Colombes, 17/2/20, match France contre Pays de Galles [rugby, les spectateurs dans les tribunes] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 58068

Colombes, 17/2/20, match France contre Pays de Galles [rugby, les spectateurs dans les tribunes] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 58067

14/2/20, stade Jean Bouin, Probables contre Possibles [hockey sur gazon féminin] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57989

Stade Elisabeth, 29/2/20, Fémina sport contre Académia [football féminin] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 58272

Parc des Princes, 29/2/20, rugby, RCF [Racing Club de France] contre Bayonne : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 58268

Stade Elisabeth, 29/2/20, Fémina sport contre Académia [football féminin] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 58273

14/2/20, stade Jean Bouin, Probables contre Possibles [hockey sur gazon féminin] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57993

Stade Elisabeth, 29/2/20, Fémina sport contre Académia [football féminin] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 58274

Parc des Princes, 29/2/20, rugby, RCF [Racing Club de France] contre Bayonne : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 58263

Suicide after successful deep brain stimulation for movement disorders.

The authors observed a high rate of suicide (6/140 patients, 4.3%) in a large cohort of patients with movement disorders treated with deep brain stimulation (DBS). Apparent risk factors included a previous history of severe depression and multiple successive DBS surgeries, whereas there was no relationship with the underlying condition, DBS target, electrical parameters, or modifications of treatment. Paradoxically, all patients experienced an excellent motor outcome following the procedure. The authors propose that patients at high risk for suicide should be excluded from DBS surgery.

25-12-19, stade Bergeyre football rugby, équipe du Stadoceste tarbais [qui va jouer contre l'équipe de l'Olympique de Paris] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57319

25-12-19, stade Bergeyre, rugby, équipe du Stadoceste tarbais [qui va jouer contre l'équipe de l'Olympique] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57320

Die epidurale Rückenmarkstimulation (SCS) zur Therapie peripherer arterieller Durchblutungsstörungen [Spinal cord stimulation (SCS) in the treatment of peripheral arterial occlusive disease]

Spinal cord stimulation (SCS) represents a well established procedure in the treatment of critical ischemia of the extremities. The knowledge and distribution of SCS in Austria are still poor despite satisfactory data. The evaluations and recommendations from the consensus group demonstrate that SCS might represent a suitable additional treatment option for selected patients with peripheral arterial disease (PAD) when performed in experienced centers under clear indications. The complication rate is low and mainly due to device-related problems. There are valid scientific criteria proving that SCS treatment can reduce the risk of amputation, decrease pain and improve wound healing in patients with non-reconstructable, non-unstable PAD in stages IV and V according to Rutherford (stages III and IV according to Fontaine).This effect is more evident when patient selection is based on tcPO(2) measurements. A careful selection of patients is essential for the success of this neuromodulatory treatment, in addition a certain degree of patient compliance in terms of perception and understanding of the therapy is mandatory.

Stimulation of ENaC activity by rosiglitazone is PPARγ-dependent and correlates with SGK1 expression increase.

Thiazolidinediones (TZDs) are peroxisome proliferator-activated receptor gamma (PPARγ) agonists used to treat type 2 diabetes. TZD treatment induces side effects such as peripheral fluid retention, often leading to discontinuation of therapy. Previous studies have shown that PPARγ activation by TZD enhances the expression or function of the epithelial sodium channel (ENaC) through different mechanisms. However, the effect of TZDs on ENaC activity is not clearly understood. Here, we show that treating Xenopus laevis oocytes expressing ENaC and PPARγ with the TZD rosiglitazone (RGZ) produced a twofold increase of amiloride-sensitive sodium current (Iam), as measured by two-electrode voltage clamp. RGZ-induced ENaC activation was PPARγ-dependent since the PPARγ antagonist GW9662 blocked the activation. The RGZ-induced Iam increase was not mediated through direct serum- and glucocorticoid-regulated kinase (SGK1)-dependent phosphorylation of serine residue 594 on the human ENaC α-subunit but by the diminution of ENaC ubiquitination through the SGK1/Nedd4-2 pathway. In accordance, RGZ increased the activity of ENaC by enhancing its cell surface expression, most probably indirectly mediated through the increase of SGK1 expression.