994 resultados para 42-372


Relevância:

20.00% 20.00%

Publicador:

Relevância:

20.00% 20.00%

Publicador:

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Welsch (Projektbearbeiter): Einladung an die Wahlglieder der Berliner Wahlbezirke 42 bis 45 und 48 zur Vorberatung über die Ausübung des Urwählerrechts für die erste Kammer

Relevância:

20.00% 20.00%

Publicador:

Resumo:

OBJECTIVE To provide information on pregnancy outcomes in women receiving certolizumab pegol (CZP). METHODS The UCB Pharma safety database was searched for pregnancies through to September 1, 2014. Reports for maternal and paternal CZP exposure were included and outcomes examined, and data on CZP exposure, pregnancy, comorbidities, and infant events were extracted by 2 independent reviewers. Concomitant medications and disease activity were reviewed for clinical trial patients. RESULTS Of 625 reported pregnancies, 372 (59.5%) had known outcomes. Paternal exposure pregnancies (n = 33) reported 27 live births, 4 miscarriages, 1 induced abortion, and 1 stillbirth. Maternal exposure pregnancies (n = 339) reported 254 live births, 52 miscarriages, 32 induced abortions, and 1 stillbirth. Almost all reported pregnancies had exposure to CZP in the first trimester, when organogenesis takes place, and a third of them continued the drug into the second and/or third trimesters. The most frequent indications for maternal CZP use were Crohn disease (192/339) and rheumatic diseases (118/339). Twelve cases of congenital malformation and a single neonatal death were reported. CONCLUSION Analysis of pregnancy outcomes after exposure to CZP supports previous reports, suggesting a lack of harmful effect of maternal CZP exposure on pregnancy outcomes. However, additional data from a larger number of outcomes after exposure and studies including an unexposed comparison group are required to fully evaluate CZP safety and tolerability in pregnancy.

Relevância:

20.00% 20.00%

Publicador:

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Hirsch Liwschütz

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Alliance Israélite Universelle / Deutsches Büro

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Viktor Aptowitzer

Relevância:

20.00% 20.00%

Publicador:

Resumo:

N. H.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Vorbesitzer: Bartholomaeusstift Frankfurt am Main;