The nu gene acts cell-autonomously and is required for differentiation of thymic epithelial progenitors.

The nude mutation (nu) causes athymia and hairlessness, but the molecular mechanisms by which it acts have not been determined. To address the role of nu in thymogenesis, we investigated whether all or part of the nude thymic epithelium could be rescued by the presence of wild-type cells in nude <--> wild-type chimeric mice. Detailed immunohistochemical analyses revealed that nude-derived cells could persist in the chimeric thymus but could not contribute to cortical or medullary epithelial networks. Nude-derived cells, present in few clusters in the medulla, expressed markers of a rare subpopulation of adult medullary epithelium. The thymic epithelial rudiment of nude mice strongly expressed these same markers, which may therefore define committed immature thymic epithelial precursor cells. To our knowledge, these data provide the first evidence that the nu gene product acts cell-autonomously and is necessary for the development of all major subpopulations of mature thymic epithelium. We propose that nu acts to regulate growth and/or differentiation, but not determination, of thymic epithelial progenitors.

Gender and health inequalities: intersections with other relevant axes of oppression

The risk of disease, disability, and mortality as well as access to health services are unfairly distributed among the population, with certain groups bearing an unequally larger burden of ill health and poorer access to care due to gender, sexual identity/orientation, ethnic background, or class. According to the WHO Commission on Social Determinants of Health (CSDH), these health inequalities emanate from socioeconomic and political factors (governance, cultural values, macroeconomic policies), which generate a set of socioeconomic positions in society according to which populations are stratified based on gender, ethnicity, education, income, or other factors. These societal inequalities influence people’s material and psychosocial circumstances as well as behavioral and biological factors, which in turn impact on health inequalities. Tackling gender, race/ethnic, and socioeconomic inequalities in society is thus recognized as the most powerful action to cope with unequal health risks distribution, and social innovations focusing on these ‘root causes’ are needed in order to prevent and stop endemic social inequalities and social exclusion in health within low-income as well as high-income countries. Increasing existing knowledge and making visible the health status of the most vulnerable and invisible groups are critical in order to contribute to this imperative challenge.

The effects of fatigue and alcohol on highway safety. Final report.

National Highway Traffic Safety Administration, Washington, D.C.

Some account of the Pennsylvania Hospital, its origin, objects, and present state.

Mode of access: Internet.

Lättläst stil : Språklig variation och likhet i tolv lättlästa litterära prosaverk

Den här uppsatsen studerar variation och likhet i och mellan tolv verk för att identifiera vad som är möjligt och omöjligt i texterna. Materialet är tolv nyutgivna verk på tre svåighetsnivåer frå Myndigheten för tillgängliga mediers lättlästförlag. Verken är litterära prosaverk. De analyseras stilistiskt båe kvantitativt och kvalitativt utifrån tre områden: lexikon och syntax, rytm och interpunktion samt färg och illustration. Resultatet visar att förlagets svårighetsnivåer inte återspeglas när det gäller variation och likhet. Verken klustrar ihop sig mot mitten och uppvisar ett normalfördelningsmönster, där vissa verk intar extrempositioner. Förutom extremverken tycks stilen uppvisa stor återhållsamhet, förutom för enstaka analysenheter per verk. Vilken analysenhet det gäller varierar mellan verken. Det beror antagligen på att verken är hårt normerade. En slutsats att vissa språkliga enheter är enkla att normera användning av, medan andra är stilistiska val öppna för författarna. En annan är att lättlästa verk innehåller variation som inte alltid går att förutsäga. 

Co-branding på sociala medier : En studie av hur betydelser skapas och förstärks i ett svenskt modevarumärkes visuella marknadsföring

