A beta-adrenergic receptor kinase-like enzyme is involved in olfactory signal termination.

We have previously shown that second-messenger-dependent kinases (cAMP-dependent kinase, protein kinase C) in the olfactory system are essential in terminating second-messenger signaling in response to odorants. We now document that subtype 2 of the beta-adrenergic receptor kinase (beta ARK) is also involved in this process. By using subtype-specific antibodies to beta ARK-1 and beta ARK-2, we show that beta ARK-2 is preferentially expressed in the olfactory epithelium in contrast to findings in most other tissues. Heparin, an inhibitor of beta ARK, as well as anti-beta ARK-2 antibodies, (i) completely prevents the rapid decline of second-messenger signals (desensitization) that follows odorant stimulation and (ii) strongly inhibits odorant-induced phosphorylation of olfactory ciliary proteins. In contrast, beta ARK-1 antibodies are without effect. Inhibitors of protein kinase A and protein kinase C also block odorant-induced desensitization and phosphorylation. These data suggest that a sequential interplay of second-messenger-dependent and receptor-specific kinases is functionally involved in olfactory desensitization.

Fertilización y estres salino en plantas ornamentales anuales

p.93-100

Relaciones suelo planta de crisantemos (Dendranthema grandiflora) en maceta

p.365-372

Presencia de una microflora patógena en lotes comerciales de Syngonium podophyllum

p.145-148

Calibración de la tecnología de forzado de bulbos en Iris x hollandica Hoog para su cultivo como flor de corte en el norte de la provincia de Buenos Aires

p.189-197

Respuestas morfo fisiológicas en Aglaonema Commutatum ante cambios en la intensidad y calidad de la luz

p.113-126

Nuevo retardante del crecimiento (Uniconazole) para el cultivo del crisantemo para corte

p.137-143

Diagnóstico de la fertilidad en rosas para corte mediante análisis foliares

p.229-234

Efecto de los cotiledones y el uso de semilla híbrida en brócoli (Brassica oleracea var. italica L.)

p.177-187

Rutinas de fertilización de plantas ornamentales anuales en contenedores pequeños

p.89-98

Efecto de la densidad de plantación sobre la productividad comercial en rosas para corte

p.7-12

Análisis de productividad y calidad comercial en plantas de rosa para corte injertadas sobre dos nuevos patrones

p.141-146

Return of deposits

Explores case law illustrating the circumstances in which the courts are likely to order the return of a deposit in the event of a buyer's default. Notes the unwillingness of the courts to apply the rule on penalties to deposits and discusses the court's discretion under the Law of Property Act 1925 s.49(2) to order repayment. Focuses on the Chancery Division ruling in Aribisala v St James Homes (Grosvenor Dock) Ltd giving guidance on the circumstances in which the discretion under s.49(2) should be exercised.

Thermoelectric MHD effects on equiaxed crystal morphology

The effects of a constant uniform magnetic field on a growing equiaxed crystal are investigated using a 3-dimensional enthalpy based numerical model. Two cases are considered: The first case looks at unconstrained growth, where the current density is generated through the thermo-electric effect and the current circulates between the tips and roots of the dendrite, the second represents an imposed potential difference across the domain. A jump in the electrical conductivity between the liquid and solid causes the current density to be non uniform. In both cases the resulting Lorentz force drives fluid flow in the liquid phase, this in turn causes advection of the thermal and solute field altering the free energy close to the interface and changing the morphology of the dendrite. In the first case the flow field is complex comprising of many circulations, the morphological changes are modelled using a 2D model with a quasi 3D approximation. The second case is comparable to classic problems involving a constant velocity boundary.