FATS: a framework for annotation of travel blogs based on subjectivity

This paper describes a framework for annotation on travel blogs based on subjectivity (FATS). The framework has the capability to auto-annotate -sentence by sentence- sections from blogs (posts) about travelling in the Spanish language. FATS is used in this experiment to annotate com- ponents from travel blogs in order to create a corpus of 300 annotated posts. Each subjective element in a sentence is annotated as positive or negative as appropriate. Currently correct annotations add up to about 95 per cent in our subset of the travel domain. By means of an iterative process of annotation we can create a subjectively annotated domain specific corpus.

Herramienta Web para el modelado de consultas CEP (Complex Event Processing)

RESUMEN En los últimos años, debido al incremento en la demanda por parte de las empresas de tecnologías que posibiliten la monitorización y el análisis de un gran volumen de datos en tiempo real, la tecnología CEP (Complex Event Processing) ha surgido como una potencia en alza y su uso se ha incrementado notablemente en ciertos sectores como, por ejemplo, la gestión y automatización de procesos de negocios, finanzas, monitorización de redes y aplicaciones, así como redes de sensores inteligentes como el caso de estudio en el que nos centraremos. CEP se basa en un lenguaje de procesamiento de eventos (Event Processing Language,EPL) cuya utilización puede resultar bastante compleja para usuarios inexpertos. Esta complejidad supone un hándicap y, por lo tanto, un problema a la hora de que su uso se extienda. Este Proyecto Fin de Grado (PFG) pretende dar una solución a este problema, acercando al usuario la tecnología CEP mediante técnicas de abstracción y modelado. Para ello, este PFG ha definido un lenguaje de modelado específico dominio, sencillo e intuitivo para el usuario inexperto, al que se ha dado soporte mediante el desarrollo de una herramienta de modelado gráfico (CEP Modeler) en la que se pueden modelar consultas CEP de forma gráfica, sencilla y de manera más accesible para el usuario. ABSTRACT Over recent years, more and more companies demand technology for monitoring and analyzing a vast volume of data in real time. In this regard, the CEP technology (Complex Event Processing) has emerged as a novel approach to that end, and its use has increased dramatically in certain domains, such as, management and automation of business processes, finance, monitoring of networks and applications, as well as smart sensor networks as the case study in which we will focus. CEP is based on in the Event Processing Language (EPL). This language can be rather difficult to use for new users. This complexity can be a handicap, and therefore, a problem at the time of extending its use. This project aims to provide a solution to this problem, trying to approach the CEP technology to users through abstraction and modelling techniques. To that end, this project has defined an intuitive and simple domain-specific modelling language for new users through a web tool (CEP Modeler) for graphically modeling CEP queries, in an easier and more accessible way.

Generación automática de la configuración de subestaciones eléctricas según el Estándar IEC 61850 a partir de una herramienta de diseño gráfico