Syftet med denna studie är att undersöka hur företag använder co-branding och sociala medier för att skapa betydelse för sitt varumärke. Detta kommer jag att undersöka utifrån följande huvudfrågeställning:  Vilka betydelser skapas, alternativt förstärks, genom StyleIn AB’s co-brandingsamarbeten på sociala medier? För att göra det tydligare har jag även två mindre frågeställningar att utgå ifrån:  Hur använder StyleIn AB sociala medier som främsta forum för co-branding samarbeten?  Hur skapas och förstärks betydelse i StyleIns inlägg på sociala medier genom cobranding? Den pågående expansionen av sociala medier och den visuella kulturens framväxt är grunden till varför jag valt att skriva denna uppsats. Betydelser, budskap och värderingar kommer till uttryck i visuellt material och sprids enkelt och snabbt via olika sociala medier. Då kanalerna är billiga att använda sig utav är det vanligt för företag att bedriva sin marknadsföring i dessa forum. I denna uppsats har jag valt att titta närmare på hur ett företag använder sociala medier för att sprida både sitt eget och andra varumärkens budskap genom vad man kallar för “co-branding” i sociala medier. Min studie är avgränsad till det svenska modeföretaget StyleIn AB’s sociala kanaler där de ihop med andra företag exponeras i visuella former. Anledningen till att jag valde företaget StyleIn har att göra med att co-branding är en stor och återkommande del av deras marknadsföring på sociala medier. Med anledning till forumet för denna marknadsföring kommer mitt bakgrundskapitel beröra just sociala medier. Eftersom co-branding är en varumärkesbyggande process kommer mitt teoretiska ramverk, inklusive mitt kapitel om tidigare forskning, att beröra olika teorier kring varumärken samt forskning i fenomenet co-branding. Teorier kring sociala mediers nytta för varumärken kommer också presenteras för att kunna besvara hela min frågeställning. Vidare använder jag mig av semiotisk analys som metod för att jag så djupt som möjligt skall kunna förklara de olika betydelserna i de tre inlägg jag använder mig utav. I mitt resultat kommer jag fram till att StyleIn’s co-branding samarbeten på sociala medier är en värdeskapande process som bygger upp StyleIn som varumärke genom att använda sig av betydelser lånade av andra varumärken. Jag kommer fram till att det handlar om värderingar som rör en viss typ av livsstil och utifrån dessa kan man urskilja betydelser och meningar uppkomna ur användandet av andra varumärken ihop med sitt eget på sociala medier.

Dimethylsulphide and halocarbon concentrations taken from 10m integrated samples during the 2012 KOSMOS Finland Mesocosm experiment

The Baltic Sea is a unique environment as the largest body of brackish water in the world. Acidification of the surface oceans due to absorption of anthropogenic CO2 emissions is an additional stressor facing the pelagic community of the already challenging Baltic Sea. To investigate its impact on trace gas biogeochemistry, a large-scale mesocosm experiment was performed off Tvärminne Research Station, Finland in summer 2012. During the second half of the experiment, dimethylsulphide (DMS) concentrations in the highest fCO2 mesocosms (1075-1333 µatm) were 34 % lower than at ambient CO2 (350 µatm). However the net production (as measured by concentration change) of seven halocarbons analysed was not significantly affected by even the highest CO2 levels after 5 weeks exposure. Methyl iodide (CH3I) and diiodomethane (CH2I2) showed 15 % and 57 % increases in mean mesocosm concentration (3.8 ± 0.6 pmol L-1 increasing to 4.3 ± 0.4 pmol L-1 and 87.4 ± 14.9 pmol L-1 increasing to 134.4 ± 24.1 pmol L-1 respectively) during Phase II of the experiment, which were unrelated to CO2 and corresponded to 30 % lower Chl-? concentrations compared to Phase I. No other iodocarbons increased or showed a peak, with mean chloroiodomethane (CH2ClI) concentrations measured at 5.3 (± 0.9) pmol L-1 and iodoethane (C2H5I) at 0.5 (± 0.1) pmol L-1. Of the concentrations of bromoform (CHBr3; mean 88.1 ± 13.2 pmol L-1), dibromomethane (CH2Br2; mean 5.3 ± 0.8 pmol L-1) and dibromochloromethane (CHBr2Cl, mean 3.0 ± 0.5 pmol L-1), only CH2Br2 showed a decrease of 17 % between Phases I and II, with CHBr3 and CHBr2Cl showing similar mean concentrations in both Phases. Outside the mesocosms, an upwelling event was responsible for bringing colder, high CO2, low pH water to the surface starting on day t16 of the experiment; this variable CO2 system with frequent upwelling events implies the community of the Baltic Sea is acclimated to regular significant declines in pH caused by up to 800 µatm fCO2. After this upwelling, DMS concentrations declined, but halocarbon concentrations remained similar or increased compared to measurements prior to the change in conditions. Based on our findings, with future acidification of Baltic Sea waters, biogenic halocarbon emissions are likely to remain at similar values to today, however emissions of biogenic sulphur could significantly decrease from this region.

