La nécessité d'une multiplicité de concepts de gène en biologie

Le concept de gène est central en biologie. Certains ont avancé (Ruse (1971, 1976)) que la génétique classique pouvait être réduite à la génétique moléculaire. Dans le même ordre d'idée, Richard Dawkins, dans The Extended Phenotype, offre une double définition de son concept de gène qui présuppose qu'il soit possible d'opérer cette réduction. Nous comptons montrer que la génétique moléculaire et la génétique des populations ont chacune leurs problématiques propres en reconstituant l'histoire de la génétique depuis Darwin. Ensuite, nous expliciterons la position de Dawkins et soulignerons les contradictions auxquelles il parvient en raison de cette réduction infondée. À la suite de quoi, nous nous attarderons aux nouvelles découvertes moléculaires qui montrent qu'il n'est pas possible d'opérer la réduction d'un des concepts à l'autre. Nous terminerons en soulignant que la thèse génocentriste de Dawkins n'est pas mise en péril par l'abandon de la réduction, mais qu'il est nécessaire de tempérer ces prétentions. La conclusion globale de ce mémoire est qu'il est possible d'admettre le concept de Dawkins, mais pas la manière dont il l'utilise. Le concept est bon, il n'est tout simplement pas dans le bon cadre théorique.

Une ethnographie de la gestion de la population rom en Albanie

Cette thèse propose une ethnographie de la gestion de la population rom en Albanie, saisie sur deux périodes historiques : communisme et postcommunisme. L’analyse porte sur la façon dont divers instruments de gestion des populations en tant que techniques de pouvoir, sont mises en œuvre ; comment une population donnée devient-elle un sujet politique ? Quels sont les effets d’une telle gestion sur les populations en général et sur les populations roms en particulier ? Cette approche, une approche foucaldienne, replace ainsi au centre de l’analyse empirique les politiques, les pratiques et les discours concernant les Roms en Albanie et essaye de saisir les effets qu’ils produisent sur cette population. Cette thèse part de ces éléments pour interroger plus largement les transformations sociétales dans l’Albanie postcommuniste. Ce travail s’inscrit dans le champ de l’anthropologie politique et conjugue à la fois une anthropologie de l’État et une anthropologie de la violence. Il s’articule autour de trois parties. La première porte sur la contextualisation de cette thèse, du point de vue conceptuel, méthodologique et théorique. La deuxième partie propose une analyse des relations que l’État a entretenues avec les Roms pendant la période communiste, phase durant laquelle la population rom a été exposée à diverses mesures administratives visant sa normalisation, à travers une sédentarisation forcée et d’autres mesures coercitives. La troisième partie, précédée par un intermède sur la période de la transition, interroge la relation entre l’État, la violence, la mobilité et la gestion de la population rom en Albanie depuis la chute du communisme. L’analyse se fait à partir d’un cas spécifique, celui des familles roms déplacées et en déplacement aux alentours de Tirana ; une mobilité forcée notamment par peu d’opportunités de sortir de la précarité pour plusieurs familles roms, mais aussi une mobilité induite par les politiques, les pratiques et les discours étatiques, notamment par leur non-action. Au fur et à mesure que l’analyse des pratiques et des discours – complétée par une ethnographie des documents d’archives et dans les quartiers et les campements roms – s’approfondit pendant les deux périodes historiques, elle dévoile de nombreuses – mais différentes – contradictions et controverses au sein du dispositif, lesquelles produisent à leur tour discrimination, exclusion, violence, indifférence et abandon.

"Contra el reino de la Bestia, nosotros, testigos, nos levantaremos" E. P. Thompson y la Campaña por el Desarme Nuclear

A fines de 1979 Edward Palmer Thompson abandonó su proyecto historiográfico para iniciar una campaña por el desarme nuclear y por la paz. Durante años el historiador marxista se abocó en exclusividad a las tareas de organizar el movimiento europeo por la paz y elaborar y difundir sus doctrinas. Este artículo presenta algunos elementos de su trayectoria intelectual que permiten comprender la articulación entre práctica política y práctica historiográfica. Al mismo tiempo, el concepto de "exterminismo" es recuperado como elemento organizador en su posicionamiento en el debate por el desarme nuclear

(Table 1) Characteristics of breeding male Adélie penguins (Pygoscelis adeliae) treated with varying degrees of corticosterone, Adélie land, Antarctica

