908 resultados para 16:1(n-7) 16:1(n-5) 20:5(n-3)
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INTRODUCTION: The dichotomization of non-small cell carcinoma (NSCLC) subtype into squamous (SQCC) and adenocarcinoma (ADC) has become important in recent years and is increasingly required with regard to management. The aim of this study was to determine the utility of a panel of commercially available antibodies in refining the diagnosis on small biopsies and also to determine whether cytologic material is suitable for somatic EGFR genotyping in a prospectively analyzed series of patients undergoing investigation for suspected lung cancer. METHODS: Thirty-two consecutive cases of NSCLC were first tested using a panel comprising cytokeratin 5/6, P63, thyroid transcription factor-1, 34betaE12, and a D-PAS stain for mucin, to determine their value in refining diagnosis of NSCLC. After this test phase, two further pathologists independently reviewed the cases using a refined panel that excluded 34betaE12 because of its low specificity for SQCC, and refinement of diagnosis and concordance were assessed. Ten cases of ADC, including eight derived from cytologic samples, were sent for EGFR mutation analysis. RESULTS: There was refinement of diagnosis in 65% of cases of NSCLC to either SQCC or ADC in the test phase. This included 10 of 13 cases where cell pellets had been prepared from transbronchial needle aspirates. Validation by two further pathologists with varying expertise in lung pathology confirmed increased refinement and concordance of diagnosis. All samples were adequate for analysis, and they all showed a wild-type EGFR genotype. CONCLUSION: A panel comprising cytokeratin 5/6, P63, thyroid transcription factor-1, and a D-PAS stain for mucin increases diagnostic accuracy and agreement between pathologists when faced with refining a diagnosis of NSCLC to SQCC or ADC. These small samples, even cell pellets derived from transbronchial needle aspirates, seem to be adequate for EGFR mutation analysis.
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Segundo a abordagem sistmica, a transio para a parentalidade demarca uma das mais intensas mudanas do ciclo de vida de uma famlia. A melhor forma de compreender a famlia, tentar entend-la como um sistema, um todo, uma globalidade, como uma rede complexa de relaes e emoes que no so susceptveis de serem pensadas isoladamente (Oliveira, 2002). Porm, relevante a forma como cada indivduo, passa pela transio para a parentalidade. Considerou-se pertinente realizar um estudo que englobe a influncia que as preocupaes parentais apresentam na relao conjugal, tendo como objectivo clarificar a interaco entre as variveis j referidas e, ainda, a influncia que o sexo dos indivduos, o tempo de casamento e a idade dos filhos exerce nessa interaco. Para tal, recorreu-se a uma amostra de 42 indivduos, casados e com um nico filho, que responderam Escala de Avaliao da Satisfao em reas da Vida Conjugal (EASAVC) (Narciso & Costa, 1996), para avaliao da satisfao conjugal, e Escala de Preocupaes Parentais (EPP) (Algarvio, Leal, & Maroco, in press). Os resultados demonstram que a satisfao conjugal e as preocupaes parentais se encontram relacionadas entre si, no apresentando uma forte correlao. Contudo, constata-se que a satisfao conjugal aumenta diante de uma preocupao parental, do mesmo modo, se a preocupao parental for fraca, a satisfao conjugal tem valores mdios mais baixos. Os resultados apontam para que o gnero e os anos de casamento no influenciem os nveis de satisfao conjugal, bem como a idade dos filhos no influncia estas preocupaes, tendo-se ainda verificado que no existem diferenas entre sexos ao nvel das preocupaes parentais.