La evolución de las redes eléctricas se dirige hacia lo que se conoce como “Smart Grids” o “Redes Eléctricas Inteligentes”. Estas “Smart Grids” se componen de subestaciones eléctricas, que a su vez se componen de unos dispositivos llamados IEDs (Dispositivos Electrónicos Inteligentes – Intelligent Electronic Devices). El diseño de IEDs se encuentra definido en la norma IEC 61850, que especifica además un Lenguaje de Configuración de Subestaciones (Substation Configuration Language SCL) para la definición de la configuración de subestaciones y sus IEDs. Hoy en día, este estándar internacional no sólo se utiliza para diseñar correctamente IEDs y asegurar su interoperabilidad, sino que también se utiliza para el diseño de otros dispositivos de la red eléctrica, como por ejemplo, medidores inteligentes. Sin embargo, aunque existe una tendencia cada vez mayor del uso de este estándar, la comprensión y el manejo del mismo resulta difícil debido al gran volumen de información que lo compone y del nivel de detalle que utiliza, por lo que su uso para el diseño de IEDs se hace tedioso sin la ayuda de un soporte software. Es por ello que, para facilitar la aplicación del estándar IEC 61850 en el diseño de IEDs se han desarrollado herramientas como “Visual SCL”, “SCL Explorer” o “61850 SCLVisual Design Tool”. En concreto, “61850 SCLVisual Design Tool” es una herramienta gráfica para el modelado de subestaciones electricas, generada mediante el uso de los frameworks Eclipse Modeling Framework (EMF) y Epsilon Generative Modeling Technologies (GMT) y desarrollada por el grupo de investigación SYST de la UPM. El objetivo de este proyecto es añadir una nueva funcionalidad a la herramienta “61850 Visual SCL DesignTool”. Esta nueva funcionalidad consiste en la generación automática de un fichero de configuración de subestaciones eléctricas según el estándar IEC 61850 a partir de de una herramienta de diseño gráfico. Este fichero, se denomina SCD (Substation Configuration Description), y se trata de un fichero XML conforme a un esquema XSD (XML Schema Definition) mediante el que se define el lenguaje de configuración de subestaciones SCL del IEC 61850. Para el desarrollo de este proyecto, es necesario el estudio del lenguaje para la configuración de subestaciones SCL, así como del lenguaje gráfico específico de dominio definido por la herramienta “61850 SCLVisual Design Tool”, la estructura de los ficheros SCD, y finalmente, del lenguaje EGL (Epsilon Generation Language) para la transformación y generación automática de código a partir de modelos EMF. ABSTRACT Electrical networks are evolving to “Smart Grids”. Smart Grids are composed of electrical substations that in turn are composed of devices called IEDs (Intelligent Electronic Devices). The design of IEDs is defined by the IEC 61850 standard, which also specifies a Substation Configuration Languaje (SCL) used to define the configuration of substations and their IEDs. Nowadays, this international standard is not only used to design properly IEDs and guarantee their interoperability, but it is also used to design different electrical network devices, such as, smart meters. However, although the use of this standard is growing, its compression as well as its management, is still difficult due to its large volume of information and its level of detail. As a result, designing IEDs becomes a tedious task without a software support. As a consequence of this, in order to make easier the application of the IEC 61850 standard while designing IEDs, some software tools have been developed, such as: “Visual SCL”, “SCL Explorer” or “61850 SCLVisual Design Tool”. In particular, “61850 SCLVisual Design Tool” is a graphical tool used to make electrical substations models, and developed with the Eclipse Modeling Framework (EMF) and Epsilon Generative Modeling Technologies (GMT) by the research group SYST of the UPM. The aim of this project is to add a new functionality to “61850 Visual SCL DesignTool”. This new functionality consists of the automatic code generation of a substation configuration file according to the IEC 61850 standard. This file is called SCD (Substation Configuration Description), and it is a XML file that follows a XSD (XML Schema Definition) that defines the Substation Configuration Language (SCL) of the IEC 61850. In order to develop this project, it is necessary to study the Substation Configuration Language (SCL), the domain-specific graphical languaje defined by the tool “61850 SCLVisual Design Tool”, the structure of a SCD file, and the Epsilon Generation Language (EGL) used for the automatic code generation from EMF models

Production, specificity, and functionality of monoclonal antibodies to specific peptide–major histocompatibility complex class II complexes formed by processing of exogenous protein

Several unanswered questions in T cell immunobiology relating to intracellular processing or in vivo antigen presentation could be approached if convenient, specific, and sensitive reagents were available for detecting the peptide–major histocompatibility complex (MHC) class I or class II ligands recognized by αβ T cell receptors. For this reason, we have developed a method using homogeneously loaded peptide–MHC class II complexes to generate and select specific mAb reactive with these structures using hen egg lysozyme (HEL) and I-Ak as a model system. mAbs specific for either HEL-(46–61)–Ak or HEL-(116–129)–Ak have been isolated. They cross-react with a small subset of I-Ak molecules loaded with self peptides but can nonetheless be used for flow cytometry, immunoprecipitation, Western blotting, and intracellular immunofluorescence to detect specific HEL peptide–MHC class II complexes formed by either peptide exposure or natural processing of native HEL. An example of the utility of these reagents is provided herein by using one of the anti-HEL-(46–61)–Ak specific mAbs to visualize intracellular compartments where I-Ak is loaded with HEL-derived peptides early after antigen administration. Other uses, especially for in vivo tracking of specific ligand-bearing antigen-presenting cells, are discussed.