Breeding individuals enter an emergency life-history stage when their body reserves reach a minimum threshold. Consequently, they redirect current activity toward survival, leading to egg abandonment in birds. Corticosterone (CORT) is known to promote this stage. How and to what extent CORT triggers egg abandonment when breeding is associated with prolonged fasting, however, requires further investigation. We manipulated free-living male Adelie penguins with CORT-pellets before their laying period. We then examined their behavioral response with respect to nest abandonment in parallel with their prolactin levels (regulating parental care), and the subsequent effects of treatment on breeding success in relieved birds. Exogenous CORT triggered nest abandonment in 60% of the treated penguins -14 days after treatment and induced a concomitant decline in prolactin levels. Interestingly, prolactin levels in treated penguins that did not abandon their nest were higher at the point of implantation and also after being relieved by females, when compared with abandoning penguins. Among successful birds, the treatment did not affect the number of chicks, nor the brood mass. Our results show the involvement of CORT in the decision-making process regarding egg abandonment in Adelie penguins when incubation is associated with a natural long fast. However, we suggest that CORT alone is not sufficient to trigger nest abandonment but that 1) prolactin levels need to reach a low threshold value, and 2) a rise in proteolysis (i.e. utilization of protein as main energy substrate) seems also to be required.

Britain's boast, her glory and her shame; or, A mirror for all ranks.

"A few months have only elapsed since this work was ushered into the world under the inauspicious cognomen of 'The Eglinton Tournament,' &c., which misnomer I abandon for ever"--Proem.

Six duets for two violins and piano /

Pastorale = Souvenir de Campagne -- Sadness = Tristesse -- Abandon -- Cradle-song = Berceuse -- Midnight = Minuit --Serenade.

On the Interest in Beauty and Disinterest

Contemporary philosophical attitudes toward beauty are hard to reconcile with its importance in the history of philosophy. Philosophers used to allow it a starring role in their theories of autonomy, morality, or the good life. But today, if beauty is discussed at all, it is often explicitly denied any such importance. This is due, in part, to the thought that beauty is the object of “disinterested pleasure”. In this paper I clarify the notion of disinterest and develop two general strategies for resisting the emphasis on it, in the hopes of getting a clearer view of beauty’s significance. I present and discuss several literary depictions of the encounter with beauty that motivate both strategies. These depictions illustrate the ways in which aesthetic experience can be personally transformative. I argue that they present difficulties for disinterest theories and suggest we abandon the concept of disinterest to focus instead on the special kind of interest beauty fuels. I propose a closer look at the Platonic thought that beauty is the object of love.

"Contra el reino de la Bestia, nosotros, testigos, nos levantaremos" E. P. Thompson y la Campaña por el Desarme Nuclear

A fines de 1979 Edward Palmer Thompson abandonó su proyecto historiográfico para iniciar una campaña por el desarme nuclear y por la paz. Durante años el historiador marxista se abocó en exclusividad a las tareas de organizar el movimiento europeo por la paz y elaborar y difundir sus doctrinas. Este artículo presenta algunos elementos de su trayectoria intelectual que permiten comprender la articulación entre práctica política y práctica historiográfica. Al mismo tiempo, el concepto de "exterminismo" es recuperado como elemento organizador en su posicionamiento en el debate por el desarme nuclear

Pensar su tiempo, deshilvanar el orden social

Edgardo Antonio Vigo fue un artista plástico que utilizó distintas técnicas y formas de expresión, como la poesía visual, las performances urbanas, el arte correo, la escritura de manifiestos y otros textos, así como la edición de revistas, entre otras actividades. Vigo produjo su poética en clave de rebeldía de su tiempo, especialmente entre los '60 y '70, pero su rebelión transcurrió también por fuera del estereotipo más consolidado para la época. La obra de Vigo retoma algunos procedimientos de las vanguardias, como la utilización del objeto ya hecho, el uso de espacios alternativos de producción y difusión de sus obras, el abandono casi completo del formato de cuadro, entre otros. Interesa pensar en este trabajo de qué modo esta apropiación de técnicas y procedimientos previos, se combina con otra ruptura dirigida no sólo al sistema artístico, sino también al orden social. En este sentido, la obra de Vigo piensa su tiempo. ;Así como tematizó ciertos acontecimientos de relevancia política de los ámbitos nacional e internacional, también realizó una operación novedosa en su obra: la utilización del discurso judicial-administrativo. Se analizan en este trabajo algunos de sus usos en acciones artísticas. Concluimos en que se trató de una materia que incorporaría en su poética para desnaturalizarla de su lugar original, aristocrático y privatista. En este sentido, toma un aspecto no menor del funcionamiento del orden social disociándolo de su lugar normal y, al ofrecerlo a todos a través de acciones artísticas, permite una apropiación descentrada, fuera de los límites impuestos por su naturaleza

