Lattice NRQCD study of in-medium bottomonium states using Nf = 2+1, 48³ × 12 HotQCD configurations

The behavior of bottomonium state correlators at non-zero temperature, 140.4(β = 6.664) ≤ T ≤ 221(β = 7.280) (MeV), where the transition temperature is 154(9) (MeV), is studied, using lattice NRQCD on 48³ ×12 HotQCD HiSQ action configurations with light dynamical Nf = 2+1 (mu,s/ms = 0.05) staggered quarks. In order to understand finite temperature effects on quarkonium states, zero temperature behavior of bottomonium correlators is compared based on 32⁴ (β = 6.664,6.800 and 6.950) and 48³ ×64 (β = 7.280) lattices. We find that temperature effects on S-wave bottomoniumstates are small but P-wave bottomoniumstates show a noticeable temperature dependence above the transition temperature.

Ubiquitin-specific protease USP2-45 acts as a molecular switch to promote α2δ-1-induced downregulation of Ca v1.2 channels

Availability of voltage-gated calcium channels (Cav) at the plasma membrane is paramount to maintaining the calcium homeostasis of the cell. It is proposed that the ubiquitylation/de-ubiquitylation balance regulates the density of ion channels at the cell surface. Voltage-gated calcium channels Cav1.2 have been found to be ubiquitylated under basal conditions both in vitro and in vivo. In a previous study, we have shown that Cav1.2 channels are ubiquitylated by neuronal precursor cell-expressed developmentally downregulated 4 (Nedd4-1) ubiquitin ligases, but the identity of the counterpart de-ubiquitylating enzyme remained to be elucidated. Regarding sodium and potassium channels, it has been reported that the action of the related isoform Nedd4-2 is counteracted by the ubiquitin-specific protease (USP) 2-45. In this study, we show that USP 2-45 also de-ubiquitylates Cav channels. We co-expressed USPs and Cav1.2 channels together with the accessory subunits β2 and α2δ-1, in tsA-201 and HEK-293 mammalian cell lines. Using whole-cell current recordings and surface biotinylation assays, we show that USP2-45 specifically decreases both the amplitude of Cav currents and the amount of Cav1.2 subunits inserted at the plasma membrane. Importantly, co-expression of the α2δ-1 accessory subunit is necessary to support the effect of USP2-45. We further show that USP2-45 promotes the de-ubiquitylation of both Cav1.2 and α2δ-1 subunits. Remarkably, α2δ-1, but not Cav1.2 nor β2, co-precipitated with USP2-45. These results suggest that USP2-45 binding to α2δ-1 promotes the de-ubiquitylation of both Cav1.2 and α2δ-1 subunits, in order to regulate the expression of Cav1.2 channels at the plasma membrane.

Chiral Templating Activity of Tris(bipyridine)ruthenium(II) Cation in the Design of Three-Dimensional (3D) Optically Active Oxalate-Bridged {[Ru(bpy) 3 ][Cu 2 x Ni 2(1 - x ) (C 2 O 4 ) 3 ]} n (0 ≤ x ≤ 1; bpy = 2,2‘-bipyridine): Structural, Optical, and Magnetic Studies

Three-dimensional oxalate-based {[Ru(bpy)3][Cu2xNi2(1-x)(ox)3]}n (0≤ x ≤ 1, ox = C2O42-, bpy = 2,2‘bipyridine) were synthesized. The structure was determined for x = 1 by X-ray diffraction on single crystal. The compound crystallizes in the cubic space group P4132. It shows a three-dimensional 10-gon 3-connected (10,3) anionic network where copper(II) has an unusual tris(bischelated) environment. X-ray powder diffraction patterns and their Rietveld refinement show that all the compounds along the series are isostructural and single-phased. According to X-ray absorption spectroscopy, copper(II) and nickel(II) have an octahedral environment, respectively elongated and trigonally distorted. As shown by natural circular dichroism, the optically active forms of {[Ru(bpy)3][CuxNi2(1-x)(ox)3]}n are obtained starting from resolved Δ- or Λ-[Ru(bpy)3]2+. The Curie−Weiss temperatures range between −55 (x = 1) and −150 K (x = 0). The antiferromagnetic exchange interaction thus decreases when the copper contents increases in agreement with the crystallographic structure of the compounds and the electronic structure of the metal ions. At low temperature, the compounds exhibit complex long-range ordered magnetic behavior.

Bicyclo[3.2.1]amide-DNA: a chiral, non-chiroselective base-pairing system

The design, synthesis and base-pairing properties of bicyclo[3.2.1]amide-(bca)DNA, a novel phosphodiester based DNA analogue, is reported. This analogue consists of a conformationally constrained backbone entity which emulates a B-DNA geometry, to which the nucleobases were attached via an extended, acyclic amide linker. Homobasic adenine-containing bca-decamers form duplexes with complementary oligonucleotides containing the bca-, the DNA the RNA and, surprisingly, also the L-RNA backbone. UV- and CD-spectroscopic investigations revealed the duplexes with D- or L-complement to be of similar stability and enantiomorphic in structure. Bca-oligonucleotides containing all four bases form strictly antiparallel, left-handed complementary duplexes with itself and complementary DNA but not with RNA. Base-mismatch discrimination is comparable to that of DNA while the overall thermal stabilities of bca-oligonucleotide duplexes are inferior relative to that of DNA or RNA. A detailed molecular modeling study of left- and right-handed bca-DNA containing duplexes showed only minor changes in the backbone structure and revealed a structural switch around the base-linker unit to be responsible for the generation of enantiomorphic duplex structures. The obtained data are discussed with respect to the structural and energetic role of the ribofuranose entities in DNA and RNA association

Rede des Studenten Edmund Monecke bei seiner Verurtheilung in zweiter Instanz zu 2 1/2 Jahren Festungsstrafe und Verlust der National-Kokarde (im Juli 1848): Wenn man heute dem preußischen Volke das ruhige klare Auge eines Geschichtsforschers leihen könnte ...

