Isla de Fuerteventura, Canary Islands, Spain, 1779 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Mapa de la isla de Fuerteventura, por Don Tomás Lopez, geografo de los dominios de S. M. de las Reales academias de la historia, de San Fernando, de la de buenas letras de Sevilla y de la Sociedad Bascongada de los amigos del pais. It was published by se hallará este con todas las obras del autor en la Calle de las Carretas entrando por la Plazuela del Angel in 1779. Scale [ca. 1:280,000]. Covers Isla de Fuerteventura, Canary Islands, Spain. Map in Spanish.The image inside the map neatline is georeferenced to the surface of the earth and fit to the World Mercator projected coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as drainage, villages and other human settlements, roads, shoreline features, ports and anchorage points, and more. Relief shown by hachures. Includes note on the mapping of Fuerteventura.This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of originators, ground condition dates, scales, and map purposes.

Isla de Lanzarote, Canary Islands, Spain, 1779 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Mapa de la isla de Lanzarote, por Don Tomás Lopez, geografo de los dominios de S. M., de las Reales academias de la historia, de San Fernando, de la de buenas letras de Sevilla y de la Sociedad Bascongada de los amigos del pais. It was published by se hallará este con todas las obras del autor en la Calle de las Carretas entrando por la Plazuela del Angel in 1779. Scale [ca. 1:280,000]. Covers Isla de Lanzarote, Canary Islands, Spain. Map in Spanish.The image inside the map neatline is georeferenced to the surface of the earth and fit to the World Mercator projected coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as drainage, land cover, villages and other human settlements, roads, shoreline features, ports and anchorage points, and more. Relief shown by hachures. Includes note on the mapping of Lanzarote and inset map: Mapa de la isla de del Hierro.This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of originators, ground condition dates, scales, and map purposes.

Isla de Tenerife, Canary Islands, Spain, 1779 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Mapa de la isla de Tenerife, por Don Tomás Lopez, geografo de los dominios de S. M., de las Reales academias de la historia, de San Fernando, de la de buenas letras de Sevilla y de la Sociedad Bascongada de los amigos del pais. It was published by se hallará este con todas las obras del autor en la Calle de las Carretas entrando por la Plazuela del Angel in 1779. Scale [ca. 1:280,000]. Covers Isla de Tenerife, Canary Islands, Spain. Map in Spanish.The image inside the map neatline is georeferenced to the surface of the earth and fit to the World Mercator projected coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as drainage, land cover, cities and towns, villages and other human settlements, fortification and watch towers, roads, shoreline features, ports and anchorage points, and more. Relief shown by hachures. Includes note on the mapping of Tenerife.This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of originators, ground condition dates, scales, and map purposes.

Instruccion que puede servir para que se cure á los enfermos de las viruelas epidémicas, que ahora se padecen en México, desde finales del Estio, en el año corriente de 1779 ... /

Palau,

Observations de médecine, sur una fievre épidémique qui a régné dans le Champsaur & le Valgaudemar en Dauphiné, pendant les années 1779 & 1780 ... /

Mode of access: Internet.

Adam Oelenschläger. : Et livs poesi. Bind 1-3.

v. 1: Ungdom.--v. 2: Manddom og alderdom.--v. 3: Eftermäle

Histoire des Mongols, depuis Tchinguiz-Khan jusqu'a Timour-Lanc, avec une carte de l'Asie au XIIIe siècle. t.1

Mode of access: Internet.

Anyang xian zhi : 14 juan, juan shou : 1 juan.

Qing Qianlong 58 nian [1793] xiu.

Travels in Europe, Africa, and Asia, made between the years 1770 and 1779 /

Vol.4: Printed for F. and C. Rivington.

Ueber die parabel vom verwalter, Lukas XVI, 1 ff.

Mode of access: Internet.

Up-regulation Of Dnam-1 And Nkp30, Associated With Improvement Of Nk Cells Activation After Long-term Culture Of Mononuclear Cells From Patients With Ovarian Neoplasia.

