Arctic searching expedition: a journal of a boat-voyage through Rupert's Land and the Arctic Sea, in search of the discovery ships under command of Sir John Franklin. With an appendix on the physical geography of North America. By Sir John Richardson ...

v. 1

Magazine of natural history and journal of zoology, botany, mineralogy, geology and meteorology.

v. 5 (1832)

Shelby County : a sociological study, 1904.

This study was written by John J. Louis and reprinted from volume II, numbers 1 and 2 of the Iowa journal of history and politics [Jan.-Apr.1904]. It examines the component society of Shelby County with reference to its social structure.

Common variants near MC4R are associated with fat mass, weight and risk of obesity.

To identify common variants influencing body mass index (BMI), we analyzed genome-wide association data from 16,876 individuals of European descent. After previously reported variants in FTO, the strongest association signal (rs17782313, P = 2.9 x 10(-6)) mapped 188 kb downstream of MC4R (melanocortin-4 receptor), mutations of which are the leading cause of monogenic severe childhood-onset obesity. We confirmed the BMI association in 60,352 adults (per-allele effect = 0.05 Z-score units; P = 2.8 x 10(-15)) and 5,988 children aged 7-11 (0.13 Z-score units; P = 1.5 x 10(-8)). In case-control analyses (n = 10,583), the odds for severe childhood obesity reached 1.30 (P = 8.0 x 10(-11)). Furthermore, we observed overtransmission of the risk allele to obese offspring in 660 families (P (pedigree disequilibrium test average; PDT-avg) = 2.4 x 10(-4)). The SNP location and patterns of phenotypic associations are consistent with effects mediated through altered MC4R function. Our findings establish that common variants near MC4R influence fat mass, weight and obesity risk at the population level and reinforce the need for large-scale data integration to identify variants influencing continuous biomedical traits.

Tal af John Stuart Mill

14 x 23 cm

Niagara-Welland Power Company Limited fonds, 1833, 1852, 1904-1906, 1909, n.d.

The Welland Power and Supply Canal Company Limited, established in 1893 and incorporated in 1894 with a capital stock of $500,000. The aim of the company was to harness the natural water supply of the Niagara and Welland Rivers. In 1898 the Canadian Electrical News published a report by Henry Symons, QC outlining the main project of the company. This project involves the construction of a canal from the Welland River to the brow of the mountain at Thorold, a distance of 8 miles; the construction at Thorold of a power house, and from Thorold to Lake Ontario, a raceway by which to carry water into the lake. The estimate for the machinery to generate 100,000 horse power is £125,000; for transmission line to Toronto at a voltage of 10,000….The total estimate therefore amounts to £2,452,162, or roughly speaking, $12,000,000. Source: Canadian Electrical News, August 1898, p. 172. In 1899 the company officers petitioned the federal government desiring a name change to the Niagara-Welland Power Company Limited. Officers of the company were Harry Symons, President; Charles A. Hesson, Vice-President; and M.R. O’Loughlin, James B. Sheehan, James S. Haydon, Frederick K. Foster, directors; John S. Campbell, secretary-treasurer. The company’s head offices were located in St. Catharines, with a New York (City) office on Broad Street. In 1905 and 1909 the company petitioned the federal government for additional time to construct its works, which was granted. The company had until May 16, 1915 to complete construction. John S. Campbell (1860-1950) was a graduate of the University of Toronto and Osgoode Hall. During his university years John began his military career first in "K" Company, Queens Own rifles and then later as Commanding Officer of the 19th Lincoln Regiment, from 1906 to 1910. Upon his return to St. Catharines John Campbell served as secretary in the St. Catharines Garrison Club, a social club for military men begun in 1899. After being called to the Bar, he became a partner in the firm of Campbell and McCarron and was appointed to the bench in 1916, serving until retirement in 1934. Judge Campbell served as an alderman for several terms and was the mayor of St. Catharines in 1908 and 1909. He also served as the first chairman of the St. Catharines Public Utilities in 1914. John S. Campbell was married to Elizabeth Oille, daughter of Jerome B. and Charlotte (St. John) Oille. The family home "Cruachan" was located at 32 Church St.

