The American vade mecum: or, The companion of youth, and guide to college : a book of miscellanies /

"To advocate the claims of the University of Virginia upon American fathers." Introd.

TransReality : en kvalitativ studie om representationer av unga transpersoner i Ryssland och USA

Denna studie undersöker hur unga transpersoner representeras i media, närmare bestämt inom genren reality tv. De två program som valts för ändamålet är amerikanska I am Jazz och ryska TransReality, där den första fokuserar på 15-åriga Jazz Jennings liv medan den andra följer ett antal unga transpersoners vardag. Valet av program bygger på att de båda släpptes under det gångna året, att samtliga huvudpersoner är ungdomar och att de har sitt ursprung i två vitt skilda kulturella kontext. Syftet är att granska hur serierna representerar transpersoner utifrån frågor som biologiskt kön, genus och könsidentitet. Frågeställningarna rör ungdomarnas sociala relationer och samhället, vad det är som serierna problematiserar och hur programmets utformning bidrar till att berätta deras historier. Inledningsvis förklaras olika definitioner av kön, samt genus och könsidentitet. För att närma mig materialet har jag valt teorier utifrån programmens utformning såväl som innehåll. Teorierna omfattar reality tv, stereotypier, Judith Butlers idéer om genus i kombination med transgender studier och transfeminism. De senare två är relativt nya akademiska ämnen/teorier i Sverige, men välbehövliga sådana då de tar transpersoners liv och erfarenheter på allvar. Studierna jag tagit del av inom tidigare forskning visar på att transpersoner ofta förbises även i queerteoretiska sammanhang. Feminismen har även inkorporerats i metodologin, för att bättre belysa det som studien avser att undersöka. Norman Faircloughs kritiska diskursanalys med sin politiska betoning utgör stommen för det analytiska arbetet. Detta har applicerats på tre avsnitt av varje program: det första, mittersta och sista. Genom att analysera dessa framkommer att bakom den överlag positiva framställningen av de unga transpersonerna i TransReality ligger konservativa värderingar om kön, genus och könsidentitet. I am Jazz är mer progressiv, men även den visar ibland på liknande tendenser som TransReality. De sociala relationerna är det som problematiseras, istället för de unga transpersonerna själva. Reality tv ger prov på att den vuxit till sig som genre i att den med dokumentär ambition berättar de unga transpersonernas historier. Denna autenticitet kan vara av vikt för samhällets förståelse av transpersoner. 

A rogue is a rogue is a rogue: US foreign policy and the Korean nuclear crisis

Two nuclear crises recently haunted the Korean peninsula, one in 1993/4, the other in 2002/3. In each case the events-were strikingly similar: North Korea made public its ambition to acquire nuclear weapons and withdrew from the Nonproliferation Treaty. Then the situation rapidly deteriorated until the peninsular was literally on the verge of war. The dangers of North Korea's actions, often interpreted as nuclear brinkmanship, are evident. and much discussed, but not so the underlying patterns that have shaped the conflict in the first place. This article sheds light on some of them. It examines the role of the United States in the crisis, arguing that Washington's inability to see North Korea as anything but a threatening 'rogue state' seriously hinders both an adequate understanding and possible resolution of the conflict. Particularly significant is the current policy of pre-emptive strikes against rogue states, for it reinforces half a century of American nuclear threats towards North Korea. The problematic role of these threats has been largely obscured, not least because the highly technical discourse of security analysis has managed to present the strategic situation on the peninsula in a manner that attributes responsibility for the crisis solely to North Korea's actions, even if the situation is in reality far more complex and interactive.

