Pollen record and age determinations of a profile at Cape Mamontov Klyk, Siberia

Non-glaciated Arctic lowlands in north-east Siberia were subjected to extensive landscape and environmental changes during the Late Quaternary. Coastal cliffs along the Arctic shelf seas expose terrestrial archives containing numerous palaeoenvironmental indicators (e.g., pollen, plant macro-fossils and mammal fossils) preserved in the permafrost. The presented sedimentological (grain size, magnetic susceptibility and biogeochemical parameters), cryolithological, geochronological (radiocarbon, accelerator mass spectrometry and infrared-stimulated luminescence), heavy mineral and palaeoecological records from Cape Mamontov Klyk record the environmental dynamics of an Arctic shelf lowland east of the Taymyr Peninsula, and thus, near the eastern edge of the Eurasian ice sheet, over the last 60 Ky. This region is also considered to be the westernmost part of Beringia, the non-glaciated landmass that lay between the Eurasian and the Laurentian ice caps during the Late Pleistocene. Several units and subunits of sand deposits, peat-sand alternations, ice-rich palaeocryosol sequences (Ice Complex) and peaty fillings of thermokarst depressions and valleys were presented. The recorded proxy data sets reflect cold stadial climate conditions between 60 and 50 Kya, moderate inderstadial conditions between 50 and 25 Kya and cold stadial conditions from 25 to 15 Kya. The Late Pleistocene to Holocene transition, including the Allerød warm period, the early to middle Holocene thermal optimum and the late Holocene cooling, are also recorded. Three phases of landscape dynamic (fluvial/alluvial, irregular slope run-off and thermokarst) were presented in a schematic model, and were subsequently correlated with the supraregional environmental history between the Early Weichselian and the Holocene.

Disertacion physico-medica : en que con la razon, authoridad y esperiencia, se demuestra la utilidad y seguridad de la inoculacion de las viruelas y las grandes ventajas que de ella se siguen à la humana sociedad y á los reynos /

Palau 321.182/4.

I. Lipsi Diua Virgo Hallensis : beneficia eius & miracula fide atque ordine descripta.

Mode of access: Internet.

Iusti Lipsi Epistolarum selectarum centuria singularis ad italos & hispanos, quíve in iis locis.

Mode of access: Internet.

Compte rendu de l'institut et constitutions des soi-disans Jésuites /

Mode of access: Internet.

Philosophical experiments : containing useful and necessary instructions for such and undertake long voyages at sea : shewing how sea-water may be made fresh and wholsome and how fresh-water may be preserv'd sweet... : to wich is added an account of several experiments and observations on Chalybeate or steel-waters ... /

Mode of access: Internet.

Symbolae litterariae opuscula varia : philologia scientifica antiquaria signa. Lapides. Numismata. Gemmas et monumenta medii aevi nunc primum edita complectentes ; decadis secundae volumen primum [-secundum] ...

Contiene: Vol. 1, Vol. 2 con paginacion y portada propias.

Caramuelis Apparatus philosophicus : quatuor libris distinctus : in primo de omnium scientiarum quae scholastice tractari possunt ..., in secundo de omnium gentivm, aegyptiorum ..., in tertio de ciphris mentis arcana ..., in quarto metaciphricae secreta ... : liber omnibus scientiarum amatoribus perquam utilis & necessarius.

Palau,

De sacro adorationis cultu disputationes quatuor /

Mode of access: Internet.

Mr. Crewe's career,

Mode of access: Internet.

OEuvres de m. Michelet ...

Mode of access: Internet.

Contributions, from the Department of Pediatrics

At head of title: The University of Minnesota

Ventilatory responses of healthy subjects to intravenous combinations of morphine and oxycodone under imposed hypercapnic and hypoxaemic conditions

Aims Previous isobolographic analysis revealed that coadministration of morphine and oxycodone produces synergistic antinociception in laboratory rodents. As both opioids can produce ventilatory depression, this study was designed to determine whether their ventilatory effects were synergistic when coadministered to healthy human subjects. Methods A placebo-controlled, randomized, crossover study was performed in 12 male volunteers. Ventilatory responses to hypoxaemia and hypercapnia were determined from 1-h intravenous infusions of saline ('placebo'), 15 mg morphine sulphate (M), 15 mg oxycodone hydrochloride (O), and their combination in the dose ratios of 1 : 2, 1 : 1, 2 : 1. Drug and metabolite concentrations in serial peripheral venous blood samples were measured by high-performance liquid chromatography-MS/MS. Results 'Placebo' treatment was without significant ventilatory effects. There were no systematic differences between active drug treatments on either the slopes or intercepts of the hypoxaemic and hypercapnia ventilation responses. During drug treatment, the mean minute ventilation at PETCO2 = 55 mmHg (V-E55) decreased to 74% of the subjects' before treatment values (95% confidence interval 62, 87), 68% (57, 80), 69% (59, 79), 68% (63, 73), and 61% (52, 69) for M15, M10/O5, M7.5/O7.5, M5/O10 and O15, respectively. Recovery was more prolonged with increasing oxycodone doses, corresponding to its greater potency and lower clearance compared with morphine. Conclusions Although adverse ventilatory effects of these drugs were found as expected, no unexpected or disproportionate effects of any of the morphine and oxycodone treatments were found that might impede their use in combination for pain management.