FASTtrack:pharmaceutical compounding and dispensing

This is a revision guide for students giving bullet points of basic information on pharmaceutical compounding and dispensing followed by questions and answers."Fast Track" is a new series of indispensable revision guides created especially for undergraduate pharmacy students.The content of each title focuses on what pharmacy students really need to know in order to pass exams, providing concise, bulleted information, key points, tips and an all-important self-assessment section which includes MCQs, case studies, sample essay questions and worked examples."The Fast Track" series provides the ultimate lecture notes and is a must-have for all pharmacy undergraduate students wanting to revise and test themselves for forthcoming exams.Based on the successful textbook, "Pharmaceutical Compounding and Dispensing", this book has been designed to assist the student compounder in understanding the key dosage forms encountered within extemporaneous dispensing.A Fast Track website will also be live at time of publication and will include MCQs, sample online content and much more.

Strategic development and physicochemical analysis of oral preparations for unstable drugs

Oral liquid formulations are ideal dosage forms for paediatric, geriatric and patient with dysphagia. Dysphagia is prominent among patients suffering from stroke, motor neurone disease, advanced Alzheimer’s and Parkinson’s disease. However oral liquid preparations are particularly difficult to formulate for hydrophobic and unstable drugs. Therefore current methods employed in solving this issue include the use of ‘specials’ or extemporaneous preparations. In order to challenge this, the government has encouraged research into the field of oral liquid formulations, with the EMEA and MHRA publishing list of drugs of interest. The current work investigates strategic formulation development and characterisation of select API’s (captopril, gliclazide, melatonin, L-arginine and lansoprazole), each with unique obstacles to overcome during solubilisation, stabilisation and when developing a palatable dosage from. By preparing a validated calibration protocol for each of the drug candidates, the oral liquid formulations were assessed for stability, according to the ICH guidelines along with thorough physiochemical characterisation. The results showed that pH and polarity of the solvent had the greatest influence on the extent of drug solubilisation, with inclusion of antioxidants and molecular steric hindrance influencing the extent of drug stability. Captopril, a hydrophilic ACE inhibitor (160 mg.mL-1), undergoes dimerisation with another captopril molecule. It was found that with the addition of EDTA and HP-β-CD, the drug molecule was stabilised and prevented from initiating a thiol induced first order free radical oxidation. The cyclodextrin provided further steric hindrance (1:1 molar ratio) resulting in complete reduction of the intensity of sulphur like smell associated with captopril. Palatability is a crucial factor in patient compliance, particularly when developing a dosage form targeted towards paediatrics. L-arginine is extremely bitter in solution (148.7 g.L-1). The addition of tartaric acid into the 100 mg.mL-1 formulation was sufficient to mask the bitterness associated with its guanidium ions. The hydrophobicity of gliclazide (55 mg.L-1) was strategically challenged using a binary system of a co-solvent and surfactant to reduce the polarity of the medium and ultimately increase the solubility of the drug. A second simpler method was developed using pH modification with L-arginine. Melatonin has two major obstacles in formulation: solubility (100 μg.mL-1) and photosensitivity, which were both overcome by lowering the dielectric constant of the medium and by reversibly binding the drug within the cyclodextrin cup (1:1 ratio). The cyclodextrin acts by preventing UV rays from reaching the drug molecule and initiated the degradation pathway. Lansoprazole is an acid labile drug that could only be delivered orally via a delivery vehicle. In oral liquid preparations this involved nanoparticulate vesicles. The extent of drug loading was found to be influenced by the type of polymer, concentration of polymer, and the molecular weight. All of the formulations achieved relatively long shelf-lives with good preservative efficacy.

Um olhar sobre a música gospel: a lógica simbólica e de mercado do Ministério de Louvor Diante do Trono

This study aims to understand how the gospel music genre - based on the gospel band Ministério de Louvor Diante do Trono - articulates itself to the logic of the market by its insertion in the music industry and use of symbolic logic in the available songs of their Cds and DVDs. Our research is a case study, methodologically being the descriptive analysis of the production process, distribution and broadcasting of the band's CDs and functional analysis of the music that permeates the entire thesis. The following songs are presented as an analytical corpus: Preciso de Ti,Quero me Apaixonar, Tua Visão, Creio, Tu Reinas e Tetelestai. Our hypothesis is that religious institutions - as a field responsible for the structure which maintains gospel artists - experiences a new dynamic that consists of a superficial modernity, ratified in the ways the symbolic goods produced communicate, that is, simulate a religious modernity maintaining traditional values regarding the dogmas of religion , but incorporate business and advertising procedures in the dissemination of its products The results point to gospel music as mediation, part of the religious ritual sometimes as prayer and other as preaching, stimulating consumption and entertainment, and performing as a device in the making of symbolic goods.

