Design of a systematic approach to workplace exposure medical surveillance protocols

Current toxic tort cases have increased national awareness of health concerns and present an important avenue in which public health scientists can perform a vital function: in litigation, and in public health initiatives and promotions which may result. This review presents a systematic approach, using the paradigm of interactive public health disciplines, for the design of a matrix framework for medical surveillance of workers exposed to toxic substances. The matrix framework design addresses the required scientific bases to support the legal remedy of medical monitoring for workers injured as a result of their exposure to toxic agents. A background of recent legal developments which have a direct impact on the use of scientific expertise in litigation is examined in the context of toxic exposure litigation and the attainment of public health goals. The matrix model is applied to five different workplace exposures: dental mercury, firefighting, vinyl chloride manufacture, radon in mining and silica. An exposure matrix designed by the Department of Energy for government nuclear workers is included as a reference comparison to the design matrix. ^

A level II reliability approach to tunnel support design

A reliability approach to tunnel support design is presented in this paper. The aim of the work is the incorporation of classical Level II techniques to the current design method based on the study of the ground-support interaction diagram.

Approach to integrate product conceptual design information into a computer-aided design system

Commercial computer-aided design systems support the geometric definition of product, but they lack utilities to support initial design stages. Typical tasks such as customer need capture, functional requirement formalization, or design parameter definition are conducted in applications that, for instance, support ?quality function deployment? and ?failure modes and effects analysis? techniques. Such applications are noninteroperable with the computer-aided design systems, leading to discontinuous design information flows. This study addresses this issue and proposes a method to enhance the integration of design information generated in the early design stages into a commercial computer-aided design system. To demonstrate the feasibility of the approach adopted, a prototype application was developed and two case studies were executed.

Design equations for reinforced concrete members strengthened in shear with external FRP reinforcement formulated in an evolutionary multi-objective framework

Methods for predicting the shear capacity of FRP shear strengthened RC beams assume the traditional approach of superimposing the contribution of the FRP reinforcing to the contributions from the reinforcing steel and the concrete. These methods become the basis for most guides for the design of externally bonded FRP systems for strengthening concrete structures. The variations among them come from the way they account for the effect of basic shear design parameters on shear capacity. This paper presents a simple method for defining improved equations to calculate the shear capacity of reinforced concrete beams externally shear strengthened with FRP. For the first time, the equations are obtained in a multiobjective optimization framework solved by using genetic algorithms, resulting from considering simultaneously the experimental results of beams with and without FRP external reinforcement. The performance of the new proposed equations is compared to the predictions with some of the current shear design guidelines for strengthening concrete structures using FRPs. The proposed procedure is also reformulated as a constrained optimization problem to provide more conservative shear predictions.

System Engineering Approach to Initial Design of LEO Remote Sensing Missions

The satellite remote sensing missions are essential for long-term research around the condition of the earth resources and environment. On the other hand, in recent years the application of microsatellites is of interest in many space programs for their less cost and response time. In microsatellite remote sensing missions there are tight interrelations between different requirements such as orbital altitude, revisit time, mission life and spatial resolution. Also, all of these requirements can affect the whole system level design characteristics. In this work, the remote sensing microsatellite sizing process is divided into three major design disciplines; a) orbit design, b) payload sizing and c) bus sizing. Finally, some specific design cases are investigated inside the design space for evaluating the effect of different design variables on the satellite total mass. Considering the results of the work, it is concluded that applying a systematic approach at the initial design phase of such projects provides a good insight to the not clearly seen interactions inside their highly extended design space

An agent-based approach for the design of the future european air traffic management system

This paper describes an agent-based approach for the simulation of air traffic management (ATM) in Europe that was designed to help analyze proposals for future ATM systems. This approach is able to represent new collaborative deci-sion processes for flow traffic management, it uses an intermediate level of ab-straction (useful for simulations at larger scales), and was designed to be a practi-cal tool (open and reusable) for the development of different ATM studies. It was successfully applied in three studies related to the design of future ATM systems in Europe.

An integrated approach to conceptual design of arch bridges with curved deck

El concepto de funicularidad se puede extender a estructuras lineales espaciales como, por ejemplo, los puentes arco con tablero curvo. Estas estructuras, especialmente pasarelas peatonales, son consecuencia de la necesidad de encajar trazados exigentes y de dar respuesta a nuevas demandas arquitectónicas. En las estructuras curvas el diseño conceptual juega un papel absolutamente esencial. Siempre ha sido así, pero en el caso presente, cabe resaltar que una errónea elección de la geometría conlleva una serie de problemas que se irán acumulando a lo largo del proceso de proyecto, de la construcción y de la vida de la estructura. En este trabajo se presenta SOFIA (Shaping Optimal Form with an Interactive Approach), una herramienta capaz de, conocida la geometría del tablero, de buscar automáticamente la forma del arco antifunicular correspondiente. El planteamiento seguido es conceptualmente el mismo que el utilizado en la búsqueda de formas óptimas en estructuras en dos dimensiones: el arco antifunicular es el que representa, para unas cargas dadas, el lugar geométrico de los puntos con momento flector nulo. La herramienta ha sido desarrollada en un entorno integrado, interactivo y paramético. Su implementación está ilustrada y unos ejemplos de análisis paramétricos están desarrollados. La posición transversal relativa entre tablero y arco ha sido investigada para obtener la configuración del puente estructuralmente más eficiente. Las pasarelas curvas se han convertido en un problema de ingeniería más común de lo habitual en el contexto de los desarrollos urbanos cuando el cliente está buscando un fuerte componente estético: un diseño conceptual adecuado permite obtener una estructura eficiente y elegante. Spatial arch bridges represent an innovative answer to demands on functionality, structural optimization and aesthetics for curved decks, popular in urban contexts. This thesis presents SOFIA (Shaping Optimal Form with an Interactive Approach), a methodology for conceptual designing of antifunicular spatial arch bridges with curved deck in a parametric, interactive and integrated environment. The approach and its implementation are in-depth described and detailed examples of parametric analyses are illustrated. The optimal deck-arch relative transversal position has been investigated for obtaining the most cost-effective bridge. Curved footbridges have become a more common engineering problem in the context of urban developments when the client is looking for a strong aesthetics component: an appropriate conceptual design allows to obtain an efficient and elegant structure.