William Van Every fonds, 1784, 1804-1806, 1815-1816, 1828, 1832, n.d.

William Van Every, son of McGregory and Mary Wilcox (Jaycocks) Van Every, was born in New York state in 1765. During the Revolutionary War he joined Butler’s Rangers and served under Captain John McDonnell. He was granted three lots of land in the Township of Niagara, with additional lands granted at later dates. William married Elizabeth, daughter of George Young. Elizabeth was the widow of Col. Frederick Dochstader and mother of Catherine Dochstader, b. 1781. William Van Every died in 1832, his wife Elizabeth in 1851. Both are buried in the Warner Cemetery, in present day Niagara Falls. The children of William Van Every and Elizabeth Young were Mary, Elizabeth, Phoebe, John, Peter, William, Rebecca, Samuel and Joseph. Source: Mary Blackadar Piersol, The Records of the Van Every Family, Toronto : Best Printing, 1947. And, Patricia M. Orr, Historic Woodend, sponsored by Niagara Peninsula Conservation Authority, 1980?

Letter to William Collver or John Roberts, 1849

A letter to “my dear Mr. Collver and co.” The writer mentions the “circuit” that she has traveled, and a conference which she attended. In regard to the circuit, she talks about her interest in the Welland Canal. The references all seem to be religious in nature. She asks Mr. Collver how he likes the new preacher and says that in a letter that the preacher published in the newspaper he refers to the “breaking of Jordan Chapel”. She says that a society of teetotalers has been established in her town and they are known as “Sons of Temperance”. She also mentions “my man Brown” who was there but has left, leaving her to have the circuit by herself. She signs off with “I am yours affectionately [Eleanor Corman]. The second part of the letter is addressed to “my dear Mr. Roberts”. She asks him for some music that she would like, but cannot find in Kingston. She would like him to “come down and teach singing” this winter. She also asks him to give her regards to Mr. P. Beamer and family. She ends this part of the letter with “Nothing further yours affectionately [Eleanor Corman]”. There are 4 red postmarks on the outside of the letter and they are: Picton, July 31, 1849 Cobourg, August 2, 1849 St. Catharines, August 4, 1849 There is one other postmark which is too faded to be legible.

Order to create a General Board of Health in the Town of Niagara, June 25, 1832

In the early nineteenth century, a widespread outbreak of cholera occurred in continental Europe, eventually spreading to the British Isles. The disease subsequently spread to Canada as impoverished British immigrants seeking a better life arrived in the country. To help curb the spread of the disease, local Boards of Health were created.

Order to create a General Board of Health in the Town of Niagara, June 25, 1832.

In the early nineteenth century, a widespread outbreak of cholera occurred in continental Europe, eventually spreading to the British Isles. The disease subsequently spread to Canada as impoverished British immigrants seeking a better life arrived in the country. To help curb the spread of the disease, local Boards of Health were created.

Letter - Julian Porter to R.A. Brown 12 July 1967

A letter from Mr. Julian Porter to R.A. Brown of Longmans Green Publishing Company. The letter indicates that Mr. Porter was introduced to Sean O'Sullivan during a political function. Mr. O'Sullivan mentioned that he had written a manuscript about Mr. J. Diefenbaker. Mr. Porter suggests that Longmans Green Publishing Company take interest in the manuscript. The company eventually rejects the book due to it being "so highly personal". The publishing company also remarks "I am personally most impressed with Mr. O'Sullivan's sincerity. I can't imagine anything will stop him from eventually going into politics."

Indenture between Richard Leonard, sheriff of the District of Niagara (regarding lands seized from John Donald McKay) to Robert Dickson

Indenture between Richard Leonard, sheriff of the District of Niagara (regarding lands seized from John Donald McKay) to Robert Dickson. The land consists of ½ an acre located in Lot no. 96 in the Town of Niagara – instrument no. 8600. This was recorded on May 4th, 1832 in Book N, folio 276- 277 in the registry of Lincoln and Haldimand Counties, Oct. 13, 1824.