A homeostatic function of CXCR2 signalling in articular cartilage

Funding This work was funded by Arthritis Research UK (grants 17859, 17971, 19654), INNOCHEM EU FP6 (grant LSHB-CT-2005-51867), MRC (MR/K013076/1) and the William Harvey Research Foundation

Constituição e instabilidade institucional

Aula inaugural dos cursos da Faculdade de Direito da Universidade Federal do Rio Grande do Sul, em 1 de abril de 1997

Instabilidade e mudanças : os condicionantes históricos da política externa brasileira sob Geisel (1974-1979)

Artigo baseado em dissertação de mestrado do autor, com o título 'Brasil, Estados Unidos e Europa Ocidental no contexto do nacional desenvolvimento : estrategias de diversificação de parcerias, defendida na Universidade de Brasília em 1994

O processo de globalização e a instabilidade dos modelos econômicos de Estado

Inclui notas explicativas, bibliográficas e bibliografia

IL-17 derived from juxta-articular bone and synovium contributes to joint degradation in rheumatoid arthritis

The origin and role of IL-17, a T-cell derived cytokine, in cartilage and bone destruction during rheumatoid arthritis (RA) remain to be clarified. In human ex vivo models, addition of IL-17 enhanced IL-6 production and collagen destruction, and inhibited collagen synthesis by RA synovium explants. On mouse cartilage, IL-17 enhanced cartilage proteoglycan loss and inhibited its synthesis. On human RA bone explants, IL-17 also increased bone resorption and decreased formation. Addition of IL-1 in these conditions increased the effect of IL-17. Blocking of bone-derived endogenous IL-17 with specific inhibitors resulted in a protective inhibition of bone destruction. Conversely, intra-articular administration of IL-17 into a normal mouse joint induced cartilage degradation. In conclusion, the contribution of IL-17 derived from synovium and bone marrow T cells to joint destruction suggests the control of IL-17 for the treatment of RA.