A Genetic Marker to Separate Emiliania Huxleyi (Prymnesiophyceae) Morphotypes

Emiliania huxleyi (Lohm.) Hay and Mohler is a ubiquitous unicellular marine alga surrounded by an elaborate covering of calcite platelets called coccoliths. It is an important primary producer involved in oceanic biogeochemistry and climate regulation. Currently, E. huxleyi is separated into five morphotypes based on morphometric, physiological, biochemical, and immunological differences. However, a genetic marker has yet to be found to characterize these morphotypes. With the use of sequence analysis and denaturing gradient gel electrophoresis, we discovered a genetic marker that correlates significantly with the separation of the most widely recognized A and B morphotypes. Furthermore, we reveal that the A morphotype is composed of a number of distinct genotypes. This marker lies within the 3' untranslated region of a coccolith associated protein mRNA, which is implicated in regulating coccolith calcification. Consequently, we tentatively termed this marker the coccolith morphology motif.

Får jämställdheten plats? En studie av översiktsplaneringens behandling av sociala kategorier

Syftet med den här studien är att undersöka hur jämställdhet har behandlats i förhållande till övriga sociala kategorier i översiktsplaneringen. Vidare är syftet att undersöka om detta skiljer sig åt mellan olika typer av kommuner och över tid. Studien bygger på en intersektionell ansats och urvalet bygger på tidigare teorier kring genuskontrakt där fem kommuner i varje genuskontraktstyp inkluderas. Kommunernas översiktsplaner, både aktuella och äldre, studeras genom att genomföra en kvantitativ textanalys där sociala kategoriers utrymme undersöks och en diskursanalys där beskrivningen av sociala kategorier studeras. Resultatet visar att tio sociala kategorier inkluderas i översiktsplaneringen. Jämställdhet har gått från att få näst minst utrymme i de äldre översiktsplanerna till att idag få näst mest utrymme jämfört med övriga sociala kategorier. Jämställdhet beskrivs på liknande sätt som barn, funktionshindrade och äldre att gynnas av en nära, funktionsblandad stad med fungerande kollektivtrafik. Vilket genuskontrakt en kommun har påverkar främst hur kommunerna beskriver jämställdhet, mångfald och äldre.

Editorial

On behalf of the Operational Research Society, Palgrave Macmillan and the editorial team, I am pleased to welcome readers to this, the first issue of Knowledge Management Research & Practice (KMRP). The aim of KMRP is to provide an outlet for rigorous, high-quality, peer-reviewed articles on all aspects of managing knowledge, organisational learning, intellectual capital and knowledge economics. The Editorial Board intends that there be a particular emphasis on cross-disciplinary approaches, and on the mixing of 'hard' (e.g. technological) and 'soft' (e.g. cultural or motivational) issues. This issue features four regular papers and an editorial paper; in addition, there are two book reviews. KMRP is intended as a truly international journal. The papers in this issue feature authors based in five different countries on three continents; eight different countries and four continents if the editorial paper is included. The first of the regular papers is 'The Knowledge-Creating Theory Revisited: Knowledge Creation as Synthesizing Process', by Ikujiro Nonaka and Ryoko Toyama. There can be few readers who are unaware of the work on knowledge creation by Nonaka and his co-workers such as Takeuchi, and this paper seeks to revisit and extend some of the earlier ideas. The second paper is 'Knowledge Sharing in a Multi-Cultural Setting: A Case Study' by Dianne Ford and Yolande Chan. They present a case study that explores the extent to which knowledge sharing is dependent on national culture. The third paper is 'R&D Collaboration: The Role of bain Knowledge-creating Networks' by Malin Brännback. She also draws upon Nonaka and Takeuchi's work on knowledge creation, using the case of knowledge-creating networks in biopharmaceutical R&D involving both universities and industry as an example. The fourth regular paper is 'The Critical Role of Leadership in Nurturing a Knowledge Supporting Culture' by Vincent Ribière and Alea Saa Sitar. They examine the role of leaders in knowledge management generally, and especially in knowledge organisations, from the viewpoint of 'leading through a knowledge lens'. In addition, this issue includes an 'editorial paper', 'Knowledge Management Research & Practice: Visions and Directions' by the editorial team of John Edwards, Meliha Handzic, Sven Carlsson, and Mark Nissen. This paper presents a small survey of academics and practitioners, outlines key directions for knowledge management research and practice, and gives the editorial team's views on how KMRP can help promote scholarly inquiry in the field. We trust that you will both enjoy reading this first issue and be stimulated by it, and cordially invite you to contribute your own paper(s) to future issues of KMRP.