The missing ingredient:inter-municipal cooperation and central-local relations in the UK

The thrust of the argument presented in this chapter is that inter-municipal cooperation (IMC) in the United Kingdom reflects local government's constitutional position and its exposure to the exigencies of Westminster (elected central government) and Whitehall (centre of the professional civil service that services central government). For the most part councils are without general powers of competence and are restricted in what they can do by Parliament. This suggests that the capacity for locally driven IMC is restricted and operates principally within a framework constructed by central government's policy objectives and legislation and the political expediencies of the governing political party. In practice, however, recent examples of IMC demonstrate that the practices are more complex than this initial analysis suggests. Central government may exert top-down pressures and impose hierarchical directives, but there are important countervailing forces. Constitutional changes in Scotland and Wales have shifted the locus of central- local relations away from Westminster and Whitehall. In England, the seeding of English government regional offices in 1994 has evolved into an important structural arrangement that encourages councils to work together. Within the local government community there is now widespread acknowledgement that to achieve the ambitious targets set by central government, councils are, by necessity, bound to cooperate and work with other agencies. In recent years, the fragmentation of public service delivery has affected the scope of IMC. Elected local government in the UK is now only one piece of a complex jigsaw of agencies that provides services to the public; whether it is with non-elected bodies, such as health authorities, public protection authorities (police and fire), voluntary nonprofit organisations or for-profit bodies, councils are expected to cooperate widely with agencies in their localities. Indeed, for projects such as regeneration and community renewal, councils may act as the coordinating agency but the success of such projects is measured by collaboration and partnership working (Davies 2002). To place these developments in context, IMC is an example of how, in spite of the fragmentation of traditional forms of government, councils work with other public service agencies and other councils through the medium of interagency partnerships, collaboration between organisations and a mixed economy of service providers. Such an analysis suggests that, following changes to the system of local government, contemporary forms of IMC are less dependent on vertical arrangements (top-down direction from central government) as they are replaced by horizontal modes (expansion of networks and partnership arrangements). Evidence suggests, however that central government continues to steer local authorities through the agency of inspectorates and regulatory bodies, and through policy initiatives, such as local strategic partnerships and local area agreements (Kelly 2006), thus questioning whether, in the case of UK local government, the shift from hierarchy to network and market solutions is less differentiated and transformation less complete than some literature suggests. Vertical or horizontal pressures may promote IMC, yet similar drivers may deter collaboration between local authorities. An example of negative vertical pressure was central government's change of the systems of local taxation during the 1980s. The new taxation regime replaced a tax on property with a tax on individual residency. Although the community charge lasted only a few years, it was a highpoint of the then Conservative government policy that encouraged councils to compete with each other on the basis of the level of local taxation. In practice, however, the complexity of local government funding in the UK rendered worthless any meaningful ambition of councils competing with each other, especially as central government granting to local authorities is predicated (however imperfectly) on at least notional equalisation between those areas with lower tax yields and the more prosperous locations. Horizontal pressures comprise factors such as planning decisions. Over the last quarter century, councils have competed on the granting of permission to out-of-town retail and leisure complexes, now recognised as detrimental to neighbouring authorities because economic forces prevail and local, independent shops are unable to compete with multiple companies. These examples illustrate tensions at the core of the UK polity of whether IMC is feasible when competition between local authorities heightened by local differences reduces opportunities for collaboration. An alternative perspective on IMC is to explore whether specific purposes or functions promote or restrict it. Whether in the principle areas of local government responsibilities relating to social welfare, development and maintenance of the local infrastructure or environmental matters, there are examples of IMC. But opportunities have diminished considerably as councils lost responsibility for services provision as a result of privatisation and transfer of powers to new government agencies or to central government. Over the last twenty years councils have lost their role in the provision of further-or higher-education, public transport and water/sewage. Councils have commissioning power but only a limited presence in providing housing needs, social care and waste management. In other words, as a result of central government policy, there are, in practice, currently far fewer opportunities for councils to cooperate. Since 1997, the New Labour government has promoted IMC through vertical drivers and the development; the operation of these policy initiatives is discussed following the framework of the editors. Current examples of IMC are notable for being driven by higher tiers of government, working with subordinate authorities in principal-agent relations. Collaboration between local authorities and intra-interand cross-sectoral partnerships are initiated by central government. In other words, IMC is shaped by hierarchical drivers from higher levels of government but, in practice, is locally varied and determined less by formula than by necessity and function. © 2007 Springer.

