Operator's manual : camera set, still picture KS-4A(2).

"10 May 1963."

X-ray crystallographic and theoretical studies of an anticonvulsant enaminone:methyl 4-(4'-bromophenyl)amino-6-methyl-2-oxocyclohex-3-en-1-oate

Objective: The aims of this study were to establish the structure of the potent anticonvulsant enaminone methyl 4-(4′-bromophenyl)amino-6-methyl-2- oxocyclohex-3-en-1-oate (E139), and to determine the energetically preferred conformation of the molecule, which is responsible for the biological activity. Materials and Methods: The structure of the molecule was determined by X-ray crystallography. Theoretical ab initio calculations with different basis sets were used to compare the energies of the different enantiomers and to other structurally related compounds. Results: The X-ray crystal structure revealed two independent molecules of E139, both with absolute configuration C11(S), C12(R), and their inverse. Ab initio calculations with the 6-31G, 3-21G and STO-3G basis sets confirmed that the C11(S), C12(R) enantiomer with both substituents equatorial had the lowest energy. Compared to relevant crystal structures, the geometry of the theoretical structures shows a longer C-N and shorter C=O distance with more cyclohexene ring puckering in the isolated molecule. Conclusion: Based on a pharmacophoric model it is suggested that the enaminone system HN-C=C-C=O and the 4-bromophenyl group in E139 are necessary to confer anticonvulsant property that could lead to the design of new and improved anticonvulsant agents. Copyright © 2003 S. Karger AG, Basel.

Lack of effect of aspirin in primary CV prevention in type 2 diabetic patients with nephropathy:results from 8 years follow-up of NID-2 study

The risk-to-benefit ratio for the use of low dose of aspirin in primary cardiovascular (CV) prevention in patients with diabetes mellitus remains to be clarified. We assessed the effect of aspirin on risk of CV events in type 2 diabetic patients with nephropathy, in order to verify the usefulness of Guidelines in clinical practice. We carried out a prospective multicentric study in 564 patients with type 2 diabetic nephropathy free of CV disease attending outpatient diabetes clinics. A total of 242 patients received antiplatelet treatment with aspirin 100 mg/day (group A), and 322 were not treated with antiplatelet drugs (group B). Primary end point was the occurrence of total major adverse cardio-vascular events (MACE). Secondary end points were the relative occurrence of fatal MACE. The average follow-up was 8 years. Total MACE occurred in 49 patients from group A and in 52 patients from group B. Fatal MACE occurred in 22 patients from group A and in 20 from group B; nonfatal MACE occurred in 27 patients from group A and in 32 patients from group B. Kaplan-Meier analysis did not show a statistically significant difference of cumulative MACE between the two groups. A not statistically significant difference in the incidence of both fatal (p = 0.225) and nonfatal CV events (p = 0.573) between the two groups was observed. These results were confirmed after adjustment for confounders (HR for MACE 1.11, 95 % CI 0.91-1.35). These findings suggest that low dose of aspirin is ineffective in primary prevention for patients with nephropathy. © 2014 Springer-Verlag Italia.

Psychosocial barriers to self -care among Hispanic women with type 2 diabetes mellitus