Dimethylsulphide (DMS), dimethylsulphonioproionate (DMSP) and halocarbon concentrations taken from 25m integrated samples during the 2011 SOPRAN Bergen Raunefjord Mesocosm experiment, Norway

The human-induced rise in atmospheric carbon dioxide since the industrial revolution has led to increasing oceanic carbon uptake and changes in seawater carbonate chemistry, resulting in lowering of surface water pH. In this study we investigated the effect of increasing CO2 partial pressure (pCO2) on concentrations of volatile biogenic dimethylsulfide (DMS) and its precursor dimethylsulfoniopropionate (DMSP), through monoculture studies and community pCO2 perturbation. DMS is a climatically important gas produced by many marine algae: it transfers sulfur into the atmosphere and is a major influence on biogeochemical climate regulation through breakdown to sulfate and formation of subsequent cloud condensation nuclei (CCN). Overall, production of DMS and DMSP by the coccolithophore Emiliania huxleyi strain RCC1229 was unaffected by growth at 900 µatm pCO2, but DMSP production normalised to cell volume was 12 % lower at the higher pCO2 treatment. These cultures were compared with community DMS and DMSP production during an elevated pCO2 mesocosm experiment with the aim of studying E. huxleyi in the natural environment. Results contrasted with the culture experiments and showed reductions in community DMS and DMSP concentrations of up to 60 and 32 % respectively at pCO2 up to 3000 µatm, with changes attributed to poorer growth of DMSP-producing nanophytoplankton species, including E. huxleyi, and potentially increased microbial consumption of DMS and dissolved DMSP at higher pCO2. DMS and DMSP production differences between culture and community likely arise from pH affecting the inter-species responses between microbial producers and consumers.

Bulk density, ash content, humification, peat accumulation and selected lithogenic data of Store Mosse peat bog

This datafile presents chemical and physical as well as age dating information from the Store Mosse peat bog in southern Sweden. This record dates back to 8900 cal yr BP. The aim of the research was to reconstruct mineral dust deposition over time. As such we have only presented the lithogenic element data (Al, Ga, Rb, Sc, Ti, Y, Zr, Th and the REE) as the sample preparation method was tailored to these. This data is supported by parameters describing the deposit including bulk density, humification, ash content and net peat accumulation rates.

Violence gratuite et adolescents-bourreaux : Réception, traduction et enjeux de deux romans suédois pour adolescents, en France, au début des années 2000

The purpose of this thesis is to contribute to a better understanding of the role of Swedish literature for adolescents in the French literary scene in the early 2000s. The sociology of literature constitutes the main theoretical framework of this thesis. Drawing from examples that broach the sensitive topic of "unprovoked violence" as it is treated in two Swedish novels for teenagers, Spelar död [Play Death] by Stefan Casta and När tågen går förbi (Train Wreck) by Malin Lindroth, this thesis shows how these novels are innovative in Even-Zohar’s sense of the term, as addressed in his Polysystem Theory (1990). By introducing "unprovoked violence" and violent teenagers via a realistic genre, such works filled a vacuum in the French system and injected a new dynamic into it. This dynamic makes it possible for new literary models to be introduced in the system and to change the standards of that system. The analyses of the French and Swedish receptions of the two novels mentioned above show that they gave rise to a moral panic in France, which is not an unusual thing to happen in periods of ongoing change. This also clarifies the differences in norms between the two systems. The French system tends to reject dark topics, while the Swedish wishes to discuss them. The investigations of the translations of unprovoked violence show that adherence to Swedish norms determine the translation’s adequacy (Toury), which may be part of the reason for the stormy reception the two works received in France, and their undergoing censure. The position of translators and publishers in the literary system also plays a major role for a translated text not being censured during the transfer from one system to another. Even if the Swedish titles translated into French are few, this thesis shows that the impact of Swedish literature on adolescents in France is certain. By introducing new and sensitive topics, such novels could be early markers of an evolution of the French field of literature for adolescents.

Medberoende : Deltagandet i Al-Anon och dess påverkan i arbetslivet

2016-06-02