Propofol sedation administered by cardiologists for patients undergoing catheter ablation for ventricular tachycardia

AIMS Propofol sedation has been shown to be safe for atrial fibrillation ablation and internal cardioverter-defibrillator implantation but its use for catheter ablation (CA) of ventricular tachycardia (VT) has yet to be evaluated. Here, we tested the hypothesis that VT ablation can be performed using propofol sedation administered by trained nurses under a cardiologist's supervision. METHODS AND RESULTS Data of 205 procedures (157 patients, 1.3 procedures/patient) undergoing CA for sustained VT under propofol sedation were analysed. The primary endpoint was change of sedation and/or discontinuation of propofol sedation due to side effects and/or haemodynamic instability. Propofol cessation was necessary in 24 of 205 procedures. These procedures (Group A; n = 24, 11.7%) were compared with those with continued propofol sedation (Group B; n = 181, 88.3%). Propofol sedation was discontinued due to hypotension (n = 22; 10.7%), insufficient oxygenation (n = 1, 0.5%), or hypersalivation (n = 1, 0.5%). Procedures in Group A were significantly longer (210 [180-260] vs. 180 [125-220] min, P = 0.005), had a lower per hour propofol rate (3.0 ± 1.2 vs. 3.8 ± 1.2 mg/kg of body weight/h, P = 0.004), and higher cumulative dose of fentanyl administered (0.15 [0.13-0.25] vs. 0.1 [0.05-0.13] mg, P < 0.001), compared with patients in Group B. Five (2.4%) adverse events occurred. CONCLUSION Sedation using propofol can be safely performed for VT ablation under the supervision of cardiologists. Close haemodynamic monitoring is required, especially in elderly patients and during lengthy procedures, which carrying a higher risk for systolic blood pressure decline.

Energy resources on federally administered lands /

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Temporary disability insurance; problems in formulating a program administered by a state employment security agency. Rev. ed. 1949. [Prepared by the Division of Research and Statistics and the Bureau of Employment Security of the Social Security Administration].

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The principles of equity : a treatise on the system of justice administered in courts of chancery /

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A treatise on the law arising before justices of the peace and in business transactions : as administered in courts of record in Ohio, and under the Revised Statutes of 1880 : with practical forms /

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Grants-in-aid and other financial assistance programs administered by the U.S. Department of Health, Education, and Welfare.

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Agriculture decisions : decisions of the Secretary of Agriculture under the regulatory laws administered in the United States Department of Agriculture

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A reference guide to federal plant quarantines and regulations administered by the Plant Quarantine Division.

Description based on: No. 2 published December 1970; title from cover.

Recherches et expériences sur les effects de l'acétate de morphine /

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Oregon laws relating to agriculture from Oregon revised statutes with 1955 amendments; administered by the State Department of Agriculture and including some agricultural laws not administered by the department but related to or associated with department responsibilities.

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National defense establishment (unification of the armed services) Hearings before the Committee on armed services, United States Senate, Eightieth Congress, first session, on S. 758, a bill to promote the national security by providing for a National defense establishment which shall be administered by a secretary of national defense, and for a Department of the Army, a Department of the Navy, and a Department of the Air Force with the Nationaldefense establishment ...

Chan Gurney, Chairman.