Psychosociale Klachten en Welbevinden van Primair Hyperaldosteronisme Patiënten na Medische Behandeling

Dit onderzoek richtte zich op psychosociale klachten en welbevinden van optimaal medische behandelde PHA patiënten ná het eerste jaar. De twee typen PHA – adenoom en hyperplasie – zijn met elkaar vergeleken en de invloed van sekse en co-morbiditeit is onderzocht. Via de patiëntenvereniging NVACP en het Radboud Universitair Medisch Centrum zijn 397 patiënten benaderd, waarvan 123 de eenmalige digitale vragenlijst hebben ingevuld. Het betrof 89 personen met adenoom en 34 met hyperplasie. De gemiddelde leeftijd was 57,45 jaar. De groep bestond voor 75% uit mannen en voor 25% uit vrouwen. De (start van de) behandeling varieerde van 13 tot 295 maanden geleden, gemiddeld was dit 59,3 maanden. De psychische klachten zijn gemeten met de subschalen voor angst, voor depressie en voor insufficiëntie van denken en handelen van de SCL-90 (Arrindell & Ettema, 2003); welbevinden is gemeten met de DMHC-SF (Lamers, Westerhof, Bohlmeijer, ten Klooster, & Keyes, 2011). De resultaten toonden geen verschil tussen de twee typen PHA noch qua psychische klachten noch qua welbevinden. Psychische klachten bleken 10,6% van de variantie in welbevinden te verklaren (β = -.34 Adjusted R2 = .106, F (1,121) = 15.44, p < .001). Ook na controle voor de variabelen sekse en co-morbiditeit bleek type PHA geen invloed te hebben op psychische klachten en op welbevinden. Wel werd duidelijk dat co-morbiditeit met 26,3% significant van invloed was op psychische klachten (β = .52, Adjusted R2 = .263, F (1,121) = 44.56, p < .001).

Life expectancy for community-based patients with heart failure from time of diagnosis

AIMS: Heart failure has been demonstrated in previous studies to have a dismal prognosis. However, the modern-day prognosis of patients with new onset heart failure diagnosed in the community managed within a disease management programme is not known. The purpose of this study is to report on prognosis of patients presenting with new onset heart failure in the community who are subsequently followed in a disease management program.

METHODS AND RESULTS: A review of patients referred to a rapid access heart failure diagnostic clinic between 2002 and 2012 was undertaken. Details of diagnosis, demographics, medical history, medications, investigations and mortality data were analysed. A total of 733 patients were seen in Rapid Access Clinic for potential new diagnosis of incident of heart failure. 38.9% (n=285) were diagnosed with heart failure, 40.7% (n=116) with HF-REF and 59.3% (n=169) with HF-PEF. There were 84 (29.5%) deaths in the group of patients diagnosed with heart failure; 41 deaths (35.3%) occurred in patients with HF-REF and 43 deaths (25.4%) occurred in patients with HF-PEF. In patients with heart failure, 52.4% (n=44) died from cardiovascular causes. 63.8% of HF patients were alive after 5 years resulting on average in a month per year loss of life expectancy over that period compared with aged matched simulated population.

CONCLUSIONS: In this community-based cohort, the prognosis of heart failure was better than reported in previous studies. This is likely due to the impact of prompt diagnosis, the improvement in therapies and care within a disease management structure.

Selective serotonin reuptake inhibitor antidepressant use in first trimester pregnancy and risk of specific congenital anomalies: a European register-based study

