Société du Double Quintette de Paris

Signatur des Originals: S 36/F06604

Zoning and the built environment: A public health analysis of zoning in Austin, Texas

The built environment is part of the physical environment made by people and for people. Because the built environment is such a ubiquitous component of the environment, it acts as an important pathway in determining health outcomes. Zoning, a type of urban planning policy, is one of the most important mechanisms connecting the built environment to public health. This policy analysis research paper explores how zoning regulations in Austin, Texas promote or prohibit the development of a healthy built environment. A systematic literature review was obtained from Active Living Research, which contained literature published about the relationships between the built environment, physical activity, and health. The results of these studies identified the following four components of the built environment that were associated to health: access to recreational facilities, sprawl and residential density, land use mix, and sidewalks and their walkability. A hierarchy analysis was then performed to demonstrate the association between these aspects of the built environment and health outcomes such as obesity, cardiovascular disease, and general health. Once these associations had been established, the components of the built environment were adapted into the evaluation criteria used to conduct a public health analysis of Austin's zoning ordinance. A total of eighty-eight regulations were identified to be related to these components and their varying associations to human health. Eight regulations were projected to have a negative association to health, three would have both a positive and negative association simultaneously, and nine were indeterminable with the information obtained through the literature review. The remaining sixty-eight regulations were projected to be associated in a beneficial manner to human health. Therefore, it was concluded that Austin's zoning ordinance would have an overwhelmingly positive impact on the public's health based on identified associations between the built environment and health outcomes.^

Riesgos de taludes y terraplenes en obras lineales de la República Dominicana

Partiendo de la idea de la concurrencia de un fenómeno y de las acciones que se deben llevar a cabo, se debe entender la Gestión de Riesgos como una determinación de relaciones entre lo que se asume como vulnerable, y la forma en la cual se estimará la probabilidad de un determinado hecho. A medida en que pasa el tiempo, se torna más importante el tema de vulnerabilidad y de riesgo a nivel mundial. La vulnerabilidad se vuelve más notoria ante la presencia de determinados peligros naturales como lo son los siguientes: deslizamientos de tierras, movimientos sísmicos, desbordes de ríos e inundaciones. (Pérez Soriano, 2014) La vulnerabilidad se ve en su mayoría más afectada por acciones antrópicas como lo son la construcción de viviendas en lugares de alto riesgo, como por ejemplo, viviendas en los taludes de obras lineales. Estas viviendas están condicionadas por la localización, el uso del suelo, la infraestructura, la distribución y la densidad de la población, su capacidad de organización, etc. La Gestión de Riesgos se vuelve cada vez más exigente en cuanto a la calidad de los servicios ofertados, además de también, cumplir con la responsabilidad jurídica que implica la concepción, diseño y construcción de taludes y terraplenes en obras lineales. (Pérez Soriano, 2014) El presente trabajo de investigación se centra en la identificación y valoración de los riesgos de taludes y terraplenes en obras lineales de la República Dominicana. De esta manera se busca disminuir el riesgo de la rotura o fallo de un talud o terraplén, y el número de víctimas que puedan ser afectadas por el mismo, concluyendo con un catálogo de riesgos para taludes y terraplenes en obras lineales. Based on the idea of the occurrence of a phenomenon and the actions to be carried out, Risk Management should be understood as a determination of relationships between what is assumed to be vulnerable, and the way in which the probability of a particular event will be estimated. The issue of vulnerability and risk becomes more important worldwide as time goes on. Vulnerability becomes more evident in the presence of certain natural hazards such as: landslides, earthquakes, overflowing rivers and flooding. (Pérez Soriano, 2014) It has become evident that vulnerability is mostly affected by human actions, such as the construction of housing in high-risk locations, for example, man-made slopes. These properties are conditioned by the location, land use, infrastructure, distribution and density of the population, organizational skills, etc. Risk management is becoming more discerning about the quality of the services offered, in addition to the compliance of the legal responsibility that the conception, design and construction of slopes and embankments in linear works require. (Pérez Soriano, 2014) This research project focuses on the identification and valuation of the risks derived from slopes and embankments in linear works of the Dominican Republic, in order to reduce the risks of failure of a slope or embankment and the number of victims who may be affected from it. Concluding with a risk catalogue for slopes and embankments in linear works.