Welsch (Projektbearbeiter): Rechtfertigung des Angeklagten gegen den Vorwurf der Majestätsbeleidigung

Na 1 Nachlass Max Horkheimer, 3 - Korrespondenzen u.a. mit Julius S. Bach (p. I 2, 1-130)

33 Briefe zwischen Julius S. Bach und Max Horkheimer, 1937-1941; 1 Brief von Julius S. Bach an Mary von Meldelsohn, 28.08.1940; 24 Briefe zwischen Richard Bach und Max Horkheimer, 1938-1940; 1 Abschrift eines Briefes von Oscar W. Gross an Emil de Leuw, 1938; 1 Brief von A. Bailer an Mr. Iggersheimer, 01.05.1940; 1 Brief von Max Horkheimer an Bailliere, Tindall & Cox London, 05.07.1949; 1 Brief von Beatrix Baird an Max Horkheimer; 5 Briefe zwischen Leonard Balet und Max Horkheimer, 1938-1949; 2 Briefe zwischen John Simon Guggenheim Memorial Foundation New York und Max Horkheimer, 22.11.1948, 05.01.1949; 1 Brief von W. H. de Graaff, Ladislaus Bálint an Max Horkheimer, 11.05.1938; 6 Briefe zwischen Bank of Manhattan Company New York und Max Horkheimer, 1934-1935; 6 Briefe zwischen Ladislaus Bálint und Max Horkheimer, 1934-1935; 2 Briefe zwischen der Bank of the Manhatten Company in New York und Max Horkheimer, 14./15.11.1934; 5 Briefe zwischen der Bankers Trust Company und Max Horkheimer, 1934; 1 Brief von R. Bárány an Max Horkheimer, 05.05.1933; 5 Briefe zwischen Hans Baron und Max Horkheimer, 1936; 3 Briefe zwischen Salo W. Baron und Max Horkheimer, 1941-1942, 16.04.1940; 1 Brief zwischen A. Barratt Brown und Max Horkheimer, 01.10.1936;

Na 1 Nachlass Max Horkheimer, 510 - Korrespondenzen mit Theodor W. Adono (p. VI 2, 1 - 212)

Briefwechsel zwischen Theodor W. Adono, Gretel Adorno und Max Horkheimer, 1955-1957; 1 Brief der Gesellschaft für soziale Betriebspraxis an Theodor W. Adorno und Max Horkheimer, 30.08.1955; 1 Brief der Gesellschaft für soziale Betriebspraxis mbH in Düsseldorf an das Rationalisierungs-Kuratorium der Deutschen Wirtschaft RG Mensch und Arbeit in Frankfurt; 1 Brief von Theodor W. Adorno an Elisabeth Calvelli-Adorno, 19.08.1955; 5 Briefe zwischen Alice Maier und Theodor W. Adorno, 1955-1956; 2 Briefe von Theodor W. Adorno an Frederick Polock, 1955; 1 Brief von Theodor W. Adorno an Herrn Ritter, Dekan der Philosphischen Fakultät der Johann Wolfgang Goethe-Universität Frankfurt am Main, 24.05.1955; 1 Brief von Marianne Regensburger an Theodor W. Adorno, 1955; 1 Brief von Marianne Regensburger an Walter Abendroth, Berlin-Schöneberg, 11.05.1955; 1 Brief von Theodor W. Adorno an Herrn von Staa, 24.03.1955; 1 Brief von Theodor W. Adorno an Herrn Kux, 08.03.1955; 1 Briefentwurf von Theodor W. Adorno an Gottfried Weber, Dekan der Philosophischen Fakultät der Johann Wolfgang Goethe-Universität Frankfurt am Main, 1956; 1 Brief von Theodor W. Adorno an Renato Solmi, 04.09.1956; 1 Brief von Theodor W. Adorno an das Kuratorium der Johann Wolfgang Goethe-Universität in Frankfurt am Main, 27.03.1956;

Na 1 Nachlass Max Horkheimer, 606 - Vorlesung: "Einführung in die Philosophie der Gegenwart" sowie drei Vorträge (p. VIII 2, 1 - VIII 2, 2-4)

Vorlesung: "Einführung in die Philosophie der Gegenwart", SS 1926, Typoskript mit eigenhändigen Korrekturen, 185 Blatt; Vortrag: "Über Sinn und Grenze einer soziologischen Behandlungen der Philosophie", 1928 (?), Typsokript mit eigenhändigen Korrekturen, 10 Blatt (GS 11, S. 209-220); Vortrag, gehalten zu Beginn der Vorlesung: "Max Scheler (1874-1928)", "Einführung in die Geschichtsphilosophie", SS 1928, Typoskript mit eigenhändigen Korrekturen, 13 Blatt (GS 11, 145-157); Vortrag: "Über Kantische und moderne Ethik" Typsokript mit eigenhändigen Korrekturen, 6 Blatt (GS 11, S. 138-144);