Identification of human granzyme B promoter regulatory elements interacting with activated T-cell-specific proteins: implication of Ikaros and CBF binding sites in promoter activation.

Granzyme B serine protease is found in the granules of activated cytotoxic T cells and in natural and lymphokine-activated killer cells. This protease plays a critical role in the rapid induction of target cell DNA fragmentation. The DNA regulatory elements that are responsible for the specificity of granzyme B gene transcription in activated T-cells reside between nt -148 and +60 (relative to the transcription start point at +1) of the human granzyme B gene promoter. This region contains binding sites for the transcription factors Ikaros, CBF, Ets, and AP-1. Mutational analysis of the human granzyme B promoter reveals that the Ikaros binding site (-143 to -114) and the AP-1/CBF binding site (-103 to -77) are essential for the activation of transcription in phytohemagglutinin-activated peripheral blood lymphocytes, whereas mutation of the Ets binding site does not affect promoter activity in these cells.

Peptide mimicry of the meningococcal group C capsular polysaccharide.

Sequence analysis of the variable regions of the heavy and light chains of the anti-idiotypic antibody 6F9, which mimics the meningococcal group C capsular polysaccharide (MCP), was performed. The immunogenic site on 6F9 responsible for inducing an anti-MCP antibody response was determined by means of sequence and computer model analysis of these data. Complementarity-determining region 3 (CDR3) was found to be unique in that the sequence tract YRY was exposed on the surface. A synthetic peptide spanning the CDR3 domain was synthesized and complexed to proteosomes (meningococcal group B outer membrane protein). Immunizations of BALB/c mice with the peptide-proteosome complex resulted in a significant anti-MCP antibody response. Immunized mice were protected against infection with a lethal dose of Neisseria meningitidis serogroup C.

Battle of Prestonpans, Highlands of Scotland, United Kingdom, 1745 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: An exact plan of His Majesty's great roads through the Highlands of Scotland, And. Rutherfurd delin. ; C. Mosley sculp. It was published in 1745. Scale [ca. 1:300,000].The image inside the map neatline is georeferenced to the surface of the earth and fit to the Europe Lambert Conformal Conic coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as drainage, cities and other human settlements, roads, selected buildings, shoreline features, fortification, troop dispositions of Jacobite and the Royal Government's troops for the Battle of Prestonpans, 1745, and more. Relief shown pictorially. Includes inset: Plan of the Battle of Preston fought 21 Sept. 1745. The inset is oriented with south at the top and the entire inset map, including text, is at right angles to the main map.This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of originators, ground condition dates, scales, and map purposes.

Battle of Corinth, Mississippi and vicinity, 1862 (Raster Image)

This layer is a georeferenced raster image of the historic paper map: Map of the country between Monterey, Tenn. & Corinth, Miss. : showing the lines of entrenchments made & the routes followed by the U.S. forces under the command of Maj. Genl. Halleck, U.S. Army, in their advance upon Corinth in May 1862, surveyed under the direction of Col. Geo. Thom, A.D.C. & Chief of Topl. Engrs., Dept. of the Mississippi ; by Lieuts. Fred. Schraag and C.L. Spangenberg, Asst. Topl. Engrs. ; drawn by Lieut. Otto H. Matz, Asst. Topl. Engr. It was printed by Lith. of J. Bien, 1862. Scale [1:31,680]. Covers Corinth, Mississippi region including portions of Alcorn County, Mississippi and McNairy County, Tennessee. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Universal Transverse Mercator projection (WGS 1984 UTM Zone 16N). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, or other information associated with the principal map. This map shows features such as houses, names of residents, fences, roads, railroads, vegetation, fields, drainage, Union and Confederate entrenchments, and more. Relief shown by hachures. This layer is part of a selection of digitally scanned and georeferenced historic maps of the Civil War from the Harvard Map Collection. Many items from this selection are from a collection of maps deposited by the Military Order of the Loyal Legion of the United States Commandery of the State of Massachusetts (MOLLUS) in the Harvard Map Collection in 1938. These maps typically portray both natural and manmade features, in particular showing places of military importance. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.

Crash protection systems for handicapped school and transit bus occupants. Volume III: appendices A, B, C and D. Interim report.

National Highway Traffic Safety Administration, Washington, D.C.

Asiatic Art, VII century B.C.-XVIII century A.D., including sculpture in bronze & stone, ceramics, miniatures and textiles.

Exhibition and sale at the American Art Galleries, New York.

Availability and use of abandoned rights of way. Task 4: A. survey of federal programs. B. survey of state and local programs.

Transportation Department, Office of Environmental Affairs, Washington, D.C.

East and west through fifteen centuries; being a general history from B.C. 44 to A.D. 1453,

No more published.

Battle of the naked men

Antonio del Pollaiuolo; 1 ft. 3 1/8 in.x 1 ft. 11 3/16 in.; engraving

A B C de l'apiculture; encyclopédie de tout ce qui a rapport à l'abeille, miel, ruches, instruments, plantes mellifères, etc., résultats d'observations et d'expériences de milliers d'apiculteurs, contrôlées ensuite par un travail pratique dans nos propres ruchers.

p. 518-524 advertising.

The speeches of the Hon. Hugh C. Wallace, American ambassador to France, 1919-1921,

Added t.-p. in French; French and English on opposite pages.

Aerology and naval warfare, the Battle of Midway.

"This is one of a series of pamphlets dealing with the weather aspects of Naval and Amphibious Warfare."

Aerology and naval warfare, the Battle of the Coral Sea.

"This is one of a series of pamphlets dealing with the weather aspects of Naval and Amphibious Warfare."

L.M.B.C. memoirs on typical British marine plants and animals

Mode of access: Internet.