Clustered DNA damages induced in isolated DNA and in human cells by low doses of ionizing radiation

Clustered DNA damages—two or more closely spaced damages (strand breaks, abasic sites, or oxidized bases) on opposing strands—are suspects as critical lesions producing lethal and mutagenic effects of ionizing radiation. However, as a result of the lack of methods for measuring damage clusters induced by ionizing radiation in genomic DNA, neither the frequencies of their production by physiological doses of radiation, nor their repairability, nor their biological effects are known. On the basis of methods that we developed for quantitating damages in large DNAs, we have devised and validated a way of measuring ionizing radiation-induced clustered lesions in genomic DNA, including DNA from human cells. DNA is treated with an endonuclease that induces a single-strand cleavage at an oxidized base or abasic site. If there are two closely spaced damages on opposing strands, such cleavage will reduce the size of the DNA on a nondenaturing gel. We show that ionizing radiation does induce clustered DNA damages containing abasic sites, oxidized purines, or oxidized pyrimidines. Further, the frequency of each of these cluster classes is comparable to that of frank double-strand breaks; among all complex damages induced by ionizing radiation, double-strand breaks are only about 20%, with other clustered damage constituting some 80%. We also show that even low doses (0.1–1 Gy) of high linear energy transfer ionizing radiation induce clustered damages in human cells.

Somatic mosaicism in Fanconi anemia: Evidence of genotypic reversion in lymphohematopoietic stem cells

Somatic mosaicism has been observed previously in the lymphocyte population of patients with Fanconi anemia (FA). To identify the cellular origin of the genotypic reversion, we examined each lymphohematopoietic and stromal cell lineage in an FA patient with a 2815–2816ins19 mutation in FANCA and known lymphocyte somatic mosaicism. DNA extracted from individually plucked peripheral blood T cell colonies and marrow colony-forming unit granulocyte–macrophage and burst-forming unit erythroid cells revealed absence of the maternal FANCA exon 29 mutation in 74.0%, 80.3%, and 86.2% of colonies, respectively. These data, together with the absence of the FANCA exon 29 mutation in Epstein–Barr virus-transformed B cells and its presence in fibroblasts, indicate that genotypic reversion, most likely because of back mutation, originated in a lymphohematopoietic stem cell and not solely in a lymphocyte population. Contrary to a predicted increase in marrow cellularity resulting from reversion in a hematopoietic stem cell, pancytopenia was progressive. Additional evaluations revealed a partial deletion of 11q in 3 of 20 bone marrow metaphase cells. By using interphase fluorescence in situ hybridization with an MLL gene probe mapped to band 11q23 to identify colony-forming unit granulocyte–macrophage and burst-forming unit erythroid cells with the 11q deletion, the abnormal clone was exclusive to colonies with the FANCA exon 29 mutation. Thus, we demonstrate the spontaneous genotypic reversion in a lymphohematopoietic stem cell. The subsequent development of a clonal cytogenetic abnormality in nonrevertant cells suggests that ex vivo correction of hematopoietic stem cells by gene transfer may not be sufficient for providing life-long stable hematopoiesis in patients with FA.

Mutations within a furin consensus sequence block proteolytic release of ectodysplasin-A and cause X-linked hypohidrotic ectodermal dysplasia

X-linked hypohidrotic ectodermal dysplasia (XLHED) is a heritable disorder of the ED-1 gene disrupting the morphogenesis of ectodermal structures. The ED-1 gene product, ectodysplasin-A (EDA), is a tumor necrosis factor (TNF) family member and is synthesized as a membrane-anchored precursor protein with the TNF core motif located in the C-terminal domain. The stalk region of EDA contains the sequence -Arg-Val-Arg-Arg156-Asn-Lys-Arg159-, representing overlapping consensus cleavage sites (Arg-X-Lys/Arg-Arg↓) for the proprotein convertase furin. Missense mutations in four of the five basic residues within this sequence account for ≈20% of all known XLHED cases, with mutations occurring most frequently at Arg156, which is shared by the two consensus furin sites. These analyses suggest that cleavage at the furin site(s) in the stalk region is required for the EDA-mediated cell-to-cell signaling that regulates the morphogenesis of ectodermal appendages. Here we show that the 50-kDa EDA parent molecule is cleaved at -Arg156Asn-Lys-Arg159↓- to release the soluble C-terminal fragment containing the TNF core domain. This cleavage appears to be catalyzed by furin, as release of the TNF domain was blocked either by expression of the furin inhibitor α1-PDX or by expression of EDA in furin-deficient LoVo cells. These results demonstrate that mutation of a functional furin cleavage site in a developmental signaling molecule is a basis for human disease (XLHED) and raise the possibility that furin cleavage may regulate the ability of EDA to act as a juxtacrine or paracrine factor.

Industry Professionals Who Attain Leadership in Energy and Environmental Design (LEED) Accreditation: An Examination of Motivations in Human Resource (HR) Training and Development

Despite the economy, the green building industry continues to grow and drive the demand for environmentally conscious, highly skilled professionals (USGBC 2009). LEED Accredited Professionals (APs) have the knowledge and skills to meet such demand; however, information is limited regarding LEED APs or their motivations and expectations toward prospective employers. The author surveyed a sample of LEED Accredited architects and found a combination of job and personal factors motivated them to attain accreditation. LEED APs value both a competitive salary and commitment to sustainability in prospective employers. To attract, retain, and utilize LEED APs, executives in this industry must reexamine corporate culture, their willingness to pay for credentialing, and the alignment of their reputation with the desires of potential applicants.

