A randomized clinical trial of hydroxymethylglutaryl-Coenzyme A reductase inhibition for Acute Lung Injury (The HARP study)

Rationale: There is no effective pharmacological treatment for acute lung injury (ALI). Statins are a potential new therapy because they modify many of the underlying processes important in ALI.

Objectives: To test whether simvastatin improves physiological and biological outcomes in ALI.

Methods: We conducted a randomized, double-blinded, placebo-controlled trial in patients with ALI. Patients received 80 mg simvastatin or placebo until cessation of mechanical ventilation or up to 14 days. Extravascular lung water was measured using thermodilution. Measures of pulmonary and nonpulmonary organ function were assessed daily. Pulmonary and systemic inflammation was assessed by bronchoalveolar lavage fluid and plasma cytokines. Systemic inflammation was also measured by plasma C-reactive protein.

Measurements and Main Results: Sixty patients were recruited. Baseline characteristics, including demographics and severity of illness scores, were similar in both groups. At Day 7, there was no difference in extravascular lung water. By Day 14, the simvastatin-treated group had improvements in nonpulmonary organ dysfunction. Oxygenation and respiratory mechanics improved, although these parameters failed to reach statistical significance. Intensive care unit mortality was 30% in both groups. Simvastatin was well tolerated, with no increase in adverse events. Simvastatin decreased bronchoalveolar lavage IL-8 by 2.5-fold (P = 0.04). Plasma C-reactive protein decreased in both groups but failed to achieve significance in the placebo-treated group.

Conclusions: Treatment with simvastatin appears to be safe and may be associated with an improvement in organ dysfunction in ALI. These clinical effects may be mediated by a reduction in pulmonary and systemic inflammation.

Trois soupirs pour ensemble sonate pour piano et un souvenir du présent pour orchestre À la recherche d'un langage personnel

La version intégrale de ce mémoire est disponible uniquement pour consultation individuelle à la Bibliothèque de musique de l'Université de Montréal (www.bib.umontreal.ca/MU).

La voix et le bruit, processus et parcours de création de mes œuvres.

La version intégrale de ce mémoire [ou de cette thèse] est disponible uniquement pour consultation individuelle à la Bibliothèque de musique de l’Université de Montréal (www.bib.umontreal.ca/MU)

Fiorello's Flute (17 October 1974)

Volume 2, Number 7 Fiorello's Flute is the official student newspaper of LaGuardia Community College. It is published by an independent student staff and financed by student activity funds. Opinions expressed in the paper are not necessarily those of the College administration, faculty, or the student body. Editorial opinion expressed herein is determined by a majority vote of the Flute staff.

Fiorello's Flute (February 1974)

Fiorello's Flute is the official student newspaper of LaGuardia Community College. It is published by an independent student staff and financed by student activity funds. Opinions expressed in the paper are not necessarily those of the College administration, faculty, or the student body. Editorial opinion expressed herein is determined by a majority vote of the Flute staff.

Fiorello's Flute (31 October 1974)

Volume 2, Number 8 Fiorello's Flute is the official student newspaper of LaGuardia Community College. It is published by an independent student staff and financed by student activity funds. Opinions expressed in the paper are not necessarily those of the College administration, faculty, or the student body. Editorial opinion expressed herein is determined by a majority vote of the Flute staff.

Efeito da chuva na eficiência de herbicidas aplicados em pós-emergência sobre corda-de-viola

O objetivo deste trabalho foi avaliar a influência da chuva na eficiência de herbicidas aplicados em pós-emergência em plantas de Ipomoea grandifolia. As plantas de I. grandifolia foram cultivadas em vasos plásticos com capacidade de 2,5 L, em casa de vegetação, com uma planta por vaso. O delineamento experimental utilizado foi o inteiramente casualizado, com quatro repetições, com os tratamentos dispostos em um esquema fatorial 7x8 (sete tratamentos químicos e oito períodos para ocorrência de chuva após a aplicação dos tratamentos). Os tratamentos químicos constaram da aplicação de glyphosate em cinco formulações comerciais (Roundup Original, Roundup WG, Roundup Transorb, Roundup Transorb R e Roundup Ultra) a 1.080 g e.a. ha-1, amônio-glufosinate (Finale) a 400 g i.a. ha-1 e 2,4-D (DMA 806) a 1.000 g e.a. ha-1 e de oito intervalos de tempo para simulação de uma chuva de 15 mm, com duração de cinco minutos: 15', 30', 1h, 2h, 4h, 6h, 8h após a aplicação dos tratamentos e uma testemunha sem chuva, Foram realizadas avaliações visuais de controle das plantas aos 7, 14, 21, 28 e 35 dias após a aplicação e, por ocasião da última avaliação, determinou-se a massa seca das plantas. A ocorrência de chuvas após a aplicação de 2,4-D não alterou a sua eficiência no controle das plantas de I. grandifolia; já os herbicidas amônio-glufosinate e glyphosate, em todas suas formulações testadas, apresentaram redução na eficiência de controle quando da ocorrência de chuvas em até oito horas após a aplicação dos tratamentos.

