Direct support and general support maintenance manual : generator set, 7.5KW, 28V, DC, G.E.D., air cooled, 2 wheel MTD, pneumatic tires, John R. Hollingsworth model JHGV7.5A, FSN 6115-074-6396.

Includes index.

Organizational, direct, and general support maintenance repair parts and special tools list : generator set, 7.5 KW, 28 V, DC, GED, air cooled, 2 wheel mtd, pneumatic tires (John R. Hollingsworth model JHGV7.5A), FSN 6115-074-6396.

Includes index.

Organizational maintenance manual : telegraph terminal TH-5/TG (NSN 5805-00-315-2858), TH-5A/TG (NSN 5805-00-246-8734).

Includes index.

Direct support and general support maintenance repair parts and special tools lists ... : terminals, telegraph TH-5/TG (FSN 5805-246-8734) and TH-5A/TG (FSN 5805-020-5720).

"31 July 1973."

Operator, organizational, direct support, general support, and depot maintenance manual, including repair parts and special tool lists : public address set AN/PIQ-5A.

"January 1969."

Organizational, direct support, and general support maintenance repair parts and special tools list ... for public address set AN/PIQ-5A (NSN 5830-00-985-9033).

"August 1976."

Hand receipt manual covering End Item/Components of End Item (COEI), Basic Issue Items (BII), and Additional Authorization List (AAL) for night vision goggles AN/PVS-5 and AN/PVS-5A, (NSN 5855-00-150-1820), line item number N04456.

"21 July 1979."

Organizational maintenance repair parts and special tools lists for radar sets AN/PPS-5 (NSN-5840-00-168-1567), AN/PPS-5A (NSN 5840-00-453-5662), and AN/PPS-5B (NSN 5840-01-009-4939).

"November 1978."

Direct support and general support maintenance repair parts and special tools lists ... for radar set AN/PPS-5A (NSN-5840-00-453-5662).

"September 1978."

Organizational, direct support , and general support maintenance repair parts and special tools list (including depot maintenance repair parts and special tools) for power supply/DC dual, (0-40VDC/0-1.5A), (NSN 6130-00-065-6811).

Includes index.

Operator's manual : radiosonde recorders, AN/TMQ-5 (NSN 6660-00-324-9426), AN/TMQ-5A (NSN 6660-00-393-2234), AN/TMQ-5B (NSN 6660-00-393-2234), AN/TMQ-5C (NSN 6660-00-682-4500).

Includes index.

Increased potency of a novel complement factor 5a receptor antagonist in a rat model of inflammatory bowel disease

We have previously shown that complement factor 5a(C5a) plays a role in the pathogenesis of 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis in rats by using the selective, orally active C5a antagonist AcF-[OP(D-Cha) WR]. This study tested the efficacy and potency of a new C5a antagonist, hydrocinnamate (HC)-[OP(D-Cha) WR], which has limited intestinal lumenal metabolism, in this model of colitis. Analogs of AcF-[OP(D-Cha) WR] were examined for their susceptibility to alimentary metabolism in the rat using intestinal mucosal washings. One metabolically stable analog, HC-[OP(D-Cha)WR], was then evaluated pharmacokinetically and investigated at a range of doses (0.03 - 10 mg/kg/ day p.o.) in the 8-day rat TNBS- colitis model, against the comparator drug AcF-[OP(D-Cha) WR]. Using various amino acid substitutions, it was determined that the AcF moiety of AcF-[OP(D-Cha) WR] was responsible for the metabolic instability of the compound in intestinal mucosal washings. The analog HC-[OP( D-Cha) WR], equiactive in vitro to AcF-[OP(D-Cha) WR], was resistant to intestinal metabolism, but it displayed similar oral bioavailability to AcF-[OP(D-Cha) WR]. However, in the rat TNBS- colitis model, HC-[OP(D-Cha) WR] was effective at reducing mortality, colon edema, colon macroscopic scores, and increasing food consumption and body weights, at 10- to 30- fold lower oral doses than AcF-[OP( D-Cha) WR]. These studies suggest that resistance to intestinal metabolism by HC-[OP(D-Cha) WR] may result in increased local concentrations of the drug in the colon, thus affording efficacy with markedly lower oral doses than AcF-[OP(D-Cha) WR] against TNBS-colitis. This large increase in potency and high efficacy of this compound makes it a potential candidate for clinical development against intestinal diseases such as inflammatory bowel disease.

Complement factor 5a as a therapeutic target

The complement system is an innate immune defense mechanism that protects the host from infection and injury. Complement activation results in the formation of anaphylatoxins, including the biologically active protein C5a. This anaphylatoxin is a potent chemotactic agent for immune and inflammatory cells and induces cell activation. In situations of excessive or uncontrolled complement activation, the overproduction of C5a can cause deleterious effects to the host, and this process is implicated in the pathogenesis of numerous immunoinflammatory disease states, including rheumatoid arthritis, psoriasis, inflammatory bowel disease, ischemia-reperfusion injuries and others. The presence of C5a in a wide variety of condition's has prompted many groups to examine the potential of inhibiting this complement activation product, with the aim of controlling these diseases and reducing the pathologic process. However, to date there is no clinically available specific C5a inhibitor and development of this new drug class is still in a relatively early stage, although limited phase I and phase II human clinical trials have been undertaken in the last few years with selected agents. In this review, examination of the current evidence supporting a specific role of C5a in selected disease states and an overview of potential therapeutic C5a inhibitors will enable the critical evaluation of the potential for C5a as a therapeutic target.

Liquid-phase adsorption of n-paraffins on type 5A molecular sieves

As a basis for the commercial separation of normal paraffins a detailed study has been made of factors affecting the adsorption of binary liquid mixtures of high molecular weight normal paraffins (C12, C16, and C20) from isooctane on type 5A molecular sieves. The literature relating to molecular sieve properties and applications, and to liquid-phase adsorption of high molecular weight normal paraffin compounds by zeolites, was reviewed. Equilibrium isotherms were determined experimentally for the normal paraffins under investigation at temperatures of 303oK, 323oK and 343oK and showed a non-linear, favourable- type of isotherm. A higher equilibrium amount was adsorbed with lower molecular weight normal paraffins. An increase in adsorption temperature resulted in a decrease in the adsorption value. Kinetics of adsorption were investigated for the three normal paraffins at different temperatures. The effective diffusivity and the rate of adsorption of each normal paraffin increased with an increase in temperature in the range 303 to 343oK. The value of activation energy was between 2 and 4 kcal/mole. The dynamic properties of the three systems were investigated over a range of operating conditions (i.e. temperature, flow rate, feed concentration, and molecular sieve size in the range 0.032 x 10-3 to 2 x 10-3m) with a packed column. The heights of adsorption zones calculated by two independent equations (one based on a constant width, constant velocity and adsorption zone and the second on a solute material balance within the adsorption zone) agreed within 3% which confirmed the validity of using the mass transfer zone concept to provide a simple design procedure for the systems under study. The dynamic capacity of type 5A sieves for n-eicosane was lower than for n-hexadecane and n-dodecane corresponding to a lower equilibrium loading capacity and lower overall mass transfer coefficient. The values of individual external, internal, theoretical and experimental overall mass transfer coefficient were determined. The internal resistance was in all cases rate-controlling. A mathematical model for the prediction of dynamic breakthrough curves was developed analytically and solved from the equilibrium isotherm and the mass transfer rate equation. The experimental breakthrough curves were tested against both the proposed model and a graphical method developed by Treybal. The model produced the best fit with mean relative percent deviations of 26, 22, and 13% for the n-dodecane, n-hexadecane, and n-eicosane systems respectively.