Neuregulins with an Ig-like domain are essential for mouse myocardial and neuronal development.

Neuregulins are ligands for the erbB family of receptor tyrosine kinases and mediate growth and differentiation of neural crest, muscle, breast cancer, and Schwann cells. Neuregulins contain an epidermal growth factor-like domain located C-terminally to either an Ig-like domain or a cysteine-rich domain specific to the sensory and motor neuron-derived isoform. Here it is shown that elimination of the Ig-like domain-containing neuregulins by homologous recombination results in embryonic lethality associated with a deficiency of ventricular myocardial trabeculation and impairment of cranial ganglion development. The erbB receptors are expressed in myocardial cells and presumably mediate the neuregulin signal originating from endocardial cells. The trigeminal ganglion is reduced in size and lacks projections toward the brain stem and mandible. We conclude that IgL-domain-containing neuregulins play a major role in cardiac and neuronal development.

Phage display selection of ligand residues important for Src homology 3 domain binding specificity.

The Src homology 3 (SH3) domain is a 50-aa modular unit present in many cellular proteins involved in intracellular signal transduction. It functions to direct protein-protein interactions through the recognition of proline-rich motifs on associated proteins. SH3 domains are important regulatory elements that have been demonstrated to specify distinct regulatory pathways important for cell growth, migration, differentiation, and responses to the external milieu. By the use of synthetic peptides, ligands have been shown to consist of a minimum core sequence and to bind to SH3 domains in one of two pseudosymmetrical orientations, class I and class II. The class I sites have the consensus sequence ZP(L/P)PP psi P whereas the class II consensus is PP psi PPZ (where psi is a hydrophobic residue and Z is a SH3 domain-specific residue). We previously showed by M13 phage display that the Src, Fyn, Lyn, and phosphatidylinositol 3-kinase (PI3K) SH3 domains preferred the same class I-type core binding sequence, RPLPP psi P. These results failed to explain the specificity for cellular proteins displayed by SH3 domains in cells. In the current study, class I and class II core ligand sequences were displayed on the surface of bacteriophage M13 with five random residues placed either N- or C-terminal of core ligand residues. These libraries were screened for binding to the Src, Fyn, Lyn, Yes, and PI3K SH3 domains. By this approach, additional ligand residue preferences were identified that can increase the affinity of SH3 peptide ligands at least 20-fold compared with core peptides. The amino acids selected in the flanking sequences were similar for Src, Fyn, and Yes SH3 domains; however, Lyn and PI3K SH3 domains showed distinct binding specificities. These results indicate that residues that flank the core binding sequences shared by many SH3 domains are important determinants of SH3 binding affinity and selectivity.

A protein-binding domain, EH, identified in the receptor tyrosine kinase substrate Eps15 and conserved in evolution.

In this report we structurally and functionally define a binding domain that is involved in protein association and that we have designated EH (for Eps15 homology domain). This domain was identified in the tyrosine kinase substrate Eps15 on the basis of regional conservation with several heterogeneous proteins of yeast and nematode. The EH domain spans about 70 amino acids and shows approximately 60% overall amino acid conservation. We demonstrated the ability of the EH domain to specifically bind cytosolic proteins in normal and malignant cells of mesenchymal, epithelial, and hematopoietic origin. These observations prompted our search for additional EH-containing proteins in mammalian cells. Using an EH domain-specific probe derived from the eps15 cDNA, we cloned and characterized a cDNA encoding an EH-containing protein with overall similarity to Eps15; we designated this protein Eps15r (for Eps15-related). Structural comparison of Eps15 and Eps15r defines a family of signal transducers possessing extensive networking abilities including EH-mediated binding and association with Src homology 3-containing proteins.