This cross-sectional survey-designed study investigated the presence and influence of psychosocial barriers to diabetes self-management practices among Hispanic women with type 2 diabetes mellitus. Women (n = 128) who were diagnosed and being treated for type 2 diabetes were recruited from the Miami-Dade area in South Florida. A Beck Depression Inventory-II, Diabetes Care Profile, Diabetes Knowledge Test, Diabetes Empowerment, Multidimensional Health Locus of Control, and Perceived Stress Scales were administered, along with assessment of diet through a 24-hour recall and anthropometric evaluation by body composition analysis and body mass index computation. ^ Mean (± SD) age for subjects was 50.15 ± 15.93 and age at diagnosis was 42.46 ± 14.69. Mean glycosylated hemoglobin (A 1C) was 8.55 ± 1.39. Diabetes education had not been received by 46.9% of subjects. Psychosocial status had previously been evaluated in only 4 participants. Forty percent of participants were assessed as depressed and 17% moderately to severely so. Depression correlated significantly (p < 0.01) with A1C (r = 0.242), perceived stress (r = 0.566), and self-rated health (r = −0.523). Perceived stress correlated significantly (p < 0.01) with A1C (r = 0.388), understanding of diabetes (r = 0.282), self-rated health (r = −0.372) and diabetes empowerment (r = −0.366). For Cuban women, perceived stress (β = 0.418, p = 0.033) was the only significant predictor of A1C, while among non-Cuban Hispanic women, self-reported health (β = −0.418, p = 0.003) and empowerment (β = 0.432, p = 0.004) were better predictors. The most desirable DM status among the women surveyed (high diet adherence, low exercise barriers, and A1C ≤ 7) was associated with superior self-rated health, more support from family and friends, and greater empowerment. ^ This study revealed the error in considering Hispanics a homogenous entity in treating disease, as their cultural backgrounds and concentration in a community can greatly influence management of a chronic disease like diabetes. The strong correlations found between diabetes-related health indicators and psychosocial factors such as depression and perceived stress suggest that psychosocial assessment of patients must be more strongly advocated in diabetes care. Psychosocial assessment of ethnically diverse diabetic populations is especially vital if greater knowledge is to be gained about their barriers to self-care so that diabetes treatment and thus outcomes are enhanced. ^

The verset and fabordão genres in the context of music manuscript 242 from the Coimbra University Library

Este artigo é o resultado de uma pesquisa exaustiva que tenho desenvolvido em torno do Manuscrito 242 da Biblioteca da Universidade de Coimbra (P-Cug MM 242). Este valioso manuscrito do século XVI destaca-se pela importância crucial para o estudo da música instrumental em Portugal, no Renascimento tardio e nas primeiras décadas do século XVII. Neste manuscrito estão reproduzidos alguns dos primeiros exemplos de tento e fantasia, como o atestam as obras para tecla de António Carrreira (c.1530c. 1594). Para além de um grande número de cópias de motetes, andamentos de Missa, canções e madrigais escritos por diversos compositores europeus de meados do século XVI, identificados e inventariados por Owen Rees, este manuscrito inclui também diversas peças instrumentais de autoria desconhecida, que ainda não receberam a atenção que merecem. Deste conjunto, seleccionei dois grupos de obras que reúnem pequenas peças instrumentais, as quais irei aprofundar neste artigo. O primeiro grupo, que representa o objecto central deste estudo, é constituído por um conjunto de obras para tecla com melodias em cantochão que proponho incluir nos géneros verso e/ou fabordão para órgão. Pretendo discutir estas obras a partir das suas características formais, estilísticas e performativas, assim como a sua inclusão nas práticas de alternatim instrumental no Mosteiro de Santa Cruz de Coimbra durante esse período.

THE VERSET AND FABORDÃO GENRES IN THE CONTEXT OF MUSIC MANUSCRIPT 242 FROM THE COIMBRA UNIVERSITY LIBRARY.

Este artigo é o resultado de uma pesquisa exaustiva que tenho desenvolvido em torno do Manuscrito 242 da Biblioteca da Universidade de Coimbra (P-Cug MM 242). Este valioso manuscrito do século XVIdestaca-se pela importância crucial para o estudo da música instrumental em Portugal, no Renascimento tardio e nas primeiras décadas do século XVII. Neste manuscrito estão reproduzidos alguns dosprimeiros exemplos de tento e fantasia, como o atestam as obras para tecla de António Carrreira (c.1530c. 1594). Para além de um grande número de cópias de motetes, andamentos de Missa, canções emadrigais escritos por diversos compositores europeus de meados do século XVI, identificados einventariados por Owen Rees, este manuscrito inclui também diversas peças instrumentais de autoriadesconhecida, que ainda não receberam a atenção que merecem. Deste conjunto, seleccionei dois grupos de obras que reúnem pequenas peças instrumentais, as quais irei aprofundar neste artigo. O primeirogrupo, que representa o objecto central deste estudo, é constituído por um conjunto de obras para teclacom melodias em cantochão que proponho incluir nos géneros verso e/ou fabordão para órgão. Pretendodiscutir estas obras a partir das suas características formais, estilísticas e performativas, assim como a suainclusão nas práticas de alternatim instrumental no Mosteiro de Santa Cruz de Coimbra durante esse período.