Evidence of an association between early pregnancy exposure to selective serotonin reuptake inhibitors (SSRI) and congenital heart defects (CHD) has contributed to recommendations to weigh benefits and risks carefully. The objective of this study was to determine the specificity of association between first trimester exposure to SSRIs and specific CHD and other congenital anomalies (CA) associated with SSRI exposure in the literature (signals). A population-based case-malformed control study was conducted in 12 EUROCAT CA registries covering 2.1 million births 1995-2009 including livebirths, fetal deaths from 20 weeks gestation and terminations of pregnancy for fetal anomaly. Babies/fetuses with specific CHD (n = 12,876) and non-CHD signal CA (n = 13,024), were compared with malformed controls whose diagnosed CA have not been associated with SSRI in the literature (n = 17,083). SSRI exposure in first trimester pregnancy was associated with CHD overall (OR adjusted for registry 1.41, 95% CI 1.07-1.86, fluoxetine adjOR 1.43 95% CI 0.85-2.40, paroxetine adjOR 1.53, 95% CI 0.91-2.58) and with severe CHD (adjOR 1.56, 95% CI 1.02-2.39), particularly Tetralogy of Fallot (adjOR 3.16, 95% CI 1.52-6.58) and Ebstein's anomaly (adjOR 8.23, 95% CI 2.92-23.16). Significant associations with SSRI exposure were also found for ano-rectal atresia/stenosis (adjOR 2.46, 95% CI 1.06-5.68), gastroschisis (adjOR 2.42, 95% CI 1.10-5.29), renal dysplasia (adjOR 3.01, 95% CI 1.61-5.61), and clubfoot (adjOR 2.41, 95% CI 1.59-3.65). These data support a teratogenic effect of SSRIs specific to certain anomalies, but cannot exclude confounding by indication or associated factors.

Clinical utility of amyloid PET imaging in the differential diagnosis of atypical dementias and its impact on caregivers

La maladie d’Alzheimer (MA) se caractérise pathologiquement par l’accumulation de plaques amyloïde dans le cerveau. La tomographie par émission de positrons (TEP) permet d’imager les plaques amyloïde in vivo. Le but de ce projet est d’évaluer le rôle de la TEP amyloïde dans le processus diagnostique de la MA dans des cas de démences atypiques. Le deuxième but de ce projet est de déterminer l’impact de la révélation d’un diagnostic plus certain chez les proches aidants. 28 patients sans diagnostic malgré une investigation exhaustive ont été sélectionnées et imagées avec le traceur amyloïde 18F-NAV4694 (âge 59,3 ans, é-t. 5,8; MMSE 21.4, é-t 6.0). Les neurologues référents documentaient par la suite tout changement de niveau de certitude, de diagnostic, de traitement et/ou de prise en charge. Les proches aidants consentants ont été rencontrés subséquemment, et un questionnaire avec une échelle de Likert a été utilisé afin de documenter l’impact de l’imagerie leur perception de la maladie. Notre cohorte a été également divisée entre amyloïde positifs (14/28) et négatifs (14/28). Un changement de diagnostic a lieu dans 9/28 cas (32,1% :17.8% ont changé de MA à non-MA, 14,3% de non-MA à MA). Il y avait une augmentation significative (p<0,05) de 44% dans la certitude du neurologue suite à cet examen. Un changement de prise en charge a été obtenu dans 20/28 (71,4%) des cas. Bien que non significatifs statistiquement, un impact favorable sur les proches-aidants a été noté. Cette étude suggère que l’imagerie amyloïde a un rôle bénéfique dans les cas de démences atypiques n’ayant pu être élucidés avec les techniques d’investigations actuellement recommandées. De plus, le processus a été perçu positivement par les proches aidants, notamment en encourageant du temps de qualité avec leurs personnes chères. Ceci illustre un rôle prometteur des biomarqueurs, qui sont de plus en plus explorés.

Moral Requirements are still not Rational Requirements

None

Le suivi des anti-épileptiques

All antiepileptic medications have potential side-effects. Some are rather specific like diplopia for carbamazepin or lamotrigin, whereas others are not, like fatigue or unsteadiness. Most are dose- related and can therefore be alleviated by dose reduction (e.g. somnolence or tremor) but a few are idiosyncratic (e.g. rash) and require cessation of the causative agent. Some can be detected and followed-up on a clinical basis but others necessitate specific examinations.