Evaluating knowledge-based approaches to the multilingual extension of a temporal expression normalizer

The extension to new languages is a well known bottleneck for rule-based systems. Considerable human effort, which typically consists in re-writing from scratch huge amounts of rules, is in fact required to transfer the knowledge available to the system from one language to a new one. Provided sufficient annotated data, machine learning algorithms allow to minimize the costs of such knowledge transfer but, up to date, proved to be ineffective for some specific tasks. Among these, the recognition and normalization of temporal expressions still remains out of their reach. Focusing on this task, and still adhering to the rule-based framework, this paper presents a bunch of experiments on the automatic porting to Italian of a system originally developed for Spanish. Different automatic rule translation strategies are evaluated and discussed, providing a comprehensive overview of the challenge.

Algoritmos metaheurísticos en el problema del particionado hardware/software de sistemas embebidos

El particionado hardware/software es una tarea fundamental en el co-diseño de sistemas embebidos. En ella se decide, teniendo en cuenta las métricas de diseño, qué componentes se ejecutarán en un procesador de propósito general (software) y cuáles en un hardware específico. En los últimos años se han propuesto diversas soluciones al problema del particionado dirigidas por algoritmos metaheurísticos. Sin embargo, debido a la diversidad de modelos y métricas utilizadas, la elección del algoritmo más apropiado sigue siendo un problema abierto. En este trabajo se presenta una comparación de seis algoritmos metaheurísticos: Búsqueda aleatoria (Random search), Búsqueda tabú (Tabu search), Recocido simulado (Simulated annealing), Escalador de colinas estocástico (Stochastic hill climbing), Algoritmo genético (Genetic algorithm) y Estrategia evolutiva (Evolution strategy). El modelo utilizado en la comparación está dirigido a minimizar el área ocupada y el tiempo de ejecución, las restricciones del modelo son consideradas como penalizaciones para incluir en el espacio de búsqueda otras soluciones. Los resultados muestran que los algoritmos Escalador de colinas estocástico y Estrategia evolutiva son los que mejores resultados obtienen en general, seguidos por el Algoritmo genético.

Partición hardware software de un codificador JPEG utilizando escalador de colinas estocástico

La partición hardware/software es una etapa clave dentro del proceso de co-diseño de los sistemas embebidos. En esta etapa se decide qué componentes serán implementados como co-procesadores de hardware y qué componentes serán implementados en un procesador de propósito general. La decisión es tomada a partir de la exploración del espacio de diseño, evaluando un conjunto de posibles soluciones para establecer cuál de estas es la que mejor balance logra entre todas las métricas de diseño. Para explorar el espacio de soluciones, la mayoría de las propuestas, utilizan algoritmos metaheurísticos; destacándose los Algoritmos Genéticos, Recocido Simulado. Esta decisión, en muchos casos, no es tomada a partir de análisis comparativos que involucren a varios algoritmos sobre un mismo problema. En este trabajo se presenta la aplicación de los algoritmos: Escalador de Colinas Estocástico y Escalador de Colinas Estocástico con Reinicio, para resolver el problema de la partición hardware/software. Para validar el empleo de estos algoritmos se presenta la aplicación de este algoritmo sobre un caso de estudio, en particular la partición hardware/software de un codificador JPEG. En todos los experimentos es posible apreciar que ambos algoritmos alcanzan soluciones comparables con las obtenidas por los algoritmos utilizados con más frecuencia.

Flexible Framework for Real-Time Embedded Systems Based on Mobile Cloud Computing Paradigm

The development of applications as well as the services for mobile systems faces a varied range of devices with very heterogeneous capabilities whose response times are difficult to predict. The research described in this work aims to respond to this issue by developing a computational model that formalizes the problem and that defines adjusting computing methods. The described proposal combines imprecise computing strategies with cloud computing paradigms in order to provide flexible implementation frameworks for embedded or mobile devices. As a result, the imprecise computation scheduling method on the workload of the embedded system is the solution to move computing to the cloud according to the priority and response time of the tasks to be executed and hereby be able to meet productivity and quality of desired services. A technique to estimate network delays and to schedule more accurately tasks is illustrated in this paper. An application example in which this technique is experimented in running contexts with heterogeneous work loading for checking the validity of the proposed model is described.