The choices for Europe:national preferences in new and old member states

Drawing on the existing body of literature that deals with national preference formation and building on the role played by vulnerability and deficits in shaping policy choices at the European level, this article provides a synthetic framework to explain the stances of the Older Member States (OMS) and New Member States (NMS). We subsequently apply the model to NMS, focusing largely, although not exclusively, on Poland. We argue that although many of the policy preferences can be explained by the framework, the size of states, especially with regard to ambition and capacity, and the nature of the country's post-communist transition appear significant for the NMS and need to be incorporated into future theory-building. We conclude by highlighting areas in need of further empirical research. © 2009 Blackwell Publishing Ltd.

Articulating discursive and materialist conceptions of practice in the logics approach to critical policy analysis

In this article it is argued that while Glynos and Howarth’s logics of critical explanation (LCE) offers an important and promising contribution to critical policy analysis, it, along with other approaches that focus on the meaning of social action, faces a growing challenge in the form of a so-called new materialist turn in social and political theory. The article argues that there is much to be gained for the logics approach in paying closer attention to the materiality of practices in terms not only of lending greater clarity to the conception and role of social practices in the logics approach but also in enabling it fully to deliver on its critical ambition. The article explores an alternative materialist approach to the study of social practices, which hails from the post-actor–networktheory tradition and which has ontological affinities with post-structuralism. The article begins with a brief analysis of the new materialist turn in its various guises. It then critically examines the logics approach, and, in particular its conception of practice. It then explores an alternative materialist and ethnographic reading of practice, focusing on medical and care practices. It concludes with an examination of the implications for a more materialist conception of practices for the LCE’s broad deconstructive, psychoanalytic and onto-political ambitions.

Reducing dependence on big brother:Higher Education looks for innovative funding opportunities

This paper presents innovative programs that business schools can utilize to reduce dependence on public funds. A review of the literature shows the theoretical and empirical foundation of higher education funding dilemmas. While higher education is moving towards a global ambition, scarcity hinders governments to fully support programs long-term; thus, cost-sharing and cost-shifting measures must occur for higher education to support current programs. In this study, we examine two universities (one U.S. and one U.K.) and provide practical summaries of programs that have provided additional funds. We show that diversity of funding sources is essential for survival of higher education institutions. Market forces require competition to reduce higher education operational costs while providing students and corporate clients an a la carte educational experience.

Evaluating the skills strategy through a Graduate Certificate in Management:an experiential learning theory approach

Purpose – The purpose of this paper is to evaluate how a UK business school is addressing the Government's skills strategy through its Graduate Certificate in Management, and to identify good practice and development needs and to clarify how the Graduate Certificate is adapting to the needs of Generation X and Millennial students. The paper also aims to test Kolb and Kolb's experiential learning theory (ELT) in a business school setting. Design/methodology/approach – A case study methodology was adopted. In order to get a cross-section of views and triangulate the data, three focus groups were held, supported by reading documentation about the programme of study. Findings – The skills strategy is not just an ambition for some business schools, but is already part of the curriculum. Generation X and the Millennials have more in common with the positive attitudes associated with older generations than stereotyped views might allow. ELT provides a useful theoretical framework for evaluating a programme of study and student attitudes. Research limitations/implications – The research findings from one case study are reported, limiting the generalisability of the study. Practical implications – Good practice and development needs are identified which support the implementation of the Government's skills strategy and address employer concerns about student skills. Originality/value – New empirical data are reported which supports the use of ELT in evaluating programmes of study and student attitudes to work.

The economics behind the move to 'localism' in England

This paper explores the economic thinking behind the UK Coalition government’s new framework for achieving local growth and the creation of Local Enterprise Partnerships in England. It does so in the light of recent debates about ‘space-neutral’ and ‘place-based’ policymaking. While the British government states its ambition to achieve greater spatial and industrial balance across England (and by implication the UK), we argue that so far at least there is a mismatch between the ‘rhetoric’ and ‘policies’ of local growth and its limitations. These relate to inconsistencies in the way that the different competing economic ideas in circulation within government have been adopted in practice. As a result, the paper highlights six key disconnects and limitations of the economics behind the move in England to local growth.