Seasonal variation of haemoglobin A1c in a Portuguese adult population

Haemoglobin A1c (Hb A1c) is routinely used for monitoring glycemic control in patients with diabetes. Hb A1c seasonal fluctuations can be directly related to different biological, geographical and cultural influences. Our purpose was to evaluate seasonal variation of Hb A1c in a hospital-based adult population over a period of 5 years.

Cardiac T2-mapping using a fast gradient echo spin echo sequence - first in vitro and in vivo experience

Background: The aim of this study was the evaluation of a fast Gradient Spin Echo Technique (GraSE) for cardiac T2-mapping, combining a robust estimation of T2 relaxation times with short acquisition times. The sequence was compared against two previously introduced T2-mapping techniques in a phantom and in vivo. Methods: Phantom experiments were performed at 1.5 T using a commercially available cylindrical gel phantom. Three different T2-mapping techniques were compared: a Multi Echo Spin Echo (MESE; serving as a reference), a T2-prepared balanced Steady State Free Precession (T2prep) and a Gradient Spin Echo sequence. For the subsequent in vivo study, 12 healthy volunteers were examined on a clinical 1.5 T scanner. The three T2-mapping sequences were performed at three short-axis slices. Global myocardial T2 relaxation times were calculated and statistical analysis was performed. For assessment of pixel-by-pixel homogeneity, the number of segments showing an inhomogeneous T2 value distribution, as defined by a pixel SD exceeding 20 % of the corresponding observed T2 time, was counted. Results: Phantom experiments showed a greater difference of measured T2 values between T2prep and MESE than between GraSE and MESE, especially for species with low T1 values. Both, GraSE and T2prep resulted in an overestimation of T2 times compared to MESE. In vivo, significant differences between mean T2 times were observed. In general, T2prep resulted in lowest (52.4 +/- 2.8 ms) and GraSE in highest T2 estimates (59.3 +/- 4.0 ms). Analysis of pixel-by-pixel homogeneity revealed the least number of segments with inhomogeneous T2 distribution for GraSE-derived T2 maps. Conclusions: The GraSE sequence is a fast and robust sequence, combining advantages of both MESE and T2prep techniques, which promises to enable improved clinical applicability of T2-mapping in the future. Our study revealed significant differences of derived mean T2 values when applying different sequence designs. Therefore, a systematic comparison of different cardiac T2-mapping sequences and the establishment of dedicated reference values should be the goal of future studies.

Impacto de la emigración sobre la morbilidad psíquica en los escolares, hijos de padres emigrantes de las escuelas de la parroquia Chiquintad del Cantón Cuenca, de la provincia del Azuay, año lectivo 2008-2009

Se realiza un estudio para determinar la prevalencia de migración y su efecto sobre la morbilidad psíquica en los escolares hijos de padres emigrantes. Participaron 651 niños de las escuelas de la parroquia Chiquintad del cantón Cuenca en el período 2008-2009 a quienes se aplicó una encuesta relacionada a la migración, que incluyó el test de valoración de funcionalidad familiar y el test de Stott modificado para niños, para los síntomas principales de: retraso del aprendizaje, depresión, ansiedad y agresividad. La prevalencia de migración fue el 31.3%, encontrándose que el padre es quien más migra (59.3%), principal lugar de destino Estados Unidos (88.2%), los hijos de emigrante quedan bajo la tutela de sus abuelos (89.9%), se encontró una prevalencia de retraso del aprendizaje de 6%, correspondiente 56.4% a hijos de emigrantes RP de 2.83 (IC:1.53-5.22), depresión 2.6%, en hijos de emigrantes 52.9% con un RP 2.46 (IC:0.96-6.29); ansiedad 2.2%, de los cuales 50% son hijos de emigrantes (RP:2.19, IC:0.77-6.16) y agresividad 2.69%, 55.2% en hijos de emigrantes (RP:2.69, IC:1.32-5.50), disfuncionalidad familiar 35.7% de familias de emigrantes (RP1.21, IC:0.66 2.23).