Expense bills, 1797

Two bills for the date spans February 23-June 1, 1797 and August 24, 1797. The workers named on both bills are Richard Hunnewell, Peter Waters, and Betsy Thomas.

Expense bill, 1799

One bill for the date span November 29, 1798-February 22, 1799. The workers named on the bill are James Fillebrown, Peter Waters, and Betsy Thomas.

Examining the Relationship Between Passion and Perceptions of Cohesion in Athletes

The purpose of the present study was to examine the relationship of harmonious and obsessive passion to perceptions of task and social cohesion in team sport athletes. Participants were 370 competitive (N=252) and recreational (N=118) athletes ranging from 18- to 28-years-old (Mage=20.20, SD=1.52) from a wide variety of team sports. Participants completed the Passion Scale (Vallerand et al., 2003) and the Group Environment Questionnaire (Carron et al., 1985). A MANOVA revealed that competitive athletes were more passionate and had higher perceptions of cohesion than did recreational athletes. Multiple regression analyses revealed a positive relationship between both harmonious and obsessive passion and both task (ATG-T, GI-T) and social (ATG-S, GI-S) cohesion. Theoretical and practical implications are discussed pertaining to the importance of harmonious and obsessive passion in athletes and perceptions of cohesion in competitive and recreational sport.

The Social Environment in Children’s Sport: Cohesion, Social Acceptance, Commitment, and Enjoyment

The primary purpose of the current study was to determine whether perceptions of cohesion mediated the relationship between social acceptance and individual commitment and enjoyment in children’s sport. A secondary purpose involved the assessment of the temporal nature of cohesion over the course of an athletic season. A total of 209 (Mage = 9.87 years; SD = 1.34) recreational soccer players completed questionnaires at three time points (T1 – social acceptance, cohesion; T2 – cohesion; T3 – commitment, enjoyment, cohesion) during an athletic season. Using structural equation modeling, the results indicated that task cohesion mediated the relationship between social acceptance and commitment and enjoyment, whereas social cohesion did not. In addition, individual perceptions of cohesion did not vary significantly over the course of the season. These results will be discussed in terms of their theoretical and practical implications. As one example, the relative stability in terms of perceptions of cohesion in this population could inform future intervention work aimed at enriching the social environment

Just Need Some Satisfaction: Examining the Relationship between Passion for Exercise and the Basic Psychological Needs

Individuals often pursue activities for which they are passionate about, and this passion is operationalized as being harmonious (an autonomous desireto engage in the activity) or obsessive (a controlled desire to engage in the activity) in nature (Vallerand et al., 2003). With regard to harmonious passion, Vallerand et al. (2003) suggests that it is fostered in environments that nurture innate needs for autonomy, competence, and relatedness. The purpose of the present study was to explore the nature of the passion-basic psychological needs (competence, autonomy, relatedness) relationship. Kinesiology students (N = 917; Mage = 18.54 SD = 1.66) completed the Passion Scale (Vallerand et al., 2003) and the Psychological Need Satisfaction in Exercise Scale (Wilson et al., 2006). Results from the SEM path analysis indicated that harmonious passion was positively related to competence (SPE = .43) and relatedness (SPE = .43) and obsessive passion was negatively related to autonomy (SPE = -.18)(CFI = .90, RMSEA = .07, SRMR = .07). Implications for exercise participation/enjoyment are discussed.

Athlete Perceptions of Intra-Group Conflict in Sport Teams

The study of conflict has been of primary interest in various fields such as organisational psychology for decades (e.g. Barki & Hartwick, 2004). In sport psychology, however, conflict research has been almost nonexistent (Lavoi, 2007) with few exceptions (e.g. Holt et al., 2012; Sullivan & Feltz, 2001). The importance of understanding conflict in sport and in groups, however, has been acknowledged because it has potentially serious implications for group outcomes (Lavoi, 2007). The present study investigated competitive sport athletes’ perceptions of intra-group conflict in sport. Ten intercollegiate athletes: (N=5 males, N=5 females; Mage=25.00, SD=2.87) participated in semi-structured interviews. Athletes perceived the nature of conflict to manifest itself in several ways including: (a) disagreements; (b) negative emotions; and (c) interference/antagonistic behaviors. In addition, conflict episodes were perceived to arise in task and social situations. The findings are discussed in terms of their contributions to current perspectives on intra-group conflict in sport.