987 resultados para Florida-keys


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El templo parroquial de San Antonio de la Florida

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Esta tesis doctoral se especializa en el estudio desde el interior de casas de maestros españoles proyectadas y construidas para ellos y sus familias. Casas proyectadas y construidas para ellos mismos por arquitectos “maestros” de la arquitectura española del siglo XX, que acabaron sus estudios de arquitectura después de la guerra civil y que se habían formado en la Escuela de Madrid. Las cinco casas escogidas están situadas en la provincia de Madrid, en la hoy definida como Comunidad de Madrid. Las cinco casas son para el arquitecto y su familia. También las cinco casas son de tipología unifamiliar aislada. Todas ellas tuvieron el carácter de vivienda estable, no de fin de semana, no de refugios experimentales. El método de análisis se estructura en dos grandes bloques, lo que hemos denominado “Enfocando” y “Desde dentro”. Enfocando: Se analizan las obras precedentes de similares características y se realiza un estudio de aproximación al lugar cuyo punto final es la entrada de la casa Desde dentro: Se Inicia el estudio de la vivienda en un recorrido que atiende a los parámetros de relaciones con el exterior, materiales de acabado, mobiliario, condiciones de flexibilidad y crecimiento y relaciones vivienda-estudio. Siempre con el espacio interior como protagonista del estudio Abstract The dissertation focuses on the interior space of "master`s houses" which were conceived and built for the architect and his family. The five houses selected were built in the XX Century .The five houses are located in Madrid. The five houses are detached houses, the five houses are "residences", not experimental houses, or weekend houses. The method has two parts. Focusing and Inside Focusing: This part studies previous works, with similar characteristics. Moreover this part looks at the path from the street to the main door, through the private exterior. Inside: This part studies the relationship between interior and exterior, finishing materials, furniture, flexibility and relation with the professional spaces. All these elements are studied, always with the interior space as the main character.

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Speciation involves the establishment of genetic barriers between closely related organisms. The extent of genetic recombination is a key determinant and a measure of genetic isolation. The results reported here reveal that genetic barriers can be established, eliminated, or modified by manipulating two systems which control genetic recombination, SOS and mismatch repair. The extent of genetic isolation between enterobacteria is a simple mathematical function of DNA sequence divergence. The function does not depend on hybrid DNA stability, but rather on the number of blocks of sequences identical in the two mating partners and sufficiently large to allow the initiation of recombination. Further, there is no obvious discontinuity in the function that could be used to define a level of divergence for distinguishing species.

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Key studies defining the DNA alkylation properties and selectivity of a new class of exceptionally potent, naturally occurring antitumor antibiotics including CC-1065, duocarmycin A, and duocarmycin SA are reviewed. Recent studies conducted with synthetic agents containing deep-seated structural changes and the unnatural enantiomers of the natural products and related analogs have defined the structural basis for the sequence-selective alkylation of duplex DNA and fundamental relationships between chemical structure, functional reactivity, and biological properties. The agents undergo a reversible, stereoelectronically controlled adenine-N3 addition to the least substituted carbon of the activated cyclopropane within selected AT-rich sites. The preferential AT-rich non-covalent binding selectivity of the agents within the narrower, deeper AT-rich minor groove and the steric accessibility to the alkylation site that accompanies deep AT-rich minor groove penetration control the sequence-selective DNA alkylation reaction and stabilize the resulting adduct. For the agents that possess sufficient reactivity to alkylate DNA, a direct relationship between chemical or functional stability and biological potency has been defined.