Technologizacja życia i tożsamości w kulturze współczesnej

The author of article considers the growing role of technology in contemporary society in the context of its role in creating identity and shaping the daily life. Various aspects of Elllul’s conception of technological determinism are reconstructed, including the problem (lack) of freedom in relationships between the individual and technology as well as the problem of annihilation of time and space. The main problem of article is analysed both on the micro and the macro levels, considering the possible contradictions in the use of modern technology devices.

Unemployment as a source of mental distress to individuals and their family: Unemployed parents perceptions during the economic recession

Background: Due to the economic recession, several people in Europe became unemployed. This situation may risk their mental health. Aim: This study explored parents’ perceptions about their unemployment’s effects in daily life during the recession. Methods: A total of 59 unemployed parents (40.7% fathers and 59.3% mothers), ageing 44.4 years (±6.2), answer a question on how the unemployment affected their family lives. Thematic analysis was used to analyse data. Results: The findings suggest that unemployment is a source of adult and youth mental distress and of economic hardship and changes in family relations. Conclusion: Support to unemployed individuals and their families could benefit from these insights when granting the needed financial and socioemotional assistance.

Gestão do stress em enfermeiros perioperatórios

Os enfermeiros não estão isentos das consequências do stress ocupacional, que embora psicológico, afeta a saúde física, constituindo um risco para a segurança e saúde quando persistente, levando ao aparecimento de Burnout. Avaliar o nível de stress e o nível de Burnout na amostra selecionada; Conhecer a relação entre as estratégias de coping e nível de stress vivenciado pelos enfermeiros. Estudo quantitativo, descritivo, correlacional e transversal. Amostra de 81 enfermeiros perioperatórios, maioritariamente do género feminino (74,1%), 66,6% dos inquiridos exercem funções nos Blocos Operatórios do Centro Hospitalar de Trás‐os‐Montes e Alto Douro, média de idades de 43 anos. A opção de trabalhar no Bloco Operatório, foi para 59,3% dos inquiridos imposta pela instituição. A experiência média neste serviço foi de 15 anos. Aplicados três instrumentos de avaliação: Maslach Burnout Inventory, Nurse Stress Index e Inventário de Resolução de Problemas. A amostra exibe um nível considerável de stress (M=81,25; DP=20,7). Observou‐se uma correlação estatisticamente significativa entre o nível de stress e o nível de Burnout (r=0,43; p<0,001); verificou‐se existir uma relação estatisticamente significativa entre o nível de stress e as estratégias de coping (r=‐0,28; p<0,05), contudo, esta relação traduziu uma relação inversa. Valores elevados de Burnout correspondem a valores elevados de stress; valores elevados nas estratégias de coping, corresponderam a níveis baixos de stress. A gestão do stress tem valorizado mais os indivíduos do que as organizações. Contudo, mais importante que prevenir o stress laboral e os riscos psicossociais, é a organização e a gestão do trabalho que deve ser prioritária.

Valores hematológicos y bioquímicos, y su asociación con el estado nutricional, en escolares urbanos. Cuenca