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Tesis (Ingeniero(a) en Automaziacin).--Universidad de La Salle. Facultad de Ingeniera. Programa de Ingeniera en Automatizacin
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El estudio de la delincuencia juvenil ha sido llevado a cabo generalmente con poblaciones pertenecientes a estratos socioecon?micos bajos, lo cual ha limitado su marco compresivo y explicativo. De tal forma que se han promovido los elevados niveles de pobreza y desigualdad social en los que vive gran parte de la poblaci?n del pa?s y de Latinoam?rica, como causa determinante de la participaci?n de j?venes en pr?cticas delincuenciales. Consideramos pertinente realizar un acercamiento a esta problem?tica, con el objetivo de comprender aquellos elementos, tanto del contexto socioecon?mico como del plano psicol?gico individual, que subyacen a la participaci?n de j?venes, de estratos altos y bajos, en din?micas delincuenciales
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This brochure, printed in Spanish, describes what to feed children ages one to five. Included are tips on how to make mealtimes happy, normal behavior and growth and appetite. A chart of daily recommended amounts from different food groups and a sample menu are included.
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This publication is volume 1, issue 5 of the University of South Carolina Publications. Series III. Biology. on taxonomic studies of the flora and fauna of South Carolina.
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A bimonthly literary magazine edited by Zhou Shoujuan , featuring fiction, topical articles, and entertainment features, published from September 1921 through November 1925.
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The crystal structures of the proton-transfer compounds of 5-sulfosalicylic acid (3-carboxy-4-hydroxybenzenesulfonic acid) with the aliphatic nitrogen Lewis bases, hydroxylamine, triethylamine, pyrrolidine, morpholine, N-methylmorpholine and piperazine, viz. hydroxyammonium 3-carboxy-4-hydroxybenzenesulfonate (1), triethylaminium 3-carboxy-4-hydroxybenzenesulfonate (2), pyrrolidinium 3-carboxy-4-hydroxybenzenesulfonate monohydrate (3), morpholinium 3-carboxy-4-hydroxybenzenesulfonate monohydrate (4), N-methylmorpholinium 3-carboxy-4-hydroxybenzenesulfonate monohydrate (5) and piperazine-1,4-diium bis(3-carboxy-4-hydroxybenzenesulfonate) hexahydrate (6) have been determined and their comparative structural features and hydrogen-bonding patterns described. Crystals of 4 are triclinic, space group P-1 while the remainder are monoclinic with space group either P21/c (1 - 3) or P21/n (5, 6). Unit cell dimensions and contents are: for 1, a = 5.0156(3), b = 10.5738(6), c = 18.4785(9) , = 96.412(5)o, Z = 4; for 2, a = 8.4998(4), b = 12.3832(6), c = 15.4875(9) , = 102.411(5)o, Z = 4; for 3, a = 6.8755(2), b = 15.5217(4), c = 12.8335(3) , = 92.074(2)o, Z = 4; for 4, a = 6.8397(2), b = 12.9756(5), c = 15.8216(6) , = 90.833(3), = 95.949(3), = 92.505(3)o, Z = 4; for 5, a = 7.0529(3), b = 13.8487(7), c = 15.6448(6) , = 90.190(6)o, Z = 4; for 6, a = 7.0561(2), b = 15.9311(4), c = 12.2102(3) , = 100.858(3)o, Z = 2. The hydrogen bonding generates structures which are either two-dimensional (2 and 5) or three-dimensional (1, 3, 4 and 6). Compound 6 represents the third reported structure of a salt of 5-sulfosalicylic acid having a dicationic piperazine species.
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Objective To determine whether a 5-day course of oral prednisolone is superior to a 3-day course in reducing the 2-week morbidity of children with asthma exacerbations who are not hospitalised. Design, setting and participants Double-blind randomised controlled trial of asthma outcomes following a 5-day course of oral prednisolone (1 mg/kg) compared with a 3-day course of prednisolone plus placebo for 2 days. Participants were children aged 215 years who presented to the emergency departments of three Queensland hospitals between March 2004 and February 2007 with an acute exacerbation of asthma, but were not hospitalised. Sample size was defined a priori for a study power of 90%. Main outcome measures Difference in proportion of children who were symptom-free at Day 7, as measured by intention-to-treat (ITT) and per-protocol analysis; quality of life (QOL) on Days 7 and 14. Results 201 children were enrolled, and there was an 82% completion rate. There was no difference between groups in the proportion of children who were symptom-free (observed difference, 0.04 [95% CI, 0.09 to 0.18] by ITT analysis; 0.04 [95% CI, 0.17 to 0.09] by per-protocol analysis). There was also no difference between groups in QOL (P = 0.42). The difference between groups for the primary outcome was within the equivalence range calculated post priori. Conclusion A 5-day course of oral prednisolone confers no advantage over a 3-day course for children with asthma exacerbations who are not hospitalised.