Flexible processing architecture for maintaining QoS in embedded systems applications

Comunicación presentada en las V Jornadas de Computación Empotrada, Valladolid, 17-19 Septiembre 2014

Aviation English: Structure and Importance of an International Airborne Language

In today’s globalized world, air travel is one of the fastest growing markets. Millions of aircrafts take off and then touch down all around the world each day. This well-synchronized symphony, however, is much more complex than it seems, and communication – language - plays a crucial role during a plane’s journey. Misunderstandings and miscommunications can have disastrous effects, so the adoption of a standard phraseology to be used during flight is a means to overcome language barriers, avoid ambiguous expressions and guarantee a safe and effective operation of an aircraft. Little is known about the interaction that goes on between pilots and air traffic controllers (ATCOs), and even though the language of aviation is English, cockpit communication can be hard to understand for people who are not familiar with this specific language. The scope of this thesis is to examine the origins of this uncommon language, the characteristics and peculiarities of air communication and to shed a little light on this mystery called Aviation English.

General language abilities following management of childhood supratentorial tumour: Part 1

Background. To date few studies have investigated the impact of management for supratentorial tumour on the language abilities of children. In reporting children with brain tumour as part of a larger cohort of various aetiologies of brain injury, such studies have failed to differentiate between the causes of acquired childhood language disorders, or specifically report associated information relating to site and treatment. Material and methods. The present study examined the general language abilities of six children managed for supratentorial tumour, using a comprehensive standardized general language assessment battery, including receptive and expressive components, receptive vocabulary, and naming. Results. At a group level, children managed for supratentorial tumour performed below an individually matched control group in the area of general expressive language. However, at an individual case level it was revealed that only two cases exhibited specific language deficits. Reduced performance in the area of expressive language and syntax was evident in the language profile of one child treated surgically for a left parietal astrocytoma, while a child treated surgically for an optic nerve glioma demonstrated difficulties in receptive semantic abilities. The remaining four cases with similar treatments and locations demonstrated intact general language abilities. Conclusions. Factors such as site, long-term presence of tumour prior to diagnosis, young age at diagnosis, and variations in time post treatment were considered to have contributed to the findings. The need for long-term monitoring of language abilities post treatment as well as larger group sizes and the investigation of higher-level abilities was highlighted

Beyond verbal fluency: Investigating the long-term effects of bilateral subthalamic (STN) deep brain stimulation (DBS) on language in two cases

Cognitive functioning has been described as largely impervious to chronic STN-DBS administered over 12-month periods. In relation to the domain of language, however, the effects of STN-DBS are yet to be thoroughly delineated. Verbal fluency tasks represent an almost exclusively applied index of linguistic proficiency relative to neuropsychological research within this population. Comprehensive investigations of the impact of STN-DBS on language function, however, have never been undertaken. The more precise elucidation of the role of the STN in the mediation of language processes, by way of assessments which probe language comprehension and production mechanisms, served as the primary focus of this research. Longitudinal analysis also afforded consideration of the way in which cognitive-linguistic circuits respond to STN-DBS over time. Bilateral STN-DBS primarily effected clinically reliable fluctuations (i.e., both improvements and declines) in performance in both subjects on tasks demanding cognitive-linguistic flexibility in the formulation and comprehension of complex language. Of particular note, both subjects demonstrated a cumulative increase in the proportion of reliable post-operative improvements achieved over time. The findings of this research lend support to models of subcortical participation in language which endorse a role for the STN, and suggest that bilateral STN-DBS may serve to enhance the proficiency of basal ganglia-thalamocortical linguistic circuits over time.