Objetivo: Determinar los valores hematológicos y bioquímicos y su asociación con el estado nutricional, en escolares urbanos de Cuenca. Materiales y métodos: Estudio transversal analítico, muestra aleatorizada por conglomerados, de 585 escolares entre 5 y 12 años de las escuelas urbanas de Cuenca, periodo 2012-2013. Se determinó el estado nutricional usando curvas de crecimiento para niños yadolescentes (z-score), índice de masa corporal por edad y sexo, según las recomendaciones de la Organización Mundial de la Salud; con los valores de los análisis hematológicos y bioquímicos practicados, se relacionaron los resultados de laboratorio con el estado nutricional. Resultados: La media de edad en la población fue de 8.87±1.9 años; promedio en valores hematológicos: glóbulos rojos 4.82±0.31 x 106/ml; glóbulos blancos 7.15±1.86 x 103/ ml; hemoglobina 13.66±1.34 g/dL; hematocrito 40.59±3.92%; volumen corpuscular medio (VCM) 83.64±4.03fl; hemoglobina corpuscular media (HCM) 38.31±1.27pg. Promedio de valores bioquímicos: proteína total 6.92±1.04g/ dL, albúmina sérica 4.37±0.7g/dL, hierro sérico 87.40±35.31μg/dL. El 19.3% presentó malnutrición (desnutrición 1.2%, sobrepeso 12.8% y obesidad 5.3%), existiendo asociación estadísticamente significativa (p<0.05) con glóbulos rojos. Existieron diferencias estadísticamente significativas, entre niños y niñas, en valores de hierro, VCM y HCM; y respecto de malnutrición, en hierro sérico, glóbulos rojos, glóbulos blancos, hematocrito y VCM. Conclusiones: Se encontró asociación entre el estado nutricional y los valores hematológicos y bioquímicos. Se determinó prevalencia alta de sobrepeso y obesidad en población escolar urbana de Cuenca, similar a la reportada en otros estudios.

Prevalencia de la luxación acromioclavicular y tratamientos en pacientes del Hospital José Carrasco Arteaga en el periodo enero 2010 a diciembre 2014

ANTECEDENTES: La luxación acromioclavicular es la lesión de hombro más prevalencia en quienes practican deportes de contacto, se relaciona con una alta tasa de accidentes de tránsito, por ello es importante conocer su prevalencia, factores de riesgo, para realizar un tratamiento adecuado. OBJETIVO GENERAL: Determinar la prevalencia de la luxación acromioclavicular y tratamientos en pacientes del Hospital José Carrasco Arteaga en el periodo enero 2010 a diciembre 2014. METODOLOGÍA: Se realizó un estudio descriptivo transversal, cuyo universo fueron las historias clínicas de pacientes que recibieron atención en el Hospital José Carrasco Arteaga entre enero del año 2010 hasta diciembre del 2014. Se recolectó la información de la base de datos (AS 400) en un formulario específico, el cual se analizó mediante el paquete estadístico SPSS 15.0 y Epi-Info 7, utilizando distribuciones de frecuencia y porcentajes. Los resultados se presentaron en gráficos, tablas simples y combinadas. USO DE RESULTADOS: De 120 pacientes con diagnóstico de luxación acromioclavicular se presentó una prevalencia de 3,7 casos por cada 1000 personas que se atendieron en emergencia del hospital José Carrasco Arteaga. Se incluyeron 86 casos en el estudio. Los hombres resultaron el grupo más afectado (91,9%). El tipo de luxación más frecuente fue el III (59,3%). La lesión que más asociada fue la fractura de clavícula (4,7%). El mecanismo de lesión directo (91,9%) fue el más prevalente. En 41.9 % de los casos la luxación se asoció con accidentes de tránsito

Neoechinorhynchus curemai (Acanthocephala : Neoechinorhynchidae) in Prochilodus lineatus (Osteichthyes : Prochilodontidae)from the Parana River, Brazil

This work evaluated, parasitic infections by Neoechinorhynchus curemai (Acanthocephala: Neoechinorhynchidae) in Prochilodus lineatus captured between August 2000 and August 2001 in the Parana River, Presidente Epitacio, São Paulo, Brazil. of 87 fishes examined, 59 were infected (25 males and 34 females). High mean intensities occurred in August 2000 (45.2, range 2-204), September 2000 (28.5, range 11-73), October 2000 (59.3, range 2-250) and February 2001 (27.3, range 3-73). There was no relationship of rainfall with mean intensity and prevalence. Males were more parasitized (P < 0.05) than females. This work contributes to the knowledge of helminth parasites of fish from a little studied region of the Parana River, showing diversity in their fauna when compared to other places in the same river. (c) 2005 Elsevier B.V. All rights reserved.