The Role of Geometry in Wordsworth's "Science of Feelings"

Thesis (Ph.D.)--University of Washington, 2016-06

Evaluating authentic behaviour change in leadership development programmes

The global economic crisis that hit the western countries strongly has emphasised the need to abandon the economic-performance significance of leadership and return to a meaning-making significance. While a lot of research has been done in the field of leadership and management disciplines, little has been done on how to develop leadership. This study evaluated the degree in which leadership training in the market-place today was effective at developing authentic leadership and, therefore, at changing individual behaviour. Since none of the leadership theories address how behavioural change is actually achieved, theories of change were integrated in the current study. A conceptual model combining Authentic Leadership Development (ALD) theory and the Theory of Planned Behaviour (TPB) was proposed. Furthermore, this study explored the relationship between a positive contemplation of change and the actual change observed in individuals after the leadership intervention. In order to test this conceptualisation, a longitudinal quasi-experimental study was conducted. Leaders were surveyed in this study one month before and one month after the programme. Three complementary questionnaires were distributed to participants in one of four leadership development programmes (two corporate initiatives and two business-school programmes). Analyses showed that leaders who attended a leadership intervention (as compared to a control group) developed higher levels of authentic leadership, as rated by them-selves and others in their working environment and controlling for baseline scores. The results also indicated that intentions were developed through the interventions and that the development of such intentions translated into changes in authentic behaviour. Intentions mediated the relationship between attitude and authentic leader-ship. In addition, when contemplation of change was high and attitudes towards authentic leadership were positive, the development of intentions was stronger. The implications of these findings for the theory and practice of leadership development programmes and the impact on organisational performance are discussed.

Enclosing the behavior of a hybrid system up to and beyond a Zeno point

Even simple hybrid systems like the classic bouncing ball can exhibit Zeno behaviors. The existence of this type of behavior has so far forced simulators to either ignore some events or risk looping indefinitely. This in turn forces modelers to either insert ad hoc restrictions to circumvent Zeno behavior or to abandon hybrid modeling. To address this problem, we take a fresh look at event detection and localization. A key insight that emerges from this investigation is that an enclosure for a given time interval can be valid independently of the occurrence of a given event. Such an event can then even occur an unbounded number of times, thus making it possible to handle certain types of Zeno behavior.

Novel expression of microRNAs in serum samples of Iraqi breast cancer women

Although a lot of hard work against cancer to reduces its spread but it still continues to kill with abandon. The need for a biomarker for cancer early detection becomes the most mind concentrated scientists. MicroRNAs the tiny non coding RNA molecules opened new path for the scientists to determine the cancer in its early stages. Expression of microRNAs profiles has been investigated to be involved in cancer development. Here we determined the expression of microRNAs in serum of Iraqi healthy volunteers and other women diagnosed with breast cancer. MicroRNAs expression has been determined by using real time qPCR and delta method has been used. Four of thirteen microRNAs were shown to be expressed in serum of Iraqi breast cancer women. Let-7a and miR-21 were shown to be significantly over expressed in serum of breast cancer compared with healthy serum volunteers (P= 0.022 and 0.026) respectively. While miR-26b and miR-429 found to be significantly down expressed in serum of breast cancer women (P= 0.0034 and 0.031) respectively. The result concluded that these expressed microRNAs in serum of breast cancer women could be used as a first indicator of breast cancer occurrence.