Probabilistic approach for longitudinal ventilation system design in fire situations

The main objective of ventilation systems in tunnels is to reach the highest possible safety level both in service and fire situation; being the fire one, the most relevant when designing the system. When designing a longitudinal ventilation system, the methodology to evaluate the capacity of the system is similar both in service and fire situation, with the exception of the chimney effect and the phenomena of thermal transfer which is responsible or the changes in the density of the air. When facing the dimensioning task for longitudinal ventilated tunnels, although similar methodologies are used in different countries, specific hypothesis (aerodynamic, thermal properties, traffic) even if discussed in the literature or current practice, are not usually detailed in the regulations or recommendations. The aim of this paper is to propose a probabilistic approach to the problem which would allow the designer, and the tunnel owner, to understand the uncertainty and sensibility adopted in the results and, eventually, identify possible ways of optimizing the ventilation solution to be adopted.

Towards an Active Design. An Approach on the Body Interaction with the Built Environment.

El impacto de la tecnología en el ambiente construido y en las actividades en él desarrolladas, es una de las causas de la progresiva sedentarización de la especie humana. Desde un enfoque que analiza la interacción del cuerpo con la arquitectura, a través de distintas referencias en escalas diversas, esta investigación intenta establecer la relación entre la evolución del ambiente pasivo y la sedentarización, proponiendo frente a un espacio mecanizado y digitalizado que disminuye la actividad física humana, la búsqueda de nuevos tipos de espacios arquitectónicos que promuevan el movimiento repercutiendo en el bienestar y la salud. Esta tesis estudia por tanto el impacto de la tecnología en el espacio, intentando aproximarse a estrategias que disminuyan el efecto pasivo y estimulen la actividad motora. Estas propuestas abarcan tanto la ciudad, como la edificación y el propio espacio doméstico afectando a los sistemas de circulación, a la configuración espacial y sobre todo a la incorporación de ”espacios activos”, en donde se contempla la posibilidad de un uso alternativo de la tecnología como un elemento positivo.

Design of Reinforcement in Concrete Shells: a unified Approach

The problem of design/verification of reinforcement in concrete shells is reviewed. Methods of analysis are classified, and the elastic-plastic approach is described in detail in the general case of shells subjected to both bending and membrane action. The procedure is then reduced to membrane shells (applicable also to concrete walls) and to pure bending, as in the case of plates. The procedure, which is based on previous research,generally requires the use of a desk-top computer.

A system of systems engineering approach to design new smarter and energy efficient products

The concept of smartness of energy efficient products and systems from a business perspective has been investigated by several authors. The problem of understanding, designing, engineering and governing these technologies requires new concepts. The emergence of these modern technologies causes a myriad of interconnected systems, which are working together to satisfy the necessities of modern life. The problem of understanding, designing, engineering, and governing these technologies requires new concepts. Development of System of System Engineering (SoSE) is an attempt by the systems engineering and science community to fulfill this requirement.

Library of libraries: approach to synthetic combinatorial library design and screening of "pharmacophore" motifs.

Construction of synthetic combinatorial libraries is described that allows for the generation of a library of motifs rather than a library of compounds. Peptide libraries based on this strategy were synthesized and screened with model targets streptavidin and anti-beta-endorphin antibody. The screens resulted in observation of expected motifs providing evidence of the effectiveness of the suggested approach.

Modified PNA design and synthesis: a novel approach using Molecular Dynamics and Metadynamics

Gli acidi peptido nucleici sono potenti strumenti utilizzati in ambito biotecnologico per colpire DNA o RNA. PNA contenenti basi o backbone modificati sono attualmente studiati per migliorarne le proprietà in ambito biologico. Bersagliare i micro RNA (anti-miR) è particolarmente interessante nell’ottica di future applicazioni terapeutiche, ma strumenti computazionali che aiutino nel design di nuovi PNA anti-miR non sono stati ancora completamente sviluppati. Le proprietà conformazionali del singolo filamento di PNA (non modificato o recante modificazioni in γ) e dei duplex PNA:RNA e i processi di re-annealing e melting sono stati studiati tramite Dinamica Molecolare e Metadinamica. L’approccio computazionale consolidato, assieme a un programma modificato per la generazione delle strutture dei duplex contenenti PNA, è stato utilizzato per il virtual screening di PNA contenenti basi modificate. Sono state inoltre sintetizzate le unità per l’ottenimento del composto più promettente e una funzione idrolitica da legare al monomero finale.

A novel hybrid simulation-optimization approach for the optimal design of multicomponent distillation columns

Póster presentado en Escape 22, European Symposium on Computer Aided Process Engineering, University College London, UK, 17-20 June 2012.

A hybrid simulation-optimization approach for the design of internally heat-integrated distillation columns

Paper submitted to AIChE 2012 Annual Meeting: Energy Efficiency by Process Intensification, Pittsburgh, PA, October 28-November 2, 2012.