Concepções dos professores da educação básica sobre as feiras de ciência

Currently the Science fairs in Brazil have gained great incentive, examples are the regulations that the government has been implementing in education and the financing of public calls for events throughout the national territory. However, even with this incentive, some researchers point out that the scientific fairs and shows are still interpreted as an extemporaneous work by teachers. In order to know the views of basic education teachers about the fairs of Science, proposed to carry out this research. Given this situation, based mediation theory and sociocultural interaction Vygotsky (2001), the theory of instrumentalism Dewey (2002) and the proposed education through research Galiazzi e Moraes (2002), we sought to understand the importance of fair and their benefits as well as the presence in the talks of respondents. In order to analyze the answers of respondents, used to discourse analysis proposed by Eni Orlandi (2009), in which it is observed and is an interpretation of the speech of teachers, considering their interpretation and how to shape their thinking on the research object. In analyzing the results of the survey, it was noted that the teachers interviewed know the importance and objectives of science fairs, however experience difficulties that often does not allow these events to be carried out. In seeking to assist them to minimize these difficulties, it was realized the need for a product to make available guidance on how to develop research projects and assemblies of science fairs, that would provide an education for the research. Thus, resulting from research, was set up a blog and a booklet with texts, articles and report templates.

La biblioteca del predicador Pere Dorchal (1419)

A partir del inventario post mortem de los libros de Pere Dorchal, sacerdote beneficiado en la catedral de Valencia, datado en 1419, se estudia la composición de la biblioteca de un predicador. Al mismo tiempo, se recompone su biografía.

El profeta Muḥammad confundido con un emperador romano. La errónea interpretación de una iluminación medieval

Un grabado frecuentemente usado para ilustrar la expulsión del pueblo judío decretada por los emperadores Adriano o Heraclio representa en realidad la predicación del profeta Muḥammad ante una asamblea de árabes y judíos. Este artículo identifica el manuscrito a partir del que se elaboró el grabado, propone la interpretación correcta de la imagen y explica el origen de la confusión.

Comparative Study of Four Portuguese 16th Century Illuminated Manueline Charters based on Spectroscopy and Chemometrics Analysis

The comparative study based on spectroscopic analysis of the materials used to produce four sixteenth-century Manueline Charters (the Charters of Alcochete, Terena, Alandroal and Evora) was performed following a systematic analytical approach. SEM–EDS, l-Raman and l-FTIR analysis highlighted interesting features between them, namely the use of different pigments and colourants (such as different green and yellow pigments), the presence of pigments alterations and the use of a non-expected extemporaneous material (with the presence of titanium white in the Charter of Alcochete). Principal component analysis restricted to the C–H absorption region (3000–2840 cm-1) was applied to 36 infrared spectra of blue historical samples from the Charters of Alcochete,Terena, Alandroal and Évora, suggesting the use of a mixture of a triglyceride and polysaccharide as binder.

Cristianismo en la sociedad indígena costarricense. Siglo XVI y XVII

ResumenEstudio acerca de los métodos misionales o de evangelización, las formas de predicación, la práctica sacramental y otras manifestaciones religiosas que caracterizaron la proyección religiosa franciscana entre 1563 y 1689.AbstractA study of the missionary and evangelizing methods, types of preaching sacraments and other religious expressions of Franciscan religious projection from 1563 and 1689.

Cristianismo en la sociedad indígena costarricense. Siglo XVI y XVII

ResumenEstudio acerca de los métodos misionales o de evangelización, las formas de predicación, la práctica sacramental y otras manifestaciones religiosas que caracterizaron la proyección religiosa franciscana entre 1563 y 1689.AbstractA study of the missionary and evangelizing methods, types of preaching sacraments and other religious expressions of Franciscan religious projection from 1563 and 1689.