Cosmopolitans and 'cliques':everyday socialisation amongst Tamil student and young professional migrants to the UK

Among student and young professional migrants to the UK the opportunity for a global or cosmopolitan experience emerges as a motivating factor for migration. This article takes the example of student and young professional migrants to the UK from the South Indian state of Tamil Nadu, and explores how this cosmopolitan ambition plays out in the formation of UK social networks. Two 'types' of research participant are identified; 'self-conscious cosmopolitans' whose social networks are cross-ethnic, and others whose networks are largely co-ethnic and who are often derided by their self-consciously cosmopolitan counterparts as 'clannish' or 'cliquey'. The article asks how ethnicity emerges as salient (or not) in these migrants' talk and practice around UK social network formations. It then considers whether a co-ethnic social network necessarily limits the cosmopolitan experience, or whether this interpretation reflects a narrow understanding of cosmopolitanism which excludes the multiple inter-cultural encounters these migrants experience in their everyday lives. © The Author(s) 2013 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

DML and RusDML – Virtual Library Initiatives for Covering All Mathematics Electronically

With the rapidly growing activities in electronic publishing ideas came up to install global repositories which deal with three mainstreams in this enterprise: storing the electronic material currently available, pursuing projects to solve the archiving problem for this material with the ambition to preserve the content in readable form for future generations, and to capture the printed literature in digital versions providing good access and search facilities for the readers. Long-term availability of published research articles in mathematics and easy access to them is a strong need for researchers working with mathematics. Hence in this domain some pioneering projects have been established addressing the above mentioned problems.

