Os Estudos Africanos no Desenvolvimento da Biblioteca Norte/Sul (BN/S) do Centro de Estudos Sociais (CES) da Universidade de Coimbra

Esta comunicação pretende constituir uma partilha das dinâmicas de apoio à pesquisa especializada e das interacções desenvolvidas pela Biblioteca Norte/Sul (BN/S) no contexto da criação de um espaço teórico alternativo não limitado às influências culturais ocidentais. A BN/S apoia a missão do Centro de Estudos Sociais (CES) da Faculdade de Economia da Universidade de Coimbra acompanhando o seu planeamento estratégico, tendo também o compromisso de apoiar a investigação dos projectos, dos núcleos e dos programas de doutoramento da instituição, alguns ministrados em parceria com as Faculdades de Direito, de Economia e de Letras. A “clientela” é – na sua grande maioria – investigadores permanentes, investigadores juniores, doutorandos, pós-doutorandos e alunos integrados em parcerias com universidades brasileiras, em particular, e com as universidades angolanas, cabo-verdianas, goesas, guineenses, moçambicanas, entre outras. A BN/S pretende criar um acervo – prioritariamente constituído por monografias e publicações periódicas – resultante da produção científica realizada nos países do hemisfério Sul – na área das ciências sociais e humanas, englobando um amplo espectro de temas. Pretende-se, assim, com esta comunicação partilhar a experiência da BN/S, resultante da necessidade de melhorar sobretudo a qualidade das publicações sobre estudos africanos, adquiridas com o intuito de apoiar o Programa de Doutoramento “Pós-colonialismo e cidadania global” que abrange temas tão diversos como Justiça, Cidadania, Religião, Feitiçaria, Conhecimentos alternativos, Literatura, etc.

IL-28A (IFN-λ2) modulates lung DC function to promote Th1 immune skewing and suppress allergic airway disease.

IL-28 (IFN-λ) cytokines exhibit potent antiviral and antitumor function but their full spectrum of activities remains largely unknown. Recently, IL-28 cytokine family members were found to be profoundly down-regulated in allergic asthma. We now reveal a novel role of IL-28 cytokines in inducing type 1 immunity and protection from allergic airway disease. Treatment of wild-type mice with recombinant or adenovirally expressed IL-28A ameliorated allergic airway disease, suppressed Th2 and Th17 responses and induced IFN-γ. Moreover, abrogation of endogenous IL-28 cytokine function in IL-28Rα(-/-) mice exacerbated allergic airway inflammation by augmenting Th2 and Th17 responses, and IgE levels. Central to IL-28A immunoregulatory activity was its capacity to modulate lung CD11c(+) dendritic cell (DC) function to down-regulate OX40L, up-regulate IL-12p70 and promote Th1 differentiation. Consistently, IL-28A-mediated protection was absent in IFN-γ(-/-) mice or after IL-12 neutralization and could be adoptively transferred by IL-28A-treated CD11c(+) cells. These data demonstrate a critical role of IL-28 cytokines in controlling T cell responses in vivo through the modulation of lung CD11c(+) DC function in experimental allergic asthma. →See accompanying Closeup by Michael R Edwards and Sebastian L Johnston http://dx.doi.org/10.1002/emmm.201100143.

Selective accumulation of mature DC-Lamp+ dendritic cells in tumor sites is associated with efficient T-cell-mediated antitumor response and control of metastatic dissemination in melanoma.

The clinical relevance of dendritic cells (DCs) at the tumor site remains a matter of debate concerning their role in the generation of effective antitumor immunity in human cancers. We performed a comprehensive immunohistochemical analysis using a panel of DC-specific antibodies on regressing tumor lesions and sentinel lymph nodes (SLNs) in melanoma patients. Here we show in a case report involving spontaneous regression of metastatic melanoma that the accumulation of DC-Lamp+ DCs, clustered with tumor cells and lymphocytes, is associated with local expansion of antigen-specific memory effector CTLs. These findings were extended in a series of 19 melanoma-positive SLNs and demonstrated a significant correlation between the density of DC-Lamp+ DC infiltrates in SLNs with the absence of metastasis in downstream lymph nodes. This study, albeit performed in a limited series of patients, points to a pivotal role of mature DCs in the local expansion of efficient antitumor T-cell-mediated immune responses at the initial sites of metastasis and may have important implications regarding the prognosis, staging, and immunotherapy of melanoma patients.

Carte itinéraire d'Espagne et de Portugal : Indiquant les différentes espèces de Routes et les distances de villes à autres, en lieues de postes de ces Royaumes / par Desimencourt

Échelle(s) : [ca 1:1 600 000]

Histoire nouvelle du nouveau monde : contenant en somme ce que les Hespagnols ont fait jusqu'à présent aux Indes occidentales, & le rude traitement qu'ils font à ces poures peuples là : ensemble, une petite histoire d'un massacre commis par les Hespagnols sur quelques François en la Floride, avec un indice des choses les plus remarquables / extraite de l'italien de M. Hierosme Benzoni... par M. Urbain Chauveton ; par M. Urbain Chauveton

Comprend : Brief discours et histoire d'un voyage de quelques François en Floride : & du massacre autant injustement que barbarement executé sur eux, par les Hespagnols, l'an mil cinq cens soixante cinq