283 resultados para GAD
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Mode of access: Internet.
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Mode of access: Internet.
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Includes bibliographies.
Danmark-Norges historie fra den store nordiske krigs slutning til rigernes adskillelse. (1720-1814).
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Includes indexes.
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Mode of access: Internet.
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Microfilm.
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Contains bibliographies.
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"Denne udgave er en fortsættelse paa den ene side af de af Kr. Erslev og W. Mollerup udg. 'Danske kancelliregistranter 1535-1550' ... paa den anden side af de i 'Danske magazin' meddelte 'Tegnelse over alle lande' [1535-1550]."
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"Published at the expenses of the Carlsberg fund."
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This study examined the psychometric properties of the parent version of the Spence Children's Anxiety Scale (SCAS-P); 484 parents of anxiety disordered children and 261 parents in a normal control group participated in the study. Results of confirmatory factor analysis provided support for six intercorrelated factors, that corresponded with the child self-report as well as with the classification of anxiety disorders by DSM-IV (namely separation anxiety, generalized anxiety, social phobia, panic/agoraphobia, obsessive-compulsive disorder, and fear of physical injuries). A post-hoc model in which generalized anxiety functioned as the higher order factor for the other five factors described the data equally well. The reliability of the subscales was satisfactory to excellent. Evidence was found for both convergent and divergent validity: the measure correlated well with the parent report for internalizing symptoms, and lower with externalizing symptoms. Parent-child agreement ranged from 0.41 to 0.66 in the anxiety-disordered group, and from 0.23 to 0.60 in the control group. The measure differentiated significantly between anxiety-disordered children versus controls, and also between the different anxiety disorders except GAD. The SCAS-P is recommended as a screening instrument for normal children and as a diagnostic instrument in clinical settings. (C) 2003 Elsevier Ltd. All rights reserved.
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Several pathogenic strains of Escherichia coli exploit type III secretion to inject effector proteins into human cells, which then subvert eukaryotic cell biology to the bacterium's advantage. We have exploited bioinformatics and experimental approaches to establish that the effector repertoire in the Sakai strain of enterohemorrhagic E. coli (EHEC) O157:H7 is much larger than previously thought. Homology searches led to the identification of > 60 putative effector genes. Thirteen of these were judged to be likely pseudogenes, whereas 49 were judged to be potentially functional. In total, 39 proteins were confirmed experimentally as effectors: 31 through proteomics and 28 through translocation assays. At the protein level, the EHEC effector sequences fall into > 20 families. The largest family, the NleG family, contains 14 members in the Sakai strain alone. EHEC also harbors functional homologs of effectors from plant pathogens (HopPtoH, HopW, AvrA) and from Shigella (OspD, OspE, OspG), and two additional members of the Map/IpgB family. Genes encoding proven or predicted effectors occur in > 20 exchangeable effector loci scattered throughout the chromosome. Crucially, the majority of functional effector genes are encoded by nine exchangeable effector loci that lie within lambdoid prophages. Thus, type III secretion in E. coli is linked to a vast phage metagenome, acting as a crucible for the evolution of pathogenicity.
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Numerous scientific disciplines suffer from a common epistemological ailment. They tend to generate impressive bodies of empirical knowledge that are otherwise disjointed. The key force that shapes this reality is the lack of organizing meta-frameworks that are capable of otherwise creating a consilient body of core knowledge. In the current paper, we seek to demonstrate the synthetic value of evolutionary theory across a wide range of neuro-business disciplines including neuroeconomics, neuromarketing, neuroentrepreneurship, and organizational neuroscience. Neuroscientists operating at the junction of the brain sciences and a wide range of business disciplines stand to benefit in recognizing that the minds of Homo consumericus, Homo corporaticus, and Homo economicus have been forged by Darwinian forces that have shaped all living organisms. A complete and accurate understanding of most neuro-business phenomena requires that these be tackled at both the proximate (i.e., how something operates) and ultimate (its adaptive function) levels.
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OBJECTIVE: The objective of this study was to examine medical illness and anxiety, depressive, and somatic symptoms in older medical patients with generalized anxiety disorder (GAD). METHOD: A case-control study was designed and conducted in the University of California, San Diego (UCSD) Geriatrics Clinics. A total of fifty-four older medical patients with GAD and 54 matched controls participated. MEASUREMENTS: The measurements used for this study include: Brief Symptom Inventory-18, Mini International Neuropsychiatric Interview, and the Anxiety Disorders Interview Schedule. RESULTS: Older medical patients with GAD reported higher levels of somatic symptoms, anxiety, and depression than other older adults, as well as higher rates of diabetes and gastrointestinal conditions. In a multivariate model that included somatic symptoms, medical conditions, and depressive and anxiety symptoms, anxiety symptoms were the only significant predictors of GAD. CONCLUSION: These results suggest first, that older medical patients with GAD do not primarily express distress as somatic symptoms; second, that anxiety symptoms in geriatric patients should not be discounted as a byproduct of medical illness or depression; and third, that older adults with diabetes and gastrointestinal conditions may benefit from screening for anxiety.