Editorial overview:new protein production tools for structural biology

Full text: The idea of producing proteins from recombinant DNA hatched almost half a century ago. In his PhD thesis, Peter Lobban foresaw the prospect of inserting foreign DNA (from any source, including mammalian cells) into the genome of a λ phage in order to detect and recover protein products from Escherichia coli [ 1 and 2]. Only a few years later, in 1977, Herbert Boyer and his colleagues succeeded in the first ever expression of a peptide-coding gene in E. coli — they produced recombinant somatostatin [ 3] followed shortly after by human insulin. The field has advanced enormously since those early days and today recombinant proteins have become indispensable in advancing research and development in all fields of the life sciences. Structural biology, in particular, has benefitted tremendously from recombinant protein biotechnology, and an overwhelming proportion of the entries in the Protein Data Bank (PDB) are based on heterologously expressed proteins. Nonetheless, synthesizing, purifying and stabilizing recombinant proteins can still be thoroughly challenging. For example, the soluble proteome is organized to a large part into multicomponent complexes (in humans often comprising ten or more subunits), posing critical challenges for recombinant production. A third of all proteins in cells are located in the membrane, and pose special challenges that require a more bespoke approach. Recent advances may now mean that even these most recalcitrant of proteins could become tenable structural biology targets on a more routine basis. In this special issue, we examine progress in key areas that suggests this is indeed the case. Our first contribution examines the importance of understanding quality control in the host cell during recombinant protein production, and pays particular attention to the synthesis of recombinant membrane proteins. A major challenge faced by any host cell factory is the balance it must strike between its own requirements for growth and the fact that its cellular machinery has essentially been hijacked by an expression construct. In this context, Bill and von der Haar examine emerging insights into the role of the dependent pathways of translation and protein folding in defining high-yielding recombinant membrane protein production experiments for the common prokaryotic and eukaryotic expression hosts. Rather than acting as isolated entities, many membrane proteins form complexes to carry out their functions. To understand their biological mechanisms, it is essential to study the molecular structure of the intact membrane protein assemblies. Recombinant production of membrane protein complexes is still a formidable, at times insurmountable, challenge. In these cases, extraction from natural sources is the only option to prepare samples for structural and functional studies. Zorman and co-workers, in our second contribution, provide an overview of recent advances in the production of multi-subunit membrane protein complexes and highlight recent achievements in membrane protein structural research brought about by state-of-the-art near-atomic resolution cryo-electron microscopy techniques. E. coli has been the dominant host cell for recombinant protein production. Nonetheless, eukaryotic expression systems, including yeasts, insect cells and mammalian cells, are increasingly gaining prominence in the field. The yeast species Pichia pastoris, is a well-established recombinant expression system for a number of applications, including the production of a range of different membrane proteins. Byrne reviews high-resolution structures that have been determined using this methylotroph as an expression host. Although it is not yet clear why P. pastoris is suited to producing such a wide range of membrane proteins, its ease of use and the availability of diverse tools that can be readily implemented in standard bioscience laboratories mean that it is likely to become an increasingly popular option in structural biology pipelines. The contribution by Columbus concludes the membrane protein section of this volume. In her overview of post-expression strategies, Columbus surveys the four most common biochemical approaches for the structural investigation of membrane proteins. Limited proteolysis has successfully aided structure determination of membrane proteins in many cases. Deglycosylation of membrane proteins following production and purification analysis has also facilitated membrane protein structure analysis. Moreover, chemical modifications, such as lysine methylation and cysteine alkylation, have proven their worth to facilitate crystallization of membrane proteins, as well as NMR investigations of membrane protein conformational sampling. Together these approaches have greatly facilitated the structure determination of more than 40 membrane proteins to date. It may be an advantage to produce a target protein in mammalian cells, especially if authentic post-translational modifications such as glycosylation are required for proper activity. Chinese Hamster Ovary (CHO) cells and Human Embryonic Kidney (HEK) 293 cell lines have emerged as excellent hosts for heterologous production. The generation of stable cell-lines is often an aspiration for synthesizing proteins expressed in mammalian cells, in particular if high volumetric yields are to be achieved. In his report, Buessow surveys recent structures of proteins produced using stable mammalian cells and summarizes both well-established and novel approaches to facilitate stable cell-line generation for structural biology applications. The ambition of many biologists is to observe a protein's structure in the native environment of the cell itself. Until recently, this seemed to be more of a dream than a reality. Advances in nuclear magnetic resonance (NMR) spectroscopy techniques, however, have now made possible the observation of mechanistic events at the molecular level of protein structure. Smith and colleagues, in an exciting contribution, review emerging ‘in-cell NMR’ techniques that demonstrate the potential to monitor biological activities by NMR in real time in native physiological environments. A current drawback of NMR as a structure determination tool derives from size limitations of the molecule under investigation and the structures of large proteins and their complexes are therefore typically intractable by NMR. A solution to this challenge is the use of selective isotope labeling of the target protein, which results in a marked reduction of the complexity of NMR spectra and allows dynamic processes even in very large proteins and even ribosomes to be investigated. Kerfah and co-workers introduce methyl-specific isotopic labeling as a molecular tool-box, and review its applications to the solution NMR analysis of large proteins. Tyagi and Lemke next examine single-molecule FRET and crosslinking following the co-translational incorporation of non-canonical amino acids (ncAAs); the goal here is to move beyond static snap-shots of proteins and their complexes and to observe them as dynamic entities. The encoding of ncAAs through codon-suppression technology allows biomolecules to be investigated with diverse structural biology methods. In their article, Tyagi and Lemke discuss these approaches and speculate on the design of improved host organisms for ‘integrative structural biology research’. Our volume concludes with two contributions that resolve particular bottlenecks in the protein structure determination pipeline. The contribution by Crepin and co-workers introduces the concept of polyproteins in contemporary structural biology. Polyproteins are widespread in nature. They represent long polypeptide chains in which individual smaller proteins with different biological function are covalently linked together. Highly specific proteases then tailor the polyprotein into its constituent proteins. Many viruses use polyproteins as a means of organizing their proteome. The concept of polyproteins has now been exploited successfully to produce hitherto inaccessible recombinant protein complexes. For instance, by means of a self-processing synthetic polyprotein, the influenza polymerase, a high-value drug target that had remained elusive for decades, has been produced, and its high-resolution structure determined. In the contribution by Desmyter and co-workers, a further, often imposing, bottleneck in high-resolution protein structure determination is addressed: The requirement to form stable three-dimensional crystal lattices that diffract incident X-ray radiation to high resolution. Nanobodies have proven to be uniquely useful as crystallization chaperones, to coax challenging targets into suitable crystal lattices. Desmyter and co-workers review the generation of nanobodies by immunization, and highlight the application of this powerful technology to the crystallography of important protein specimens including G protein-coupled receptors (GPCRs). Recombinant protein production has come a long way since Peter Lobban's hypothesis in the late 1960s, with recombinant proteins now a dominant force in structural biology. The contributions in this volume showcase an impressive array of inventive approaches that are being developed and implemented, ever increasing the scope of recombinant technology to facilitate the determination of elusive protein structures. Powerful new methods from synthetic biology are further accelerating progress. Structure determination is now reaching into the living cell with the ultimate goal of observing functional molecular architectures in action in their native physiological environment. We anticipate that even the most challenging protein assemblies will be tackled by recombinant technology in the near future.

