Annual report of the Secretary of the State Board of Agriculture of the State of Michigan ...

18

L-arginine may mediate the therapeutic effects of low protein diets.

We have previously shown beneficial effects of dietary protein restriction on transforming growth factor beta (TGF-beta) expression and glomerular matrix accumulation in experimental glomerulonephritis. We hypothesized that these effects result from restriction of dietary L-arginine intake. Arginine is a precursor for three pathways, the products of which are involved in tissue injury and repair: nitric oxide, an effector molecule in inflammatory and immunological tissue injury; polyamines, which are required for DNA synthesis and cell growth; and proline, which is required for collagen production. Rats were fed six isocaloric diets differing in L-arginine and/or total protein content, starting immediately after induction of glomerulonephritis by injection of an antibody reactive to glomerular mesangial cells. Mesangial cell lysis and monocyte/macrophage infiltration did not differ with diet. However, restriction of dietary L-arginine intake, even when total protein intake was normal, resulted in decreased proteinuria, decreased expression of TGF-beta 1 mRNA and TGF-beta 1 protein, and decreased production and deposition of matrix components. L-Arginine, but not D-arginine, supplementation to low protein diets reversed these effects. These results implicate arginine as a key component in the beneficial effects of low protein diet.

Annual report of the Secretary of the State Board of Agriculture of the State of Michigan ...

48

Agriculture of Maine. ... annual report of the Secretary of the Maine Board of Agriculture.

1878

Memorial to the Harvard Board of Overseers, 1822 April

Two drafts of a letter.

Memorial to the Harvard Board of Overseers, 1823 November 3

Five drafts of a letter.

Minutes of the Proceedings of the Board of Overseers of Harvard College, 1775-1776

This is a small, paper-bound "waste book" containing minutes taken by the Secretary pro tempore, Samuel Cooke, at meetings held on the following dates: July 31, 1775; August 8, 1775; August 22, 1775; September 5, 1775; October 3, 1775; October 23, 1775 (fragmentary); November 5, 1775; April 16, 1776; and April 23, 1776. Because these meetings took place during the American Revolutionary War, they were held in the "Council chamber at Watertown."

Annual report of the Director to the Board of Trustees for the year ... / Field Museum of Natural History

9, no. 2

Annual report of the Director to the Board of Trustees for the year ... / Field Museum of Natural History

10, no. 2

Annual report of the Director to the Board of Trustees for the year ... / Field Museum of Natural History

5, no. 6

Annual report of the Director to the Board of Trustees for the year ... / Field Museum of Natural History

6, no. 1

Annual report of the Director to the Board of Trustees for the year ... / Field Museum of Natural History

3, no. 2