universitarios, aportarán al colectivo social, una ampliación de la esfera de conocimientos de la realidad sobre la que viven y luchan. El artículo comienza definiendo qué se entiende por PSC. Luego, atendiendo específicamente a nuestra práctica, desarrollamos lo que para nosotros son las dos lógicas que sustentan el trabajo en terreno. Una, referida a la construcción del conocimiento, a los modos diversos de aprender y de saber. Otra, vinculada a la comprensión del conflicto socioterritorial, en relación con el escenario donde se realiza la práctica: la Mesa del Agua y Ambiente de La Granja. Incluimos un apartado sobre la descripción de la experiencia y los resultados, para finalizar con algunas reflexiones pensadas en función de la continuidad de la práctica.

Relanzando la Respuesta Rápida Militar: Los Battlegroups

La utilidad de los Battlegroups, casi una década después de declarar capacidad operativa plena, ha estado y continuará estando en duda debido a la inacción europea. Para que la UE se convierta en el actor internacional que durante tantos años ha proclamado, necesitará consolidar su capacidad de respuesta rápida militar para hacer frente a crisis multidimensionales y llevar a cabo todo el espectro de Misiones Petersberg. El artículo hace un repaso a la concepción y el desarrollo de los Battlegroups y propone un conjunto de reformas para que puedan llegar a ser un instrumento efectivo de respuesta rápida militar.

Distributional effects and individual differences in L2 morphology learning

Second language (L2) learning outcomes may depend on the structure of the input and learners’ cognitive abilities. This study tested whether less predictable input might facilitate learning and generalization of L2 morphology while evaluating contributions of statistical learning ability, nonverbal intelligence, phonological short-term memory, and verbal working memory. Over three sessions, 54 adults were exposed to a Russian case-marking paradigm with a balanced or skewed item distribution in the input. Whereas statistical learning ability and nonverbal intelligence predicted learning of trained items, only nonverbal intelligence also predicted generalization of case-marking inflections to new vocabulary. Neither measure of temporary storage capacity predicted learning. Balanced, less predictable input was associated with higher accuracy in generalization but only in the initial test session. These results suggest that individual differences in pattern extraction play a more sustained role in L2 acquisition than instructional manipulations that vary the predictability of lexical items in the input.

Caminos en la formación en Psicología Social Comunitaria: Procesos y rupturas

Durante el año 2013 se implementó el proyecto de prácticas innovadoras en enseñanza financiado por la Comisión Sectorial de Enseñanza de la Universidad de la República (UdelaR) de Uruguay, denominado “Dispositivo de reflexión colectiva para la formación en intervención comunitaria en la Facultad de Psicología” en el marco del Programa Psicología Social Comunitaria (PPSC) de la Facultad de Psicología. El objetivo principal del proyecto implicó la creación e implementación de un dispositivo didáctico-pedagógico que permitiera visibilizar y analizar las particularidades del enseñar aprendiendo en un espacio de reflexión colectiva sobre la práctica, integrado por docentes y estudiantes. Enseñar aprendiendo con la comunidad implica un posicionamiento ético, estético, político y epistemológico que interpela el modelo universitario hegemónico y remite al diálogo de saberes como herramienta democratizadora. De la evaluación realizada respecto a los resultados obtenidos podemos decir que la innovación educativa introducida a través de este proyecto generó cambios significativos y satisfactorios. A punto de partida de la mencionada experiencia, en la presente revisión teórica y metodológica nos proponemos analizar algunas dimensiones del proceso desde la especificidad de la formación en Psicología Social Comunitaria (PSC). Haremos foco en las condiciones pedagógicas que hacen posible el despliegue de capacidades reflexivas de todos los actores involucrados y en los efectos transformadores que nuestras prácticas docentes producen, asumiendo que se trata de un movimiento con rupturas y tensiones constantes.