Online-questionnaire design:establishing guidelines and evaluating existing eupport

As a new medium for questionnaire delivery, the internet has the potential to revolutionise the survey process. Online (web-based) questionnaires provide several advantages over traditional survey methods in terms of cost, speed, appearance, flexibility, functionality, and usability [1, 2]. For instance, delivery is faster, responses are received more quickly, and data collection can be automated or accelerated [1- 3]. Online-questionnaires can also provide many capabilities not found in traditional paper-based questionnaires: they can include pop-up instructions and error messages; they can incorporate links; and it is possible to encode difficult skip patterns making such patterns virtually invisible to respondents. Like many new technologies, however, online-questionnaires face criticism despite their advantages. Typically, such criticisms focus on the vulnerability of online-questionnaires to the four standard survey error types: namely, coverage, non-response, sampling, and measurement errors. Although, like all survey errors, coverage error (“the result of not allowing all members of the survey population to have an equal or nonzero chance of being sampled for participation in a survey” [2, pg. 9]) also affects traditional survey methods, it is currently exacerbated in online-questionnaires as a result of the digital divide. That said, many developed countries have reported substantial increases in computer and internet access and/or are targeting this as part of their immediate infrastructural development [4, 5]. Indicating that familiarity with information technologies is increasing, these trends suggest that coverage error will rapidly diminish to an acceptable level (for the developed world at least) in the near future, and in so doing, positively reinforce the advantages of online-questionnaire delivery. The second error type – the non-response error – occurs when individuals fail to respond to the invitation to participate in a survey or abandon a questionnaire before it is completed. Given today’s societal trend towards self-administration [2] the former is inevitable, irrespective of delivery mechanism. Conversely, non-response as a consequence of questionnaire abandonment can be relatively easily addressed. Unlike traditional questionnaires, the delivery mechanism for online-questionnaires makes estimation of questionnaire length and time required for completion difficult1, thus increasing the likelihood of abandonment. By incorporating a range of features into the design of an online questionnaire, it is possible to facilitate such estimation – and indeed, to provide respondents with context sensitive assistance during the response process – and thereby reduce abandonment while eliciting feelings of accomplishment [6]. For online-questionnaires, sampling error (“the result of attempting to survey only some, and not all, of the units in the survey population” [2, pg. 9]) can arise when all but a small portion of the anticipated respondent set is alienated (and so fails to respond) as a result of, for example, disregard for varying connection speeds, bandwidth limitations, browser configurations, monitors, hardware, and user requirements during the questionnaire design process. Similarly, measurement errors (“the result of poor question wording or questions being presented in such a way that inaccurate or uninterpretable answers are obtained” [2, pg. 11]) will lead to respondents becoming confused and frustrated. Sampling, measurement, and non-response errors are likely to occur when an online-questionnaire is poorly designed. Individuals will answer questions incorrectly, abandon questionnaires, and may ultimately refuse to participate in future surveys; thus, the benefit of online questionnaire delivery will not be fully realized. To prevent errors of this kind2, and their consequences, it is extremely important that practical, comprehensive guidelines exist for the design of online questionnaires. Many design guidelines exist for paper-based questionnaire design (e.g. [7-14]); the same is not true for the design of online questionnaires [2, 15, 16]. The research presented in this paper is a first attempt to address this discrepancy. Section 2 describes the derivation of a comprehensive set of guidelines for the design of online-questionnaires and briefly (given space restrictions) outlines the essence of the guidelines themselves. Although online-questionnaires reduce traditional delivery costs (e.g. paper, mail out, and data entry), set up costs can be high given the need to either adopt and acquire training in questionnaire development software or secure the services of a web developer. Neither approach, however, guarantees a good questionnaire (often because the person designing the questionnaire lacks relevant knowledge in questionnaire design). Drawing on existing software evaluation techniques [17, 18], we assessed the extent to which current questionnaire development applications support our guidelines; Section 3 describes the framework used for the evaluation, and Section 4 discusses our findings. Finally, Section 5 concludes with a discussion of further work.

Enclosing the behavior of a hybrid automaton up to and beyond a Zeno point

Even simple hybrid automata like the classic bouncing ball can exhibit Zeno behavior. The existence of this type of behavior has so far forced a large class of simulators to either ignore some events or risk looping indefinitely. This in turn forces modelers to either insert ad-hoc restrictions to circumvent Zeno behavior or to abandon hybrid automata. To address this problem, we take a fresh look at event detection and localization. A key insight that emerges from this investigation is that an enclosure for a given time interval can be valid independent of the occurrence of a given event. Such an event can then even occur an unbounded number of times. This insight makes it possible to handle some types of Zeno behavior. If the post-Zeno state is defined explicitly in the given model of the hybrid automaton, the computed enclosure covers the corresponding trajectory that starts from the Zeno point through a restarted evolution.