Marcadores de Microssatélites para estudos de conservação da Raia-viola Rhinobatos percellens (Chondrichthyes, Rhinobatidae)

A exploração pesqueira, tanto artesanal quanto industrial, se constitui na maior ameaça à biodiversidade dos elasmobrânquios. Em escala mundial, o manejo adequado destes recursos é dificultado pela escassez de informações básicas sobre a dinâmica populacional destes organismos. A captura comercial de elasmobrânquios tem alcançado números alarmantes, com a inclusão de diversas espécies nas listas de risco de extinção nacional e também internacional. A identificação e a conservação de estoques geneticamente diferenciados e adaptados ao seu habitat, representam um ponto fundamental para o setor pesqueiro, pela sua relação direta com a produtividade total e o uso sustentável dos recursos. Entre as raias marinhas, a família Rhinobatidae é representada pelos gêneros Rhinobatos, Zapteryx, Trygonorhina e Aptychotrema, sendo registrada a ocorrência da espécie Rhinobatos percellens no Oceano Atlântico adesde as Antilhas e Panamá, Venezuela, Jamaica, Brasil, Uruguai, até a Argentina. No presente trabalho foram desenvolvidos marcadores moleculares do tipo microssatélites para raiaviola, Rhinobatos percellens, para serem utilizados em estudo populacionais. Cinco locus polimórficos foram isolados utilizando um protocolo de enriquecimento. Nos experimentos, foram testados 13 pares de primers, sendo 10 isolados no presente trabalho e 3 isolados para a espécie de tubarão azul (Prionance glauca). Dos primers isolados em Rhinobatos percellens, 5 são polimórficos, 2 monomórficos e 3 apresentaram bandas muito fracas, enquanto os primers testados de tubarão azul mostraram-se monomórficos. Todos os locus estão em equilíbrio de Wardy-Weinberg, exceto o RVA9 (de R. percellens). Os locus polimórficos apresentam de 3 a 6 alelos por locus e heterozigosidade média esperada de 0.62. Considera-se que estes marcadores polimórficos...(Resumo completo, clicar acesso eletrônico abaixo)

THE FLUTE MUSIC OF PAUL DESENNE: A COMPARATIVE ANALYTICAL STUDY OF REPRESENTATIVE WORKS

The significance of the works by Venezuelan-born composer Paul Desenne lies in his unique compositional style that incorporates elements of Latin American folk, pop, and traditional music within the framework of the Western European tradition. His works, though easily classified as art music, nevertheless gain much of their emotional and referential meaning through this rich borrowing. This document focuses on three of Desenne’s flute pieces: the Solo Flute Sonata (2001), Gurrufío for flute orchestra (1997), and Guasa Macabra for flute and clarinet (2003). It provides an analysis of the three works, examining formal, structural, motivic, and rhythmic aspects. Scores and interviews with the composer have been employed as primary sources. Bibliographical material closely related to his music and other secondary sources support this analytical approach. This document also provides an introduction and stylistic discussion of Desenne’s other pieces that incorporate the flute. Chapter one consists of an introduction to Desenne’s life and general considerations of his musical style. Each of the following three chapters focuses on one the three aforementioned flute works, including information about the composition and premiere of each piece as well as analysis and an examination of its incorporation of traditional folk elements. The final chapter presents an introduction to and stylistic discussion of the other flute pieces by this composer. This study intends to provide a basic understanding of Desenne’s flute music, including general characteristics of his musical style, paving the way for further investigation of Desenne’s music, and flute music in particular.

The Amplifier - v. 2, no. 6

In this issue...Butte Civic Center, ROTC program, It Club, Miner's Union Building, Butte, Montana, George Huber, Viola Vestal Coulter Award, Pan American Games

New insights into the pathobiology of Down syndrome--hyaluronan synthase-2 overexpression is regulated by collagen VI α2 chain.

Down syndrome (DS) is a common birth defect characterized by the trisomy of chromosome 21. DS-affected umbilical cords (UCs) of fetuses show altered architecture of the extracellular matrix. Overexpression of the chromosome 21 genes encoding the collagen type VI (COLVI) chains α1(VI) and α2(VI), COL6A1 and COL6A2, respectively, has also reported to occur in the nuchal skin of DS fetuses. The aim of this study was therefore to evaluate the COLVI content in euploid and DS-affected UCs and human skin fibroblasts, and to investigate the relationships between COLVI and hyaluronan (HA) and HA synthase-2 (HAS2). We found that the UCs of DS fetuses showed denser staining of COLVI and increased COL6A2 expression at both early and term gestational ages. In vitro expression studies in DS-derived fibroblasts showed similarly increased amounts of α1(VI) and α2(VI) chains at the protein and transcriptional level, supporting the hypothesis of the gene dosage effect. Furthermore, increased levels of HA and HAS2 were also found in DS-derived skin fibroblast cultures. Notably, silencing of COL6A2 in DS-derived cells resulted in downregulation of HAS2, with a simultaneous decrease in secreted HA. Exogenous addition of COLVI to normal fibroblasts did not have any effect on HAS2 expression. In conclusion, UCs and skin fibroblasts in DS show significant increases in COLVI and HA; the overexpression of COL6A2 in DS tissue and cells is closely related to the increased expression of HAS2. These data may explain the DS phenotypes and their effects in organ tissue maturation.

Hebräische Melodien : (nach Eindrücken der Byronschen Gesänge) ; für Viola und Pianoforte ; op. 9

Joseph Joachim

Grand duo pour piano e viola

arr. par F. Hermann d'après Le Grand Septuor Oeuvre 20 composé par L. van Beethoven

Hebraeische Melodien : (nach Eindrücken der Byronschen Gesänge) ; für Viola und Pianoforte ; op. 9

Joseph Joachim. Für Violoncell und Pianoforte bearb. von Philipp Roth