This study aimed at evaluating the functional activation and activating receptors expression on resting, short- and long-term NK and NK-like T cells from blood of ovarian neoplasia patients. Blood from patients with adnexal benign alterations (n = 10) and ovarian cancer (grade I-IV n = 14) were collected after signed consent. Effector cells activation was evaluated by the expression of the CD107a molecule. Short-term culture was conducted overnight with IL-2 and long-term culture for 21 days, by a method designed to expand CD56(+) lymphocytes. Short-term culture significantly increased NK cells activation compared to resting NK cells (p<0.05), however, the long-term procedure supported an even higher increase (p<0.001). Resting NK-like T cells showed poor activation, which was not altered by the culture procedures. The long-term culture effectively increased the expression of the activating receptors on NK and NK-like T cells, either by increasing the number of cells expressing a given receptor and/or by up-regulating their expression intensity. As a conclusion, the long-term culture system employed, resulted in a high number of functional NK cells. The culture system was particularly efficient on the up-regulation of NKp30 and DNAM-1 receptors on NK cells.

Hypertrophic Adenoid Is A Major Infection Site Of Human Bocavirus 1.

Human bocavirus 1 (HBoV1) is associated with respiratory infections worldwide, mainly in children. Similar to other parvoviruses, it is believed that HBoV1 can persist for long periods of time in humans, probably through maintaining concatemers of the virus single-stranded DNA genome in the nuclei of infected cells. Recently, HBoV-1 was detected in high rates in adenoid and palatine tonsils samples from patients with chronic adenotonsillar diseases, but nothing is known about the virus replication levels in those tissues. A 3-year prospective hospital-based study was conducted to detect and quantify HBoV1 DNA and mRNAs in samples of the adenoids (AD), palatine tonsils (PT), nasopharyngeal secretions (NPS), and peripheral blood (PB) from patients undergoing tonsillectomy for tonsillar hypertrophy or recurrent tonsillitis. HBoV1 was detected in 25.3% of the AD samples, while the rates of detection in the PT, NPS, and PB samples were 7.2%, 10.5%, and 1.7%, respectively. The viral loads were higher in AD samples, and 27.3% of the patients with HBoV had mRNA detectable in this tissue. High viral loads and detectable mRNA in the AD were associated with HBoV1 detection in the other sample sites. The adenoids are an important site of HBoV1 replication and persistence in children with tonsillar hypertrophy. The adenoids contain high HBoV1 loads and are frequently positive for HBoV mRNA, and this is associated with the detection of HBoV1 in secretions.

A Putative Otu Domain-containing Protein 1 Deubiquitinating Enzyme Is Differentially Expressed In Thyroid Cancer And Identifies Less-aggressive Tumours.

This study aimed to identify novel biomarkers for thyroid carcinoma diagnosis and prognosis. We have constructed a human single-chain variable fragment (scFv) antibody library that was selected against tumour thyroid cells using the BRASIL method (biopanning and rapid analysis of selective interactive ligands) and phage display technology. One highly reactive clone, scFv-C1, with specific binding to papillary thyroid tumour proteins was confirmed by ELISA, which was further tested against a tissue microarray that comprised of 229 thyroid tissues, including: 110 carcinomas (38 papillary thyroid carcinomas (PTCs), 42 follicular carcinomas, 30 follicular variants of PTC), 18 normal thyroid tissues, 49 nodular goitres (NG) and 52 follicular adenomas. The scFv-C1 was able to distinguish carcinomas from benign lesions (P=0.0001) and reacted preferentially against T1 and T2 tumour stages (P=0.0108). We have further identified an OTU domain-containing protein 1, DUBA-7 deubiquitinating enzyme as the scFv-binding antigen using two-dimensional polyacrylamide gel electrophoresis and mass spectrometry. The strategy of screening and identifying a cell-surface-binding antibody against thyroid tissues was highly effective and resulted in a useful biomarker that recognises malignancy among thyroid nodules and may help identify lower-risk cases that can benefit from less-aggressive management.