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C18H2204, orthorhombic, P212~21, a = 7.343 (4), b = 11.251 (4), c = 19.357 (4)A, Z = 4, Dr, ' = 1.20, D e = 1.254 g cm -3, F(000) = 648, p(Mo Ka) = 0.94 cm -~. X-ray intensity data were collected on a Nonius CAD-4 diffractometer and the structure was solved by direct methods. Full-matrix least-squares refinement gave R = 0.052 (R w = 0.045) for 1053 observed reflections. The stereochemical configuration at C(2) has been shown to be 2-exo-methyl-2-endo- (2,6-dimethoxyphenyl), i.e. (3) in contrast to the structure (2) assigned earlier based on its ~H NMR data.
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The title compound, C29H20ClNOS, is a 1-substituted-3-phenylisoquinoline that crystallizes with four independent molecules in the asymmtric unit. The four molecules have similar C-S-C angles. The most noteworthy differences between the molecules relate to the inclination of the 3-phenyl subsituent with respect to the isoquinoline fused-ring [dihedral angles of 21.2 (1), 25.6 (2), 34.3 (1) and 36.5 (2)degrees].
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A series of 2-5-oligoguanylic acids are prepared by reacting G(cyclic)p with takadiastase T1 ribonuclease and separating the products chromatographically. The 3-5-oligoguanylic acids are obtained by separating the products of alkaline degradation of 3-5-poly(G). The optical rotatory dispersion and hypochromism of both 2-5- and 3-5-oligoguanylic acids are studied at two different pH. The optical rotatory dispersion spectrum of 2-5-GpG is significantly different from that of 3-5-GpG. The magnitude of rotation of the long-wavelength peak of 2-5-GpG is larger than that of 3-5-GpG. This finding contradicts the explanation that the extra stability and more intense circular dichroism band of other 3-5-dinucleoside monophosphates is due to H-bond formation between 2-OH and either the base or the phosphate oxygen. The end phosphate group has a marked effect on the spectrum of GpG between 230 and 250 m. In addition the optical rotatory dispersion spectra of 2-5 exhibit strong pH, temperature, and solvent dependence between 230 and 250 m. H and AS for order disorder transition is estimated to be 9.7 kcal/mole and 35.2 eu, respectively. The optical rotatory dispersion spectra of guanine-rich oligoribonucleotides, GpGpC, GpGpU, GpGpGpC, and GpGpGpU are compared to the calculated optical rotatory dispersion from the semiempirical expression of Cantor and Tinoco, using measured optical rotatory dispersion of dimers. Contrary to previous studies, agreement is found not at all satisfactory. However, optical rotatory dispersion of 3-5-GpGpGpC and GpGpGpU can be estimated from the semiempirical expression, if a next-nearest interaction parameter is introduced empirically. Such interaction parameter can be calculated from the measured properties of trinucleotide sequences like GpGpG, GpGpC, and GpGpU, assuming that only the nearest-neighbor interaction is important. The optical rotatory dispersion of single-stranded poly(G) is also predicted. The importance of syn-anti equilibrium and next-nearest-neighbor interaction in oligoguanylic acids is suggested as a probable explanation.
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: p5 3 : 363114 16 p5 3 ,PCR SSCP p5 3 5 :p5 3 02 2 6 % (7/ 31)42 8% (6 / 14)5 0 % (8/ 16 ) ,PCR SSCP 5 : p5 3 , 5
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ZodiacSquareZodiac8Square,,Zodiac4,9Square,ZodiacSquare,12,13,14,1516Zodiac237.3,262.9,296.1,2137.12189.5,210.3,211,211.6,212.1212.6:16192bitZodiacSquare
