Henny Molling nee Meyerhof, Therese Gottschalk nee Molling, Kurt, Elizabeth and Hal Gottschalk on the beach; Norderney, Germany.

Sitting in the Strandkorb (beach chair) at Norderney are Henny Molling and Therese Gottschalk; sitting in the sand are Kurt, Elizabeth and Hal Gottschalk

Elizabeth Krakauer nee Gottschalk in an unknown early Krakauer apartment.

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Studio portrait of Elizabeth Krakauer nee Gottschalk; Hannover, Germany.

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Therese Godshaw (Gottschalk) nee Molling reading with her daughter Elizabeth; Hannover, Germany.

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Wedding portrait of Hans Krakauer and Elizabeth Gottschalk; Hannover, Germany. Portraits Couples

In the apartment on Ruemkorffstrasse that the Gottschalks occupied after being forced to sell their house.

Unidentified man, Elizabeth Krakauer nee Gottschalk and Hans Krakauer on board the ship Koenigstein traveling from Antwerp to New York City on their emigration voyage from Germany.

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Elizabeth Krakauer nee Gottschalk with her mother-in-law Auguste Krakauer nee Mayer in front of a house.

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Elizabeth nee Gottschalk and Hans Krakauer's first house in Boston with descriptions on the picture; Boston, Erie County, New York.

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Portrait of Liesel (Elizabeth) Gottschalk as a baby; Hannover, Germany.

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Portrait of Liesel (Elizabeth) Gottschalk with her grandfather Adolf Molling; Germany.

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Portrait of siblings Hans Ludwig (Hal) and Elizabeth Gottschalk.

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Studio portrait of Martin Goldschmidt; Leipzig Portraits Men

Signed lower right by photographer

Genetic burden associated with varying degrees of disease severity in endometriosis

Endometriosis is primarily characterized by the presence of tissue resembling endometrium outside the uterine cavity and is usually diagnosed by laparoscopy. The most commonly used classification of disease, the revised American Fertility Society (rAFS) system to grade endometriosis into different stages based on disease severity (I to IV), has been questioned as it does not correlate well with underlying symptoms, posing issues in diagnosis and choice of treatment. Using two independent European genome-wide association (GWA) datasets and top-level classification of the endometriosis cases based on rAFS [minimal or mild (Stage A) and moderate-to-severe (Stage B) disease], we previously showed that Stage B endometriosis has greater contribution of common genetic variation to its aetiology than Stage A disease. Herein, we extend our previous analysis to four endometriosis stages [minimal (Stage I), mild (Stage II), moderate (Stage III) and severe (Stage IV) disease] based on the rAFS classification system and compared the genetic burden across stages. Our results indicate that genetic burden increases from minimal to severe endometriosis. For the minimal disease, genetic factors may contribute to a lesser extent than other disease categories. Mild and moderate endometriosis appeared genetically similar, making it difficult to tease them apart. Consistent with our previous reports, moderate and severe endometriosis showed greater genetic burden than minimal or mild disease. Overall, our results provide new insights into the genetic architecture of endometriosis and further investigation in larger samples may help to understand better the aetiology of varying degrees of endometriosis, enabling improved diagnostic and treatment modalities.

Exterior view of Martin Goldschmidt's business; Kurfuerstendamm 34, Berlin W.15 Portraits Men

Born 1879?; Married September 2, 1903 in Leipzig to Paula Harmelin; Father of Henry H. Goldschmidt Gould and Ruth Augusta Beatrice Goldschmidt

Martin Goldschmidt reading on a park bench Portraits Men

Handwritten postcard addressed to Ruth Goldschmidt in Italy and dated 1937 from Zurich