Le groupe du Fer de Lance mélanésien face à ses défis

Cet article examine la complexité du processus d’intégration régionale en Océanie à travers le cas du groupe du Fer de Lance mélanésien (gflm). L’émergence de cette structure subrégionale en 1988 avait pour but d’affirmer la spécificité mélanésienne au cœur du Pacifique Sud. Or, en vingt-cinq années d’existence, le Fer de Lance ne semble pas avoir pleinement réalisé tous les objectifs qu’il s’était initialement fixés. Ses ambitions, politiques en particulier, ne sont qu’en partie réalisées. Quant à la récente présidence fidjienne du Fer de Lance, elle a tenté de donner une nouvelle stature régionale au groupe, mais y est-elle parvenue ? Cet article analyse les défis politiques, intérieurs et extérieurs, que le gflm rencontre depuis sa création et considère ceux qui lui restent à relever. This paper examines the complexities of regional integration in Oceania through the case study of the Melanesian Spearhead Group (MSG). The emergence of a new subregional structure in 1988 aimed to support the development of the Melanesian identity within the South Pacific. However, after twenty-five years of existence, the Spearhead Group does not seem to have reached all its initial objectives. Its political ambition has only partly been achieved. The recent Fijian leadership of the MSG has attempted to give a new regional dimension to the Melanesian group, but has it succeeded? This paper analyses how the subregional group has faced the challenges that emerged from its regional environment as well as from within its own structure. It fnally considers the new challenges ahead for the Melanesian group.

Bulgariana: A Bulgarian Aggregator to Europeana

Europeana is the European virtual museum which was established in 2008. Its ambition is to create a common space allowing to access the cultural heritage of Europe from a single portal, by creating a network in all European countries. To make the initiative technically possible, Europeana has built a technological infrastructure to aggregate metadata from the different Europeana countries and memory institutions, while keeping the original digitized content on their sites. This paper presents Bulgariana, the Bulgarian chapter of Europeana. It is part of the technical infrastructure of Europeana, an established technical aggregator of Bulgarian cultural heritage content. It uses the two Europeana representation models ESE and EDM. Bulgariana is also a community building initiative putting in place a Bulgarian wide network of professionals and institutions working together to preserve and present Bulgarian cultural heritage around the world.

Infant voices: embryonic and neonatal personhood in two recent French Catholic novels

There are almost no literary or artistic representations that take the unborn or neonatal infants as their subject. Two exceptions to this as Claire Daudin’s Le Sourire and Antoine Beauquier’s Pavillon 7: la révolte des embryons. What these novels share is the ambition to frame such subjects as full and complete persons. Thus in their distinct ways both novels engage with the familial, social and biological problems that arise when personhood is attributed to embryos or neo-natal infants. Their creation of an embryonic or infant ‘voice’ associates the dignity of such subjects with divine origins.